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Diabetes, ISSN 0012-1797, 09/2018, Volume 67, Issue 9, pp. 1867 - 1879
Intermittent fasting (IF) protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is... 
DIABETIC-RETINOPATHY | BILE-ACID | CELLS | ACTIVATION | BACTERIA | OBESITY | METABOLISM | FARNESOID X RECEPTOR | C57BL/6 MICE | ENDOCRINOLOGY & METABOLISM | TAUROURSODEOXYCHOLIC ACID | Retina - drug effects | Leukocytes - pathology | Receptors, G-Protein-Coupled - metabolism | Colon - drug effects | Microvessels - metabolism | Microvessels - pathology | Colon - immunology | Male | Ganglia, Sensory - metabolism | Retina - immunology | Intestinal Mucosa - drug effects | Diabetic Retinopathy - complications | Retinal Vessels - pathology | Feces - microbiology | Intestinal Mucosa - immunology | Bacteroidetes - isolation & purification | Firmicutes - growth & development | Diabetic Retinopathy - immunology | Firmicutes - isolation & purification | Retinal Vessels - metabolism | Colon - pathology | Retinal Vessels - drug effects | Dysbiosis - therapy | Goblet Cells - metabolism | Colon - metabolism | Ganglia, Sensory - pathology | Diabetic Retinopathy - prevention & control | Gastrointestinal Microbiome - drug effects | Bile Acids and Salts - therapeutic use | Survival Analysis | Leukocytes - drug effects | Diabetes Mellitus, Type 2 - pathology | Dysbiosis - pathology | Retina - pathology | Intestinal Mucosa - pathology | Intestinal Mucosa - metabolism | Retina - metabolism | Diabetes Mellitus, Type 2 - microbiology | Ganglia, Sensory - drug effects | Goblet Cells - drug effects | Diabetic Retinopathy - pathology | Receptors, G-Protein-Coupled - agonists | Dysbiosis - microbiology | Microvessels - immunology | Ganglia, Sensory - immunology | Goblet Cells - immunology | Leukocytes - immunology | Retinal Vessels - immunology | Mice, Mutant Strains | Diabetes Mellitus, Type 2 - therapy | Bacteroidetes - immunology | Mice, Inbred DBA | Verrucomicrobia - growth & development | Verrucomicrobia - immunology | Diabetes Mellitus, Type 2 - complications | Fasting | Microvessels - drug effects | Firmicutes - immunology | Verrucomicrobia - isolation & purification | Dysbiosis - complications | Animals | Bacteroidetes - growth & development | Gastrointestinal Microbiome - immunology | Goblet Cells - pathology | Prevention | Diabetic retinopathy | Usage | Diet therapy | Low-calorie diet | Rattus | Rats | Health aspects | Complications | 0107
Journal Article
Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 91 - 97
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that... 
CELL LUNG-CANCER | MELANOMA | MICROENVIRONMENT | INTESTINAL MICROBIOTA | CYCLOPHOSPHAMIDE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | ANTITUMOR IMMUNITY | NIVOLUMAB | CD4 Antigens - immunology | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Gastrointestinal Microbiome - genetics | Fecal Microbiota Transplantation | Anti-Bacterial Agents - therapeutic use | Feces - microbiology | Metagenome - genetics | Neoplasms - therapy | Animals | Receptors, CCR - immunology | Interleukin-12 - immunology | Receptors, CXCR3 - immunology | T-Lymphocytes - immunology | Mice | Gastrointestinal Microbiome - immunology | Verrucomicrobia - genetics | Verrucomicrobia - immunology | Care and treatment | Cell receptors | Microbiota (Symbiotic organisms) | Immunotherapy | Epithelial tumors | Physiological aspects | Health aspects | Methods | Apoptosis | PD-1 protein | Interleukin | Microbiomes | Transplantation | Lymphocytes T | Anticancer properties | Microbiota | Lymphocytes | Bacteria | Feces | Supplementation | Gnotobiotics | Kidneys | Melanoma | Dietary supplements | Interleukin 12 | Abundance | CXCR3 protein | Patients | CD4 antigen | Immune checkpoint | Antibiotics | Lungs | Flora | PD-L1 protein | Relative abundance | Antitumor activity | CCR9 protein | Tumors | Kidney transplantation | Cancer | Life Sciences
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2016, Volume 6, Issue 1, p. 39026
Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether... 
