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1. Antitumor activity of isosteroidal alkaloids from the plants in the genus veratrum and fritillaria
by Shang, Yuanhong and Du, Qingdan and Liu, Simei and Staadler, Maksorvor and Wang, Shu and Wang, Dongdong
Current protein & peptide science, ISSN 1389-2037, 2018, Volume 19, Issue 3, pp. 302 - 310
Antitumor activity | Fritillaria | Veratrum | Traditional chinese medicine | Isosteroidal alkaloids | Mechanism | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Alkaloids - pharmacology | Veratrum Alkaloids - therapeutic use | Apoptosis - drug effects | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents, Phytogenic - chemistry | Autophagy - drug effects | Neoplasms - drug therapy | Veratrum Alkaloids - chemistry | Animals | Fritillaria - chemistry | Signal Transduction - drug effects | Veratrum Alkaloids - pharmacology | Alkaloids - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Cell Cycle - drug effects | Neoplasms - pathology | Veratrum - chemistry | Alkaloids - chemistry | Plants (botany) | Caspase | Pharmacology | Inflammation | Autophagy | Caspase-3 | Anticancer properties | Alkaloids | Signal transduction | Signaling | Bioactive compounds | Hedgehog protein | Cell cycle | Phagocytosis | Tumors | Apoptosis
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2. Full Text Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense
by Li, Qiong and Yang, Kun-Xian and Zhao, Yun-Li and Qin, Xu-Jie and Yang, Xing-Wei and Liu, Lu and Liu, Ya-Ping and Luo, Xiao-Dong
Journal of ethnopharmacology, ISSN 0378-8741, 02/2016, Volume 179, pp. 274 - 279
Pimacao | Analgesic | Steroidal alkaloids | Anti-inflammatory | V. taliense | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Analgesics - isolation & purification | Analgesics - pharmacology | Analgesics - therapeutic use | Plant Extracts - chemistry | Drugs, Chinese Herbal - pharmacology | Male | Pain Measurement - drug effects | Edema - drug therapy | Animals | Rhizome - chemistry | Drugs, Chinese Herbal - chemistry | Pain - drug therapy | Plant Roots - chemistry | Anti-Inflammatory Agents - therapeutic use | Female | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Phytotherapy | Veratrum - chemistry | Drugs, Chinese Herbal - therapeutic use | Plant Extracts - therapeutic use | Anti-inflammatory drugs | Alkaloids | Medicine, Chinese | Carrageenin | Acetic acid | Organic acids | Index Medicus
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3. Full Text Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases
by Jiang, Qi‐Wei and Chen, Mei‐Wan and Cheng, Ke‐Jun and Yu, Pei‐Zhong and Wei, Xing and Shi, Zhi
Medicinal research reviews, ISSN 0198-6325, 01/2016, Volume 36, Issue 1, pp. 119 - 143
anticancer effects | apoptosis | steroidal alkaloids | bioactivities | Anticancer effects | Bioactivities | Steroidal alkaloids | Apoptosis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Tomatine - chemistry | Tomatine - analogs & derivatives | Diosgenin - chemistry | Antineoplastic Agents - chemistry | Solanaceous Alkaloids - chemistry | Neoplasms - drug therapy | Veratrum Alkaloids - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Estrogens - chemistry | Cell Line, Tumor | Alkaloids - therapeutic use | Androgens - chemistry | Mice | Steroids - therapeutic use | Alkaloids - chemistry | Alkaloids | Health aspects | Plant metabolites | Cancer | Pharmaceutical industry | Index Medicus
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4. The Veratrum and Solanum Alkaloids
by Heretsch, Philipp and Giannis, Athanassios
The Alkaloids. Chemistry and biology, ISSN 1099-4831, 2015, Volume 74, pp. 201 - 232
Medicinal properties | Veratrum alkaloids | Solanum alkaloids | Synthesis | C-nor-D-homo-Steroids | Cyclopamine | Isolation | Animals | Diosgenin - pharmacology | Humans | Solanaceous Alkaloids - pharmacology | Veratrum Alkaloids - isolation & purification | Veratrum Alkaloids - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Molecular Structure | Diosgenin - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Solanaceous Alkaloids - chemistry | Veratrum Alkaloids - chemistry
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5. Full Text A Structure‐Activity Relationship between the Veratrum Alkaloids on the Antihypertension and DNA Damage Activity in Mice
by Cong, Yue and Wu, Yantong and Shen, Shan and Liu, Xiping and Guo, Jinggong
Chemistry & biodiversity, ISSN 1612-1872, 02/2020, Volume 17, Issue 2, pp. e1900473 - n/a
