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Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3645 - 3655
Journal Article
Glia, ISSN 0894-1491, 11/2011, Volume 59, Issue 11, pp. 1600 - 1611
We have previously demonstrated that human astrocytes are GABAergic cells. Throughout the adult human brain, they express the GABA synthesizing enzyme GAD 67,... 
D‐serine | calcium chelation | glycine | GABA transporters | GABA receptors | glutamate | glutamate receptors | Glutamate receptors | D-serine | Glutamate | Glycine | Calcium chelation | CA2+ INFLUX | CELLS | TRANSPORTER | RAT | SYNAPTIC-TRANSMISSION | RECEPTOR | IDENTIFICATION | NEUROSCIENCES | INDICATORS | BRAIN | Receptors, Glutamate - metabolism | Calcium - metabolism | gamma-Aminobutyric Acid - metabolism | Humans | Calcium - analysis | RNA, Messenger - biosynthesis | Vigabatrin - pharmacology | Culture Media | Egtazic Acid - analogs & derivatives | Astrocytes - chemistry | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Glutamic Acid - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Excitatory Amino Acid Agonists - pharmacology | Chelating Agents - pharmacology | DNA Primers | Vesicular Glutamate Transport Proteins - metabolism | Vesicular Glutamate Transport Proteins - genetics | Blotting, Western | Vesicular Glutamate Transport Proteins - antagonists & inhibitors | Egtazic Acid - pharmacology | Cyclohexanecarboxylic Acids - pharmacology | Astrocytes - metabolism | Cell culture | Enzymes | Glutamic acid | Calcium (intracellular) | 4-Aminobutyrate transaminase | Calcium | Astrocytes | Glutamic acid receptors (ionotropic) | Data processing | N-Methyl-D-aspartic acid receptors | Glutamate decarboxylase | Glutamic acid receptors | mRNA | gamma -Aminobutyric acid transporter | gamma -Aminobutyric acid B receptors | Neurotransmitters | gamma -Aminobutyric acid A receptors | Chelating agents
Journal Article
Journal Article
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 08/2017, Volume 56, Issue 30, pp. 3962 - 3971
The uptake of glutamate by synaptic vesicles is mediated by vesicular glutamate transporters (VGLUTs). The central role of these transporters in excitatory... 
PROTEIN FACTOR | BRAIN SYNAPTIC VESICLES | STRUCTURAL BIOLOGY | QUANTAL SIZE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VESICULAR GLUTAMATE TRANSPORTER | RELEASE | DEPENDENT GLUTAMATE | EXPRESSION | ASTROCYTES | TEMPORAL-LOBE | Membrane Transport Modulators - chemistry | Synaptic Vesicles - metabolism | Single-Domain Antibodies - metabolism | Vesicular Glutamate Transport Protein 1 - chemistry | Humans | Neurons - cytology | Green Fluorescent Proteins - genetics | Peptide Library | Central Nervous System Depressants - chemistry | Cerebral Cortex - cytology | Recombinant Fusion Proteins - metabolism | Cerebral Cortex - metabolism | Vesicular Glutamate Transport Protein 1 - genetics | Central Nervous System Depressants - pharmacology | Nerve Tissue Proteins - chemistry | Membrane Transport Modulators - pharmacology | HEK293 Cells | Synaptic Transmission - drug effects | Biological Transport - drug effects | Neurons - metabolism | Cerebral Cortex - drug effects | Green Fluorescent Proteins - chemistry | Neurons - drug effects | Vesicular Glutamate Transport Protein 1 - antagonists & inhibitors | Green Fluorescent Proteins - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Vesicular Glutamate Transport Protein 1 - metabolism | Cells, Cultured | Models, Molecular | Rats | Recombinant Fusion Proteins - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Membrane Transport Modulators - metabolism | Single-Domain Antibodies - pharmacology | Camelids, New World | Animals | Embryo, Mammalian - cytology | Single-Domain Antibodies - chemistry | Synaptic Vesicles - drug effects | Glutamic Acid - metabolism | Mice | Single-Domain Antibodies - genetics | Central Nervous System Depressants - metabolism | Llamas | Immunization | Usage | Research | Green fluorescent protein
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2014, Volume 24, Issue 3, pp. 850 - 854
Journal Article
Protein Science, ISSN 0961-8368, 09/2007, Volume 16, Issue 9, pp. 1819 - 1829
As membrane transporter proteins, VGLUT1–3 mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells.... 
