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1.
Antitumor activity of isosteroidal alkaloids from the plants in the genus veratrum and fritillaria
Current protein & peptide science, ISSN 1389-2037, 2018, Volume 19, Issue 3, pp. 302 - 310
Antitumor activity | Fritillaria | Veratrum | Traditional chinese medicine | Isosteroidal alkaloids | Mechanism | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Alkaloids - pharmacology | Veratrum Alkaloids - therapeutic use | Apoptosis - drug effects | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents, Phytogenic - chemistry | Autophagy - drug effects | Neoplasms - drug therapy | Veratrum Alkaloids - chemistry | Animals | Fritillaria - chemistry | Signal Transduction - drug effects | Veratrum Alkaloids - pharmacology | Alkaloids - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Cell Cycle - drug effects | Neoplasms - pathology | Veratrum - chemistry | Alkaloids - chemistry | Plants (botany) | Caspase | Pharmacology | Inflammation | Autophagy | Caspase-3 | Anticancer properties | Alkaloids | Signal transduction | Signaling | Bioactive compounds | Hedgehog protein | Cell cycle | Phagocytosis | Tumors | Apoptosis
Journal Article
Journal of ethnopharmacology, ISSN 0378-8741, 02/2016, Volume 179, pp. 274 - 279
Pimacao | Analgesic | Steroidal alkaloids | Anti-inflammatory | V. taliense | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Analgesics - isolation & purification | Analgesics - pharmacology | Analgesics - therapeutic use | Plant Extracts - chemistry | Drugs, Chinese Herbal - pharmacology | Male | Pain Measurement - drug effects | Edema - drug therapy | Animals | Rhizome - chemistry | Drugs, Chinese Herbal - chemistry | Pain - drug therapy | Plant Roots - chemistry | Anti-Inflammatory Agents - therapeutic use | Female | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Phytotherapy | Veratrum - chemistry | Drugs, Chinese Herbal - therapeutic use | Plant Extracts - therapeutic use | Anti-inflammatory drugs | Alkaloids | Medicine, Chinese | Carrageenin | Acetic acid | Organic acids | Index Medicus
Journal Article
Medicinal research reviews, ISSN 0198-6325, 01/2016, Volume 36, Issue 1, pp. 119 - 143
anticancer effects | apoptosis | steroidal alkaloids | bioactivities | Anticancer effects | Bioactivities | Steroidal alkaloids | Apoptosis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Tomatine - chemistry | Tomatine - analogs & derivatives | Diosgenin - chemistry | Antineoplastic Agents - chemistry | Solanaceous Alkaloids - chemistry | Neoplasms - drug therapy | Veratrum Alkaloids - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Estrogens - chemistry | Cell Line, Tumor | Alkaloids - therapeutic use | Androgens - chemistry | Mice | Steroids - therapeutic use | Alkaloids - chemistry | Alkaloids | Health aspects | Plant metabolites | Cancer | Pharmaceutical industry | Index Medicus
Journal Article
The Alkaloids. Chemistry and biology, ISSN 1099-4831, 2015, Volume 74, pp. 201 - 232
Medicinal properties | Veratrum alkaloids | Solanum alkaloids | Synthesis | C-nor-D-homo-Steroids | Cyclopamine | Isolation | Animals | Diosgenin - pharmacology | Humans | Solanaceous Alkaloids - pharmacology | Veratrum Alkaloids - isolation & purification | Veratrum Alkaloids - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Molecular Structure | Diosgenin - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Solanaceous Alkaloids - chemistry | Veratrum Alkaloids - chemistry
Journal Article
Chemistry & biodiversity, ISSN 1612-1872, 02/2020, Volume 17, Issue 2, pp. e1900473 - n/a
chemometrics | Veratrum species | steroidal alkaloid | antihypertension | DNA damage | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | DNA Damage - drug effects | Plant Extracts - chemistry | Antihypertensive Agents - pharmacology | Veratrum - metabolism | Administration, Oral | Structure-Activity Relationship | Cerebral Cortex - metabolism | Veratrum Alkaloids - chemistry | Antihypertensive Agents - chemistry | Animals | Veratrum Alkaloids - pharmacology | Blood Pressure - drug effects | Mice | Cerebral Cortex - drug effects | Veratrum - chemistry | Principal Component Analysis | Cluster Analysis | Cerebellum | Hypertension | Cluster analysis | Cerebral cortex | Oral administration | Amino acid sequence | Esters | Principal components analysis | Alkaloids | Organic chemistry | Neurotoxicity | Ring structures | Benzene | Chemical activity | Brain damage | In vivo methods and tests | Blood pressure | Brain injury | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
6.
