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Science, ISSN 0036-8075, 3/2012, Volume 335, Issue 6074, pp. 1355 - 1359
Journal Article
Neuron, ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 425 - 439
Recent genome-wide association studies have linked common variants in the human genome to Parkinson@s disease (PD) risk. Here we show that the consequences of... 
LOCALIZATION | RETROMER | TRANSPORT | ELEGANS | GENE-EXPRESSION | TRAFFICKING | ALPHA | NEURODEGENERATION | MICE | NEUROSCIENCES | DROSOPHILA | rab5 GTP-Binding Proteins - genetics | Immunoprecipitation | Humans | Middle Aged | Cerebral Cortex - pathology | Male | Tubulin - genetics | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Statistics as Topic | Vesicle-Associated Membrane Protein 2 - genetics | Cerebral Cortex - cytology | Tyrosine 3-Monooxygenase | rab5 GTP-Binding Proteins - metabolism | Tubulin - metabolism | Transfection | Aged, 80 and over | Female | Neurons - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | Animals, Newborn | Synaptosomal-Associated Protein 25 - genetics | rab GTP-Binding Proteins - metabolism | Genetic Predisposition to Disease | Genome-Wide Association Study | Parkinson Disease - pathology | Animals, Genetically Modified | Drosophila | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Mutation - genetics | Rats, Sprague-Dawley | Protein Transport - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Polymorphism, Single Nucleotide - genetics | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Parkinson's disease | Neurons | Genomics | Risk factors | Brain | Laboratories | Parkinsons disease | Kinases | Gene expression | Experiments | Defects | Proteins | Pathology | Insects | Neurodegeneration | Gene loci | Mutation | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 07/2010, Volume 277, Issue 14, pp. 3051 - 3067
The cognitive impairment in patients with Alzheimer's disease is closely associated with synaptic loss in the neocortex and limbic system. Although the... 
amyloid | PSD95 | Shank | Alzheimer's disease | oligomers | BIOCHEMISTRY & MOLECULAR BIOLOGY | COGNITIVE IMPAIRMENT | DELETION SYNDROME | DENDRITIC SPINES | GLUTAMATE RECEPTORS | POSTSYNAPTIC DENSITY PROTEINS | SOLUBLE BETA-AMYLOID(1-40) | A-BETA | LONG-TERM POTENTIATION | NMDA RECEPTOR SUBUNITS | SECRETED OLIGOMERS | Disks Large Homolog 4 Protein | Amyloid beta-Peptides - pharmacology | Humans | Cerebral Cortex - pathology | Male | Dendritic Spines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Alzheimer Disease - diagnosis | Brain - metabolism | Dementia - metabolism | Synapses - metabolism | Protein Multimerization - physiology | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Mice, Inbred DBA | Cell Membrane - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Peptide Fragments - genetics | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Nerve Tissue Proteins - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Carrier Proteins - metabolism | Guanylate Kinases | Qa-SNARE Proteins - metabolism | Alzheimer Disease - metabolism | Brain - pathology | Cytosol - metabolism | Aged | Mice | Synaptosomal-Associated Protein 25 - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Protein Binding - physiology | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1530 - 1534
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor KB (NF-KB)-dependent... 
T lymphocytes | Molecules | Cytokines | Microscopy | Genes | REPORTS | Toll like receptors | Agonists | Macrophages | Cells | Endosomes | LOCALIZATION | ACTIVATION | DENDRITIC CELLS | TRAF3 | MULTIDISCIPLINARY SCIENCES | TLR9 | TOLL-LIKE-RECEPTOR-9 | INDUCTION | INTERFERON-ALPHA PRODUCTION | I INTERFERON | AP-3 ADAPTER | Recombinant Fusion Proteins - immunology | Dendritic Cells - immunology | Transcriptional Activation | Interferon Type I - immunology | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Toll-Like Receptor 9 - immunology | Cytoplasmic Vesicles - metabolism | Interferon Type I - metabolism | Membrane Transport Proteins - metabolism | Cytokines - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Cytokines - immunology | Oligodeoxyribonucleotides - immunology | Cytokines - metabolism | Signal Transduction | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 3 - metabolism | Adaptor Protein Complex beta Subunits | Interferon Regulatory Factor-7 - metabolism | Adaptor Protein Complex 3 - metabolism | Protein Transport | Animals | Adaptor Protein Complex 3 - genetics | Interferon Type I - genetics | Mice | Toll-Like Receptor 9 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Cellular control mechanisms | Physiological aspects | TLR7 | Research | Health aspects | Immune system | Proteins | Signal transduction | Interferon | Cellular biology | Index Medicus | Receptors | Compartments | Bifurcations | Activation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 34, pp. 14318 - 14323
Exocytosis of synaptic vesicles (SVs) during fast synaptic transmission is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor... 
