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Molecular and Cellular Biochemistry, ISSN 0300-8177, 2/2007, Volume 296, Issue 1, pp. 85 - 95
Many studies have been performed with the aim of developing effective resistance modulators to overcome the multidrug resistance (MDR) of human cancers. Potent... 
Life Sciences | Biochemistry, general | P-glycoprotein | tetrahydrocurcumin | multidrug resistance | ATP hydrolysis | drug transport | Oncology | Medical Biochemistry | Cardiology | chemosensitivity | ABC transporter | Drug transport | Multidrug resistance | Chemosensitivity | Tetrahydrocurcumin | MECHANISM | INVOLVEMENT | CHEMOPREVENTIVE AGENT CURCUMIN | CATALYTIC TRANSITION-STATE | CELL BIOLOGY | MICROORGANISMS | BREAST-CANCER CELLS | IN-VITRO | INHIBITION | PROTECTIVE ROLE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Vinblastine - metabolism | Curcumin - analogs & derivatives | Fluorides - metabolism | Curcumin - chemistry | Fluoresceins - metabolism | Humans | Chlorophyll - analogs & derivatives | Fluorescent Dyes - metabolism | Drug Resistance, Neoplasm | Curcumin - metabolism | Neoplasm Proteins - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 | Organic Anion Transporters - metabolism | Antineoplastic Agents - metabolism | Beryllium - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Molecular Structure | Drug Resistance, Multiple - physiology | Mitoxantrone - metabolism | Etoposide - metabolism | Chlorophyll - metabolism | Antineoplastic Agents - chemistry | Rhodamine 123 - metabolism | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | Proteins | Medical research | Binding sites
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2008, Volume 28, Issue 27, pp. 6926 - 6937
Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer's disease (AD). The basis for the... 
Neuroprotection | Neurotoxicity | Neuron | Storage | Neuropathology | Lysosome | Neuron death | Aging | Neuronal death | Alzheimer | Autophagy | Culture | NEURODEGENERATIVE DISEASE | RAT-LIVER | APOPTOSIS | autophagy | neuron | VINBLASTINE | storage | MACROAUTOPHAGY | MAMMALIAN-CELLS | NEUROSCIENCES | neuron death | TRANSPORT | neurotoxicity | culture | neuronal death | neuroprotection | MONITORING AUTOPHAGY | DEGRADATION | MICE | aging | lysosome | neuropathology | Protein Kinases - metabolism | Neurons - pathology | Microtubule-Associated Proteins - metabolism | Tubulin Modulators - pharmacology | Peptide Hydrolases - drug effects | Autophagy - physiology | Alzheimer Disease - pathology | Brain - metabolism | Lysosomes - metabolism | Neurons - ultrastructure | Neurites - ultrastructure | Brain - ultrastructure | Lysosomes - pathology | Phagosomes - ultrastructure | Neurons - metabolism | Peptide Hydrolases - metabolism | Animals, Newborn | Alzheimer Disease - physiopathology | Protein Kinases - drug effects | Phagosomes - metabolism | Cells, Cultured | Rats | Neurites - metabolism | Phagosomes - pathology | Rats, Sprague-Dawley | Lysosomes - ultrastructure | Neurites - pathology | Animals | Cathepsins - metabolism | Alzheimer Disease - metabolism | Brain - pathology | TOR Serine-Threonine Kinases | Vinblastine - pharmacology
Journal Article
Journal of Hazardous Materials, ISSN 0304-3894, 05/2013, Volume 252-253, pp. 367 - 374
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2007, Volume 35, Issue 11, pp. 2076 - 2085
P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily... 
