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Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 169 - 172
Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no... 
SYSTEM | NIEMANN-PICK C1 | ENTRY | CHOLESTEROL | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ANTIBODY | RECEPTOR | INFECTION | HIV-1 VIRION FUSION | Temperature | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antiviral Agents - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ebolavirus - drug effects | Ibuprofen - chemistry | Antiviral Agents - chemistry | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Conserved Sequence | Marburgvirus - chemistry | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Membrane Fusion - drug effects | Toremifene - metabolism | Toremifene - pharmacology | Cell Line | Antiviral Agents - pharmacology | Ibuprofen - pharmacology | Models, Molecular | Protein Structure, Quaternary - drug effects | Ibuprofen - metabolism | Virus Attachment - drug effects | Ebolavirus - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Protein Stability - drug effects | Viral Envelope Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Protein Subunits - chemistry | Toremifene - chemistry | Ebola virus | Glycoproteins | Host-virus relationships | Observations | Health aspects | Drug interactions | Drug therapy | Binding sites | Viral infections | Crystal structure
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 24, pp. 11075 - 11086
The glycoprotein of Ebola virus (EBOV GP), a member of the family Filoviridae, facilitates viral entry into target cells. In addition, EBOV GP antagonizes the... 
NIEMANN-PICK C1 | PROTEIN | VIROLOGY | HEMORRHAGIC-FEVER | ENVELOPE GLYCOPROTEIN | DC-SIGNR | INFECTION | HUMAN-IMMUNODEFICIENCY-VIRUS | MONOCLONAL-ANTIBODIES | HIV-1 VPU | VIRAL ENTRY | Antigens, CD - immunology | Virus Release | Antibodies, Viral - metabolism | Protein Subunits - immunology | Antibodies, Viral - pharmacology | Humans | Antibodies, Neutralizing - metabolism | Ebolavirus - genetics | Antigens, CD - genetics | Ebolavirus - immunology | Virus Internalization | Ebolavirus - drug effects | HEK293 Cells | Protein Domains | Antigens, CD - chemistry | Glycoproteins - chemistry | Protein Subunits - genetics | Glycoproteins - genetics | Amino Acid Sequence | Viral Envelope Proteins - genetics | GPI-Linked Proteins - immunology | Signal Transduction | Gene Expression Regulation | Glycoproteins - antagonists & inhibitors | Antibodies, Neutralizing - pharmacology | Polysaccharides - immunology | Polysaccharides - metabolism | Host-Pathogen Interactions | Ebolavirus - chemistry | Glycoproteins - immunology | Sequence Alignment | GPI-Linked Proteins - chemistry | Virus Replication | Viral Envelope Proteins - antagonists & inhibitors | Viral Envelope Proteins - chemistry | Protein Binding | Viral Envelope Proteins - immunology | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | GPI-Linked Proteins - genetics
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 2014, Volume 4, Issue 1, p. 6881
Ebola virus (EBOV) causes severe viral hemorrhagic fever in humans and non-human primates, with a case fatality rate of up to 88% in human outbreaks. Over the... 
NONHUMAN-PRIMATES | INFECTION | GLYCOPROTEIN | MULTIDISCIPLINARY SCIENCES | EPITOPES | TOOL | Ebola Vaccines - genetics | Recombinant Fusion Proteins - immunology | Hemorrhagic Fever, Ebola - prevention & control | Antibodies, Monoclonal - biosynthesis | Humans | Molecular Sequence Data | Green Fluorescent Proteins - genetics | Ebolavirus - genetics | Antigen-Antibody Reactions | Ebolavirus - immunology | Epitopes - immunology | Hemorrhagic Fever, Ebola - virology | Ebola Vaccines - chemistry | Vesiculovirus - genetics | Antigen-Antibody Complex - genetics | Ebola Vaccines - immunology | Hemorrhagic Fever, Ebola - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Genes, Reporter | Antibodies, Viral - biosynthesis | Amino Acid Sequence | Gene Expression | Viral Envelope Proteins - genetics | Models, Molecular | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Antibodies, Monoclonal - genetics | Ebolavirus - chemistry | Sequence Alignment | Animals | Green Fluorescent Proteins - immunology | Immune Evasion | Antigen-Antibody Complex - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Viral Envelope Proteins - chemistry | Antibodies, Viral - chemistry | Recombinant Fusion Proteins - genetics | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Epitopes - chemistry | Mice | Mutation | Antigen-Antibody Complex - immunology | Antibodies, Viral - genetics | Ebola virus | Epidemics | Immunoglobulins | Hemorrhagic fever | Variable region | Monoclonal antibodies | Amino acids | Outbreaks | Surface plasmon resonance | Hemorrhage
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0130517
Respiratory syncytial virus (RSV) is the principal cause of bronchiolitis in infants and a significant healthcare problem. The RSV Glycoprotein (G) mediates... 
