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The Journal of Immunology, ISSN 0022-1767, 02/2004, Volume 172, Issue 3, pp. 1777 - 1785
DNA rich in nonmethylated CG motifs (CpGs) greatly facilitates induction of immune responses against coadministered Ags. CpGs are therefore among the most... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CORE PARTICLES | DENDRITIC CELLS | IMMUNE-RESPONSES | TOLL-LIKE RECEPTORS | TH1 IMMUNITY | IMMUNOLOGY | BACTERIAL-DNA | INNATE IMMUNITY | CUTTING EDGE | ANTIGEN | Allolevivirus - immunology | Oligodeoxyribonucleotides - administration & dosage | Dendritic Cells - immunology | Virion - genetics | Lymphocyte Activation - genetics | Oligodeoxyribonucleotides - genetics | Recombination, Genetic | Peptide Fragments - immunology | Viral Proteins - administration & dosage | Peptide Fragments - genetics | Glycoproteins - genetics | Virion - immunology | Oligodeoxyribonucleotides - immunology | Viral Proteins - genetics | Antigen Presentation - genetics | Antigen Presentation - immunology | Virion - metabolism | Glycoproteins - administration & dosage | Hepatitis B Core Antigens - genetics | Hepatitis B Core Antigens - immunology | Antigens, Viral - immunology | Glycoproteins - immunology | B-Lymphocytes - immunology | Virus Assembly - immunology | CpG Islands - genetics | T-Lymphocytes - immunology | Mice | Hepatitis B Core Antigens - administration & dosage | Dose-Response Relationship, Immunologic | Antigens, Viral - administration & dosage | Vaccines, DNA - immunology | Viral Proteins - immunology | RNA, Viral - administration & dosage | Antigens, Viral - genetics | Fibrosarcoma - immunology | Vaccines, DNA - administration & dosage | DNA Methylation | RNA, Viral - genetics | Virus Assembly - genetics | Allolevivirus - genetics | Dendritic Cells - virology | Dendritic Cells - metabolism | Liposomes - immunology | T-Lymphocytes, Cytotoxic - immunology | Thionucleotides - antagonists & inhibitors | Cytotoxicity, Immunologic - genetics | CpG Islands - immunology | T-Lymphocytes, Cytotoxic - virology | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Animals | Thionucleotides - toxicity | Fibrosarcoma - prevention & control | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 5/2010, Volume 328, Issue 5979, pp. 745 - 748
Journal Article
Blood, ISSN 0006-4971, 12/2012, Volume 120, Issue 24, pp. 4744 - 4750
Natural killer (NK) cells become activated during viral infection in response to cytokines or to engagement of NK cell activating receptors. However, the... 
NODES | NATURAL-KILLER-CELLS | VIRUS | DENDRITIC CELLS | INNATE | INFECTION | T-CELL | IL-15R-ALPHA | IN-VIVO ABLATION | HEMATOLOGY | CUTTING EDGE | Lymph - immunology | Antigens, Ly - genetics | Receptors, CCR5 - genetics | Male | Green Fluorescent Proteins - genetics | Interleukin-15 - immunology | Lymph - virology | Vaccinia virus - genetics | Receptors, CCR5 - immunology | Vaccinia virus - immunology | Host-Pathogen Interactions - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Natural Cytotoxicity Triggering Receptor 1 - genetics | Recombination, Genetic | Killer Cells, Natural - immunology | Antigens, Ly - metabolism | Female | Receptor, Interferon alpha-beta - genetics | Receptors, CXCR3 - deficiency | Microscopy, Fluorescence, Multiphoton | Natural Cytotoxicity Triggering Receptor 1 - immunology | Macrophages - immunology | Virion - immunology | Green Fluorescent Proteins - metabolism | Receptor, Interferon alpha-beta - deficiency | Mice, Inbred C57BL | Virion - physiology | Lymph Nodes - metabolism | Receptors, CCR5 - deficiency | Mice, Transgenic | Lymph Nodes - virology | Lymph Nodes - immunology | Interleukin-15 - deficiency | Mice, Knockout | Macrophages - metabolism | Animals | Interleukin-15 - genetics | Antigens, Ly - immunology | Receptor, Interferon alpha-beta - immunology | Receptors, CXCR3 - genetics | Receptors, CXCR3 - immunology | Natural Cytotoxicity Triggering Receptor 1 - metabolism | Mice | Killer Cells, Natural - metabolism | Viral Vaccines - immunology | Vaccinia virus - physiology | Index Medicus | Abridged Index Medicus | Life Sciences | Innate immunity | Immunology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 19, pp. 7439 - 7444
Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50... 
