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FEBS Journal, ISSN 1742-464X, 05/2010, Volume 277, Issue 10, pp. 2268 - 2281
TDP‐43 has recently been described as the major component of the inclusions found in the brain of patients with a variety of neurodegenerative diseases, such... 
microRNAs | miR‐663 | amyotrophic lateral sclerosis | TDP‐43 | let‐7b | Let-7b | Amyotrophic lateral sclerosis | MiR-663 | MicroRNAs | TDP-43 | BIOCHEMISTRY & MOLECULAR BIOLOGY | AMYOTROPHIC-LATERAL-SCLEROSIS | FRONTOTEMPORAL LOBAR DEGENERATION | let-7b | STRUCTURAL DETERMINANTS | RNA-BINDING PROTEIN | CELLULAR TOXICITY | miR-663 | EXPRESSION PATTERNS | DOWN-SYNDROME | GENE-EXPRESSION | CFTR EXON-9 | HNRNP A1 | RNA, Small Interfering - genetics | Protein Binding - genetics | Luciferases - metabolism | Gene Expression - genetics | Humans | MicroRNAs - metabolism | RNA, Messenger - metabolism | Luciferases - genetics | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Qa-SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 3 - genetics | Recombinant Proteins - metabolism | Base Sequence - genetics | Ribonuclease III - metabolism | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Genes, Reporter - genetics | Up-Regulation - genetics | Recombinant Proteins - genetics | DNA-Binding Proteins - genetics | Down-Regulation - genetics | Epoxide Hydrolases - genetics | Laminin - genetics | Cell Line, Tumor | MicroRNAs - genetics | HeLa Cells | Messenger RNA | Genetically modified organisms | Proteins | Brain | Biochemistry | Ribonucleic acid--RNA | Neurological disorders | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2017, Volume 13, Issue 4, pp. e1006698 - e1006698
The cellular machinery required for the fusion of constitutive secretory vesicles with the plasma membrane in metazoans remains poorly defined. To address this... 
CELLS | CYTOKINE SECRETION | SNARE COMPLEX | EXOCYTOSIS | PATHWAY | GENETICS & HEREDITY | GOLGI TRANSPORT | VAMP FAMILY | ENDOPLASMIC-RETICULUM | SYNTAXIN | SYNAPTIC VESICLE PROTEINS | Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins - genetics | R-SNARE Proteins - genetics | SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 3 - metabolism | Humans | R-SNARE Proteins - metabolism | Membrane Fusion - genetics | Shiga Toxin 1 - metabolism | Cell Membrane - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Protein Transport - genetics | Drosophila melanogaster - metabolism | Animals | RNA Interference | Golgi Apparatus - metabolism | Heterozygote | Cell Membrane - metabolism | Drosophila Proteins - genetics | SNARE Proteins - metabolism | Shiga Toxin 1 - genetics | Golgi Apparatus - genetics | Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins - metabolism | Vesicle-Associated Membrane Protein 3 - genetics | Physiological aspects | Genetic aspects | Cell membranes | Research | Gene expression | Drosophila | Medical research | Cytokines | Lipids | Genomes | Biology | Cell fusion | Ribonucleic acid--RNA | Machinery | Studies | Proteins | Molecular evolution | Cell growth | Secretory vesicles | Eukaryotes | Depletion | Insects | Plasma membranes | Extracellular matrix | Physiology | Endoplasmic reticulum | Combinatorial analysis | Plasmas (physics) | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2016, Volume 18, Issue 4, pp. 355 - 365
Aim: To determine the impact of a functional human islet clock on insulin secretion and gene transcription. Methods: Efficient circadian clock disruption was... 