docking | homology modeling | inhibitor | membrane protein structure | molecular dynamics | vesicular glutamate transporter | Molecular dynamics | Docking | Inhibitor | Membrane protein structure | Homology modeling | Vesicular glutamate transporter | SYNAPTIC VESICLES | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MAJOR FACILITATOR SUPERFAMILY | INORGANIC-PHOSPHATE COTRANSPORTER | SUGAR-BINDING | LACTOSE PERMEASE | GLYCEROL-3-PHOSPHATE TRANSPORTER | TRANSMEMBRANE TOPOLOGY | MEMBRANE-PROTEINS | Protein Structure, Tertiary | Amino Acid Sequence | Vesicular Glutamate Transport Protein 2 - chemistry | Protein Structure, Secondary | Vesicular Glutamate Transport Protein 1 - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Vesicular Glutamate Transport Proteins - metabolism | Vesicular Glutamate Transport Protein 2 - antagonists & inhibitors | Vesicular Transport Proteins - physiology | Sequence Homology, Amino Acid | Vesicular Glutamate Transport Proteins - antagonists & inhibitors | Transport Vesicles - metabolism | Vesicular Glutamate Transport Proteins - chemistry | Computer Simulation | Surface Properties | Conserved Sequence | Protein Binding | Protein Conformation | Glutamic Acid - metabolism | Binding Sites | Vesicular Glutamate Transport Protein 1 - antagonists & inhibitors | Naturvetenskap | vesicular glutamate transporter; homology modeling; membrane protein structure; inhibitor; docking; molecular dynamics | Natural Sciences
Journal Article
Brain Research, ISSN 0006-8993, 2012, Volume 1448, pp. 153 - 162
Abstract Loss of astrocytic glutamate transport capacity in ALS spinal cord supports an excitotoxic contribution to motor neuron (MN) damage in the disease,... 
Neurology | G93A | NOS | N-nitro-l-arginine methyl ester | Excitotoxicity | Amyotrophic lateral sclerosis | Motor neuron | 1-naphthyl acetylspermine | GLT-1 | NITRIC-OXIDE SYNTHASE | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | SELECTIVE MOTONEURON VULNERABILITY | NEUROSCIENCES | RAT MODEL | INCREASED 3-NITROTYROSINE | CU/ZN-SUPEROXIDE-DISMUTASE | IN-VITRO | MICE | TRANSGENIC MOUSE MODEL | Superoxide Dismutase - genetics | Spinal Cord - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Male | Nerve Degeneration - chemically induced | Polymerase Chain Reaction | Spinal Cord - cytology | Motor Neurons - drug effects | Organ Culture Techniques | Spermine - analogs & derivatives | NG-Nitroarginine Methyl Ester - pharmacology | Cell Survival - drug effects | Superoxide Dismutase - pharmacology | Rats, Transgenic | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Rats | Nerve Degeneration - pathology | Drug Synergism | Vesicular Glutamate Transport Proteins - antagonists & inhibitors | Amyotrophic Lateral Sclerosis - pathology | Animals | Spermine - pharmacology | Superoxide Dismutase-1 | Receptors, AMPA - antagonists & inhibitors | Nitrogen oxide | Zinc compounds | Cruelty to animals | Neurons | Analysis | Nitric oxide | Physiological aspects | Amino acids | Superoxide | Glutamate | motor neuron | excitotoxicity | amyotrophic lateral sclerosis
Journal Article
Neuroscience, ISSN 0306-4522, 2012, Volume 207, pp. 25 - 36
Abstract Metabotropic glutamate receptors (mGluR) can control neuronal excitability by modulating several ionic channels. In hippocampal pyramidal cells,... 
Neurology | slow afterhyperpolarization current | seizure | hippocampus | NMDA receptor | glutamate transporter | metabotropic glutamate receptor | Slow afterhyperpolarization current | Seizure | Glutamate transporter | Hippocampus | Metabotropic glutamate receptor | CURRENT I-AHP | NMDA RECEPTORS | K+ CURRENT | SYNAPTIC-TRANSMISSION | NEUROSCIENCES | CA1 PYRAMIDAL NEURONS | KAINATE RECEPTORS | DEVELOPING RAT HIPPOCAMPUS | MOSSY FIBER TERMINALS | SLOW AFTERHYPERPOLARIZATION | POSTNATAL-DEVELOPMENT | Animals, Newborn | Epilepsy - prevention & control | Synaptic Transmission - physiology | Vesicular Glutamate Transport Proteins - physiology | Rats, Wistar | Epilepsy, Temporal Lobe - drug therapy | Glutamic Acid - physiology | Rats | Receptors, Metabotropic Glutamate - physiology | Epilepsy - metabolism | Male | Epilepsy, Temporal Lobe - metabolism | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - metabolism | Vesicular Glutamate Transport Proteins - antagonists & inhibitors | Animals | Epilepsy - drug therapy | Female | Synaptic Transmission - drug effects | Receptors, Metabotropic Glutamate - agonists | Hippocampus - growth & development | Hippocampus - physiopathology | Epilepsy, Temporal Lobe - prevention & control | Organ Culture Techniques | Prevention | Methyl aspartate | Brain | Neurosciences | Pyridine | Phenylalanine | Marine toxins | Heterocyclic compounds | Sulfonamides | Amino acids | Seizures (Medicine) | Glutamate
Journal Article