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Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 20, pp. 2457 - 2464
Highlights • We developed and tested a new oral ETEC vaccine in mice, alone and with an adjuvant. • The vaccine contains E. coli overexpressing CFA/I, CS3, CS5... 
Allergy and Immunology | Vaccine | Mucosal immunity | Immune responses | ETEC | dmLT | Colonization factors | DmLT | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | DIARRHEA | PREVENTION | IMMUNOLOGY | VIBRIO-CHOLERAE | CELL CHOLERA VACCINE | TRAVELERS | CONSTRUCTION | ENTEROTOXIGENIC ESCHERICHIA-COLI | INTRANASAL IMMUNIZATION | ANTIBODY-RESPONSES | Immunity, Mucosal - immunology | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Intestines - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - immunology | Cholera Toxin - immunology | Bacterial Toxins - genetics | Female | Escherichia coli Proteins - immunology | Immunoglobulin G - analysis | Mutant Proteins - immunology | Fimbriae Proteins - immunology | Cholera Toxin - administration & dosage | Antibody Formation - immunology | Vaccines, Inactivated - genetics | Administration, Oral | Bacterial Toxins - immunology | Escherichia coli Infections - microbiology | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Mutant Proteins - administration & dosage | Enterotoxins - administration & dosage | Vaccines, Inactivated - adverse effects | Enterotoxins - genetics | Vaccines, Inactivated - immunology | Animals | Escherichia coli Vaccines - adverse effects | Fimbriae Proteins - genetics | Vaccines, Inactivated - administration & dosage | Cholera Toxin - genetics | Immunoglobulin A - immunology | Escherichia coli Proteins - genetics | Immunoglobulin A - blood | Bacterial Toxins - administration & dosage | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Mice | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Immunoglobulin A - analysis | Antigens | Safety and security measures | Analysis | Escherichia coli | Bacteria | Vaccines | Contamination | Proteins | Studies | Immunology | E coli | Rodents | Index Medicus | Basic Medicine | Medicinska grundvetenskaper
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2699 - 2714
The long-held paradigm that B cells cannot uptake nonspecific particulate Ags for the initiation of primary adaptive immunity has been challenged by the recent... 
MICROBICIDAL ABILITIES | ZEBRAFISH | DENDRITIC CELLS | EARLY VERTEBRATES | INFECTION | IMMUNOLOGY | EXPRESSION | T-CELLS | RELEVANT GENES | ANTIGEN | LYMPHOCYTES | Antigens, CD - immunology | B7-2 Antigen - genetics | B7-1 Antigen - genetics | Zebrafish - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Molecular Sequence Data | Male | B7 Antigens - immunology | Gene Expression Profiling | Immunoglobulins - genetics | Phylogeny | Antigens, CD - genetics | Adaptive Immunity - genetics | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Immunoglobulins - metabolism | Lymphocyte Activation - immunology | B7 Antigens - genetics | Base Sequence | Zebrafish Proteins - immunology | B-Lymphocyte Subsets - immunology | Female | Membrane Glycoproteins - immunology | Adaptive Immunity - immunology | B7-2 Antigen - immunology | B-Lymphocytes - metabolism | Amino Acid Sequence | Antigen-Presenting Cells - metabolism | Vibrio alginolyticus - immunology | B7-1 Antigen - immunology | Zebrafish Proteins - metabolism | CD4-Positive T-Lymphocytes - metabolism | B7-1 Antigen - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Antigen-Presenting Cells - immunology | Blotting, Western | Zebrafish - genetics | B7 Antigens - metabolism | Membrane Glycoproteins - genetics | Sequence Homology, Amino Acid | B7-2 Antigen - metabolism | Animals | B-Lymphocytes - immunology | B-Lymphocyte Subsets - metabolism | Zebrafish Proteins - genetics | Evolution, Molecular
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 9, p. e106543
NK-lysin is an antimicrobial protein produced by cytotoxic T lymphocytes and natural killer cells. In this study, we examined the biological property of a... 
