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Drugs, ISSN 0012-6667, 06/2000, Volume 59, Issue 6, pp. 1261 - 1277
Neuroblastoma represents one of the most challenging malignancies for treatment decisions because of its unusual biological behaviour. The features include... 
Melphalan, pharmacokinetics | Topoisomerase inhibitors, therapeutic use | Cytarabine, pharmacokinetics | Teniposide, therapeutic use | Fluorouracil, pharmacokinetics | Research and development | Thioguanine, pharmacokinetics | Hydroxycarbamide, pharmacokinetics | Etoposide, pharmacokinetics | Vincristine, pharmacokinetics | Thiotepa, pharmacokinetics | Cisplatin, pharmacokinetics | Doxorubicin, pharmacokinetics | Zilascorb, pharmacokinetics | Procarbazine, pharmacokinetics | Cyclophosphamide, pharmacokinetics | Antineoplastics, therapeutic use | Bleomycin, pharmacokinetics | Busulfan, pharmacokinetics | Dacarbazine, therapeutic use | Ifosfamide, pharmacokinetics | Vinblastine, therapeutic use | Dactinomycin, pharmacokinetics | Lomustine, pharmacokinetics | Mercaptopurine, pharmacokinetics | Carboplatin, pharmacokinetics | Mitoxantrone, pharmacokinetics | Neuroblastoma, treatment | Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | NEURO-BLASTOMA | BONE-MARROW TRANSPLANTATION | MESSENGER-RNA | CHROMOSOME 1P | PEDIATRIC-ONCOLOGY-GROUP | METASTATIC NEUROBLASTOMA | CHILDHOOD NEUROBLASTOMA | CLINICAL RELEVANCE | GENE AMPLIFICATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MULTIDRUG-RESISTANCE | Prognosis | Humans | Neuroblastoma - drug therapy | Hematopoietic Stem Cell Transplantation | Drug Resistance, Neoplasm | Transplantation, Autologous | Neuroblastoma - mortality
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2018, Volume 81, Issue 3, pp. 455 - 460
The purpose of this report is to describe, for the first time, the pharmacokinetics of dacarbazine (DTIC) and its metabolites... 
Pregnancy | Dacarbazine | Medicine & Public Health | Metabolites | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | TRIMESTER | CANCER | METABOLITE 5-AMINOIMIDAZOLE-4-CARBOXAMIDE | WOMEN | PLASMA | 24-HOUR CREATININE CLEARANCE | ONCOLOGY | POSTPARTUM | CYP1A2 | NON-HODGKINS-LYMPHOMA | PHARMACOLOGY & PHARMACY | Dacarbazine - adverse effects | Area Under Curve | Hodgkin Disease - pathology | Humans | Antineoplastic Agents, Alkylating - administration & dosage | Drug Monitoring - methods | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Antineoplastic Agents, Alkylating - blood | Hodgkin Disease - drug therapy | Pregnancy Complications, Neoplastic - drug therapy | Adult | Dacarbazine - pharmacokinetics | Female | Infant, Newborn | Dacarbazine - administration & dosage | Treatment Outcome | Antineoplastic Agents, Alkylating - pharmacokinetics | Pregnancy Complications, Neoplastic - pathology | Administration, Intravenous | Dacarbazine - blood | Bleomycin - pharmacology | Vinblastine - pharmacology | Antineoplastic Agents, Alkylating - adverse effects | Neoplasm Staging | Doxorubicin - pharmacology | Pregnancy Outcome | Anthracyclines | Lymphomas | Pregnant women | Vinblastine | Cytochrome P450 | Case reports | Pharmacology | Liquid chromatography | Gestation | CYP1A2 protein | Metabolism | High-performance liquid chromatography | Doxorubicin | Lymphoma | Postpartum | Bleomycin | Imidazole | Drug metabolism | Remission
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 03/2012, Volume 53, Issue 3, pp. 406 - 410
Abstract Polymorphisms of the Glutathione-S Transferase (GST) family may influence the prognosis in lymphoma patients. We aimed to validate the impact of GSTT1... 