Molecules | Histograms | Neurons | Bleaching | Synaptic transmission | SNARE proteins | Fluorescence | Recycling | Exocytosis | Synapses | Membrane fusion | SynaptopHluorin | Single molecule bleaching | SNARE density | CELLS | SECRETORY VESICLES | MULTIDISCIPLINARY SCIENCES | single molecule bleaching | SYNAPTIC-TRANSMISSION | ENERGETICS | 3 SNARE COMPLEXES | CA2+-TRIGGERED EXOCYTOSIS | synaptopHluorin | ENDOCYTOSIS | membrane fusion | HIPPOCAMPAL SYNAPSES | MEMBRANE-FUSION | PROTEINS | Green Fluorescent Proteins - metabolism | Synaptic Vesicles - metabolism | Calcium - pharmacology | Central Nervous System - metabolism | Vesicle-Associated Membrane Protein 3 - metabolism | Mice, Inbred C57BL | Vesicle-Associated Membrane Protein 2 - deficiency | Neurons - cytology | Hippocampus - cytology | Recombinant Fusion Proteins - metabolism | Exocytosis - drug effects | Mice, Knockout | Gene Dosage - drug effects | Animals | Central Nervous System - drug effects | Synaptic Vesicles - drug effects | Synaptic Transmission - drug effects | Mice | Neurons - metabolism | Vesicle-Associated Membrane Protein 3 - deficiency | Neurons - drug effects | Vesicle-Associated Membrane Protein 2 - metabolism | Membrane Fusion - drug effects | Physiological aspects | Health aspects | Central nervous system | Membrane proteins | Proteins | Nervous system | Membranes | Index Medicus | Biological Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2017, Volume 474, Issue 12, pp. 2039 - 2049
Misfolded alpha-synuclein (A-syn) is widely recognized as the primal cause of neurodegenerative diseases including Parkinson's disease and dementia with Lewy... 
MEMBRANE INTERACTIONS | SYNAPTIC VESICLES | IN-VITRO | NEUROTRANSMITTER RELEASE | LIPID VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINE | PROTEINS | BINDING | LEWY BODIES | PARKINSONS-DISEASE | Synaptic Vesicles - metabolism | SNARE Proteins - genetics | Humans | Syntaxin 1 - metabolism | Vesicle-Associated Membrane Protein 2 - genetics | Recombinant Fusion Proteins - metabolism | Nerve Tissue Proteins - chemistry | SNARE Proteins - chemistry | Syntaxin 1 - genetics | Vesicle-Associated Membrane Protein 2 - chemistry | Micelles | Protein Interaction Domains and Motifs | Syntaxin 1 - chemistry | alpha-Synuclein - genetics | Peptide Fragments - genetics | Synaptosomal-Associated Protein 25 - genetics | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Membrane Fusion | Phosphatidylserines - metabolism | Rats | Synaptotagmin I - chemistry | Synaptosomal-Associated Protein 25 - chemistry | Recombinant Fusion Proteins - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | alpha-Synuclein - chemistry | Nerve Tissue Proteins - metabolism | Peptide Fragments - chemistry | Animals | Models, Biological | Synaptotagmin I - metabolism | Synaptosomal-Associated Protein 25 - metabolism | Liposomes | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | alpha-Synuclein - metabolism | Amino Acid Substitution | Index Medicus
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 2011, Volume 18, Issue 5, pp. 542 - 549
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 39, pp. 16199 - 16210
Tumor cell invasion involves targeted localization of proteins required for interactions with the extracellular matrix and for proteolysis. The localization of... 
