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PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
... with the mitochondrial adaptor protein MAVS (also known as IPS-1, CARDIF and VISA) and initiates a signalling cascade that culminates in the activation of the transcriptional... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 4, p. e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1 beta response is mediated by innate receptors in... 
INTERLEUKIN-1 | RNA | RESPIRATORY VIRAL-INFECTION | INNATE IMMUNE-RESPONSE | RIG-I | MICROBIOLOGY | INDUCTION | NS1 PROTEIN | ANTIVIRAL RESPONSES | INTERFERON | VIROLOGY | EPITHELIAL-CELLS | PARASITOLOGY | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Virology | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7747, pp. 262 - 266
...). Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK and TBK1 to induce interferons and other cytokines(2-6... 
SYNTHASE | CYCLIC GMP-AMP | MAVS | PROTEIN | ROLES | MULTIDISCIPLINARY SCIENCES | ADAPTER | SENSOR | Nucleotides, Cyclic - metabolism | Interferons - biosynthesis | Beclin-1 - deficiency | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Autophagy-Related Protein 5 - genetics | Autophagy-Related Protein-1 Homolog - metabolism | DNA Viruses - metabolism | Interferons - immunology | Autophagy | DNA Viruses - genetics | Sea Anemones | Membrane Proteins - deficiency | HEK293 Cells | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Phosphate-Binding Proteins | Signal Transduction | Membrane Proteins - genetics | DNA, Viral - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Autophagosomes - metabolism | Cytosol - virology | Protein Transport | Carrier Proteins - genetics | Animals | Autophagy-Related Protein-1 Homolog - deficiency | Carrier Proteins - metabolism | Monomeric GTP-Binding Proteins - metabolism | Autophagy-Related Protein 5 - deficiency | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Golgi Apparatus - metabolism | Mice | Beclin-1 - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Nucleotides, Cyclic - immunology | Evolution, Molecular | Biological research | Autophagy (Cytology) | Enzymes | Physiological aspects | Interferon | Research | Cytoplasm | Biology, Experimental | G proteins | Biological response modifiers | Health aspects | Protein binding
Journal Article
PLoS pathogens, ISSN 1553-7374, 2011, Volume 7, Issue 2, p. e1001278
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 13, pp. 6714 - 6722
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered partners, as a part of their ubiquitous role in facilitating transcription of genes... 
ACTIVATION DOMAIN | UNSTRUCTURED PROTEINS | viral oncoprotein | intrinsically disordered protein | coupled folding and binding | intrinsically disordered region | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | STAT transcription factor | C-MYB | transcriptional coactivator | VIRAL-PROTEINS | transcriptional activation | P53 TRANSACTIVATION DOMAIN | COMPLEX-FORMATION | cAMP response element-binding protein (CREB) | hypoxia-inducible factor (HIF) | IDP | STRUCTURAL BASIS | IDR | KIX DOMAIN | TAZ2 DOMAIN | PEPTIDE MOTIFS | protein-protein interaction | Humans | E1A-Associated p300 Protein - genetics | STAT Transcription Factors - metabolism | CREB-Binding Protein - chemistry | NF-kappa B - metabolism | E1A-Associated p300 Protein - metabolism | NF-kappa B - chemistry | Viral Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Transcription, Genetic | Protein Interaction Domains and Motifs | Protein Structure, Secondary | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Viral Proteins - chemistry | E1A-Associated p300 Protein - chemistry | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Viral Proteins - genetics | Intrinsically Disordered Proteins - genetics | Protein Folding | STAT Transcription Factors - genetics | NF-kappa B - genetics | Intrinsically Disordered Proteins - chemistry | Protein Binding | STAT Transcription Factors - chemistry | Tumor Suppressor Protein p53 - chemistry | Intrinsically Disordered Proteins - metabolism | Minireviews
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 609 - 621
MLL is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity... 
CELLCYCLE | DNA | HUMDISEASE | RNA-POLYMERASE-II | CHROMOSOMAL TRANSLOCATIONS | TARGET GENES | STEM-CELLS | HISTONE H2B | ONCOLOGY | H3 METHYLATION | TUMOR-SUPPRESSOR PROTEIN | LEUKEMIA | EXPRESSION | TRANSCRIPTIONAL ELONGATION | CELL BIOLOGY | Myeloid Cells - cytology | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Transcriptional Activation - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Leukemia - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Transfection | RNA Interference | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia - genetics | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Sequence Deletion - physiology | Mice, Inbred C57BL | Gene Expression Regulation | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Transcription, Genetic - physiology | Animals | Carrier Proteins - metabolism | Models, Biological | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Myeloid Cells - metabolism | Mice | HeLa Cells | Myeloid Ecotropic Viral Integration Site 1 Protein | Cell Transformation, Neoplastic - pathology | Protein Binding - physiology | Proteins | RNA | Gene expression
Journal Article
Microbial biotechnology, ISSN 1751-7915, 2016, Volume 9, Issue 3, pp. 355 - 368
...) in the yeast Pichia pastoris; this membrane protein is responsible for the synthesis of rabies neutralizing antibodies... 
