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Molecular cell, ISSN 1097-2765, 09/2009, Volume 35, Issue 5, pp. 563 - 573
The target of rapamycin complex 1 (TORC1) is a central regulator of eukaryotic cell growth that is activated by a variety of hormones (e.g., insulin) and... 
CELLBIO | PROTEINS | SIGNALING | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Vacuoles - enzymology | Intracellular Membranes - enzymology | Saccharomyces cerevisiae - genetics | Multiprotein Complexes | Adaptor Proteins, Vesicular Transport - genetics | Saccharomyces cerevisiae - drug effects | Guanosine Triphosphate - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Vacuoles - drug effects | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Time Factors | Guanine Nucleotide Exchange Factors - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Guanosine Diphosphate - metabolism | Protein Synthesis Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Monomeric GTP-Binding Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Transport Systems - metabolism | Sirolimus - pharmacology | Cycloheximide - pharmacology | Protein Transport | Transcription Factors - metabolism | Monomeric GTP-Binding Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Endosomes - enzymology | Intracellular Membranes - drug effects | Mutation | Saccharomyces cerevisiae - growth & development | Proteins | Purines | Amino acids | Gross domestic product | Guanosine | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila. Here... 
Cytoskeletal Proteins | Flagellin | Immunoblotting | Legionella pneumophila | Macrophages | Adaptor Proteins, Vesicular Transport | Necrosis | Receptor, Interferon alpha-beta | Caspase 1 | Carrier Proteins | Calcium-Binding Proteins | Cytokines | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 | Mice, Knockout | Host-Pathogen Interactions | Animals | Apoptosis Regulatory Proteins | Bone Marrow Cells | Mice | Caspases | Enzyme Activation | Mutation | Apoptosis | Cell death | Innate immunity | Inflammasome | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Macrophages - metabolism | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Calcium-Binding Proteins - genetics | Genetic aspects | Research | Properties | Immunological research | Index Medicus | Biological Sciences | innate immunity | cell death | inflammasome
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2013, Volume 110, Issue 24, pp. 9800 - 9805
.... Here we show that transport protein particle III (TRAPPIII), a conserved autophagy-specif ic guanine nucleotide exchange factor for Ypt1/Rab1, is recruited to the PAS by Atg17... 
Proteins | Spheroplasts | Yeasts | Gels | Biological transport | Antibodies | HeLa cells | Physiological regulation | Nitrogen | Goods and services tax | Membrane tethering | GEF | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Kinases - metabolism | NIH 3T3 Cells | Autophagy-Related Proteins | Protein Kinases - genetics | Saccharomyces cerevisiae - genetics | Vesicular Transport Proteins - metabolism | Humans | Cercopithecus aethiops | Immunoblotting | rab GTP-Binding Proteins - genetics | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | Autophagy-Related Protein-1 Homolog | Saccharomyces cerevisiae - metabolism | Guanine Nucleotide Exchange Factors - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | rab GTP-Binding Proteins - metabolism | Green Fluorescent Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | rab1 GTP-Binding Proteins - metabolism | Membrane Proteins - genetics | Phagosomes - metabolism | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | rab1 GTP-Binding Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Golgi Apparatus - metabolism | Mice | HeLa Cells | COS Cells | Microscopy, Fluorescence | Autophagy (Cytology) | Research | Properties | Phosphotransferases | Golgi apparatus | Index Medicus | membrane tethering | Biological Sciences
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 221 - 235
Journal Article
Biochimica et biophysica acta. Molecular basis of disease, ISSN 0925-4439, 04/2015, Volume 1852, Issue 4, pp. 679 - 684
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 03/2016, Volume 126, Issue 4, pp. 1323 - 1336
