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Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7557, pp. 487 - 491
HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was... 
THERAPY | VIRUS | HIV-1 NEUTRALIZATION | GENETIC-DETERMINANTS | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | PASSIVE TRANSFER | IN-VIVO | VACCINE | MICE | MONOCLONAL-ANTIBODIES | Antibodies, Neutralizing - administration & dosage | Humans | Middle Aged | Viremia - therapy | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Male | Case-Control Studies | HIV Envelope Protein gp120 - immunology | Young Adult | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - adverse effects | HIV Antibodies - immunology | Time Factors | HIV-1 - chemistry | Antibodies, Neutralizing - therapeutic use | Adult | Antibodies, Neutralizing - adverse effects | Female | HIV Antibodies - therapeutic use | HIV Envelope Protein gp120 - chemistry | HIV Antibodies - pharmacology | Binding Sites | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Immunization, Passive - methods | HIV-1 - drug effects | HIV Infections - virology | Antibodies, Monoclonal - pharmacokinetics | Antibodies, Neutralizing - pharmacology | HIV Antibodies - administration & dosage | Viral Load - immunology | HIV-1 - immunology | Viremia - virology | Antibodies, Monoclonal - administration & dosage | HIV Infections - therapy | Viremia - immunology | Viral Load - drug effects | CD4 Antigens - metabolism | Evolution, Molecular | Viral antibodies | Virus diseases | Physiological aspects | Antibodies | HIV infection | Antigens | Immunoglobulins | Human immunodeficiency virus--HIV | Immunotherapy | Infections | Drug dosages | Binding sites | Immune system
Journal Article
Journal of General Virology, ISSN 0022-1317, 12/2017, Volume 98, Issue 12, pp. 2993 - 3007
Plasma leakage is the main pathophysiological feature in severe dengue, resulting from altered vascular barrier function associated with an inappropriate... 
Junctional proteins | Dengue | Cytokine | Electrical impedance | cytokine | NATURAL-HISTORY | dengue | TIGHT JUNCTION | junctional proteins | IN-VITRO | VIROLOGY | HEMORRHAGIC-FEVER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROTEIN NS1 | SERUM-LEVELS | GENE-EXPRESSION | VE-CADHERIN | electrical impedance | SEROTYPE-SPECIFIC DIFFERENCES | PLASMA LEAKAGE | Endothelium, Vascular - cytology | Claudin-1 - immunology | Chemokine CCL2 - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Brain - virology | Retina - immunology | Lung - cytology | Antigens, CD - genetics | Platelet Endothelial Cell Adhesion Molecule-1 - immunology | Virus Internalization | Dengue Virus - immunology | Retina - cytology | Tumor Necrosis Factor-alpha - immunology | Chemokine CCL20 - genetics | Cadherins - genetics | Endothelial Cells - virology | Endothelium, Vascular - immunology | Zonula Occludens-1 Protein - genetics | Vascular Cell Adhesion Molecule-1 - immunology | Interleukin-6 - genetics | Signal Transduction | Chemokine CX3CL1 - genetics | Electric Impedance | Viral Load - immunology | Host-Pathogen Interactions | Claudin-1 - genetics | Interleukin-6 - immunology | Antigens, CD - immunology | Chemokines, CXC - immunology | Platelet Endothelial Cell Adhesion Molecule-1 - genetics | Chemokine CCL20 - immunology | Lung - virology | Cadherins - immunology | Vascular Cell Adhesion Molecule-1 - genetics | Dermis - cytology | Cell Line | Brain - cytology | Gene Expression Regulation | Chemokine CCL2 - genetics | Dermis - virology | Permeability | Chemokines, CXC - genetics | Organ Specificity | Dermis - immunology | Retina - virology | Dengue Virus - growth & development | Endothelial Cells - immunology | Dengue Virus - genetics | Endothelial Cells - cytology | Endothelium, Vascular - virology | Zonula Occludens-1 Protein - immunology | Chemokine CX3CL1 - immunology | Brain - immunology | Lung - immunology
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2014, Volume 44, Issue 9, pp. 2802 - 2810
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2016, Volume 354, Issue 6309, pp. 237 - 240
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7613, pp. 556 - 560
Interruption of combination antiretroviral therapy in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open... 
POTENT | REPLICATION | GENETIC-DETERMINANTS | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | PASSIVE TRANSFER | SEQUENCE | CD4 BINDING | ANTIRETROVIRAL THERAPY | INFECTION | MONOCLONAL-ANTIBODIES | Anti-HIV Agents - pharmacology | Antibodies, Neutralizing - administration & dosage | Disease Reservoirs - virology | Humans | Middle Aged | Male | Proviruses - immunology | Anti-HIV Agents - administration & dosage | Tissue Distribution | Young Adult | HIV Infections - immunology | Proviruses - drug effects | Antibodies, Neutralizing - immunology | HIV-1 - growth & development | HIV Antibodies - immunology | HIV Envelope Protein gp160 - chemistry | Time Factors | Antibodies, Neutralizing - therapeutic use | Binding Sites - immunology | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Antibodies - therapeutic use | Historically Controlled Study | Binding Sites - drug effects | HIV Envelope Protein gp160 - metabolism | Drug Administration Schedule | HIV-1 - drug effects | HIV Infections - virology | HIV Antibodies - administration & dosage | Viral Load - immunology | Proviruses - growth & development | HIV-1 - immunology | HIV Envelope Protein gp160 - antagonists & inhibitors | Adolescent | HIV Infections - drug therapy | Aged | HIV Envelope Protein gp160 - immunology | Viral Load - drug effects | CD4 Antigens - metabolism | Prevention | Antiviral agents | HIV antibodies | Dosage and administration | Host-virus relationships | Drug therapy, Combination | Drug therapy | Health aspects | HIV infection | Methods | Clinical trials | Antiretroviral drugs | Immunoglobulins | Human immunodeficiency virus--HIV | Binding sites
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 537, Issue 7620, pp. 412 - 416
Journal Article