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Journal of medicinal chemistry, ISSN 0022-2623, 02/2013, Volume 56, Issue 3, pp. 625 - 627
Journal Article
Organic letters, ISSN 1523-7060, 10/2013, Volume 15, Issue 20, pp. 5306 - 5309
.... The resulting cycloadducts provide the basis for the synthesis of unique analogues of vinblastine containing metabolically benign deep-seated cyclic modifications at the C3/C4 centers... 
Molecular Structure | Vinblastine - chemistry | Cyclization | Oxadiazoles - chemistry | Vinblastine - chemical synthesis | Stereoisomerism | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2010, Volume 132, Issue 38, pp. 13533 - 13544
Concise asymmetric total syntheses of vindoline (1) and vindorosine (2) are detailed based on a unique intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of... 
Vinblastine - chemistry | Vinblastine - analogs & derivatives | Vinblastine - chemical synthesis | Stereoisomerism | Diazo compounds | Vinblastine | Ring formation (Chemistry) | Chemical properties | Structure | Analysis | Index Medicus
Journal Article
British journal of cancer, ISSN 1532-1827, 06/2017, Volume 117, Issue 1, pp. 33 - 40
Background: Pembrolizumab (P) is an anti-PD-1 antibody that blocks the interaction between programmed cell death protein 1 (PD-1) on T-cells and PD-L1 and... 
clinical trial | pembrolizumab | advanced/metastatic solid tumours | phase I | chemotherapy | immunotherapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Nausea - chemically induced | Humans | Middle Aged | Male | Fatigue - chemically induced | Vinblastine - administration & dosage | Diarrhea - chemically induced | Small Cell Lung Carcinoma - drug therapy | Pancreatic Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Adult | Camptothecin - administration & dosage | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Camptothecin - analogs & derivatives | Doxorubicin - administration & dosage | Drug Eruptions - etiology | Deoxycytidine - administration & dosage | Albumins - administration & dosage | Treatment Outcome | Sarcoma - drug therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Taxoids - administration & dosage | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Index Medicus | metastatic solid tumours | advanced | Clinical Study
Journal Article
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 2/2007, Volume 59, Issue 2, pp. 157 - 164
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2009, Volume 8, Issue 10, pp. 2852 - 2860
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 8, pp. 4501 - 4511
.... MDR1 may therefore interact with GSLs. AdamantylGb 3 , a water-soluble Gb 3 mimic, but not other GSL analogs, reversed MDR1-MDCK cell drug resistance... 
Neoplasms - metabolism | Intestinal Mucosa - metabolism | Protein Binding - genetics | Shiga Toxins - pharmacology | Cyclosporine - pharmacology | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Biological Availability | Cell Membrane - genetics | Protein Transport - drug effects | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Rhodamine 123 - pharmacology | Time Factors | Protein Binding - drug effects | Fluorescent Dyes - pharmacology | Cell Membrane - metabolism | Cell Polarity - drug effects | Endocytosis - genetics | Protein Synthesis Inhibitors - pharmacology | Adamantane - pharmacokinetics | Adamantane - analogs & derivatives | Caco-2 Cells | Adamantane - pharmacology | Drug Resistance, Multiple - genetics | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Up-Regulation - genetics | Calcium Channel Blockers - pharmacology | Verapamil - pharmacology | Protein Transport - genetics | Neoplasms - drug therapy | Protein Structure, Secondary - genetics | Up-Regulation - drug effects | Cell Polarity - genetics | Drug Resistance, Neoplasm - genetics | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Trihexosylceramides - biosynthesis | Trihexosylceramides - pharmacology | Dogs | Golgi Apparatus - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Vinblastine - pharmacology | Trihexosylceramides - pharmacokinetics | Antineoplastic Agents, Phytogenic - pharmacology | Drug Resistance, Neoplasm - drug effects | Golgi Apparatus - genetics | Index Medicus
Journal Article