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Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 609 - 621
MLL is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity... 
CELLCYCLE | DNA | HUMDISEASE | RNA-POLYMERASE-II | CHROMOSOMAL TRANSLOCATIONS | TARGET GENES | STEM-CELLS | HISTONE H2B | ONCOLOGY | H3 METHYLATION | TUMOR-SUPPRESSOR PROTEIN | LEUKEMIA | EXPRESSION | TRANSCRIPTIONAL ELONGATION | CELL BIOLOGY | Myeloid Cells - cytology | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Transcriptional Activation - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Leukemia - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Transfection | RNA Interference | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia - genetics | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Sequence Deletion - physiology | Mice, Inbred C57BL | Gene Expression Regulation | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Transcription, Genetic - physiology | Animals | Carrier Proteins - metabolism | Models, Biological | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Myeloid Cells - metabolism | Mice | HeLa Cells | Myeloid Ecotropic Viral Integration Site 1 Protein | Cell Transformation, Neoplastic - pathology | Protein Binding - physiology | Proteins | RNA | Gene expression
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 514, Issue 7523, pp. 455 - 461
..., to a post-fusion state. As the sole viral antigen on the HIV-1 virion surface, Env is both the target of neutralizing antibodies and a focus of vaccine efforts... 
ENVELOPE GLYCOPROTEIN TRIMERS | B-CELL RESPONSES | POTENT NEUTRALIZATION | NEUTRALIZING ANTIBODY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | INFLUENZA-VIRUS | CORE STRUCTURE | DEPENDENT EPITOPE | EBOLA-VIRUS | HIV Envelope Protein gp120 - genetics | HIV Envelope Protein gp41 - genetics | Protein Subunits - immunology | HIV Envelope Protein gp41 - immunology | Humans | Protein Multimerization | AIDS Vaccines - immunology | Molecular Sequence Data | Crystallography, X-Ray | HIV Envelope Protein gp41 - chemistry | Virus Internalization | Genetic Variation | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | Protein Structure, Quaternary | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Protein Subunits - genetics | Amino Acid Sequence | Membrane Fusion | Models, Molecular | Glycosylation | Polysaccharides - immunology | AIDS Vaccines - chemistry | Immune Evasion | Protein Subunits - chemistry | Structural Homology, Protein | Cohort Studies | Physiological aspects | HIV antibodies | Viral proteins | Structure | Health aspects | Infections | Immunology | Peptides | Human immunodeficiency virus--HIV | Crystals | X-ray crystallography | HIV infections | Protein function predictions | Protein vaccines | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2017, Volume 168, Issue 5, pp. 904 - 915.e10
... membrane fusion proteins. We further show that targeting the segment corresponding to the fusion loop by mutagenesis or by antibodies blocks gamete fusion... 
Chlamydomonas reinhardtii | gamete fusion | crystal structure | sexual reproduction | virus entry | HAP2 | transmission-blocking malaria vaccine | lipid insertion | class II fusion protein | membrane fusion | SEXUAL REPRODUCTION | VIRUS ENVELOPE PROTEIN | FERTILIZATION | GENE | CRYSTAL-STRUCTURE | MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEMLIKI-FOREST-VIRUS | GLYCOPROTEIN | GCS1 | CHLAMYDOMONAS | CELL BIOLOGY | Membrane Fusion Proteins - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Plasmodium - metabolism | Plasmodium - cytology | Recombinant Proteins - chemistry | Crystallography, X-Ray | Recombinant Proteins - genetics | Chlamydomonas - metabolism | Protozoan Proteins - genetics | Membrane Fusion Proteins - metabolism | Biological Evolution | Plant Proteins - genetics | Sequence Alignment | Protozoan Proteins - metabolism | Membrane Fusion Proteins - genetics | Plant Proteins - chemistry | Chlamydomonas - cytology | Germ Cells - chemistry | Protein Domains | Protozoan Proteins - chemistry | Plant Proteins - metabolism | Germ Cells - metabolism | Proteins | Viral antibodies | Antibodies | Plants | Cells | Malaria | Malaria vaccine | Crystals | Structure | Recombinant Proteins | Protozoan Proteins | Germ Cells | Membrane Fusion Proteins | Chlamydomonas | Life Sciences | Plasmodium | Plant Proteins
Journal Article
Oncogene, ISSN 0950-9232, 01/2018, Volume 37, Issue 4, pp. 450 - 460
.... 11q23 translocations involving the H3K4 methyltransferase MLL1 (KMT2A) generate oncogenic fusion proteins with deregulated transcriptional potential... 
