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Journal of Immunology, ISSN 0022-1767, 2011, Volume 186, Issue 2, pp. 1022 - 1031
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 10/2014, Volume 71, Issue 19, pp. 3659 - 3683
Influenza viruses are major human pathogens responsible for respiratory diseases affecting millions of people worldwide and characterized by high morbidity and... 
Life Sciences | Biochemistry, general | Signaling pathways | New antivirals | Virus–host interaction | Life Sciences, general | Drug targets | Influenza virus | Drug discovery | Biomedicine general | Cell Biology | Virus-host interaction | VIRAL-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR EXPORT | POTENT INHIBITORS | CELL BIOLOGY | NS1 PROTEIN | IN-VITRO | CONFORMATIONAL-CHANGE | STRUCTURE-BASED DISCOVERY | SIALIDASE FUSION PROTEIN | SMALL-MOLECULE INHIBITORS | RNA-POLYMERASE | Virus Replication - drug effects | Antiviral Agents - pharmacology | DNA-Directed RNA Polymerases - antagonists & inhibitors | Antiviral Agents - therapeutic use | Humans | Neuraminidase - metabolism | Orthomyxoviridae - metabolism | Virus Internalization - drug effects | Hemagglutinins - immunology | Hemagglutinins - metabolism | Viral Core Proteins - antagonists & inhibitors | Antibodies, Neutralizing - immunology | Viral Matrix Proteins - antagonists & inhibitors | Viral Core Proteins - metabolism | Influenza, Human - virology | Neuraminidase - antagonists & inhibitors | Viral Matrix Proteins - metabolism | Orthomyxoviridae - drug effects | Influenza, Human - drug therapy | DNA-Directed RNA Polymerases - metabolism | Influenza viruses | Antiviral agents | Influenza | Vaccination | Mortality | Drug resistance | Health aspects | Drug approval | Signal transduction | Pharmacology | Antiviral drugs
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7543, pp. 366 - 369
After stimulation, dendritic cells(DCs) mature andmigrate to draining lymph nodes to induce immune responses(1). As such, autologous DCs generated ex vivo have... 
MALIGNANT GLIOMA | RESPONSES | IMMUNITY | MULTIDISCIPLINARY SCIENCES | HUMAN CYTOMEGALOVIRUS | VACCINATION | PERIPHERAL-BLOOD | MELANOMA-CELLS | MIP-1-ALPHA | TUMORS | T-CELLS | Phosphoproteins - immunology | Immunotherapy - methods | Viral Matrix Proteins - genetics | Chemokine CCL3 - immunology | Dendritic Cells - immunology | Humans | Substrate Specificity | Phosphoproteins - chemistry | CD4-Positive T-Lymphocytes - immunology | Cancer Vaccines - therapeutic use | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Tetanus Toxoid - pharmacology | Antigens, Neoplasm - immunology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Tetanus Toxoid - therapeutic use | Survival Rate | Treatment Outcome | Lymph Nodes - immunology | Phosphoproteins - genetics | Lymph Nodes - cytology | Tetanus Toxoid - administration & dosage | Glioblastoma - therapy | Cancer Vaccines - immunology | Cell Movement - drug effects | Animals | Glioblastoma - immunology | Viral Matrix Proteins - chemistry | Glioblastoma - pathology | Dendritic Cells - cytology | Mice | Viral Matrix Proteins - immunology | Glioblastoma - drug therapy | CD4-Positive T-Lymphocytes - drug effects | Medical research | Dendritic cells | Physiological aspects | Medicine, Experimental | Vaccines | Research | Glioblastoma multiforme | Immunization | Lymphocytes | Medical prognosis | Clinical trials | Tetanus | Chemokines
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, p. e78355
Approximately 30% of patients with Epstein-Barr virus (EBV)-positive advanced nasopharyngeal carcinoma (NPC) display chemoresistance to cisplatin-based... 