human pancreatic islet | circadian bioluminescence | insulin secretion | RNA | circadian clock | sequencing | Circadian clock | RNA sequencing | Circadian bioluminescence | Human pancreatic islet | Insulin secretion | PERIPHERAL CLOCKS | SYSTEM | TRANSCRIPTOME | BEHAVIOR | BETA-CELLS | METABOLISM | CHANNEL | GENES | ENDOCRINOLOGY & METABOLISM | OSCILLATIONS | EXPRESSION | Islets of Langerhans - drug effects | Sodium-Potassium-Exchanging ATPase - genetics | Cation Transport Proteins - antagonists & inhibitors | Sodium-Potassium-Exchanging ATPase - chemistry | Zinc Transporter 8 | Humans | CLOCK Proteins - genetics | Gene Expression Profiling | Potassium Channels, Inwardly Rectifying - chemistry | Qa-SNARE Proteins - chemistry | CLOCK Proteins - metabolism | Insulin-Secreting Cells - metabolism | Vesicle-Associated Membrane Protein 3 - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | RNA Interference | Cation Transport Proteins - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Qa-SNARE Proteins - genetics | Cation Transport Proteins - genetics | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Insulin-Secreting Cells - cytology | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin Secretion | Vesicle-Associated Membrane Protein 3 - antagonists & inhibitors | Vesicle-Associated Membrane Protein 3 - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Circadian Clocks - drug effects | Colforsin - pharmacology | Vesicle-Associated Membrane Protein 3 - metabolism | CLOCK Proteins - antagonists & inhibitors | Cells, Cultured | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Potassium Channels, Inwardly Rectifying - genetics | Gene Expression Regulation - drug effects | Hyperglycemia - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Qa-SNARE Proteins - metabolism | Genes, Reporter - drug effects | Qa-SNARE Proteins - antagonists & inhibitors | RNA, Small Interfering | Cation Transport Proteins - chemistry | Potassium Channels, Inwardly Rectifying - metabolism | Pancreatic beta cells | Analysis | Glucose | Insulin | Dextrose | Circadian rhythm | Pancreas | Rodents | Circadian rhythms | Transcription | Secretion | Islet cells | siRNA | Islets of Langerhans | Gene expression | Index Medicus
Journal Article
Journal Article
Journal of Dental Research, ISSN 0022-0345, 7/2012, Volume 91, Issue 7_suppl, pp. S21 - S28
Pathological shifts of the human microbiome are characteristic of many diseases, including chronic periodontitis. To date, there is limited evidence on host... 
infection | genetics | bacteria | dentistry | genome-wide association studies | chronic periodontitis | VISUALIZATION | ADULTS | RISK | MICROBIOTA | HEALTHY | GENE POLYMORPHISMS | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | AGGREGATIBACTER-ACTINOMYCETEMCOMITANS | THICKNESS | Humans | Middle Aged | Periodontium - microbiology | Campylobacter rectus - classification | Male | Prevotella nigrescens - classification | Fusobacterium nucleatum - genetics | Prevotella intermedia - genetics | Interleukins - genetics | Metagenome - genetics | Chronic Periodontitis - microbiology | Trans-Activators - genetics | Treponema denticola - classification | Female | Bacteroides - classification | Porphyromonas gingivalis - genetics | Vesicle-Associated Membrane Protein 3 - genetics | Aggregatibacter actinomycetemcomitans - classification | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Nucleic Acid Hybridization | Interleukin-33 | Fusobacterium nucleatum - classification | Prevotella intermedia - classification | Potassium Channels, Tandem Pore Domain - genetics | Bacterial Load | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Prevotella nigrescens - genetics | Bacteroides - genetics | Campylobacter rectus - genetics | DNA, Bacterial - genetics | Treponema denticola - genetics | Aggregatibacter actinomycetemcomitans - genetics | Zinc Fingers - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Calcium-Binding Proteins - genetics | Porphyromonas gingivalis - classification | Index Medicus | Dentistry | Clinical Trials and Human Investigations
Journal Article
European Journal of Immunology, ISSN 0014-2980, 03/2008, Volume 38, Issue 3, pp. 855 - 863
Mediator release from mast cells (MC) is a crucial step in allergic and non-allergic inflammatory disorders. However, the final events in response to... 