RNA-POLYMERASE-II | ARGININE-METHYLTRANSFERASE | CELLS | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ACUTE MYELOID-LEUKEMIA | CELL BIOLOGY | MOUSE DEVELOPMENT | H2B UBIQUITYLATION | ONCOLOGY | JAW TUMOR SYNDROME | GENETICS & HEREDITY | GENE-EXPRESSION | Myeloid Ecotropic Viral Integration Site 1 Protein - metabolism | Epigenesis, Genetic | Homeodomain Proteins - metabolism | Humans | Protein-Arginine N-Methyltransferases - antagonists & inhibitors | Gene Knockdown Techniques | Tumor Suppressor Proteins - genetics | Myeloid Ecotropic Viral Integration Site 1 Protein - genetics | Female | Protein-Arginine N-Methyltransferases - genetics | Nuclear Proteins - genetics | Cell Proliferation - genetics | Histone-Lysine N-Methyltransferase - genetics | Tumor Suppressor Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Transgenic | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | Disease Progression | G1 Phase Cell Cycle Checkpoints - genetics | Homeodomain Proteins - genetics | Protein-Arginine N-Methyltransferases - metabolism | Xenograft Model Antitumor Assays | Animals | Histones - genetics | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Leukemia, Myeloid, Acute - genetics | Epigenetic inheritance | Gene expression | Health aspects | Oncogenes | Translocation | Transcription | Platelet-activating factor | Myeloid leukemia | Therapeutic applications | Leukemia | Protein arginine methyltransferase | Stat5 protein | Ribonucleic acid--RNA | Hemopoiesis | Latency | Arginine | Epigenetics | Acute myeloid leukemia | small molecule inhibitors | PRMT5 | PAFc | MLL
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46039
...(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. We demonstrate that the N-terminal fused T4L is sufficiently rigid... 
COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GPCR | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Protein Engineering - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Tritium | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Sf9 Cells | Bacteriophage T4 - enzymology | Binding Sites | Binding, Competitive | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Muramidase - chemistry | Receptors, Adrenergic, beta-2 - genetics | Viral Proteins - chemistry | Muramidase - genetics | Crystallization | Models, Molecular | Viral Proteins - genetics | Muramidase - metabolism | Recombinant Fusion Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Animals | Dihydroalprenolol - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Dihydroalprenolol - chemistry | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Proteins | Lysozyme | G proteins | Protein engineering | G protein-coupled receptors | Crystal lattices | Science | Catecholamines | Crystallography | Medicine | Signaling | N-Terminus | Chemical bonds | Adrenergic receptors | Physiology | Crystal structure
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2016, Volume 60, Issue 11, pp. 6532 - 6539
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 342, Issue 6158, pp. 592 - 598
Journal Article
PLoS biology, ISSN 1545-7885, 2019, Volume 17, Issue 2, p. e3000164
Throughout the last several decades, vaccination has been key to prevent and eradicate infectious diseases. However, many pathogens (e.g., respiratory... 