CANCER-CELLS | B-CELLS | SURVIVAL | MEMBRANE-PROTEIN 1 | MULTIDISCIPLINARY SCIENCES | EBV | MIR-21 | LATENCY | LIGAND | EXPRESSION | LINES | RNA-Binding Proteins - genetics | Carcinoma | Apoptosis - drug effects | Humans | Nasopharyngeal Neoplasms - virology | MicroRNAs - metabolism | Viral Matrix Proteins - pharmacology | Tetrazolium Salts | Forkhead Transcription Factors - metabolism | Luciferases | Thiazoles | Apoptosis Regulatory Proteins - genetics | Inhibitory Concentration 50 | Viral Matrix Proteins - metabolism | Colony-Forming Units Assay | Gene Expression Regulation, Neoplastic - drug effects | Nasopharyngeal Neoplasms - drug therapy | Real-Time Polymerase Chain Reaction | RNA-Binding Proteins - antagonists & inhibitors | Cell Line | Nasopharyngeal Carcinoma | Cisplatin - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Fas Ligand Protein - antagonists & inhibitors | Cisplatin - therapeutic use | Signal Transduction - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | MicroRNAs - genetics | Fas Ligand Protein - genetics | Forkhead Box Protein O3 | Infection | Prognosis | MicroRNA | Tumor necrosis factor | Epstein-Barr virus | B cells | Health aspects | Cisplatin | Apoptosis | Cancer | Cell proliferation | Laboratories | Genes | Crosstalk | Chemoresistance | Viruses | Oncology | Homology | AKT protein | Infections | Metastasis | Proteins | Nasopharyngeal carcinoma | Disease resistance | Signal transduction | Coding | Tumor necrosis factor-TNF | miRNA | Tumorigenesis | Bioindicators | FOXO3 protein | Ribonucleic acid--RNA | 1-Phosphatidylinositol 3-kinase | Membrane proteins | Medicine | Signaling | Chemotherapy | FasL protein | Cell death | MicroRNAs | Medical prognosis | Biomarkers | Ligands | Latent membrane protein 1 | RNA | Ribonucleic acid
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 03/2014, Volume 306, Issue 6, pp. C531 - C539
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2017, Volume 23, Issue 8, pp. 1898 - 1909
Purpose: Patients with glioblastoma have less than 15-month median survival despite surgical resection, high-dose radiation, and chemotherapy with... 
REGRESSION | TRIAL | ONCOLOGY | HOMEOSTATIC EXPANSION | DENDRITIC CELL VACCINES | PROLIFERATION | MICE | COMPARTMENT | T-CELLS | ADJUVANT TEMOZOLOMIDE | Phosphoproteins - immunology | Viral Matrix Proteins - therapeutic use | Dendritic Cells - immunology | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | T-Lymphocytes, Regulatory - immunology | Cancer Vaccines - therapeutic use | Brain Neoplasms - immunology | Dacarbazine - analogs & derivatives | Female | Phosphoproteins - therapeutic use | Brain Neoplasms - mortality | Dacarbazine - administration & dosage | Adjuvants, Immunologic | Kaplan-Meier Estimate | Combined Modality Therapy | Glioblastoma - therapy | Disease-Free Survival | Glioblastoma - immunology | Brain Neoplasms - therapy | Aged | Viral Matrix Proteins - immunology | Dendritic Cells - transplantation | Glioblastoma - mortality | Granulocyte-Macrophage Colony-Stimulating Factor | Cell proliferation | Vaccination | Glioblastoma | Radiation | Lymphocytes T | mRNA | Vaccines | Macrophages | Confidence intervals | Lymphocytes | Surgery | Design standards | DNA methylation | Colony-stimulating factor | Cytomegalovirus | Cell survival | Immune response | Dendritic cells | Immunoregulation | Granulocyte-macrophage colony-stimulating factor | Glycoprotein | Survival | Patients | Radiation dosage | Chemotherapy | Experimental design | Medical prognosis | Pp65 protein | Temozolomide | Methylation | Cancer | dose-intensified temozolomide | glioblastoma | pp65 | cytomegalovirus
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 11/2012, Volume 70, pp. 408 - 414
This paper summarizes the development and validation of five enzyme activity methods to assess the specific inhibition of human endogenous matrix... 