chemometrics | Veratrum species | steroidal alkaloid | antihypertension | DNA damage | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | DNA Damage - drug effects | Plant Extracts - chemistry | Antihypertensive Agents - pharmacology | Veratrum - metabolism | Administration, Oral | Structure-Activity Relationship | Cerebral Cortex - metabolism | Veratrum Alkaloids - chemistry | Antihypertensive Agents - chemistry | Animals | Veratrum Alkaloids - pharmacology | Blood Pressure - drug effects | Mice | Cerebral Cortex - drug effects | Veratrum - chemistry | Principal Component Analysis | Cluster Analysis | Cerebellum | Hypertension | Cluster analysis | Cerebral cortex | Oral administration | Amino acid sequence | Esters | Principal components analysis | Alkaloids | Organic chemistry | Neurotoxicity | Ring structures | Benzene | Chemical activity | Brain damage | In vivo methods and tests | Blood pressure | Brain injury | Deoxyribonucleic acid--DNA | Index Medicus
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6. Advances in studies on steroidal alkaloids and their pharmacological activities in genus Veratrum
by Meng-Zhen, Zhang and Li-Juan, Gao and Shi-Fang, X U and Wen-Kang, Huang and Xiao-Yu, L I and Yi-Ping, Y E
Zhongguo zhongyao zazhi, ISSN 1001-5302, 11/2020, Volume 45, Issue 21, p. 5129
Platelet Aggregation | Steroids - pharmacology | Alkaloids - pharmacology | Analgesics | Veratrum
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7. Full Text Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
by Tremblay, Martin R and Lescarbeau, André and Grogan, Michael J and Tan, Eddy and Lin, Grace and Austad, Brian C and Yu, Lin-Chen and Behnke, Mark L and Nair, Somarajan J and Hagel, Margit and White, Kerry and Conley, James and Manna, Joseph D and Alvarez-Diez, Teresa M and Hoyt, Jennifer and Woodward, Caroline N and Sydor, Jens R and Pink, Melissa and MacDougall, John and Campbell, Matthew J and Cushing, Jill and Ferguson, Jeanne and Curtis, Michael S and McGovern, Karen and Read, Margaret A and Palombella, Vito J and Adams, Julian and Castro, Alfredo C
Journal of medicinal chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4400 - 4418
Biological and medical sciences | General aspects | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Veratrum Alkaloids - administration & dosage | Cell Line | Microsomes - metabolism | Administration, Oral | Stereoisomerism | Veratrum Alkaloids - pharmacokinetics | Humans | Hedgehog Proteins - metabolism | Antineoplastic Agents - administration & dosage | Hedgehog Proteins - antagonists & inhibitors | Antineoplastic Agents - chemistry | Drug Discovery | Veratrum Alkaloids - chemistry | Microsomes - drug effects | Animals | Signal Transduction - drug effects | Medulloblastoma - pathology | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Liver - cytology | Medulloblastoma - drug therapy | Index Medicus
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8. Full Text Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum
by Tang, Jian and Li, Hui‐Liang and Shen, Yun‐Heng and Jin, Hui‐Zi and Yan, Shi‐Kai and Liu, Xiao‐Hua and Zeng, Hua‐Wu and Liu, Run‐Hui and Tan, Ye‐Xiong and Zhang, Wei‐Dong
Phytotherapy research, ISSN 0951-418X, 06/2010, Volume 24, Issue 6, pp. 821 - 826
hedgehog | steroidal alkaloid | antitumor | antiplatelet | Veratrum dahuricum | Antiplatelet | Hedgehog | Antitumor | Steroidal alkaloid | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Rabbits | Plant Extracts - pharmacology | Male | Animals | Veratrum Alkaloids - isolation & purification | Veratrum Alkaloids - pharmacology | Platelet Aggregation Inhibitors - pharmacology | Female | Mice | Mice, Inbred BALB C | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Veratrum - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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9. Full Text Alkaloid profiling of crude and processed Veratrum nigrum L. through simultaneous determination of ten steroidal alkaloids by HPLC–ELSD
by Cong, Yue and Zhou, Yu-Bo and Chen, Jing and Zeng, Yi-Mei and Wang, Jin-Hui
Journal of pharmaceutical and biomedical analysis, ISSN 0731-7085, 2008, Volume 48, Issue 3, pp. 573 - 578
Veratrum nigrum L | HPLC–ELSD | Quantification | Alkaloid profiling | Processing | HPLC-ELSD | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Chemistry, Analytical | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Analytical, structural and metabolic biochemistry | General pharmacology | Analysis | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Reproducibility of Results | Chromatography, High Pressure Liquid - methods | Medicine, Chinese Traditional | Light | Volatilization | Molecular Structure | Scattering, Radiation | Calibration | Veratrum Alkaloids - analysis | Veratrum - chemistry | Veratrum Alkaloids - chemistry | Index Medicus
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10. Full Text Steroidal alkaloids from Veratrum nigrum enhance glucose uptake in skeletal muscle cells
