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1. Full Text Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
by Tremblay, Martin R and Lescarbeau, André and Grogan, Michael J and Tan, Eddy and Lin, Grace and Austad, Brian C and Yu, Lin-Chen and Behnke, Mark L and Nair, Somarajan J and Hagel, Margit and White, Kerry and Conley, James and Manna, Joseph D and Alvarez-Diez, Teresa M and Hoyt, Jennifer and Woodward, Caroline N and Sydor, Jens R and Pink, Melissa and MacDougall, John and Campbell, Matthew J and Cushing, Jill and Ferguson, Jeanne and Curtis, Michael S and McGovern, Karen and Read, Margaret A and Palombella, Vito J and Adams, Julian and Castro, Alfredo C
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of... 
CELL LUNG-CANCER | TERATOGENIC COMPOUNDS | CHEMISTRY, MEDICINAL | INHIBITION | SMALL-MOLECULE | SIGNALING PATHWAY | PANCREATIC-CANCER | PROSTATE-CANCER | IN-VIVO | CYCLOPAMINE | VERATRUM CALIFORNICUM DURAND | Veratrum Alkaloids - administration & dosage | Cell Line | Microsomes - metabolism | Administration, Oral | Stereoisomerism | Veratrum Alkaloids - pharmacokinetics | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - administration & dosage | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Veratrum Alkaloids - chemistry | Microsomes - drug effects | Animals | Signal Transduction - drug effects | Medulloblastoma - pathology | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Liver - cytology | Medulloblastoma - drug therapy | Index Medicus
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2. Full Text Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
by Chen, James K and Taipale, Jussi and Cooper, Michael K and Beachy, Philip A
Genes and Development, ISSN 0890-9369, 11/2002, Volume 16, Issue 21, pp. 2743 - 2748
The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to... 
Development | Hedgehog signaling | Smoothened | Teratogen | Cyclopamine | ENCODES | development | SONIC HEDGEHOG | SUBCELLULAR-LOCALIZATION | teratogen | RECEPTOR | DEVELOPMENTAL BIOLOGY | cyclopamine | DROSOPHILA | MEMBER | FAMILY | PATHWAY | GENETICS & HEREDITY | MUTATIONS | CUBITUS-INTERRUPTUS PROTEIN | Veratrum Alkaloids - toxicity | Teratogens - toxicity | Endoplasmic Reticulum - physiology | Receptors, G-Protein-Coupled | Antineoplastic Agents - toxicity | Trans-Activators - physiology | Veratrum Alkaloids - chemistry | Hedgehog Proteins | Animals | Receptors, Cell Surface - drug effects | Signal Transduction - drug effects | Teratogens - pharmacology | Endoplasmic Reticulum - drug effects | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Protein Binding | Protein Conformation | Receptors, Cell Surface - chemistry | Antineoplastic Agents - pharmacology | Mice | Receptors, Cell Surface - physiology | Binding Sites | 3T3 Cells | Hedgehogs | Antimitotic agents | Alkaloids | Analysis | Genetic research | Physiological aspects | Genetic aspects | Antineoplastic agents | Steroids (Drugs) | Index Medicus | Research Communication
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3. Full Text Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: Evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer
by Cho, Hyunah and Lai, Tsz Chung and Kwon, Glen S
Journal of Controlled Release, ISSN 0168-3659, 02/2013, Volume 166, Issue 1, pp. 1 - 9
Ovarian cancer is the most lethal gynecological malignancy, characterized by a high rate of chemoresistance. Current treatment strategies for ovarian cancer... 