Enzyme therapeutics | Matrix metalloproteinases | Cross-reactivity of anti-drug antibodies | MMP enzyme activity inhibition assay method development and validation | CHEMISTRY, ANALYTICAL | MMP enzyme activity inhibition assay | DUPUYTRENS CONTRACTURE | COLLAGENASE CLOSTRIDIUM-HISTOLYTICUM | method development and validation | PHARMACOLOGY & PHARMACY | Antibody Specificity | Temperature | Matrix Metalloproteinase 1 - analysis | Recombinant Proteins - analysis | Humans | Matrix Metalloproteinase 8 - immunology | Matrix Metalloproteinase 13 - analysis | Matrix Metalloproteinase 1 - immunology | Reference Standards | Matrix Metalloproteinase 3 - immunology | Time Factors | Matrix Metalloproteinases - immunology | Matrix Metalloproteinase 2 - analysis | Antibodies, Bacterial - blood | Microbial Collagenase - therapeutic use | Matrix Metalloproteinase 2 - immunology | Recombinant Proteins - antagonists & inhibitors | Reproducibility of Results | Biological Assay - standards | Enzyme Stability | Matrix Metalloproteinase 13 - immunology | Matrix Metalloproteinases - analysis | Biological Assay - methods | Calibration | Matrix Metalloproteinase 3 - analysis | Clostridium histolyticum - enzymology | Microbial Collagenase - immunology | Cross Reactions | Matrix Metalloproteinase Inhibitors - pharmacology | Recombinant Proteins - immunology | Matrix Metalloproteinase 8 - analysis | Hydrogen-Ion Concentration | Viral antibodies | Antibodies | Enzymes | Consulting services | Analysis | Methods
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0121491
The severity of influenza-related illness is mediated by many factors, including in vivo cell tropism, timing and magnitude of the immune response, and... 
MORTALITY | NS1 PROTEIN | REPLICATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | DYNAMICS | INFECTION | GENERATION | RECEPTOR SPECIFICITY | CLEAVAGE | BINDING | Orthomyxoviridae Infections - prevention & control | Influenza A virus - genetics | Antibodies, Monoclonal - therapeutic use | Monocytes - metabolism | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Tropism - drug effects | Madin Darby Canine Kidney Cells | Protein Stability | Dendritic Cells - virology | Dendritic Cells - metabolism | Oseltamivir - pharmacology | Green Fluorescent Proteins - metabolism | Influenza A virus - physiology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Orthomyxoviridae Infections - metabolism | Cells, Cultured | Viral Nonstructural Proteins - genetics | Recombinant Fusion Proteins - chemistry | Antiviral Agents - administration & dosage | Monocytes - virology | Animals | Antibodies, Monoclonal - administration & dosage | Oseltamivir - administration & dosage | Viral Matrix Proteins - antagonists & inhibitors | Dogs | Recombinant Fusion Proteins - genetics | Viral Nonstructural Proteins - metabolism | Mice | Influenza A virus - drug effects | Orthomyxoviridae Infections - virology | Monoclonal antibodies | Health aspects | Influenza | Tropism | Flow cytometry | Pandemics | Epithelial cells | Amino acids | Viruses | Infections | Genomes | Vaccines | Immunity | Proteins | Reporter gene | Coding | Matrix protein | Protein transport | Dimerization | Immune system | Antigen presentation | CD11c antigen | Myeloid cells | CD11b antigen | Immune response | Dendritic cells | Inflammation | Nuclear transport | Oseltamivir | Monocytes | In vivo methods and tests | Molecular biology | Laboratory animals | NS1 protein
Journal Article