.... Sortilin regulated the loading of the calcification protein tissue nonspecific alkaline phosphatase (TNAP... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phosphorylation | Muscle, Smooth, Vascular - metabolism | Casein Kinase I - genetics | Humans | Vascular Calcification - genetics | Adaptor Proteins, Vesicular Transport - genetics | Myocytes, Smooth Muscle - pathology | rab GTP-Binding Proteins - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Vascular Calcification - metabolism | Cell-Derived Microparticles - metabolism | Plaque, Atherosclerotic - pathology | Myocytes, Smooth Muscle - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | rab GTP-Binding Proteins - metabolism | Alkaline Phosphatase - genetics | Plaque, Atherosclerotic - metabolism | Cell-Derived Microparticles - genetics | Carrier Proteins - biosynthesis | Extracellular Matrix Proteins - genetics | Cells, Cultured | Vascular Calcification - pathology | Mice, Knockout | Protein Transport | Carrier Proteins - genetics | Muscle, Smooth, Vascular - pathology | Animals | Alkaline Phosphatase - biosynthesis | Casein Kinase I - metabolism | Mice | Casein Kinase II - metabolism | Calcium-Binding Proteins - genetics | Calcification | Phosphatases | Cellular proteins | Molecular targeted therapy | Innovations | Development and progression | Genetic aspects | Properties | Coronary heart disease | Proteins | Statistical analysis | Rodents | Acute coronary syndromes | Metabolism | Experiments | Manuscripts | Carotid arteries | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
FEBS letters, ISSN 0014-5793, 07/2015, Volume 589, Issue 16, pp. 2100 - 2109
...‐tagged ATG9, and increased autophagic flux independent of its transport activity. G6PT negatively regulated mTORC1 activity, demonstrating that G6PT functions upstream of mTORC1 in stimulating autophagy... 
Screening | G6PT | ULK1 | ATG9 | Autophagy modulator | glucose-6-phosphate transporter | N-terminus of Venus vector | chlorogenic acid | BiFC | bimolecular fluorescence complementation | CHA | C-terminus of Venus vector | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Vesicular Transport Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Intracellular Signaling Peptides and Proteins - genetics | Monosaccharide Transport Proteins - metabolism | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Monosaccharide Transport Proteins - genetics | Membrane Proteins - genetics | Phagosomes - metabolism | Recombinant Proteins - chemistry | Antiporters - metabolism | Recombinant Fusion Proteins - chemistry | Huntingtin Protein | Peptide Fragments - chemistry | Models, Biological | Protein-Serine-Threonine Kinases - chemistry | Antiporters - antagonists & inhibitors | Hepatocytes - enzymology | Autophagy-Related Proteins | Phagosomes - enzymology | Cricetulus | Hepatocytes - metabolism | Autophagy | Recombinant Fusion Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Hepatocytes - cytology | Nerve Tissue Proteins - chemistry | Antiporters - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Monosaccharide Transport Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Mutant Proteins - metabolism | Vesicular Transport Proteins - chemistry | Recombinant Proteins - genetics | Nerve Tissue Proteins - genetics | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Mutant Proteins - chemistry | Amino Acid Substitution | Phosphates | Enzymes | Glucose | Analysis | Dextrose | Index Medicus
Journal Article
Nature cell biology, ISSN 1476-4679, 06/2015, Volume 17, Issue 7, pp. 893 - 906
.... This allows for the sustained localization of PtdIns(3)P, which is critical for recruitment of downstream autophagic proteins and stabilization of the NOX2 complex to produce reactive oxygen species. Both PtdIns(3... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phagosomes - microbiology | Autophagy-Related Proteins | Phosphatidylinositol Phosphates - metabolism | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Vesicular Transport Proteins - metabolism | NADPH Oxidases - metabolism | Immunoblotting | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy | RNA Interference | Tumor Suppressor Proteins - genetics | Aspergillus fumigatus - physiology | NADPH Oxidases - genetics | Female | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - microbiology | Cell Line | Green Fluorescent Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Vesicular Transport Proteins - genetics | Class III Phosphatidylinositol 3-Kinases - metabolism | Mice, Transgenic | NADPH Oxidase 2 | Membrane Glycoproteins - genetics | Mice, Knockout | Host-Pathogen Interactions | Microscopy, Confocal | Macrophages - metabolism | Animals | Phagocytosis | Cellular proteins | Development and progression | Genetic aspects | Properties | Communicable diseases | Index Medicus
Journal Article