CELLS | DEFENSE | CYNOGLOSSUS-SEMILAEVIS | MULTIDISCIPLINARY SCIENCES | ANTIMICROBIAL PEPTIDE | INNATE | FISH | SYNTHETIC PEPTIDE | IDENTIFICATION | EXPRESSION | GRANULYSIN | Antimicrobial Cationic Peptides - immunology | DNA, Bacterial - metabolism | Streptococcal Infections - veterinary | Molecular Sequence Data | Flatfishes - genetics | Vibrio Infections - immunology | Antimicrobial Cationic Peptides - administration & dosage | Host-Pathogen Interactions - immunology | Vibrio - metabolism | Streptococcal Infections - genetics | Fish Proteins - genetics | Bacterial Infections - genetics | Vibrio Infections - genetics | Proteolipids - immunology | Bacterial Infections - immunology | Fish Diseases - immunology | Antimicrobial Cationic Peptides - genetics | Virus Diseases - genetics | Vibrio Infections - veterinary | Amino Acid Sequence | Proteolipids - administration & dosage | Gene Expression | Fish Diseases - microbiology | Proteolipids - genetics | Virus Diseases - immunology | Fish Proteins - immunology | Flatfishes - immunology | Pseudomonas fluorescens | Bacterial Infections - veterinary | Fish Proteins - administration & dosage | Pseudomonas Infections - genetics | Pseudomonas Infections - immunology | Sequence Homology, Amino Acid | Pseudomonas Infections - veterinary | Animals | Fish Diseases - virology | Host-Pathogen Interactions - genetics | Virus Diseases - veterinary | Streptococcal Infections - immunology | Vibrio - pathogenicity | Peptides | DNA | Aquaculture industry | Fishes | Bacteria | Bacterial genetics | Health aspects | Biological properties | Laboratories | Gram-positive bacteria | Cytotoxicity | Amino acids | Lymphocytes T | Infections | Antiinfectives and antibacterials | Degradation | Killer cells | Clonal deletion | E coli | Lymphocytes | Animal tissues | Antimicrobial peptides | Deletion | Fish | Natural killer cells | Deoxyribonucleic acid--DNA | Immune system | Biodegradation | Pathogens | Immune response | Staphylococcus infections | Marine biology | Antimicrobial agents | Gene expression | Bactericidal activity | In vivo methods and tests | Cytoplasm | Viral infections | Aquaculture | Deoxyribonucleic acid
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 08/2015, Volume 66, Issue 2, pp. 439 - 450
C-type lectin receptors (CTLRs) play vital roles in immune responses as pattern-recognition receptors (PRRs). In this study, we identified a novel C-type... 
C-type lectin receptor | Monocytes/macrophages | Pathogen recognition | Phagocytic activity | Bacterial killing | PHAGOCYTOSIS | PROTEIN | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MANNOSE-RECEPTOR | IMMUNOLOGY | DC-SIGN | TELEOST FISH | EXPRESSION | INNATE IMMUNITY | Vibrio - immunology | Lectins, C-Type - immunology | Lipopolysaccharides - metabolism | Molecular Sequence Data | Monocytes - immunology | Listeria monocytogenes - immunology | Phylogeny | Lectins, C-Type - genetics | Aeromonas hydrophila - immunology | Lipopolysaccharides - immunology | Fish Proteins - genetics | Receptors, Mitogen - immunology | Hexoses - immunology | Macrophages - immunology | Macrophages - microbiology | Osmeriformes - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Monocytes - microbiology | Fish Proteins - chemistry | Fish Proteins - immunology | Signal Transduction | Osmeriformes - classification | Gene Expression Regulation | Escherichia coli - immunology | Hexoses - metabolism | Receptors, Mitogen - chemistry | Salmo salar - classification | Salmo salar - genetics | Sequence Homology, Amino Acid | Salmo salar - immunology | Osmeriformes - immunology | Sequence Alignment | Animals | Staphylococcus aureus - immunology | Phagocytosis | Receptors, Mitogen - genetics | Lectins | Bacteria | Genes | Escherichia coli | Analysis | Immunoglobulin G | Genetic research | Cellular signal transduction | Mitogens | Sugars | Monosaccharides
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4299 - 4309
Like other Gram-negative pathogens, Vibrio cholerae, the causative agent of the diarrheal disease cholera, secretes outer membrane vesicles (OMVs). OMVs are... 