Bioluminescence imaging | PET imaging | Polymeric micelles | Paclitaxel | Combination drug delivery | Ovarian cancer | SYSTEM | CELLS | EFFICACY | CHEMISTRY, MULTIDISCIPLINARY | CHEMOTHERAPY | THERAPY | INHIBITION | RESISTANCE | PHARMACOLOGY & PHARMACY | Veratrum Alkaloids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Gossypol - therapeutic use | Paclitaxel - pharmacology | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Ovarian Neoplasms - pathology | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Paclitaxel - chemistry | Micelles | Surface Properties | Veratrum Alkaloids - pharmacology | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Lactones - chemistry | Cell Survival - drug effects | Veratrum Alkaloids - therapeutic use | Injections, Intraperitoneal | Kaplan-Meier Estimate | Solubility | Treatment Outcome | Paclitaxel - therapeutic use | Veratrum Alkaloids - chemistry | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Cell Line, Tumor | Mice | Gossypol - chemistry | Gossypol - administration & dosage | Drugs | Ethylene glycol | Drug delivery systems | Polyethylene | Care and treatment | Models | Drug therapy, Combination | Gossypol | Cancer | Vehicles | Index Medicus | paclitaxel | polymeric micelles | combination drug delivery | ovarian cancer
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4. Full Text Native V. Californicum alkaloid combinations induce differential inhibition of sonic hedgehog signaling
by Turner, Matthew W and Cruz, Roberto and Elwell, Jordan and French, John and Mattos, Jared and McDougal, Owen M
Molecules, ISSN 1420-3049, 09/2018, Volume 23, Issue 9, p. 2222
Veratrum californicum is a rich source of steroidal alkaloids such as cyclopamine, a known inhibitor of the Hedgehog (Hh) signaling pathway. Here we provide a... 
Hedgehog signaling | Shh-Light II cells | Veratrum californicum | HPLC-MS | Cyclopamine | TERATOGENIC COMPOUNDS | STEROIDAL ALKALOIDS | VISMODEGIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | hedgehog signaling | cyclopamine | CHEMISTRY, MULTIDISCIPLINARY | VERATRAMINE | EXTRACTION | PATHWAY | RESISTANCE | MUTATIONS | Plant Leaves - chemistry | NIH 3T3 Cells | Alkaloids - pharmacology | Plant Extracts - pharmacology | Hedgehog Proteins - metabolism | Biomass | Reference Standards | Animals | Signal Transduction - drug effects | Plant Roots - chemistry | Mice | Plant Stems - chemistry | Veratrum - chemistry | Index Medicus
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5. Full Text Three new alkaloids from Veratrum grandiflorum Loes with inhibition activities on Hedgehog pathway
by Gao, Lijuan and Chen, Fengyang and Li, Xiaoyu and Xu, Shifang and Huang, Wenhai and Ye, Yiping
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2016, Volume 26, Issue 19, pp. 4735 - 4738
Three new steroidal alkaloids – , together with four known compounds – , were isolated from the ethanol extract of Loes. Their structures were elucidated by... 
Veratrum grandiflorum Loes | Shh-LIGHT 2 cells | Alkaloids | Cancers | Hedgehog pathway | STEROIDAL ALKALOIDS | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | CANCER | Cell Line | Spectrometry, Mass, Electrospray Ionization | Magnetic Resonance Spectroscopy | Humans | Veratrum Alkaloids - isolation & purification | Veratrum Alkaloids - pharmacology | Hedgehog Proteins - antagonists & inhibitors | Veratrum - chemistry | Veratrum Alkaloids - chemistry | Index Medicus
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6. Full Text Steroidal alkaloids from Veratrum nigrum enhance glucose uptake in skeletal muscle cells
by Kang, ChuHyun and Han, Joo-Hui and Oh, Joonseok and Kulkarni, Roshan and Zhou, Wei and Ferreira, Daneel and Jang, Tae Su and Myung, Chang-Seon and Na, MinKyun
Journal of Natural Products, ISSN 0163-3864, 04/2015, Volume 78, Issue 4, pp. 803 - 810
Veratrum nigrum is recognized as a medicinal plant used for the treatment of hypertension, stroke, and excessive phlegm. Chemical investigation of the roots... 