Advances in studies on steroidal alkaloids and their pharmacological activities in genus Veratrum
Zhongguo zhongyao zazhi, ISSN 1001-5302, 11/2020, Volume 45, Issue 21, p. 5129
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Veratrum Alkaloids - administration & dosage | Cell Line | Microsomes - metabolism | Administration, Oral | Stereoisomerism | Veratrum Alkaloids - pharmacokinetics | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - administration & dosage | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Veratrum Alkaloids - chemistry | Microsomes - drug effects | Animals | Signal Transduction - drug effects | Medulloblastoma - pathology | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Liver - cytology | Medulloblastoma - drug therapy | Index Medicus
Journal Article
Phytotherapy research, ISSN 0951-418X, 06/2010, Volume 24, Issue 6, pp. 821 - 826
hedgehog | steroidal alkaloid | antitumor | antiplatelet | Veratrum dahuricum | Antiplatelet | Hedgehog | Antitumor | Steroidal alkaloid | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Rabbits | Plant Extracts - pharmacology | Male | Animals | Veratrum Alkaloids - isolation & purification | Veratrum Alkaloids - pharmacology | Platelet Aggregation Inhibitors - pharmacology | Female | Mice | Mice, Inbred BALB C | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Veratrum - chemistry | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal of pharmaceutical and biomedical analysis, ISSN 0731-7085, 2008, Volume 48, Issue 3, pp. 573 - 578
Veratrum nigrum L | HPLC–ELSD | Quantification | Alkaloid profiling | Processing | HPLC-ELSD | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Analytical, structural and metabolic biochemistry | General pharmacology | Analysis | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Medicine, Chinese Traditional | Light | Volatilization | Molecular Structure | Scattering, Radiation | Calibration | Veratrum Alkaloids - analysis | Veratrum - chemistry | Veratrum Alkaloids - chemistry | Index Medicus
Journal Article
10.
Full Text
Steroidal alkaloids from Veratrum nigrum enhance glucose uptake in skeletal muscle cells
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 04/2015, Volume 78, Issue 4, pp. 803 - 810
Plants, Medicinal - chemistry | Alkaloids - pharmacology | Stereoisomerism | Alkaloids - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Muscle, Skeletal - metabolism | Rhizome - chemistry | Plant Roots - chemistry | Glucose - metabolism | Steroids - isolation & purification | Steroids - pharmacology | Molecular Structure | Diabetes Mellitus, Type 2 - drug therapy | Thiazolidinediones - pharmacology | Veratrum - chemistry | Alkaloids - chemistry | Republic of Korea | Steroids - chemistry | Index Medicus
Journal Article
11.
Full Text
The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
Development (Cambridge), ISSN 0950-1991, 09/1998, Volume 125, Issue 18, pp. 3553 - 3562
Teratogenesis | Sonic hedgehog | Veratrum | Cyclopamine | Chick development | Cholesterol | Holoprosencephaly | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Antihypertensive Agents - pharmacology | Trans-Activators | PAX7 Transcription Factor | Cholesterol - metabolism | Central Nervous System - embryology | Chick Embryo | Muscle Proteins - biosynthesis | Hedgehog Proteins | Proteins - genetics | Animals | Transfection | trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride - pharmacology | Signal Transduction - drug effects | Teratogens - pharmacology | Homeodomain Proteins | Body Patterning | Nerve Tissue Proteins - biosynthesis | Veratrum Alkaloids - pharmacology | COS Cells | Proteins - antagonists & inhibitors | Anticholesteremic Agents - pharmacology | Index Medicus
Journal Article
Journal of controlled release, ISSN 0168-3659, 02/2013, Volume 166, Issue 1, pp. 1 - 9
Bioluminescence imaging | PET imaging | Polymeric micelles | Paclitaxel | Combination drug delivery | Ovarian cancer | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Veratrum Alkaloids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Gossypol - therapeutic use | Paclitaxel - pharmacology | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Ovarian Neoplasms - pathology | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Paclitaxel - chemistry | Micelles | Surface Properties | Veratrum Alkaloids - pharmacology | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Lactones - chemistry | Cell Survival - drug effects | Veratrum Alkaloids - therapeutic use | Injections, Intraperitoneal | Kaplan-Meier Estimate | Solubility | Treatment Outcome | Paclitaxel - therapeutic use | Veratrum Alkaloids - chemistry | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Cell Line, Tumor | Mice | Gossypol - chemistry | Gossypol - administration & dosage | Drugs | Ethylene glycol | Drug delivery systems | Polyethylene | Care and treatment | Models | Drug therapy, Combination | Gossypol | Cancer | Vehicles | Index Medicus | paclitaxel | polymeric micelles | combination drug delivery | ovarian cancer
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2018, Volume 23, Issue 9, p. 2222
Hedgehog signaling | Shh-Light II cells | Veratrum californicum | HPLC-MS | Cyclopamine | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Leaves - chemistry | NIH 3T3 Cells | Alkaloids - pharmacology | Plant Extracts - pharmacology | Hedgehog Proteins - metabolism | Biomass | Reference Standards | Animals | Signal Transduction - drug effects | Plant Roots - chemistry | Mice | Plant Stems - chemistry | Veratrum - chemistry | Transcription factors | Congenital defects | Mass spectroscopy | Birth defects | Liquid chromatography | Metastasis | Standards | Investigations | Biological activity | Alkaloids | Signaling | Signal transduction | Side effects | Natural products | Ionization | Hedgehog protein | Ligands | Scientific imaging | Mass spectrometry | Index Medicus | hedgehog signaling | cyclopamine
Journal Article