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Journal Article
Planta, ISSN 0032-0935, 1/2018, Volume 247, Issue 1, pp. 155 - 169
Monoterpenoid indole alkaloids (MIAs) have remarkable biological properties that have led to their medical uses for a variety of human diseases... 
Life Sciences | Tabersonine-2,3-epoxide | Forestry | Mutant | Monoterpenoid indole alkaloids | Pathway suppression | Agriculture | Ecology | Biosynthesis | Epoxides | Plant Sciences | 16-Methoxytabersonine-2,3-epoxide | MADAGASCAR PERIWINKLE | ELUCIDATION | STEP | INDOLE ALKALOID BIOSYNTHESIS | IRIDOID BIOSYNTHESIS | SALT-TOLERANT | PLANT SCIENCES | LEAF SURFACE | 7-DEOXYLOGANETIC ACID | DRUG COMPONENTS | INHERITANCE | Epoxy Compounds - metabolism | Vinblastine - metabolism | Catharanthus - chemistry | Humans | Vinca Alkaloids - chemistry | Vinca Alkaloids - metabolism | Antineoplastic Agents - metabolism | Vinblastine - analogs & derivatives | Indole Alkaloids - chemistry | Plant Leaves - enzymology | Plant Leaves - chemistry | Secologanin Tryptamine Alkaloids - chemistry | Vinblastine - chemistry | Catharanthus - enzymology | Oxidoreductases - metabolism | Oxidoreductases - genetics | Quinolines - chemistry | Secologanin Tryptamine Alkaloids - metabolism | Antineoplastic Agents - chemistry | Quinolines - metabolism | Phenotype | Plant Leaves - genetics | Epoxy Compounds - chemistry | Catharanthus - genetics | Mutation | Indole Alkaloids - metabolism | Alkaloids | Pyrimidines | Analysis | Biological properties | Vindoline | Indole | Amino acid substitution | Substitutes | Coupling (molecular) | Leaves | Genotype & phenotype | Metabolites | Cytosine | Plants (botany) | Cloning | Heredity | Mutants | Intermediates | Thin layer chromatography | Plant diseases | Mutagenesis | Acids | Dimers | Ethyl methanesulfonate | Reductase
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 34, pp. 15287 - 15292
The monoterpenoid indole alkaloids (MIAs) of Madagascar periwinkle (Catharanthus roseus) continue to be the most important source of natural drugs in chemotherapy treatments for a range of human cancers... 
Leaves | Alkaloids | Diet | Secretion | Epidermal cells | Epidermis | Biosynthesis | Plants | Waxes | Plant cells | Surface secretion | Catharanthus roseus | Vindoline | Catharanthine | TRANSLOCATION | CATHARANTHUS-ROSEUS | MULTIDISCIPLINARY SCIENCES | VINBLASTINE | ALKALOID BIOSYNTHESIS | PATHWAY | EPIDERMAL-CELLS | LEUROSIDINE | catharanthine | SURFACE | MOLECULAR-CLONING | surface secretion | vindoline | Vinblastine - metabolism | Oomycetes - drug effects | Species Specificity | Catharanthus - parasitology | Humans | Vinca Alkaloids - chemistry | Vinca Alkaloids - metabolism | Catharanthus - metabolism | Tissue Distribution | Vinca Alkaloids - biosynthesis | Bombyx - pathogenicity | Vinblastine - analogs & derivatives | Hybridization, Genetic | Vinca Alkaloids - pharmacology | Antifungal Agents - metabolism | Antineoplastic Agents, Phytogenic - metabolism | Pesticides - metabolism | Dimerization | Antifungal Agents - pharmacology | Catharanthus - microbiology | Oomycetes - pathogenicity | Animals | Plant Leaves - metabolism | Models, Biological | Pesticides - pharmacology | Antimitotic agents | Care and treatment | Research | Properties | Antineoplastic agents | Madagascar periwinkle | Catharanthus | Cancer | Index Medicus | Drugs | Toxicity | Indole | Cell division | Zoospores | Exudates | Chemotherapy | Antitumor agents | monoterpenoids | Biological Sciences
Journal Article
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2007, Volume 121, Issue 7, pp. 1585 - 1592
EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome‐cleavable acyl hydrazone bond.... 
folate receptor | endocytosis | targeting | Vinca alkaloid | chemotherapy | Chemotherapy | Endocytosis | Folate receptor | Targeting | BINDING-PROTEIN | Vinea alkaloid | RADIOLIGAND BINDING | CELL-LINES | DELIVERY | RECEPTOR-MEDIATED ENDOCYTOSIS | ONCOLOGY | IN-VIVO | BIOLOGICAL EVALUATION | CHOROID-PLEXUS | TISSUES | ANTITUMOR EFFICACY | Adenocarcinoma - pathology | Folic Acid - pharmacology | Pterins - metabolism | Folate Receptors, GPI-Anchored | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Vinca Alkaloids - chemistry | Vinca Alkaloids - metabolism | Blood Proteins - metabolism | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Adenocarcinoma - metabolism | Time Factors | Vinca Alkaloids - pharmacology | Molecular Structure | Pterins - chemistry | Binding, Competitive | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Folic Acid - analogs & derivatives | Folic Acid - chemistry | Neoplasms, Experimental - prevention & control | Receptors, Cell Surface - metabolism | Tumor Burden | Xenograft Model Antitumor Assays | Adenocarcinoma - prevention & control | Animals | Carrier Proteins - metabolism | Lung Neoplasms - prevention & control | Pterins - pharmacology | Mice, Nude | Cell Line, Tumor | Protein Binding | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism
Journal Article
Pharmaceutical Biology, ISSN 1388-0209, 3/2013, Volume 51, Issue 3, pp. 304 - 310
Context: Catharanthus roseus (L.) G. Don (Apocynaceae) is a medicinal plant that produces more than 130 alkaloids, with special attention given... 
elicitation | plant cell cultures | leukemia | metabolites | Antitumor | Elicitation | Metabolites | Plant cell cultures | Leukemia | GROWTH | PHARMACOLOGY & PHARMACY | MEDICAL LABORATORY TECHNOLOGY | CANCER | LINES | PLANT SCIENCES | Plant Extracts - chemistry | Plant Extracts - pharmacology | Catharanthus - chemistry | Humans | Vinca Alkaloids - chemistry | Chromatography, High Pressure Liquid | Vinca Alkaloids - metabolism | Quinolines - pharmacology | Catharanthus - metabolism | Catharanthus - drug effects | Spectrometry, Mass, Electrospray Ionization | Vinca Alkaloids - pharmacology | Catharanthus - cytology | Inhibitory Concentration 50 | Plant Leaves - drug effects | Indole Alkaloids - chemistry | Cell Survival - drug effects | Secologanin Tryptamine Alkaloids - chemistry | Secologanin Tryptamine Alkaloids - pharmacology | Quinolines - chemistry | Cells, Cultured | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Secologanin Tryptamine Alkaloids - metabolism | Cyclopentanes - pharmacology | Drug Discovery | Plant Leaves - cytology | Antineoplastic Agents, Phytogenic - biosynthesis | Quinolines - metabolism | Plant Leaves - metabolism | Indole Alkaloids - pharmacology | Oxylipins - pharmacology | Cell Line, Tumor | Acetates - pharmacology | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Indole Alkaloids - metabolism | Cyclodextrins - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182400
Journal Article