CHEMISTRY, MEDICINAL | TYROSINE-PHOSPHATASE 1B | MYOTUBES | RESISTANCE | RECEPTOR | ROOTS | PHARMACOLOGY & PHARMACY | MICE | INHIBITORS | INSULIN SENSITIVITY | RHIZOMES | PLANT SCIENCES | Plants, Medicinal - chemistry | Alkaloids - pharmacology | Stereoisomerism | Alkaloids - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Muscle, Skeletal - metabolism | Rhizome - chemistry | Plant Roots - chemistry | Glucose - metabolism | Steroids - isolation & purification | Steroids - pharmacology | Molecular Structure | Diabetes Mellitus, Type 2 - drug therapy | Thiazolidinediones - pharmacology | Veratrum - chemistry | Alkaloids - chemistry | Republic of Korea | Steroids - chemistry | Index Medicus
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7. Full Text Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
by Feldmann, Georg and Dhara, Surajit and Fendrich, Volker and Bedja, Djahida and Beaty, Robert and Mullendore, Michael and Karikari, Collins and Alvarez, Hector and Iacobuzio-Donahue, Christine and Jimeno, Antonio and Gabrielson, Kathleen L and Matsui, William and Maitra, Anirban
Cancer Research, ISSN 0008-5472, 03/2007, Volume 67, Issue 5, pp. 2187 - 2196
In the context of pancreatic cancer, metastasis remains the most critical determinant of resectability, and hence survival. The objective of this study was to... 
PATHWAYS | CELLS | NUDE-MOUSE | ONCOLOGY | ALDEHYDE DEHYDROGENASE-ACTIVITY | GROWTH | RECEPTOR | MICE | MODEL | EXPRESSION | CARCINOMA | Veratrum Alkaloids - administration & dosage | Neoplasm Invasiveness | Deoxycytidine - administration & dosage | Humans | Pancreatic Neoplasms - pathology | Male | Hedgehog Proteins - physiology | Hedgehog Proteins - antagonists & inhibitors | Drug Synergism | Pancreatic Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Neoplasm Metastasis - drug therapy | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Veratrum Alkaloids - pharmacology | Cell Proliferation - drug effects | Mice | Tumor Cells, Cultured | Deoxycytidine - analogs & derivatives | Index Medicus
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8. Full Text White-to-brown metabolic conversion of human adipocytes by JAK inhibition
by Moisan, A and Lee, Y. K and Zhang, J.D and Hudak, C.S and Meyer, C.A and Prummer, M and Zoffmann, S and Truong, H.H and Ebeling, M and Kiialainen, A and Gerard, R and Xia, F and Schinzel, R.T and Amrein, K.E and Cowan, C.A
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 1, pp. 57 - 67
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of new... 
ACTIVATION | OBESITY | THYROID-HORMONE | TYROSINE KINASE | MOUSE | FAT | UNCOUPLING PROTEIN GENE | CELLULAR PLASTICITY | DISCOVERY | ADIPOSE-TISSUE | CELL BIOLOGY | Adipocytes, White - cytology | Humans | Hedgehog Proteins - metabolism | Male | Gene Expression Profiling | Janus Kinase 3 - antagonists & inhibitors | Piperidines - pharmacology | Veratrum Alkaloids - pharmacology | Phosphorylation - drug effects | Oxazines - pharmacology | Ion Channels - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Mitochondrial Proteins - biosynthesis | Pyrimidines - pharmacology | Janus Kinase 1 - antagonists & inhibitors | STAT1 Transcription Factor - antagonists & inhibitors | Tumor Necrosis Factor-alpha - pharmacology | Pyrroles - pharmacology | Animals | Cell Differentiation - drug effects | Obesity - prevention & control | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Uncoupling Protein 1 | STAT3 Transcription Factor - antagonists & inhibitors | Adipocytes, Brown - cytology | Bone Morphogenetic Protein 7 | Interferon-gamma - biosynthesis | Interferon-gamma - pharmacology | Obesity | Care and treatment | Physiological aspects | Genetic aspects | Diagnosis | Biological response modifiers | Mammals | Health aspects | Risk factors | Index Medicus