CELLS | FUSION-GLYCOPROTEIN VACCINE | HEMAGGLUTININ-STEM | HIV | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | INFECTION | RSV ANTIBODY | DEPENDENT ENHANCEMENT | DENGUE VIRUS | RESPIRATORY SYNCYTIAL VIRUS | Immunogenicity, Vaccine | Recombinant Fusion Proteins - immunology | Viral Fusion Proteins - administration & dosage | Nanoparticles - chemistry | Viral Fusion Proteins - genetics | Respiratory Syncytial Viruses - immunology | Viral Fusion Proteins - immunology | Epitopes - immunology | Viral Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Female | Recombinant Fusion Proteins - administration & dosage | Antibodies, Viral - biosynthesis | Gene Expression | Genetic Vectors - chemistry | Respiratory Syncytial Virus Vaccines - biosynthesis | Immunization - methods | Genetic Vectors - metabolism | Antibodies, Neutralizing - genetics | Palivizumab - chemistry | Palivizumab - immunology | Recombinant Fusion Proteins - chemistry | Receptors, Antigen, B-Cell - immunology | Animals | Antibodies, Neutralizing - biosynthesis | Escherichia coli - genetics | Respiratory Syncytial Virus Vaccines - administration & dosage | Recombinant Fusion Proteins - genetics | Receptors, Antigen, B-Cell - genetics | Epitopes - chemistry | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Structural Homology, Protein | Computer-Aided Design | Antibodies, Monoclonal, Humanized - immunology | Respiratory Syncytial Virus Vaccines - genetics | Antibodies, Viral - genetics | Antibodies, Monoclonal, Humanized - chemistry | Viral antibodies | Immunogenetics | Usage | Vaccination | Analysis | Antibodies | Physiological aspects | Health aspects | Antigenic determinants | Bioengineering | Profiling | Laboratories | Pathogenesis | Viral diseases | Viruses | Infections | Zika virus | Vaccines | Immunodominance | Proteins | Design | Hierarchies | Fusion protein | Bioinformatics | Supervision | Vector-borne diseases | Dengue | Epitopes | Depth profiling | Infectious diseases | Respiratory syncytial virus | Lymphocytes B | Influenza | Neutralizing | Software | Binding sites | Neutralization | Life Sciences | Immunology
Journal Article
Protein expression and purification, ISSN 1046-5928, 01/2019, Volume 153, pp. 7 - 17
.... Multiple studies have identified the P. falciparum proteins Pfs25 and Pfs48/45 as prime targets for transmission-blocking vaccines... 
Bacterial protein expression | Plasmodium | Particle-based vaccine | Tetrahymena | Malaria | Solubility tag | TRANSMISSION-BLOCKING IMMUNITY | PROLYL ISOMERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | ISOMERASE ACTIVITY | BINDING PROTEIN | PERIPLASMIC PROTEIN | VACCINE CANDIDATE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PFS25 PROTEIN | PARASITE PLASMODIUM-FALCIPARUM | MONOCLONAL-ANTIBODIES | EXPRESSION | Immunogenicity, Vaccine | Recombinant Fusion Proteins - immunology | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Membrane Glycoproteins - chemistry | Tetrahymena thermophila - chemistry | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Nanoparticles | Calcium-Binding Proteins - immunology | Antigens, Protozoan - administration & dosage | Cloning, Molecular | Escherichia coli - metabolism | Biological Assay | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Membrane Glycoproteins - immunology | Protozoan Proteins - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Tetrahymena thermophila - immunology | Plasmodium falciparum - chemistry | Calcium-Binding Proteins - chemistry | Rabbits | Gene Expression | Antigens, Protozoan - chemistry | Genetic Vectors - chemistry | Mosquito Vectors - parasitology | Solubility | Genetic Vectors - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Recombinant Fusion Proteins - chemistry | Protein Folding | Recombinant Proteins - administration & dosage | Antibodies, Protozoan - biosynthesis | Calcium-Binding Proteins - administration & dosage | Membrane Glycoproteins - genetics | Malaria, Falciparum - parasitology | Membrane Glycoproteins - administration & dosage | Animals | Malaria Vaccines - administration & dosage | Recombinant Proteins - immunology | Escherichia coli - genetics | Malaria, Falciparum - immunology | Recombinant Fusion Proteins - genetics | Protozoan Proteins - immunology | Calcium-Binding Proteins - genetics | Malaria Vaccines - genetics | Proteins | Viral antibodies | Plasmodium falciparum | Antigens | Analysis | Escherichia coli | Antibodies | EPA, ExoProtein A | TBV, transmission-blocking vaccine | SMFA, standard membrane feeding assay | VLP, virus-like particle | G-SOME, self-assembling Grl particle | Grl1p, granule lattice protein 1
Journal Article