Antiserum | Virions | Dengue | Vaccination | Antibodies | Viruses | Infections | Dimers | Epitopes | Dengue virus | DOMAIN-III | PROTEIN | ENCEPHALITIS-VIRUS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | WEST-NILE-VIRUS | ENVELOPE GLYCOPROTEIN | JAPANESE ENCEPHALITIS | INFECTION | MONOCLONAL-ANTIBODIES | TYPE-2 | Antibodies, Viral - metabolism | Epitopes - metabolism | Humans | Protein Multimerization | Antibodies, Neutralizing - metabolism | Cercopithecus aethiops | Molecular Sequence Data | Neutralization Tests | Macaca mulatta | Epitopes - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Dengue Virus - immunology | Viral Envelope Proteins - metabolism | Dengue - immunology | Vero Cells | Antibodies, Monoclonal - immunology | Recombinant Proteins - metabolism | Virion - immunology | Amino Acid Sequence | Immune Sera - immunology | Viral Envelope Proteins - genetics | Enzyme-Linked Immunosorbent Assay | Models, Molecular | Recombinant Proteins - chemistry | Dengue - virology | Protein Binding - immunology | Sequence Homology, Amino Acid | Dengue Virus - genetics | Animals | Recombinant Proteins - immunology | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Antibodies, Monoclonal - metabolism | Dengue Virus - metabolism | Mutation | Viral antibodies | Physiological aspects | Research | Antigenic determinants | Proteins | Monoclonal antibodies | Mosquitoes | Dengue fever | Rodents | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e61101 - e61101
Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent... 
3-DIMENSIONAL STRUCTURE | B-CELLS | VISUALIZATION | PROTECTIVE IMMUNITY | CRYOELECTRON MICROSCOPY | PROTEIN-STRUCTURE | MULTIDISCIPLINARY SCIENCES | VIRUS-LIKE PARTICLES | CRYO-EM | MASS-SPECTROMETRY | YOUNG-CHILDREN | Antibodies, Viral - metabolism | Antigens, Viral - metabolism | Epitopes - metabolism | Virus Replication - genetics | Humans | Rotavirus - physiology | Rotavirus - immunology | Molecular Sequence Data | Virion - genetics | Antigens, Viral - genetics | Neutralization Tests | Host-Pathogen Interactions - immunology | Epitopes - immunology | Rotavirus - metabolism | HEK293 Cells | B-Lymphocytes - virology | Capsid Proteins - immunology | Transcription, Genetic | Rotavirus Infections - virology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Caco-2 Cells | Protein Structure, Tertiary | Virion - immunology | Amino Acid Sequence | Cell Line | Immunoglobulin A - metabolism | Capsid Proteins - metabolism | Models, Molecular | Virus Replication - immunology | Protein Binding - immunology | Virion - metabolism | Rotavirus Infections - immunology | Sequence Homology, Amino Acid | Antigens, Viral - immunology | Animals | B-Lymphocytes - immunology | Immunoglobulin A - immunology | Antibodies, Viral - immunology | Epitopes - chemistry | Antibodies, Monoclonal - metabolism | Capsid Proteins - genetics | Genetic aspects | Genetic transcription | B cells | Vaccines | Immunoglobulin A | Pediatrics | Transcription | Mucosa | Antibodies | Viruses | Infections | Biochemistry | Immunity | Crystallography | Proteins | Immunology | Physiology | Immunoglobulins | Automation | Quaternary | Particulates | Biophysics | Medicine | Pathology | Lymphocytes B | Quaternary structure | Scientific imaging | Intracellular | Human behavior | Mass spectrometry | Protein structure | Immunoassays | Neutralization | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 27, pp. 11181 - 11186
To guide vaccine design, we assessed whether human monoclonal antibodies (MAbs) b12 and b6 against the CD4 binding site (CD4bs) on HIV-1 gp120 and F240 against... 