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9. Full Text Synthesis of cyclopamine using a biomimetic and diastereoselective approach
by Giannis, Athanassios and Heretsch, Philipp and Sarli, Vasiliki and Stößel, Anne
Angewandte Chemie - International Edition, ISSN 1433-7851, 10/2009, Volume 48, Issue 42, pp. 7911 - 7914
Alkaloids | Antitumor agents | Natural products | Biomimetic synthesis | Cyclopamine | natural products | alkaloids | biomimetic synthesis | cyclopamine | CHEMISTRY, MULTIDISCIPLINARY | HEDGEHOG | antitumor agents | Veratrum Alkaloids - chemical synthesis | Biomimetics - methods | Signal Transduction - drug effects | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Veratrum Alkaloids - chemistry | Index Medicus
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10. Full Text Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
by Robert L. Yauch and Gerrit J. P. Dijkgraaf and Bruno Alicke and Thomas Januario and Christina P. Ahn and Thomas Holcomb and Kanan Pujara and Jeremy Stinson and Christopher A. Callahan and Tracy Tang and J. Fernando Bazan and Zhengyan Kan and Somasekar Seshagiri and Christine L. Hann and Stephen E. Gould and Jennifer A. Low and Charles M. Rudin and Frederic J. de Sauvage
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
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11. Full Text The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
by J.P. Incardona and W. Gaffield and R.P. Kapur and H. Roelink
Development, ISSN 0950-1991, 09/1998, Volume 125, Issue 18, pp. 3553 - 3562
The steroidal alkaloid cyclopamine produces cyclopia and holoprosencephaly when administered to gastrulation-stage amniote embryos. Cyclopamine-induced... 
Teratogenesis | Sonic hedgehog | Veratrum | Cyclopamine | Chick development | Cholesterol | Holoprosencephaly | COENZYME-A REDUCTASE | LEMLI-OPITZ-SYNDROME | TERMINAL CLEAVAGE PRODUCT | DEVELOPMENTAL BIOLOGY | holoprosencephaly | cyclopamine | SCLEROTOME INDUCTION | chick development | MOTOR-NEURON INDUCTION | teratogenesis | FLOOR PLATE | GENE | sonic hedgehog | cholesterol | DIFFERENTIATION | EXPRESSION | CHOLESTEROL-BIOSYNTHESIS | Antihypertensive Agents - pharmacology | Trans-Activators | PAX7 Transcription Factor | Cholesterol - metabolism | Central Nervous System - embryology | Chick Embryo | Muscle Proteins - biosynthesis | Hedgehog Proteins | Proteins - genetics | Animals | Transfection | trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride - pharmacology | Signal Transduction - drug effects | Teratogens - pharmacology | Homeodomain Proteins | Body Patterning | Nerve Tissue Proteins - biosynthesis | Veratrum Alkaloids - pharmacology | COS Cells | Proteins - antagonists & inhibitors | Anticholesteremic Agents - pharmacology | Index Medicus
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12. Full Text An intrinsic mechanism of corticogenesis from embryonic stem cells
by Passante, Lara and Espuny-Camacho, Ira and Dimidschstein, Jordane and Herpoel, Adèle and Hourez, Raphael and Schiffmann, Serge N and Vanderhaeghen, Pierre and van den Ameele, Jelle and Gaillard, Afsaneh and Naeije, Gilles and Gaspard, Nicolas and Bouschet, Tristan
Nature, ISSN 0028-0836, 09/2008, Volume 455, Issue 7211, pp. 351 - 357
The cerebral cortex develops through the coordinated generation of dozens of neuronal subtypes, but the mechanisms involved remain unclear. Here we show that... 