HETEROLOGOUS PROTEIN EXPRESSION | YEAST | SYSTEM | SECRETORY EXPRESSION | OVEREXPRESSION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENE DOSAGE | PHYSIOLOGICAL-RESPONSE | MICROBIOLOGY | ENDOPLASMIC-RETICULUM | STRESS | INSULIN PRECURSOR | Metabolic Engineering | Glycoproteins - metabolism | Antigens, Viral - genetics | Neutralization Tests | Recombinant Proteins - biosynthesis | Antibodies, Neutralizing - immunology | Pichia - metabolism | Codon | Viral Envelope Proteins - metabolism | Antigens, Viral - biosynthesis | Glycoproteins - genetics | Recombinant Proteins - metabolism | Gene Expression | Viral Envelope Proteins - genetics | Viral Envelope Proteins - biosynthesis | Gene Dosage | Recombinant Proteins - genetics | Unfolded Protein Response | Protein Folding | Glycoproteins - biosynthesis | Antigens, Viral - immunology | Glycoproteins - immunology | Recombinant Proteins - immunology | Pichia - genetics | Viral Envelope Proteins - immunology | Pichia - growth & development | Yeasts | Baking yeast | Yeast | Copy number | Secretion | Antibodies | Viruses | Glycoproteins | Gene expression | Optimization | Membrane proteins | Proteins | Protein folding | Rabies | Neutralizing | Protein expression | Acid phosphatase | Folding | Viral Envelope Proteins/genetics | Viral Envelope Proteins/immunology | Glycoproteins/immunology | Antigens, Viral/biosynthesis | Recombinant Proteins/immunology | Pichia/growth & development | Antigens, Viral/genetics | Recombinant Proteins/metabolism | Life Sciences | Viral Envelope Proteins/metabolism | Viral Envelope Proteins/biosynthesis | Glycoproteins/biosynthesis | Antibodies, Neutralizing/immunology | Antigens, Viral/immunology | Glycoproteins/metabolism | Recombinant Proteins/biosynthesis | Recombinant Proteins/genetics | Pichia/genetics | Glycoproteins/genetics | Pichia/metabolism
Journal Article
The Journal of cell biology, ISSN 1540-8140, 1999, Volume 146, Issue 6, pp. 1239 - 1254
Formation of a novel structure, the aggresome, has been proposed to represent a general cellular response to the presence of misfolded proteins (Johnston, J.A... 
COS cells | Vimentin | Transfection | Ubiquitins | Microtubules | Antibodies | Cell aggregates | Chimeras | Cells | Microtubule organizing center | Aggresome | Chaperones | p50/dynamitin | Proteasome | proteasome | CELLS | MEMBRANE-PROTEIN | ORNITHINE DECARBOXYLASE | microtubules | QUALITY-CONTROL | CELL BIOLOGY | GREEN FLUORESCENT PROTEIN | PATHWAY | VIRUS G-PROTEIN | GOLGI TRANSPORT | DEGRADATION | ENDOPLASMIC-RETICULUM | chaperones | aggresome | Organelles - chemistry | Green Fluorescent Proteins | Molecular Chaperones - metabolism | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Microtubules - metabolism | Organelles - ultrastructure | Biological Transport | Membrane Glycoproteins | Peptide Fragments - genetics | Ubiquitins - metabolism | Dyneins - metabolism | Viral Envelope Proteins - genetics | Membrane Proteins - genetics | Cytosol - ultrastructure | Solubility | Dynactin Complex | Recombinant Fusion Proteins - chemistry | Cytosol - chemistry | Peptide Fragments - chemistry | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Luminescent Proteins - genetics | Protein Processing, Post-Translational | Kinetics | COS Cells | Organelles - metabolism | Microtubule-Associated Proteins - metabolism | Vimentin - metabolism | Endoplasmic Reticulum - metabolism | Golgi Matrix Proteins | Recombinant Fusion Proteins - metabolism | Centrosome - ultrastructure | Cysteine Endopeptidases - metabolism | Viral Envelope Proteins - metabolism | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Vesicular Transport Proteins | Peptide Fragments - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Protein Folding | Centrosome - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Membrane Proteins - chemistry | Dyneins - antagonists & inhibitors | Golgi Apparatus - metabolism | Luminescent Proteins - metabolism | Protein folding | Cell organelles | Research | p50 | dynamitin | Original
Journal Article