Allergology | Cellular immunology | Mast cells | Mucosal immunity | FUSION | INVOLVEMENT | IMMUNOLOGY | mast cells | COMPOUND EXOCYTOSIS | IDENTIFICATION | cellular immunology | MEDIATOR RELEASE | HUMAN EOSINOPHILS | allergology | SNARE COMPLEXES | SNAP-23 | RECEPTORS | EXPRESSION | mucosal immunity | Gene Expression - drug effects | SNARE Proteins - genetics | Humans | Qb-SNARE Proteins - metabolism | R-SNARE Proteins - metabolism | Qb-SNARE Proteins - genetics | Cytoplasm - metabolism | Qc-SNARE Proteins - immunology | Vesicle-Associated Membrane Protein 2 - physiology | Vesicle-Associated Membrane Protein 2 - genetics | Vesicle-Associated Membrane Protein 3 - physiology | Qc-SNARE Proteins - metabolism | Mast Cells - metabolism | Qa-SNARE Proteins - genetics | Cell Membrane - metabolism | Histamine Release - drug effects | Vesicle-Associated Membrane Protein 3 - genetics | R-SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 3 - metabolism | Histamine Release - physiology | Mast Cells - physiology | Tetanus Toxin - pharmacology | Qa-SNARE Proteins - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mast Cells - drug effects | Blotting, Western | Antibodies - pharmacology | R-SNARE Proteins - physiology | Metalloendopeptidases - pharmacology | Qa-SNARE Proteins - metabolism | Fluorescent Antibody Technique | Qb-SNARE Proteins - immunology | Qc-SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 2 - metabolism | SNARE Proteins - metabolism | Cell Degranulation - physiology | Cell Degranulation - drug effects | Index Medicus | Qb-SNARE Proteins | Cell Membrane | Vesicle-Associated Membrane Protein 2 | Gene Expression | Vesicle-Associated Membrane Protein 3 | Cell Degranulation | Tetanus Toxin | R-SNARE Proteins | Antibodies | Metalloendopeptidases | Life Sciences | Immunology | Qa-SNARE Proteins | Qc-SNARE Proteins | Histamine Release | SNARE Proteins | Cytoplasm | Mast Cells
Journal Article
Journal of cell science, ISSN 0021-9533, 08/2015, Volume 128, Issue 15, pp. 2891 - 2902
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 913 - 18
Journal Article
FEBS Journal, ISSN 1742-464X, 2014, Volume 281, Issue 3, pp. 750 - 765
Fibroblast-like synoviocytes are important mediators of inflammatory joint damage in arthritis through the release of cytokines, but it is unknown whether... 
TNFα | Arthritis | SW982 | SNAREs | IL-6 | RHEUMATOID-ARTHRITIS | CYTOKINE SECRETION | TOXIN-A | TNF alpha | PROTEIN | BOTULINUM-NEUROTOXIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN SYNOVIOCYTES | SENSORY NEURONS | MEMBRANE-FUSION | arthritis | JOINT PAIN | CLOSTRIDIAL NEUROTOXINS | Arthritis - metabolism | Membrane Glycoproteins - metabolism | Humans | Qb-SNARE Proteins - metabolism | Qb-SNARE Proteins - genetics | Synovial Membrane - immunology | Protein Transport - drug effects | Synovial Membrane - drug effects | Molecular Targeted Therapy | Exocytosis - drug effects | Membrane Glycoproteins - antagonists & inhibitors | Protein Isoforms - metabolism | Qc-SNARE Proteins - metabolism | RNA Interference | Interleukin-1beta - metabolism | Anti-Inflammatory Agents - therapeutic use | Arthritis - immunology | Qa-SNARE Proteins - genetics | Vesicle-Associated Membrane Protein 3 - antagonists & inhibitors | Vesicle-Associated Membrane Protein 3 - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Vesicle-Associated Membrane Protein 3 - metabolism | Tumor Necrosis Factor-alpha - secretion | Interleukin-6 - secretion | Nerve Tissue Proteins - genetics | Synovial Membrane - metabolism | Membrane Glycoproteins - genetics | Receptors, Interleukin-1 - metabolism | Nerve Tissue Proteins - metabolism | Synovial Membrane - secretion | Calcium Signaling - drug effects | Qa-SNARE Proteins - metabolism | Arthritis - drug therapy | Cell Line, Tumor | Qc-SNARE Proteins - genetics | Qa-SNARE Proteins - antagonists & inhibitors | Qc-SNARE Proteins - antagonists & inhibitors | RNA, Small Interfering | Qb-SNARE Proteins - antagonists & inhibitors | Protein Isoforms - antagonists & inhibitors | Protein Isoforms - genetics | Index Medicus
Journal Article