GSTT1 | polymorphism | GSTM1 | prognosis | Hodgkin's lymphoma | Prognosis | Polymorphism | SUSCEPTIBILITY | RISK | ACUTE MYELOID-LEUKEMIA | CANCER | CHEMOTHERAPY | GENOTYPES | THERAPY | ONCOLOGY | DISEASE | HEMATOLOGY | ASSOCIATION | Procarbazine - administration & dosage | Cyclophosphamide - administration & dosage | Dacarbazine - adverse effects | Humans | Middle Aged | Biotransformation - genetics | Male | Carboplatin - pharmacokinetics | Vinblastine - administration & dosage | Cyclophosphamide - adverse effects | Carboplatin - adverse effects | Anemia - genetics | Glutathione Transferase - physiology | Gene Deletion | Hodgkin Disease - mortality | Vincristine - administration & dosage | Neoplasm Proteins - genetics | Glutathione S-Transferase pi - genetics | Dacarbazine - administration & dosage | Genetic Predisposition to Disease | Prednisone - adverse effects | Anemia - chemically induced | Carboplatin - administration & dosage | Etoposide - administration & dosage | Genotype | Bleomycin - administration & dosage | Doxorubicin - pharmacokinetics | Polymorphism, Genetic | Lomustine - pharmacokinetics | Procarbazine - adverse effects | Vincristine - adverse effects | Cyclophosphamide - pharmacokinetics | Lomustine - administration & dosage | Epirubicin - adverse effects | Etoposide - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Hodgkin Disease - genetics | Lomustine - adverse effects | Neoplasm Proteins - physiology | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Bleomycin - pharmacokinetics | Epirubicin - administration & dosage | Glutathione S-Transferase pi - physiology | Hodgkin Disease - enzymology | Vinblastine - pharmacokinetics | Glutathione Transferase - genetics | Vinblastine - adverse effects | Vindesine - adverse effects | Hodgkin Disease - drug therapy | Adult | Dacarbazine - pharmacokinetics | Female | Vindesine - pharmacokinetics | Vincristine - pharmacokinetics | Doxorubicin - administration & dosage | Prednisone - administration & dosage | Etoposide - adverse effects | Treatment Outcome | Bleomycin - adverse effects | Procarbazine - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Prednisone - pharmacokinetics | Vindesine - administration & dosage | Epirubicin - pharmacokinetics | Polymorphism, Single Nucleotide | Doxorubicin - adverse effects | Index Medicus
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 2010, Volume 119, Issue 3, pp. 594 - 600
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2009, Volume 330, Issue 3, pp. 956 - 963
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2011, Volume 104, Issue 4, pp. 719 - 725
PURPOSE: Treatment efficacy and toxicity are difficult to predict in lymphoma patients. In this study, the utility of circulating biomarkers in predicting... 
FLT3 ligand | nucleosomal DNA | cytokeratin 18 | Hodgkin and non-Hodgkin lymphoma | biomarkers | NUCLEOSOMES | CHEMOTHERAPY | CELL-DEATH | IRRADIATION | CANCER-PATIENTS | THERAPY | PLASMA | ONCOLOGY | DNA | MICE | Doxorubicin - therapeutic use | Predictive Value of Tests | Dacarbazine - adverse effects | Keratin-18 - analysis | Humans | Middle Aged | Antibodies, Monoclonal, Murine-Derived - administration & dosage | Male | Vinblastine - therapeutic use | Cyclophosphamide - adverse effects | Lymphoma - blood | Young Adult | Lymphoma - drug therapy | Bleomycin - therapeutic use | fms-Like Tyrosine Kinase 3 - analysis | Aged, 80 and over | Keratin-18 - blood | Prednisone - adverse effects | Antibodies, Monoclonal, Murine-Derived - pharmacokinetics | Rituximab | Nucleosomes - genetics | Doxorubicin - pharmacokinetics | Adolescent | Vincristine - therapeutic use | Vincristine - adverse effects | Cyclophosphamide - pharmacokinetics | Antibodies, Monoclonal, Murine-Derived - adverse effects | Prednisone - therapeutic use | Prognosis | Dacarbazine - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Bleomycin - pharmacokinetics | Cyclophosphamide - therapeutic use | Vinblastine - pharmacokinetics | DNA - blood | Lymphoma - metabolism | DNA - analysis | Vinblastine - adverse effects | Adult | Dacarbazine - pharmacokinetics | Female | Vincristine - pharmacokinetics | Biomarkers, Pharmacological - analysis | Lymphoma - diagnosis | Biomarkers, Tumor - analysis | Bleomycin - adverse effects | Biomarkers, Pharmacological - blood | Biomarkers, Tumor - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Prednisone - pharmacokinetics | Aged | fms-Like Tyrosine Kinase 3 - blood | Doxorubicin - adverse effects | Molecular Diagnostics
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 11/2007, Volume 35, Issue 11, pp. 2076 - 2085
P-glycoprotein (P-gp)-mediated efflux at the blood-brain barrier has been implicated in limiting the brain distribution of many anti-HIV1 drugs, primarily... 
