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1. Full Text Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b–infected null responders
by Chayama, Kazuaki and Takahashi, Shoichi and Toyota, Joji and Karino, Yoshiyasu and Ikeda, Kenji and Ishikawa, Hiroki and Watanabe, Hideaki and McPhee, Fiona and Hughes, Eric and Kumada, Hiromitsu
Hepatology (Baltimore, Md.), ISSN 0270-9139, 03/2012, Volume 55, Issue 3, pp. 742 - 748
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Antiviral agents | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antibiotics. Antiinfectious agents. Antiparasitic agents | Recombinant Proteins - therapeutic use | Isoquinolines - adverse effects | Hepatitis C - drug therapy | Humans | Middle Aged | Hepacivirus - genetics | Diarrhea - epidemiology | Male | Diarrhea - chemically induced | Polyethylene Glycols - therapeutic use | Incidence | Hepatitis C - ethnology | Treatment Failure | Protease Inhibitors - adverse effects | Adult | Female | Imidazoles - therapeutic use | Drug Therapy, Combination | Protease Inhibitors - therapeutic use | Headache - chemically induced | Antiviral Agents - therapeutic use | Imidazoles - adverse effects | Japan | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Genotype | Treatment Outcome | Headache - epidemiology | Sulfonamides - therapeutic use | Antiviral Agents - adverse effects | Isoquinolines - therapeutic use | Sulfonamides - adverse effects | Aged | Viral Nonstructural Proteins - antagonists & inhibitors | Proteins | Hepatitis | Genotype & phenotype | Interferon | Infections | Index Medicus
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2. Full Text Nonstructural protein 3‐4A: the Swiss army knife of hepatitis C virus
by Morikawa, K and Lange, C. M and Gouttenoire, J and Meylan, E and Brass, V and Penin, F and Moradpour, D
Journal of viral hepatitis, ISSN 1352-0504, 05/2011, Volume 18, Issue 5, pp. 305 - 315
replication | innate immunity | NS3‐4A | directly acting antiviral | hepatitis C virus | helicase | interferon | serine protease | mitochondrial antiviral signalling protein | NS3-4A | Gastroenterology & Hepatology | Infectious Diseases | Life Sciences & Biomedicine | Science & Technology | Virology | Serine Proteases - genetics | RNA Helicases - metabolism | Humans | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Nucleoside-Triphosphatase - genetics | Mitochondrial Proteins - genetics | RNA Helicases - chemistry | Adaptor Proteins, Vesicular Transport - metabolism | Hepacivirus - metabolism | Serine Proteinase Inhibitors - therapeutic use | Viral Nonstructural Proteins - chemistry | Mitochondrial Proteins - metabolism | Nucleoside-Triphosphatase - metabolism | Carrier Proteins - chemistry | RNA Helicases - genetics | Serine Proteases - chemistry | Serine Proteinase Inhibitors - pharmacology | Nucleoside-Triphosphatase - chemistry | Serine Proteases - metabolism | Antiviral Agents - pharmacology | Signal Transduction | Antiviral Agents - therapeutic use | Mitochondrial Proteins - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Viral Nonstructural Proteins - genetics | Hepatitis C, Chronic - drug therapy | RNA Helicases - antagonists & inhibitors | Nucleoside-Triphosphatase - antagonists & inhibitors | Carrier Proteins - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Drug Resistance, Viral - genetics | Hepacivirus - enzymology | Carrier Proteins - metabolism | Virus Replication | Mitochondrial Proteins - chemistry | Viral Nonstructural Proteins - metabolism | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Cellular proteins | Protease inhibitors | RNA | Interferon alpha | Thrombin | Biological response modifiers | Hepatitis C | Hepatitis C virus | Index Medicus
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3. Full Text SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
by Subissi, Lorenzo and Imbert, Isabelle and Ferron, François and Collet, Axelle and Coutard, Bruno and Decroly, Etienne and Canard, Bruno
Antiviral research, ISSN 0166-3542, 01/2014, Volume 101, Issue 1, pp. 122 - 130
