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Cell reports (Cambridge), ISSN 2211-1247, 2016, Volume 16, Issue 10, pp. 2576 - 2592
.... We also found that nucleoside analogs inhibit ZIKV replication in NES cells, protecting... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 530, Issue 7588, pp. 51 - 56
.... Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral... 
EVOLUTION | SEQUENCE DATA | COMBINATION THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) T-CELLS | PERIPHERAL-BLOOD | INFECTION | Anti-HIV Agents - pharmacology | Carrier State - blood | Humans | Molecular Sequence Data | Phylogeny | Selection, Genetic - drug effects | Anti-HIV Agents - administration & dosage | HIV-1 - growth & development | Time Factors | HIV-1 - isolation & purification | Haplotypes - drug effects | Anti-HIV Agents - therapeutic use | Lymph Nodes - drug effects | Spatio-Temporal Analysis | HIV Infections - blood | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Lymph Nodes - virology | HIV-1 - genetics | Sequence Analysis, DNA | Carrier State - virology | Models, Biological | Carrier State - drug therapy | Drug Resistance, Viral - drug effects | HIV Infections - drug therapy | Viral Load - drug effects | Infection | Highly active antiretroviral therapy | Care and treatment | Analysis | Patient outcomes | Physiological aspects | Development and progression | HIV (Viruses) | Health aspects | HIV infection | Haplotypes | Antiretroviral drugs | Tissue | Lymphatic system | Human immunodeficiency virus--HIV | Phylogenetics | Infections | Drug resistance
Journal Article
Journal of Virology, ISSN 0022-538X, 2016, Volume 90, Issue 21, pp. 9683 - 9692
.... While several compounds show promise in vitro and in vivo, these outbreaks underscore the need to accelerate drug discovery... 
DRUG | EFLORNITHINE | REPLICATION | VIROLOGY | ALPHA-DIFLUOROMETHYLORNITHINE | DEPLETION | INFECTION | TRANSLATION | MAMMALIAN-CELLS | RESPIRATORY SYNDROME CORONAVIRUS | SPERMIDINE | Zika Virus Infection - drug therapy | Acetyltransferases - metabolism | Ebolavirus - metabolism | Chikungunya virus - metabolism | Humans | Eflornithine - pharmacology | Ebolavirus - drug effects | Zika Virus Infection - virology | Disease Outbreaks | RNA Viruses - drug effects | Hemorrhagic Fever, Ebola - virology | Hemorrhagic Fever, Ebola - drug therapy | Spermine - analogs & derivatives | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Chikungunya Fever - drug therapy | Zika Virus - drug effects | Chikungunya Fever - virology | Polyamines - metabolism | Chikungunya virus - drug effects | Animals | Spermine - pharmacology | Mice | Spermine/analogs & derivatives | Virus Replication/drug effects | Hemorrhagic Fever, Ebola/virology | Life Sciences | Zika Virus/drug effects | Immunology | Chikungunya virus/metabolism | Chikungunya Fever/drug therapy | Zika Virus Infection/drug therapy | Ebolavirus/drug effects | Acetyltransferases/metabolism | Chikungunya virus/drug effects | Eflornithine/pharmacology | Spermine/pharmacology | Polyamines/metabolism | Chikungunya Fever/virology | Hemorrhagic Fever, Ebola/drug therapy | Virology | Microbiology and Parasitology | Zika Virus Infection/virology | Ebolavirus/metabolism | Antiviral Agents/pharmacology | RNA Viruses/drug effects
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 5, pp. 1094 - 1105.e25
... and induction of the membranous web, which is the site of HCV replication. Analyses were conducted with replicons, infectious virus, and human hepatoma cells that express a HCV polyprotein... 