RABBIT BRAIN | HIV-1 PROTEASE INHIBITORS | CF-1 MICE DEFICIENT | IN-VITRO | REVERSE-TRANSCRIPTASE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTED PATIENTS | ZIDOVUDINE TRANSPORT | MULTIDRUG-RESISTANCE | CEREBROSPINAL-FLUID | ANTIRETROVIRAL TREATMENT | Vinblastine - metabolism | Zidovudine - metabolism | Dibenzocycloheptenes - chemistry | Area Under Curve | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Zidovudine - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Reverse Transcriptase Inhibitors - chemistry | Vinblastine - pharmacokinetics | Brain - metabolism | Quinolines - pharmacokinetics | Biological Transport, Active | Reverse Transcriptase Inhibitors - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Tetrahydroisoquinolines - chemistry | Dibenzocycloheptenes - metabolism | ATP-Binding Cassette Transporters - metabolism | Acridines - pharmacokinetics | Cell Membrane - metabolism | Molecular Structure | Anti-HIV Agents - metabolism | Acridines - chemistry | Dideoxynucleosides - metabolism | Cell Line | Vinblastine - chemistry | Acridines - metabolism | Dibenzocycloheptenes - pharmacokinetics | Quinolines - chemistry | Adenosine Triphosphatases - metabolism | Mice, Inbred Strains | Dideoxynucleosides - chemistry | Zidovudine - chemistry | Mice, Knockout | Dideoxynucleosides - pharmacokinetics | Quinolines - metabolism | Anti-HIV Agents - chemistry | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Anti-HIV Agents - pharmacokinetics | Tetrahydroisoquinolines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 12/2012, Volume 8, Issue 12, pp. 1741 - 1756
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2017, Volume 474, Issue 16, pp. 2841 - 2859
Journal Article
Seminars in Oncology, ISSN 0093-7754, 06/2017, Volume 44, Issue 3, pp. 218 - 225
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3671 - 13
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e69394
We have reported that the P-gp substrate digoxin required basolateral and apical uptake transport in excess of that allowed by digoxin passive permeability (as... 
MEMBRANE TRANSPORTERS | IN-VITRO | EFFLUX | MULTIDISCIPLINARY SCIENCES | CONFLUENT MONOLAYER | GLYCOPROTEIN | CANDIDATES | PHARMACEUTICAL DRUGS | IDENTIFICATION | CACO-2 CELLS | MDCKII-HMDR1 CELLS | Vinblastine - metabolism | Digoxin - metabolism | Cyclosporine - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Ketoconazole - metabolism | Ketoconazole - pharmacology | Carbamates - metabolism | Madin Darby Canine Kidney Cells | Digoxin - antagonists & inhibitors | Cyclosporine - metabolism | Carbamates - pharmacology | Caco-2 Cells | Quinidine - metabolism | Tetrahydroisoquinolines - pharmacology | Gene Expression | Acridines - metabolism | Loperamide - pharmacology | Quinidine - pharmacology | Sulfonamides - pharmacology | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Cell Membrane Permeability - drug effects | Dogs | Sulfonamides - metabolism | Protein Binding | Loperamide - metabolism | Vinblastine - pharmacology | Kinetics | Loperamide | Permeability | Ketoconazole | Digoxin | Analysis | Monomolecular films | Drugs | Biotechnology | Cyclosporins | Membrane permeability | Biochemistry | Biology | Kinases | MDR1 protein | Inhibition | P-Glycoprotein | Dimerization | Efflux | Enzymes | Vinblastine | Glycoproteins | Metabolism | Substrates | Quinidine | Cell lines | Verapamil | Transport | Amprenavir | Transporter | Cancer | Pharmaceuticals
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2010, Volume 285, Issue 10, pp. 7575 - 7586
Journal Article
Leukemia, ISSN 0887-6924, 06/2008, Volume 22, Issue 6, pp. 1106 - 1116
A significant impediment to the success of cancer chemotherapy is the occurrence of multidrug resistance, which, in many cases, is attributable to... 
CANCER-CELLS | MULTIPLE-MYELOMA | targeted therapy | ACTIVATION | KINASE | apoptosis | DEATH | ACUTE MYELOID-LEUKEMIA | PI3K/Akt | ONCOLOGY | PATHWAY | perifosine | ACUTE LYMPHOBLASTIC-LEUKEMIA | LIPID RAFTS | drug resistance | HEMATOLOGY | PHASE-I | Apoptosis - drug effects | Drug Resistance, Multiple | Membrane Microdomains - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphorylcholine - analogs & derivatives | RNA, Messenger - metabolism | Immunoenzyme Techniques | Caspases - metabolism | Flow Cytometry | Phosphorylcholine - pharmacology | Electrophoretic Mobility Shift Assay | JNK Mitogen-Activated Protein Kinases - genetics | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Cell Survival - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Signal Transduction | Cytochromes c - metabolism | Down-Regulation | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Mitochondria - metabolism | Leukemia-Lymphoma, Adult T-Cell - pathology | Mitochondria - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Leukemia-Lymphoma, Adult T-Cell - metabolism | Vinblastine - pharmacology | Enzyme Activation | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Care and treatment | Enzyme inhibitors | Genetic aspects | Dosage and administration | Glycoproteins | Acute lymphocytic leukemia | Health aspects | Protein kinases
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 04/2014, Volume 426, Issue 8, pp. 1848 - 1860
Journal Article