ACTIVATION | PEPTIDOGLYCAN | INTERLEUKIN-17 | PSEUDOMONAS-AERUGINOSA | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-17 | INNATE IMMUNE-RESPONSE | VIRULENCE | NF-KAPPA-B | EXPRESSION | INFLAMMATORY MEDIATORS | Intestinal Mucosa - metabolism | Epithelial Cells - metabolism | Dendritic Cells - immunology | Humans | Mitogen-Activated Protein Kinase Kinases - immunology | NF-kappa B - immunology | NF-kappa B - metabolism | Th2 Cells - immunology | MAP Kinase Signaling System - immunology | Nod1 Signaling Adaptor Protein - metabolism | Host-Pathogen Interactions - immunology | Th2 Cells - microbiology | Mitogen-Activated Protein Kinase Kinases - metabolism | Th17 Cells - metabolism | Intestinal Mucosa - immunology | HEK293 Cells | Cholera - immunology | Dendritic Cells - metabolism | Cytokines - immunology | Gene Expression Regulation - immunology | Cholera - metabolism | Intestinal Mucosa - microbiology | Nod1 Signaling Adaptor Protein - immunology | Th2 Cells - metabolism | Epithelial Cells - immunology | Epithelial Cells - microbiology | Dendritic Cells - microbiology | Th17 Cells - immunology | Vibrio cholerae - physiology | Cytokines - biosynthesis | Th17 Cells - microbiology | Cholera - microbiology | Vesicles | Immunology | Dendritic Cells | Vibrio cholerae | Immune Response | Cytokine | Inflammation | Epithelial Cells | Cellular Immune Response | Chemokines | Outer Membrane Vesicles
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 11/2018, Volume 88, pp. 152 - 160
The Notch signaling pathway transcriptional regulator, CSL (also called as CBF1, Suppressor of Hairless or Lag-1 in different species, generally designated as... 
Hemocytes proliferation | Immune resistance | Litopenaeus vannamei | LvCSL | PENAEID SHRIMP | DENDRITIC CELLS | NOTCH | IMMUNOLOGY | ADAPTIVE IMMUNITY | NEURAL STEM-CELLS | FISHERIES | ZOOLOGY | DISEASE | VIBRIO-ALGINOLYTICUS | INFECTION | DIFFERENTIATION | NF-KAPPA-B | Vibrio parahaemolyticus - immunology | Hemocytes - immunology | Arthropod Proteins - isolation & purification | Disease Resistance - immunology | Phylogeny | Vibrio Infections - immunology | Protein Domains - genetics | Gene Knockdown Techniques | Host-Pathogen Interactions - immunology | Cloning, Molecular | Fish Diseases - immunology | Protein Domains - immunology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - genetics | Vibrio Infections - veterinary | Gene Expression Regulation - immunology | Penaeidae - genetics | Penaeidae - microbiology | Arthropod Proteins - genetics | Arthropod Proteins - immunology | Sequence Homology, Nucleic Acid | Vibrio Infections - virology | Sequence Alignment | Animals | Fish Diseases - virology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - immunology | Immunoglobulin J Recombination Signal Sequence-Binding Protein - isolation & purification | Aquaculture | Hepatopancreas - immunology | Penaeidae - immunology | Immune response | Analysis | Cloning | Mortality | Genetic aspects | Genetic transcription | Cell differentiation | Health aspects | Mitogens
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1606 - 13
The recognition of pathogen-derived ligands by pattern recognition receptors activates the innate immune response, but the potential interaction of... 
RESPONSES | ACTIVATION | GRAM-NEGATIVE BACTERIA | UBIQUITIN LIGASE | MULTIDISCIPLINARY SCIENCES | HEPATITIS-C-VIRUS | TOLL-LIKE RECEPTORS | INFECTION | RNA RECOGNITION | INTERFERON-BETA | LIVER-DISEASE | Vibrio vulnificus - immunology | DEAD Box Protein 58 - metabolism | Interferon-beta - immunology | RNA Viruses - pathogenicity | Humans | Male | Vibrio Infections - immunology | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Vibrio Infections - microbiology | RNA Viruses - immunology | HEK293 Cells | Superinfection - microbiology | RNA Virus Infections - immunology | Disease Models, Animal | Immunity, Innate - drug effects | Quorum Sensing - immunology | Mice, Inbred C57BL | Peptides, Cyclic - immunology | Mice, SCID | DEAD Box Protein 58 - immunology | Superinfection - immunology | Animals | Dipeptides - immunology | Hepatocytes | Interferon-beta - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Mice, Inbred NOD | RAW 264.7 Cells | RNA Virus Infections - microbiology | Mice | Mice, Inbred BALB C | Primary Cell Culture | Water-borne diseases | Antiviral agents | Immune response | Melanoma | Viruses | Innate immunity | Pattern recognition | Immunity | Hepatitis | Receptors | Microorganisms | Ubiquitination | Influenza | Interferon | Hepatitis C virus | Hepatitis C | Detection | Viral infections | Vibrio | Immune system
Journal Article