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Immunity, ISSN 1074-7613, 06/2014, Volume 40, Issue 6, pp. 961 - 973
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 10/2015, Volume 43, Issue 4, pp. 647 - 659
Pattern-recognition receptors (PRRs) including Toll-like receptors, RIG-I-like receptors, and cytoplasmic DNA receptors are essential for protection against... 
RESPONSES | CYLD | PROTEIN | EPIGENETIC CONTROL | CELL-DEVELOPMENT | UBIQUITYLATION | HISTONE H2A DEUBIQUITINASE | DIFFERENTIATION | IMMUNOLOGY | NF-KAPPA-B | A20 | RNA, Small Interfering - genetics | Receptors, Pattern Recognition - immunology | Vesiculovirus - immunology | Cytoplasm - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Listeria monocytogenes - immunology | Shock, Septic - immunology | TNF Receptor-Associated Factor 3 - chemistry | Interferon Type I - immunology | Proteasome Endopeptidase Complex | Endopeptidases - chemistry | Ubiquitination | Transfection | RNA Interference | Proteolysis | Listeriosis - immunology | Protein Structure, Tertiary | TNF Receptor-Associated Factor 3 - antagonists & inhibitors | Disease Susceptibility | Gene Expression Regulation - immunology | Infection - immunology | Mice, Transgenic | Inflammation - immunology | Endopeptidases - deficiency | Endopeptidases - immunology | Protein Interaction Mapping | Vesicular Stomatitis - immunology | Immunity, Innate - immunology | Models, Immunological | Animals | Endopeptidases - genetics | TNF Receptor-Associated Factor 6 - chemistry | RAW 264.7 Cells | Mice | Epigenetic inheritance | Septic shock | Biological response modifiers | Molecular biology | Health aspects | Proteins | Statistical analysis | Cytokines | Kinases | Basic Medicine | Medical and Health Sciences | Microbiology in the medical area | Mikrobiologi inom det medicinska området | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2010, Volume 185, Issue 10, pp. 6226 - 6233
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 22002
When retinoic acid-inducible gene 1 protein (RIG-I)-like receptors sense viral dsRNA in the cytosol, RIG-I and melanoma differentiation-associated gene 5... 
RNA | PATHWAY | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INNATE | MECHANISMS | INDUCTION | NF-KAPPA-B | ADAPTER PROTEIN | VIRAL REPLICATION | MDA5 | Enterovirus A, Human - genetics | RNA, Small Interfering - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Humans | NF-kappa B - immunology | Vesiculovirus - immunology | eIF-2 Kinase - immunology | NF-KappaB Inhibitor alpha - genetics | Influenza A Virus, H3N2 Subtype - genetics | Interferon Type I - immunology | Luciferases - genetics | RNA, Viral - genetics | RNA, Small Interfering - immunology | DEAD Box Protein 58 - genetics | Luciferases - immunology | HEK293 Cells | Pyruvate Carboxylase - immunology | Adaptor Proteins, Signal Transducing - immunology | Vesiculovirus - genetics | Cytokines - genetics | Genes, Reporter | Cytokines - immunology | eIF-2 Kinase - genetics | Signal Transduction | Enterovirus A, Human - immunology | Gene Expression Regulation | Pyruvate Carboxylase - genetics | NF-KappaB Inhibitor alpha - immunology | Hepatocytes - immunology | Immunity, Innate | Influenza A Virus, H3N2 Subtype - immunology | Pyruvate Carboxylase - antagonists & inhibitors | Interferon-Induced Helicase, IFIH1 - immunology | DEAD Box Protein 58 - immunology | Animals | NF-kappa B - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Hepatocytes - virology | Interferon Type I - genetics | RNA, Viral - immunology | RNA viruses | eIF-2 kinase | Phosphorylation | Immune response | Cytokines | Myxovirus resistance proteins | Double-stranded RNA | Melanoma | Pyruvic acid | Viruses | Biotin | Inflammation | Kinases | Cytosol | Pyruvate carboxylase | Nuclear transport | Proteins | Stomatitis | Mitochondria | Protein kinase | Transcription activation | Antiviral activity | Interferon | Retinoic acid
Journal Article
Nature Immunology, ISSN 1529-2908, 02/2013, Volume 14, Issue 2, pp. 179 - 185
The innate immune system senses viral DNA that enters mammalian cells, or in aberrant situations self-DNA, and triggers type I interferon production. Here we... 