NONHUMAN-PRIMATES | LIFE-SPAN | IMMUNE-SYSTEM | GENETICALLY HETEROGENEOUS MICE | MULTIDISCIPLINARY SCIENCES | CALORIC RESTRICTION | LACTOBACILLUS-CASEI | REGULATORY T-CELLS | GENE-EXPRESSION | INFLUENZA VACCINATION | FOXO TRANSCRIPTION FACTORS | Bifidobacterium - immunology | T-Lymphocyte Subsets - immunology | Area Under Curve | Furans - pharmacology | Immunosenescence - drug effects | Male | Gastrointestinal Microbiome - physiology | Lignans - pharmacology | Verrucomicrobia - physiology | Furans - pharmacokinetics | Aging - immunology | Forkhead Box Protein O3 - immunology | Lactobacillus - drug effects | T-Lymphocyte Subsets - drug effects | Female | Verrucomicrobia - immunology | Bifidobacterium - physiology | Lactobacillus - immunology | Mice, Inbred C57BL | CD3 Complex - metabolism | Rats, Sprague-Dawley | Forkhead Box Protein O3 - metabolism | Mice, Inbred ICR | Lignans - pharmacokinetics | Bifidobacterium - drug effects | Animals | Gastrointestinal Microbiome - drug effects | T-Lymphocyte Subsets - metabolism | CD3 Complex - immunology | Immunosenescence - immunology | Lactobacillus - physiology | Gastrointestinal Microbiome - immunology | Verrucomicrobia - drug effects | Lipopolysaccharide-binding protein | Middle age | Immunoregulation | Vaccination | Lymphocytes T | CD3 antigen | Inflammation | Cell activation | Lymphocytes | Influenza | Rodents | Immunosenescence | Foxp3 protein | Immunity (humoral) | FOXO3 protein | Immune system
Journal Article
Journal Article
PLoS One, ISSN 1932-6203, 2017, Volume 12, Issue 3, p. e0173004
Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well... 
GEN. NOV | INTESTINAL EPITHELIUM | BACTEROIDES-FRAGILIS | BACTERIA | MUCIN | ENTEROCYTES | ADHERES | MULTIDISCIPLINARY SCIENCES | ULCERATIVE-COLITIS | MICROBIOTA | INFECTION | Cell Line | Bacterial Outer Membrane Proteins - immunology | Toll-Like Receptor 2 - genetics | Cytokines - metabolism | Humans | Cells, Cultured | Gastrointestinal Microbiome | Toll-Like Receptor 4 - genetics | Intestinal Mucosa - microbiology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Intestinal Mucosa - immunology | Verrucomicrobia - pathogenicity | Verrucomicrobia - immunology | Cytokines - genetics | Bacterial Outer Membrane Proteins - genetics | Immune response | Microbiota (Symbiotic organisms) | Analysis | Mucins | Genetic aspects | Research | Health aspects | Lactobacillus plantarum | Laboratories | Genomics | Mucosa | Body weight | Microbiomes | Homeostasis | Mucus | Veterinary medicine | Proteins | Microorganisms | Microbiota | Protein composition | Immunology | Restoration | E coli | Rodents | Toll-like receptors | Bacteria | Immune system | Cytokines | Hematology | Immunoregulation | Animal sciences | Inflammation | TLR4 protein | Metabolism | Body weight gain | Bacteriology | Membrane proteins | Thickness | Inflammatory bowel disease | Pili | Molecular modelling | Interleukin 10 | Weight reduction | Diabetes | Host-Microbe Interactomics | Leerstoelgroep Host Microbe Interactomics | VLAG | Microbiologie | Microbiology | Laboratorium voor Microbiologie | Host Microbe Interactomics | Biochemistry | Microbiological Laboratory | WIAS | Biochemie | WIMEK
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 05/2016, Volume 7, Issue 22, pp. 31790 - 31799
Journal Article
Nature Medicine, ISSN 1078-8956, 2017, Volume 23, Issue 1, pp. 107 - 113
Obesity and type 2 diabetes are associated with low-grade inflammation and specific changes in gut microbiota composition. We previously demonstrated that... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUCIN | SAFETY | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | GUT MICROBIOTA | CELL BIOLOGY | INTESTINAL EPITHELIUM | DIET | INTEGRITY | INSULIN-RESISTANCE | INFLAMMATION | Intestines - drug effects | Humans | Middle Aged | Insulin Resistance | Male | Metabolic Syndrome - metabolism | Intestines - metabolism | Membrane Proteins - pharmacology | Diabetes Mellitus, Type 2 - metabolism | Toll-Like Receptor 2 - metabolism | Blotting, Western | Obesity - metabolism | Blood Glucose - drug effects | Animals | Verrucomicrobia | Toll-Like Receptor 2 - drug effects | Chromatography, Liquid | Dyslipidemias - metabolism | Adult | Female | Mice, Obese | Blood Glucose - metabolism | Adipose Tissue - drug effects | Disease Models, Animal | Obesity | Care and treatment | Development and progression | Genetic aspects | Gram-negative bacteria | Health aspects | Membrane proteins | Type 2 diabetes | Physiological aspects | Bacteria | Slopes | Metabolomics | Body fat | Complications | Digestive system | Diabetes mellitus | Pasteurization | Dyslipidemia | Metabolism | Insulin | Proteins | Microbiota | Intestine | Toll-like receptors | Mice | Diabetes mellitus (non-insulin dependent) | Digestive tract | Energy absorption | Immune system | Microbiological Laboratory | Microbiologie | Microbiology | VLAG | WIMEK | Laboratorium voor Microbiologie
Journal Article