Replication | Coronavirus | Nonstructural proteins | Transcription | SARS-CoV | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Virology | Antiviral agents | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | RNA Helicases - metabolism | Antiviral Agents - pharmacology | Humans | Methyltransferases - metabolism | RNA-Dependent RNA Polymerase - metabolism | RNA Helicases - antagonists & inhibitors | Ribonucleases - metabolism | Ribonucleases - antagonists & inhibitors | RNA-Dependent RNA Polymerase - antagonists & inhibitors | Methyltransferases - antagonists & inhibitors | Virus Replication | Viral Nonstructural Proteins - metabolism | SARS Virus - physiology | Viral Nonstructural Proteins - antagonists & inhibitors | SARS Virus - enzymology | Enzymes | RNA | Health aspects | Severe acute respiratory syndrome | Index Medicus
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4. Full Text Porcine reproductive and respiratory syndrome virus nonstructural protein 4 antagonizes beta interferon expression by targeting the NF-κB essential modulator
by Huang, Chen and Zhang, Qiong and Guo, Xue-kun and Yu, Zhi-bin and Xu, Ao-Tian and Tang, Jun and Feng, Wen-hai
Journal of virology, ISSN 0022-538X, 2014, Volume 88, Issue 18, pp. 10934 - 10945
Life Sciences & Biomedicine | Science & Technology | Virology | Signal Transduction | Down-Regulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Porcine Reproductive and Respiratory Syndrome - metabolism | Viral Nonstructural Proteins - genetics | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Porcine respiratory and reproductive syndrome virus - genetics | Host-Pathogen Interactions | Porcine Reproductive and Respiratory Syndrome - virology | Macrophages - metabolism | Porcine respiratory and reproductive syndrome virus - metabolism | Animals | Macrophages - virology | Interferon-beta - metabolism | NF-kappa B - genetics | Porcine Reproductive and Respiratory Syndrome - genetics | Swine | Interferon-beta - genetics | Viral Nonstructural Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Index Medicus | Virus-Cell Interactions
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5. Full Text Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist
by Chen, Z and Lawson, S and Sun, Z and Zhou, X and Guan, X and Christopher-Hennings, J and Nelson, E.A and Fang, Y
Virology (New York, N.Y.), ISSN 0042-6822, 2009, Volume 398, Issue 1, pp. 87 - 97
Infectious Disease | Interferon antagonist | nsp1 | Proteolytic cleavage | PRRSV | Life Sciences & Biomedicine | Science & Technology | Virology | Amino Acid Sequence | Cell Line | Porcine respiratory and reproductive syndrome virus - metabolism | Viral Nonstructural Proteins - chemistry | Animals | Humans | Molecular Sequence Data | Viral Nonstructural Proteins - genetics | Viral Nonstructural Proteins - metabolism | Interferons - antagonists & inhibitors | Virus diseases | Cell research | Interferon | Biological response modifiers | Porcine reproductive and respiratory syndrome | Health aspects | Index Medicus | TRANSLOCATION | PARASITES | ORGANIC COMPOUNDS | MITOGENS | CLEAVAGE | 60 APPLIED LIFE SCIENCES | CELL NUCLEI | PATHOGENESIS | MICROORGANISMS | GROWTH FACTORS | INTERFERON | LYMPHOKINES | SYNTHESIS | PROTEINS | VIRUSES | CELL CONSTITUENTS | MICROSTRUCTURE | VACCINES
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6. Full Text Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection
by Wang, Chunxiao and Yang, Sundy N.Y and Smith, Kate and Forwood, Jade K and Jans, David A
Biochemical and biophysical research communications, ISSN 0006-291X, 12/2017, Volume 493, Issue 4, pp. 1555 - 1559
Nuclear transport inhibitors | Zika virus | Importins | Viral infection | Flavivirus | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Amino Acid Sequence | Virus Replication - drug effects | Zika Virus Infection - drug therapy | Antiviral Agents - pharmacology | Zika Virus - genetics | Active Transport, Cell Nucleus - physiology | Humans | Zika Virus - physiology | beta Karyopherins - physiology | Cercopithecus aethiops | Fenretinide - pharmacology | Viral Nonstructural Proteins - genetics | Zika Virus - drug effects | Viral Nonstructural Proteins - physiology | Zika Virus Infection - virology | Animals | alpha Karyopherins - physiology | Active Transport, Cell Nucleus - drug effects | Conserved Sequence | Viral Nonstructural Proteins - antagonists & inhibitors | Zika Virus Infection - prevention & control | Vero Cells | Health aspects | Dengue viruses | Virus diseases | International trade | Therapeutics | Molecular biology | Protein binding | Homeopathy | Materia medica and therapeutics | Index Medicus