RABBIT BRAIN | HIV-1 PROTEASE INHIBITORS | CF-1 MICE DEFICIENT | IN-VITRO | REVERSE-TRANSCRIPTASE INHIBITORS | PHARMACOLOGY & PHARMACY | INFECTED PATIENTS | ZIDOVUDINE TRANSPORT | MULTIDRUG-RESISTANCE | CEREBROSPINAL-FLUID | ANTIRETROVIRAL TREATMENT | Vinblastine - metabolism | Zidovudine - metabolism | Dibenzocycloheptenes - chemistry | Area Under Curve | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Zidovudine - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Reverse Transcriptase Inhibitors - chemistry | Vinblastine - pharmacokinetics | Brain - metabolism | Quinolines - pharmacokinetics | Biological Transport, Active | Reverse Transcriptase Inhibitors - pharmacokinetics | ATP-Binding Cassette Transporters - genetics | Tetrahydroisoquinolines - chemistry | Dibenzocycloheptenes - metabolism | ATP-Binding Cassette Transporters - metabolism | Acridines - pharmacokinetics | Cell Membrane - metabolism | Molecular Structure | Anti-HIV Agents - metabolism | Acridines - chemistry | Dideoxynucleosides - metabolism | Cell Line | Vinblastine - chemistry | Acridines - metabolism | Dibenzocycloheptenes - pharmacokinetics | Quinolines - chemistry | Adenosine Triphosphatases - metabolism | Mice, Inbred Strains | Dideoxynucleosides - chemistry | Zidovudine - chemistry | Mice, Knockout | Dideoxynucleosides - pharmacokinetics | Quinolines - metabolism | Anti-HIV Agents - chemistry | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Tetrahydroisoquinolines - metabolism | Anti-HIV Agents - pharmacokinetics | Tetrahydroisoquinolines - pharmacokinetics | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Reverse Transcriptase Inhibitors - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 01/2009, Volume 328, Issue 1, pp. 321 - 330
Effective liposomal formulations of vinorelbine (5' nor-anhydro-vinblastine; VRL) have been elusive due to vinorelbine's hydrophobic structure and resulting... 
CHOLESTEROL | SULFATE | DOXORUBICIN | COMPLEXES | VINBLASTINE | PHARMACOLOGY & PHARMACY | LIPOSOMAL VINCRISTINE | TOXICITY | AGENTS | ANTITUMOR-ACTIVITY | CANCER | Nanoparticles | Vinblastine - chemistry | Vinblastine - analogs & derivatives | Drug Stability | Humans | Phospholipids - blood | Tritium | Liposomes | Vinblastine - pharmacokinetics | Drug Carriers | Index Medicus
Journal Article
Current Medical Research & Opinion, ISSN 0300-7995, 6/2014, Volume 30, Issue 6, pp. 1017 - 1024
Abstract Objectives: This study proposed a conception of individualized chemotherapy based on organ selectivity of drug distribution by retrospectively... 
Capecitabine | Liver | Lung | Individualized chemotherapy | Metastatic breast cancer | Pharmacokinetics | Vinorelbine | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | MULTICENTER | MONOTHERAPY | PHASE-II | TRIAL | PLUS CAPECITABINE | MEDICINE, GENERAL & INTERNAL | ANTHRACYCLINE | COLORECTAL-CANCER | 1ST-LINE | EXPRESSION | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Agents - therapeutic use | Vinblastine - administration & dosage | Vinblastine - therapeutic use | Vinblastine - pharmacokinetics | Breast Neoplasms - metabolism | Fluorouracil - therapeutic use | Deoxycytidine - pharmacokinetics | Deoxycytidine - therapeutic use | Organoplatinum Compounds - administration & dosage | Anthracyclines - administration & dosage | Fluorouracil - administration & dosage | Lung Neoplasms - secondary | Vinblastine - analogs & derivatives | Organoplatinum Compounds - pharmacokinetics | Adult | Female | Retrospective Studies | Liver Neoplasms - secondary | Precision Medicine | Anthracyclines - pharmacokinetics | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Taxoids - pharmacokinetics | Taxoids - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Liver Neoplasms - metabolism | Aged | Fluorouracil - pharmacokinetics | Bridged-Ring Compounds - administration & dosage | Bridged-Ring Compounds - pharmacokinetics | Deoxycytidine - analogs & derivatives
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2006, Volume 28, Issue 1, pp. 34 - 42
Journal Article
16.