AICARDI-GOUTIERES-SYNDROME | INTRACELLULAR DNA | NUCLEIC-ACID | PATHWAY | RIG-I | MUTATIONS | IMMUNOLOGY | PROTEINS | EXONUCLEASE TREX1 | AUTOIMMUNE-DISEASE | CELL-DEATH | Phosphoproteins - immunology | HMGB2 Protein - genetics | RNA, Small Interfering - genetics | Small Molecule Libraries - pharmacology | Dendritic Cells - immunology | Humans | Cytosol - drug effects | Cell Cycle Proteins - antagonists & inhibitors | Signal Transduction - immunology | Cell Cycle Proteins - immunology | HIV-1 - physiology | ATP-Binding Cassette Transporters - genetics | HSP90 Heat-Shock Proteins - immunology | Cell Cycle Proteins - genetics | Dendritic Cells - drug effects | HSP90 Heat-Shock Proteins - genetics | Dendritic Cells - virology | Nuclear Proteins - genetics | Fibroblasts - virology | Gene Expression Regulation - immunology | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphoproteins - genetics | Chaperonins - immunology | Immunity, Innate | Nuclear Proteins - immunology | Cytosol - virology | Gene Expression Regulation - drug effects | HMGB2 Protein - immunology | DNA, Viral - immunology | Animals | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Fibroblasts - drug effects | Proteomics | Cytosol - metabolism | Fibroblasts - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | DNA, Viral - genetics | ATP-Binding Cassette Transporters - immunology | Chaperonins - genetics | Vesiculovirus - physiology | Chaperonins - antagonists & inhibitors | Retrovirus infections | Heat shock proteins | Physiological aspects | Natural immunity | Genetic aspects | Research | Health aspects | Risk factors
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 267 - 281
TBK1 is a component of the type I interferon (IFN) signaling pathway, yet the mechanisms controlling its activity and degradation remain poorly understood.... 
TBK1 ubiquitination | K33 ubiquitination | USP38 deubiquitination | innate immune signaling | type I interferon response | TBK1 degradation | ANTIVIRAL RESPONSE | IMMUNITY | ACTIVATION | IFN-BETA PRODUCTION | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOSOLIC DNA | SENSOR | DEGRADATION | BINDING KINASE 1 | NF-KAPPA-B | CELL BIOLOGY | Phosphorylation | Ubiquitin-Specific Proteases - genetics | Vesiculovirus - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Interferon Type I - immunology | Polyubiquitin - genetics | DNA-Binding Proteins - metabolism | Bone Marrow Cells - virology | Signal Transduction - immunology | Ubiquitination | Macrophages - virology | Eukaryotic Initiation Factors - immunology | Herpesvirus 1, Human - growth & development | Bone Marrow Cells - immunology | Interferon Type I - metabolism | Herpesvirus 1, Human - immunology | Ubiquitin-Specific Proteases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Polyubiquitin - metabolism | Amino Acid Sequence | DNA-Binding Proteins - immunology | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | Proteins - immunology | Mice, Knockout | Host-Pathogen Interactions | Proteins - genetics | Macrophages - metabolism | Animals | Proteins - metabolism | Polyubiquitin - immunology | Vesiculovirus - growth & development | Ubiquitin-Specific Proteases - immunology | Interferon Type I - genetics | Protein-Serine-Threonine Kinases - immunology | Mice | Bone Marrow Cells - metabolism | Ubiquitin | Epigenetic inheritance | Medical colleges | Biological control | Genetically modified organisms | Genetic engineering | Interferon | Pests | Biological response modifiers
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 10, pp. 2121 - 2130
Journal Article
Immunity, ISSN 1074-7613, 02/2013, Volume 38, Issue 2, pp. 384 - 398
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3067 - 17
Current efforts to develop Zika virus (ZIKV) subunit vaccines have been focused on premembrane (prM) and envelope (E) proteins, but the role of NS1 in... 
PROTECTIVE IMMUNITY | NONSTRUCTURAL PROTEIN NS1 | DNA VACCINE | ENCEPHALITIS-VIRUS | MULTIDISCIPLINARY SCIENCES | WEST-NILE-VIRUS | CROSS-REACTIVITY | CANDIDATE VACCINE | VESICULAR STOMATITIS-VIRUS | DENGUE VIRUS | SEXUAL TRANSMISSION | Antigens, Viral - metabolism | Zika Virus - genetics | Vaccination | Viral Vaccines - genetics | Vaccines, DNA - immunology | Polyproteins - immunology | Vesiculovirus - immunology | Antigens, Viral - genetics | Male | Antibodies, Neutralizing - immunology | Th17 Cells - metabolism | Female | Zika Virus Infection - prevention & control | Zika Virus - metabolism | Disease Models, Animal | Viral Nonstructural Proteins - immunology | Zika Virus - immunology | Viral Envelope Proteins - genetics | Cytokines - metabolism | Genetic Vectors - immunology | Viral Nonstructural Proteins - genetics | Polyproteins - genetics | Th2 Cells - metabolism | Antigens, Viral - immunology | Animals | Vaccines, Attenuated | Vaccines, Synthetic | Zika Virus Infection - immunology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Viral Nonstructural Proteins - metabolism | Mice | Mice, Inbred BALB C | Viral Vaccines - immunology | Vector-borne diseases | Immunization | Immune response | Helper cells | Antibodies | Viruses | Zika virus | Lymphocytes T | Infections | Vaccines | Proteins | Stomatitis | Lymphocytes | Attenuation | Recombinant | Immune system
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 6, pp. 4517 - 4524
Journal Article