Shivs | Neutralizing antibodies | Vaccination | Virions | Antibodies | Viruses | Infections | Epitopes | Dosage | HIV 1 | Passive immunization | Binding antibodies | HIV VACCINES | MULTIDISCIPLINARY SCIENCES | HUMAN MONOCLONAL-ANTIBODY | ENVELOPE GLYCOPROTEIN | binding antibodies | IN-VITRO | TRANSMISSION | IMMUNODEFICIENCY-VIRUS TYPE-1 | passive immunization | INFECTION | MONKEYS | BINDING | RHESUS MACAQUES | Antibodies, Neutralizing - administration & dosage | HIV Infections - prevention & control | HIV Envelope Protein gp41 - immunology | Humans | AIDS Vaccines - immunology | Vagina - immunology | Molecular Sequence Data | Macaca mulatta | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | Simian Immunodeficiency Virus - genetics | Female | Membrane Glycoproteins - immunology | Simian Immunodeficiency Virus - immunology | SAIDS Vaccines - administration & dosage | HIV-1 - genetics | HIV Antibodies - administration & dosage | Simian Acquired Immunodeficiency Syndrome - prevention & control | HIV-1 - immunology | Animals | SAIDS Vaccines - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Antibodies, Monoclonal - administration & dosage | Vagina - virology | Immunization, Passive | Viral Envelope Proteins - immunology | AIDS Vaccines - administration & dosage | Monoclonal antibodies | Physiological aspects | Vaginal diseases | Genetic aspects | HIV (Viruses) | Health aspects | Vaccines | Monkeys & apes | Human immunodeficiency virus--HIV | Binding sites | Index Medicus | Biological Sciences
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 35, pp. 5911 - 5918
Abstract Despite existing vaccines and specific therapies, epidemics of seasonal influenza annually claim 200,000–500,000 lives worldwide. Pandemic influenza... 
Allergy and Immunology | VLP | Trivalent | Influenza vaccine | Influenza | Virus-like particles | UNITED-STATES | MEDICINE, RESEARCH & EXPERIMENTAL | VACCINATION | IMMUNOLOGY | IN-VITRO | IMMUNE-RESPONSES | A VIRUSES | H5N1 VIRUSES | FERRETS | MICE | EXPRESSION | VACCINES | Influenza A Virus, H1N1 Subtype - immunology | Orthomyxoviridae Infections - prevention & control | Influenza Vaccines - administration & dosage | Pandemics | Humans | Virion - genetics | Influenza A Virus, H5N1 Subtype - genetics | Hemagglutinin Glycoproteins, Influenza Virus - immunology | Influenza A Virus, H3N2 Subtype - genetics | Vaccines, Synthetic - immunology | Orthomyxoviridae - classification | Influenza A Virus, H7N2 Subtype - immunology | Hemagglutinin Glycoproteins, Influenza Virus - genetics | Orthomyxoviridae - immunology | Spodoptera | Influenza B virus - genetics | Influenza, Human - virology | Influenza B virus - immunology | Seasons | Influenza A Virus, H1N1 Subtype - genetics | Virion - immunology | Vaccines, Synthetic - genetics | Cells, Cultured | Ferrets | Influenza A Virus, H3N2 Subtype - immunology | Virion - metabolism | Hemagglutinin Glycoproteins, Influenza Virus - metabolism | Animals | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Influenza A Virus, H5N1 Subtype - immunology | Orthomyxoviridae - genetics | Vaccines, Synthetic - administration & dosage | Influenza, Human - prevention & control | Orthomyxoviridae Infections - virology | Influenza A Virus, H7N2 Subtype - genetics | Orthomyxoviridae Infections - immunology | Influenza, Human - immunology | Avian influenza viruses | Lectins | Epidemics | Global economy | Proteins | Genes | Viruses | Vaccines | Avian flu | Fever | Eggs | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 16, pp. 6205 - 6210
Hepatitis C virus (HCV) infects ~2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt the country... 
Hepatitis | Antigens | Vaccination | Virions | Antibodies | Viruses | Glycoproteins | Infections | Epitopes | Genotypes | Cross-neutralizing antibody | Virus challenge | Antigenic determinant | Chronic viral infection | Protective determinant | chronic viral infection | DESIGN | STRATEGY | MULTIDISCIPLINARY SCIENCES | E1 GLYCOPROTEIN | virus challenge | antigenic determinant | cross-neutralizing antibody | EPITOPE | CELL-CULTURE SYSTEMS | E2 GLYCOPROTEIN | INFECTION | HUMAN MONOCLONAL-ANTIBODIES | protective determinant | VACCINES | REVEALS | Hepacivirus - immunology | Viral Hepatitis Vaccines - administration & dosage | Humans | Hepacivirus - genetics | Molecular Sequence Data | Immunoblotting | Epitopes, B-Lymphocyte - immunology | Hepatitis C Antibodies - immunology | Peptide Library | Tetraspanin 28 - immunology | Hepatitis C - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | HEK293 Cells | Hepatitis C - prevention & control | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Viral Envelope Proteins - genetics | Enzyme-Linked Immunosorbent Assay | Genotype | Viral Hepatitis Vaccines - immunology | Animals | Hepatitis C - virology | Cell Line, Tumor | Viral Envelope Proteins - immunology | Mice | Viral antibodies | Physiological aspects | Hepatitis C virus | Health aspects | Vaccines | Polyclonal antibodies | Binding sites | Index Medicus | Biological Sciences
Journal Article
Journal Article