DIRECTED DIFFERENTIATION | NEOCORTEX | MULTIDISCIPLINARY SCIENCES | SPECIFICATION | FATE | DEVELOPING CEREBRAL-CORTEX | CORTICAL DEVELOPMENT | RADIAL GLIA | PRECURSORS | PROJECTION NEURON | TRANSPLANTATION | Embryonic Stem Cells - cytology | Axons - drug effects | Axons - physiology | Cell Lineage - drug effects | Cerebral Cortex - cytology | Animals | Cerebral Cortex - embryology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Veratrum Alkaloids - pharmacology | Mice | Pyramidal Cells - drug effects | Cerebral Cortex - drug effects | Usage | Cerebral cortex | Animal models in research | Neurons | Physiological aspects | Research | Embryonic stem cells | Neurosciences | Specifications | Stem cells | Gene expression | Embryos | Methods | Index Medicus | Life Sciences | Development Biology | Neurons and Cognition | Embryology and Organogenesis | Neurobiology
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13. Full Text Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
by Chen, Alan and VanArsdale, Todd and Munchhof, Michael and Kwon, Hyog Young and Beachy, Philip A and Chute, John P and Blum, Jordan and Kim, Jynho and Fereshteh, Mark and Zhao, Chen and Reya, Tannishtha and Rizzieri, David and Jamieson, Catriona H and Abrahamsson, Annelie
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7239, pp. 776 - 779
Although the role of Hedgehog (Hh) signalling in embryonic pattern formation is well established, its functions in adult tissue renewal and maintenance remain... 
CHRONIC MYELOGENOUS LEUKEMIA | PATHWAYS | PROGENITORS | THERAPY | GENE | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | BCR-ABL | RESISTANCE | PROLIFERATION | MECHANISMS | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Cells, Cultured | Hedgehog Proteins - physiology | Tomatine - analogs & derivatives | Tomatine - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Smoothened Receptor | Receptors, G-Protein-Coupled - antagonists & inhibitors | Veratrum Alkaloids - pharmacology | Proto-Oncogene Proteins c-abl - metabolism | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Mice | Receptors, G-Protein-Coupled - genetics | Neoplastic Stem Cells - physiology | Hedgehogs | Usage | Care and treatment | Myelocytic leukemia | Genetic aspects | Models | Nonlymphoid leukemia | Research | Drug resistance | Health aspects | Hematopoietic stem cells | Studies | Leukemia | Stem cells | Bone marrow | Cell division | Kinases | Binding sites | Cancer | Index Medicus
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14. Full Text The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence
by Jorge Ivan Alvarez and Aurore Dodelet-Devillers and Hania Kebir and Igal Ifergan and Pierre J. Fabre and Simone Terouz and Mike Sabbagh and Karolina Wosik and Lyne Bourbonnière and Monique Bernard and Jack van Horssen and Helga E. de Vries and Frédéric Charron and Alexandre Prat
Science, ISSN 0036-8075, 12/2011, Volume 334, Issue 6063, pp. 1727 - 1731
The blood-brain barrier (BBB) is composed of tightly bound endothelial cells (ECs) and perivascular astrocytes that regulate central nervous system (CNS)... 
T lymphocytes | Up regulation | Messenger RNA | Astrocytes | REPORTS | Central nervous system | Cell adhesion | Leukocytes | Lesions | Blood brain barrier | Blood proteins | DISRUPTION | MULTIPLE-SCLEROSIS | ANGIOGENESIS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ASTROCYTE-ENDOTHELIAL INTERACTIONS | CENTRAL-NERVOUS-SYSTEM | SPECIFICATION | EXPRESSION | AUTOIMMUNE ENCEPHALOMYELITIS | LYMPHOCYTES | Blood-Brain Barrier - cytology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Hedgehog Proteins - metabolism | Brain - physiology | CD4-Positive T-Lymphocytes - physiology | Hedgehog Proteins - genetics | Inflammation Mediators - metabolism | Veratrum Alkaloids - pharmacology | Blood-Brain Barrier - physiology | Female | Multiple Sclerosis - metabolism | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Electric Impedance | Permeability | Cell Adhesion | Animals | Multiple Sclerosis - immunology | Chemokines - metabolism | Mice | Brain - immunology | Astrocytes - metabolism | Cell Movement | Physiological aspects | Immunology | Research | Blood-brain barrier | Health aspects | Brain | Molecules | Pharmacology | Immune system | Index Medicus
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