by Kang, ChuHyun and Han, Joo-Hui and Oh, Joonseok and Kulkarni, Roshan and Zhou, Wei and Ferreira, Daneel and Jang, Tae Su and Myung, Chang-Seon and Na, MinKyun
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 04/2015, Volume 78, Issue 4, pp. 803 - 810
Plants, Medicinal - chemistry | Alkaloids - pharmacology | Stereoisomerism | Alkaloids - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Muscle, Skeletal - metabolism | Rhizome - chemistry | Plant Roots - chemistry | Glucose - metabolism | Steroids - isolation & purification | Steroids - pharmacology | Molecular Structure | Diabetes Mellitus, Type 2 - drug therapy | Thiazolidinediones - pharmacology | Veratrum - chemistry | Alkaloids - chemistry | Republic of Korea | Steroids - chemistry | Index Medicus
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11. Full Text The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
by J.P. Incardona and W. Gaffield and R.P. Kapur and H. Roelink
Development (Cambridge), ISSN 0950-1991, 09/1998, Volume 125, Issue 18, pp. 3553 - 3562
Teratogenesis | Sonic hedgehog | Veratrum | Cyclopamine | Chick development | Cholesterol | Holoprosencephaly | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Antihypertensive Agents - pharmacology | Trans-Activators | PAX7 Transcription Factor | Cholesterol - metabolism | Central Nervous System - embryology | Chick Embryo | Muscle Proteins - biosynthesis | Hedgehog Proteins | Proteins - genetics | Animals | Transfection | trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride - pharmacology | Signal Transduction - drug effects | Teratogens - pharmacology | Homeodomain Proteins | Body Patterning | Nerve Tissue Proteins - biosynthesis | Veratrum Alkaloids - pharmacology | COS Cells | Proteins - antagonists & inhibitors | Anticholesteremic Agents - pharmacology | Index Medicus
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12. Full Text Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: Evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer
by Cho, Hyunah and Lai, Tsz Chung and Kwon, Glen S
Journal of controlled release, ISSN 0168-3659, 02/2013, Volume 166, Issue 1, pp. 1 - 9
Bioluminescence imaging | PET imaging | Polymeric micelles | Paclitaxel | Combination drug delivery | Ovarian cancer | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Veratrum Alkaloids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Gossypol - therapeutic use | Paclitaxel - pharmacology | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Ovarian Neoplasms - pathology | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Paclitaxel - chemistry | Micelles | Surface Properties | Veratrum Alkaloids - pharmacology | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Lactones - chemistry | Cell Survival - drug effects | Veratrum Alkaloids - therapeutic use | Injections, Intraperitoneal | Kaplan-Meier Estimate | Solubility | Treatment Outcome | Paclitaxel - therapeutic use | Veratrum Alkaloids - chemistry | Xenograft Model Antitumor Assays | Gossypol - pharmacology | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Cell Line, Tumor | Mice | Gossypol - chemistry | Gossypol - administration & dosage | Drugs | Ethylene glycol | Drug delivery systems | Polyethylene | Care and treatment | Models | Drug therapy, Combination | Gossypol | Cancer | Vehicles | Index Medicus | paclitaxel | polymeric micelles | combination drug delivery | ovarian cancer
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13. Full Text Native V. Californicum alkaloid combinations induce differential inhibition of sonic hedgehog signaling
by Turner, Matthew W and Cruz, Roberto and Elwell, Jordan and French, John and Mattos, Jared and McDougal, Owen M
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2018, Volume 23, Issue 9, p. 2222
Hedgehog signaling | Shh-Light II cells | Veratrum californicum | HPLC-MS | Cyclopamine | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Leaves - chemistry | NIH 3T3 Cells | Alkaloids - pharmacology | Plant Extracts - pharmacology | Hedgehog Proteins - metabolism | Biomass | Reference Standards | Animals | Signal Transduction - drug effects | Plant Roots - chemistry | Mice | Plant Stems - chemistry | Veratrum - chemistry | Transcription factors | Congenital defects | Mass spectroscopy | Birth defects | Liquid chromatography | Metastasis | Standards | Investigations | Biological activity | Alkaloids | Signaling | Signal transduction | Side effects | Natural products | Ionization | Hedgehog protein | Ligands | Scientific imaging | Mass spectrometry | Index Medicus | hedgehog signaling | cyclopamine
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