Gastroenterology and Hepatology | Viral Replication | Viral Replication Factory | Drug Mechanism | Chronic Hepatitis C | DOMAIN | NONSTRUCTURAL PROTEIN 5A | CRYSTAL-STRUCTURE | LIVER-DISEASES | VIRAL GENOME | CELL-LINES | CULTURE | IN-VITRO | POTENT | BMS-790052 | GASTROENTEROLOGY & HEPATOLOGY | Minor Histocompatibility Antigens | Humans | Protein Multimerization | Drug Resistance, Viral | Imidazoles - chemistry | Hepacivirus - genetics | Structure-Activity Relationship | Protease Inhibitors - pharmacology | Viral Nonstructural Proteins - chemistry | Transfection | Time Factors | Antiviral Agents - chemistry | Drug Design | Molecular Structure | Binding Sites | Cell Membrane - drug effects | Hepatocytes - drug effects | Hepacivirus - drug effects | Virus Replication - drug effects | Antiviral Agents - pharmacology | Protease Inhibitors - chemistry | Viral Nonstructural Proteins - genetics | Cell Membrane - ultrastructure | Imidazoles - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Host-Pathogen Interactions | Cell Membrane - enzymology | Hepacivirus - enzymology | Cell Line, Tumor | Hepatocytes - ultrastructure | Hepatocytes - virology | Cell Membrane - virology | Protein Conformation | Viral Nonstructural Proteins - metabolism | Molecular Docking Simulation | Mutation | Viral Nonstructural Proteins - antagonists & inhibitors | Hepatocytes - enzymology | Virus diseases | RNA | Hepatitis C virus | Health aspects
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 494, Issue 7438, pp. 492 - 496
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2014, Volume 124, Issue 8, pp. 3479 - 3488
A wide range of antiviral drugs is currently available; however, drug-resistant viruses have begun to emerge and represent a potential public health risk... 
CYCLIN-DEPENDENT KINASES | MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | IN-VITRO | FACTOR P-TEFB | PROTEIN-KINASE | TRANSCRIPTION | ANTIVIRAL ACTIVITY | HOST | HIV-1 REPLICATION | IDENTIFICATION | Transcription, Genetic - drug effects | Rats, Wistar | Antiviral Agents - toxicity | Pyridines - chemistry | Humans | Drug Resistance, Viral | Host-Pathogen Interactions - drug effects | DNA Viruses - genetics | Herpes Simplex - drug therapy | Herpesvirus 1, Human - physiology | Protein Kinase Inhibitors - chemistry | Piperidines - pharmacology | Antiviral Agents - chemistry | HEK293 Cells | Flavonoids - pharmacology | DNA Viruses - physiology | Cytomegalovirus - physiology | Herpesvirus 2, Human - drug effects | Disease Models, Animal | Virus Replication - drug effects | Antiviral Agents - pharmacology | Acyclovir - pharmacology | Adenoviruses, Human - physiology | Rats | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Transcriptome - drug effects | Mice, Inbred ICR | Herpesvirus 1, Human - drug effects | Herpes Simplex - virology | Animals | Host-Pathogen Interactions - genetics | Pyridines - toxicity | Herpes Simplex - pathology | Adenoviruses, Human - drug effects | Protein Kinase Inhibitors - toxicity | Herpesvirus 2, Human - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | HeLa Cells | DNA Viruses - drug effects | Cytomegalovirus - drug effects | Physiological aspects | Research | DNA viruses | Health aspects | Protein kinases | Medical research | Drug resistance | Kinases | Cell cycle
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, p. 40920
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2016, Volume 60, Issue 4, pp. 2195 - 2208
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2009, Volume 53, Issue 12, pp. 5251 - 5258
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
IN-VITRO | CYCLIC CIDOFOVIR | RETINOBLASTOMA PROTEIN | 2-DEOXY-4-THIOPYRIMIDINE NUCLEOSIDES | SIMPLEX-VIRUS | VACCINIA | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | VIRUS THYMIDINE KINASE | LIPID-ESTER PRODRUGS | ANTIVIRAL DRUGS | ORTHOPOXVIRUS INFECTIONS | Herpesvirus 8, Human - drug effects | Humans | DNA-Directed DNA Polymerase - genetics | Herpesvirus 2, Human - genetics | Antiviral Agents - chemistry | Herpesviridae - genetics | Viral Proteins - physiology | Molecular Structure | Herpesvirus 2, Human - drug effects | Pyrimidine Nucleosides - chemical synthesis | Fluorescent Antibody Technique, Indirect | Herpesvirus 6, Human - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Herpesviridae - drug effects | Antiviral Agents - therapeutic use | Cells, Cultured | Viral Proteins - genetics | Herpesvirus 8, Human - genetics | Herpesvirus 6, Human - genetics | Herpesviridae Infections - virology | Herpesviridae Infections - drug therapy | Herpesvirus 1, Human - drug effects | Pyrimidine Nucleosides - therapeutic use | Drug Resistance, Viral - genetics | Animals | Pyrimidine Nucleosides - chemistry | Antiviral Agents - adverse effects | DNA-Directed DNA Polymerase - physiology | Drug Resistance, Viral - drug effects | Herpesvirus 1, Human - genetics | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Pyrimidine Nucleosides - pharmacology | Microscopy, Fluorescence | Antiviral Agents
Journal Article