MOLECULAR CHARACTERIZATION | VACCINE DEVELOPMENT | REPLICATION IN-VITRO | ATTACHMENT | EPITHELIAL-CELLS | CX3C-CX3CR1 BINDING | RSV | MULTIDISCIPLINARY SCIENCES | INFECTION | FUSION GLYCOPROTEIN | RECEPTOR CXCR1 | Respiratory Syncytial Virus, Human - metabolism | Sequence Deletion | Epithelial Cells - metabolism | Viral Fusion Proteins - metabolism | Viral Fusion Proteins - genetics | Humans | Molecular Sequence Data | Respiratory Mucosa - virology | Epitopes - immunology | Respiratory Mucosa - pathology | Respiratory Syncytial Virus, Human - genetics | Viral Fusion Proteins - chemistry | Base Sequence | Viral Envelope Proteins - metabolism | Cell Differentiation | Receptors, Chemokine - antagonists & inhibitors | Receptors, Chemokine - chemistry | Receptors, Chemokine - genetics | Binding Sites | Child | Gene Expression | Viral Envelope Proteins - genetics | Cilia - pathology | Receptors, Chemokine - metabolism | Epithelial Cells - pathology | Cilia - metabolism | Antibodies - pharmacology | Viral Envelope Proteins - antagonists & inhibitors | Epithelial Cells - virology | Viral Envelope Proteins - chemistry | Protein Binding | Epitopes - chemistry | Primary Cell Culture | Respiratory Mucosa - metabolism | CX3C Chemokine Receptor 1 | Cilia - virology | Infection | G proteins | Health aspects | Protein binding | Asthma | Health care | Cell culture | Membranes | Animal models | Epithelial cells | Bronchopneumonia | Prophylaxis | Viruses | CX3CR1 protein | Infections | Infants | Respiratory tract | Proteins | Clonal deletion | Lymphocytes | Deletion | Fusion protein | nucleolin | Cilia | Binding | Heparan sulfate | Immunization | Immunoglobulins | Glycoprotein | Gene expression | Virology | Respiratory syncytial virus | Microscopy | Lungs | Respiratory diseases | Chemokines
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2013, Volume 57, Issue 10, pp. 4937 - 4944
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2009, Volume 5, Issue 7, pp. e1000511 - e1000511
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2015, Volume 11, Issue 4, p. e1004840
Hepatitis D virus (HDV) is the smallest virus known to infect human. About 15 million people worldwide are infected by HDV among those 240 million infected by... 
COTRANSPORTING POLYPEPTIDE | RNA | MOUSE | SUSCEPTIBILITY | MICROBIOLOGY | GENOME | TRANSMISSION | REPLICATION | VIROLOGY | DELTA-VIRUS | LIVER | PARASITOLOGY | TRANSGENIC MICE | Antibodies, Viral - pharmacology | Hepatitis D - metabolism | Humans | Hepatocytes - pathology | Male | Host-Pathogen Interactions - drug effects | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Hepatitis D - drug therapy | Viral Envelope Proteins - metabolism | Female | Hepatitis Delta Virus - drug effects | Receptor, Interferon alpha-beta - genetics | Hepatocytes - drug effects | Receptor, Interferon alpha-beta - metabolism | Specific Pathogen-Free Organisms | Immunity, Innate - drug effects | Antibodies, Monoclonal - pharmacology | Hepatitis D - virology | Hepatitis Delta Virus - physiology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Symporters - metabolism | Mice, Knockout | Animals | Hepatitis Delta Virus - immunology | Viral Envelope Proteins - antagonists & inhibitors | Symporters - genetics | Hepatocytes - virology | Organic Anion Transporters, Sodium-Dependent - metabolism | Crosses, Genetic | Hepatitis D - pathology | Cell culture | Data analysis | Polypeptides | Pathogenesis | Science | Editing | Infections | Genomes | Mammals | Experiments | Proteins | Studies | Hepatitis | Rodents | Hepatitis delta virus
Journal Article
Journal Article