MEMBRANE-FUSION | MIGRATION | GLUT4 TRANSLOCATION | SM PROTEIN | METALLOPROTEINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | TRAFFICKING | PLASMA-MEMBRANE | SNARE | VAMP3 | Qb-SNARE Proteins - chemistry | Adenocarcinoma - pathology | Humans | Protein Multimerization | Qb-SNARE Proteins - metabolism | Extracellular Matrix - metabolism | Munc18 Proteins - metabolism | Neoplasm Proteins - antagonists & inhibitors | Green Fluorescent Proteins - genetics | Fibrosarcoma - metabolism | Neoplasm Proteins - metabolism | Vesicle-Associated Membrane Protein 2 - antagonists & inhibitors | Recombinant Fusion Proteins - metabolism | Podosomes - metabolism | Qa-SNARE Proteins - chemistry | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Fibrosarcoma - pathology | Qc-SNARE Proteins - metabolism | RNA Interference | Vesicle-Associated Membrane Protein 2 - chemistry | Munc18 Proteins - chemistry | Qa-SNARE Proteins - genetics | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Peptide Fragments - genetics | Binding, Competitive | Green Fluorescent Proteins - metabolism | Peptide Fragments - metabolism | Munc18 Proteins - genetics | Neoplasm Invasiveness | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Matrix Metalloproteinase 14 - metabolism | Munc18 Proteins - antagonists & inhibitors | Protein Transport | Podosomes - pathology | Peptide Fragments - chemistry | Qc-SNARE Proteins - chemistry | Qa-SNARE Proteins - metabolism | Cell Line, Tumor | Qc-SNARE Proteins - antagonists & inhibitors | Qb-SNARE Proteins - antagonists & inhibitors | Vesicle-Associated Membrane Protein 2 - metabolism | Extracellular Matrix - pathology | Index Medicus | invadopodia | epidermal growth factor receptor (EGFR) | matrix metalloproteinase (MMP) | syntaxin4 | cell invasion | trafficking | Munc18c | Cell Biology
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, pp. e03756 - e03756
Previously we showed that fast Ca2+-triggered vesicle fusion with reconstituted neuronal SNAREs and synaptotagmin-1 begins from an initial hemifusion-free... 
synaptic vesicle fusion | synaptotagmin | complexin | neurotransmitter release | membrane fusion | SNARE | MEMBRANE-FUSION | IN-VITRO | SNARE COMPLEX | EXOCYTOSIS | NEUROTRANSMITTER RELEASE | SYNAPTOTAGMIN | ESCHERICHIA-COLI | BIOLOGY | SWITCH | PROTEINS | BINDING | Synaptic Vesicles - metabolism | Calcium - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Neurons - cytology | Syntaxin 1 - metabolism | Exocytosis | Vesicle-Associated Membrane Protein 2 - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Calcium - chemistry | Nerve Tissue Proteins - chemistry | Syntaxin 1 - genetics | Biological Transport | Vesicle-Associated Membrane Protein 2 - chemistry | Escherichia coli - metabolism | Synaptic Vesicles - chemistry | Biological Assay | Adaptor Proteins, Vesicular Transport - chemistry | Neurons - metabolism | Syntaxin 1 - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Synaptosomal-Associated Protein 25 - genetics | Gene Expression | Membrane Fusion | Neurons - chemistry | Protein Refolding | Rats | Recombinant Proteins - chemistry | Synaptotagmin I - chemistry | Recombinant Proteins - genetics | Synaptosomal-Associated Protein 25 - chemistry | Synaptotagmin I - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Escherichia coli - genetics | Models, Biological | Synaptotagmin I - metabolism | Protein Binding | Synaptosomal-Associated Protein 25 - metabolism | Mutation | Vesicle-Associated Membrane Protein 2 - metabolism | Proteins | Dyes | Insects | Calcium | Physiology | Titration | Synaptotagmin | Vesicle fusion | Diaphragm | Associations | Synchronization | Index Medicus
Journal Article