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7. Full Text Identification, design and synthesis of novel pyrazolopyridine influenza virus nonstructural protein 1 antagonists
by Patnaik, Samarjit and Basu, Dipanwita and Southall, Noel and Dehdashti, Seameen and Wan, Kanny K and Zheng, Wei and Ferrer, Marc and Taylor, Mercedes and Engel, Daniel A and Marugan, Juan Jose
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 9, pp. 1113 - 1119
Antiviral | Antagonist | NS1 | Influenza | Pyrazolopyridine | YBRHGNCGFMRGSV-UHFFFAOYSA-N | NPDYBEJUGJIPPR-UHFFFAOYSA-N | ZXQUYTHURXXUPT-UHFFFAOYSA-N | Pyridines - chemistry | Humans | Half-Life | Male | Structure-Activity Relationship | Antiviral Agents - metabolism | Pyrazoles - chemistry | Drug Design | HEK293 Cells | Madin Darby Canine Kidney Cells | Pyrazoles - pharmacology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Pyrazoles - metabolism | Animals | Influenza A virus - metabolism | Pyridines - metabolism | Interferon-beta - metabolism | Dogs | Antiviral Agents - chemical synthesis | Viral Nonstructural Proteins - metabolism | Mice | Pyridines - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Influenza viruses | Antiviral agents | Medical colleges | Medical research | Medicine, Experimental | Gene expression | Health aspects | Index Medicus
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8. Full Text The Interferon Signaling Antagonist Function of Yellow Fever Virus NS5 Protein Is Activated by Type I Interferon
by Laurent-Rolle, Maudry and Morrison, Juliet and Rajsbaum, Ricardo and Macleod, Jesica M. Levingston and Pisanelli, Giuseppe and Pham, Alissa and Ayllon, Juan and Miorin, Lisa and Martínez-Romero, Carles and tenOever, Benjamin R and García-Sastre, Adolfo
Cell host & microbe, ISSN 1931-3128, 09/2014, Volume 16, Issue 3, pp. 314 - 327
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Phosphorylation | Humans | GTP-Binding Proteins - genetics | STAT1 Transcription Factor - metabolism | Viral Nonstructural Proteins - chemistry | Yellow Fever - metabolism | Yellow Fever - virology | STAT1 Transcription Factor - chemistry | Yellow fever virus - metabolism | Cell Line | Signal Transduction | Viral Nonstructural Proteins - genetics | STAT1 Transcription Factor - genetics | Amino Acid Motifs | Host-Pathogen Interactions | Animals | Interferon-beta - metabolism | STAT2 Transcription Factor - genetics | Protein Binding | Yellow Fever - genetics | Viral Nonstructural Proteins - metabolism | STAT2 Transcription Factor - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | GTP-Binding Proteins - metabolism | Yellow fever virus - genetics | Interferon | Biological response modifiers | Ligases | Health aspects | Yellow fever | Index Medicus
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9. Full Text Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling
by Jelke J. Fros and Wen Jun Liu and Natalie A. Prow and Corinne Geertsema and Maarten Ligtenberg and Dana L. Vanlandingham and Esther Schnettler and Just M. Vlak and Andreas Suhrbier and Alexander A. Khromykh and Gorben P. Pijlman
Journal of Virology, ISSN 0022-538X, 10/2010, Volume 84, Issue 20, pp. 10877 - 10887
induction | disease | cells | replication complex | alphaviruses | gene-expression | persistent infection | wild-type | rnase-l | equine encephalitis | Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | Chikungunya virus - genetics | Humans | Cercopithecus aethiops | Recombinant Proteins | Viral Nonstructural Proteins - chemistry | Interferon Type I - pharmacology | Base Sequence | Genes, Viral | Chikungunya virus - physiology | Vero Cells | Chikungunya virus - pathogenicity | Cell Line | Virus Replication - drug effects | Cricetinae | Sindbis Virus - genetics | Mutant Proteins - genetics | Viral Nonstructural Proteins - genetics | Mutant Proteins - physiology | Viral Nonstructural Proteins - physiology | Janus Kinases - antagonists & inhibitors | Chikungunya virus - drug effects | Animals | Signal Transduction - drug effects | Mutant Proteins - chemistry | STAT Transcription Factors - antagonists & inhibitors | Mutation | DNA, Viral - genetics | Virus Replication - physiology | Interferon-gamma - pharmacology | Amino Acid Substitution | Replicon | Index Medicus | Virus-Cell Interactions
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