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Chemical Communications, ISSN 1359-7345, 9/2015, Volume 51, Issue 74, pp. 144 - 1417
This Feature Article highlights recent developments in the field of vitamin B 12 derivatives for medicinal applications. The following topics are emphasized:... 
Vitamin B 12 - chemistry | Molecular Structure | Vitamin B 12 - therapeutic use | Vitamin B 12 - analogs & derivatives | Drug Discovery - trends
Journal Article
Journal of inorganic biochemistry, 07/2015, Volume 148, p. 62
Crystal structure analyses have helped to decipher the mode of binding of coenzyme B12 (AdoCbl) in the active site of AdoCbl-dependent enzymes. However, the... 
Vitamin B 12 - chemistry | Cobamides - chemistry | Magnetic Resonance Spectroscopy | Models, Chemical | Solutions | Vitamin B 12 - analogs & derivatives | Crystallography, X-Ray | Molecular Structure | Circular Dichroism | Vitamin B 12 - chemical synthesis | Fluorine - chemistry
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 08/2013, Volume 42, Issue 16, pp. 6605 - 6619
Vitamin B12 plays a key role in many metabolic processes occurring in all mammals. Over the years its biological role has been extensively studied generating a... 
Vitamin B 12 - chemistry | Cobamides - chemistry | Vitamin B 12 - analogs & derivatives | Vitamin B 12 - metabolism | Cobalt - chemistry | Lactams - chemistry | Lactones - chemistry
Journal Article
AMERICAN JOURNAL OF CLINICAL NUTRITION, ISSN 0002-9165, 05/2008, Volume 87, Issue 5, pp. 1324 - 1335
Background: Cobalamin (vitamin B-12) and cobalamin analogues are present in human feces, but a complete identification has not been established, and the... 
VITAMIN-B12 | BACTERIA | NUTRITION & DIETETICS | PLASMA TRANSPORT | BIOSYNTHESIS | MECHANISMS | COBAMIDE | TRANSCOBALAMIN | PROTEINS | CHROMATOGRAPHY | BINDING | Vitamin B12 | Health aspects | Feces
Journal Article
Journal of Medical Toxicology, ISSN 1556-9039, 12/2016, Volume 12, Issue 4, p. 370
  Introduction Cyanide is a major chemical threat, and cyanide ingestion carries a higher risk for a supra-lethal dose exposure compared to inhalation but... 
Poisons | Vitamin B | Drug overdose | Drug therapy
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 11/2015, Volume 48, Issue 11, pp. 2866 - 2874
Light-responsive agents offer the promise of targeted therapy, whose benefits include (i) prolonged action at the target site, (ii) overall reduced systemic... 
Fluorescent Dyes - chemistry | Vitamin B 12 - radiation effects | Photochemotherapy - methods | Humans | Vitamin B 12 - analogs & derivatives | Fluorescent Dyes - radiation effects | HeLa Cells | Chemical bonds | Research | Chemical properties | Vitamin B12 | Optical properties
Journal Article
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, ISSN 1463-9076, 12/2017, Volume 19, Issue 45, pp. 30310 - 30315
Journal Article
World Journal of Microbiology and Biotechnology, ISSN 0959-3993, 05/2012, Volume 28, Issue 5, p. 2267
Strain improvement by genetic manipulation or optimization of fermentation conditions for overproduction of vitamin B^sub 12^ has a drawback due to feed back... 
Studies | Biotechnology | Analysis | Bacteria | Fermentation | Vitamins
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 38, pp. 14551 - 14554
Journal Article
Inorganic Chemistry, ISSN 0020-1669, 12/2013, Volume 52, Issue 23, pp. 13392 - 13401
CF2HCbl, CF3Cbl , and CF3CH2Cbl have been synthesized and characterized in solution by 1H NMR and UV–vis spectroscopy, and their X-ray crystal structures have... 
Vitamin B Complex - chemistry | Vitamin B 12 - analogs & derivatives | Halogenation | Models, Molecular | Crystallography, X-Ray | Isomerism | Alkylation
Journal Article
Biochemistry, ISSN 0006-2960, 05/2007, Volume 46, Issue 21, pp. 6446 - 6458
Three proteins, intrinsic factor (IF), transcobalamin (TC), and haptocorrin (HC), all have an extremely high affinity for the cobalamins (Cbls, K d ≈ 5 fM) but... 
Carrier Proteins - metabolism | Humans | Vitamin B 12 - analogs & derivatives | Transcobalamins - metabolism | Protein Binding | Ligands | Binding Sites | Vitamin B 12 - metabolism | Intrinsic Factor - metabolism
Journal Article
Organic Letters, ISSN 1523-7060, 09/2013, Volume 15, Issue 18, pp. 4630 - 4633
A synthetic route toward B ring opened 7,8-seco-cyanocobalamins is described. Hydrolysis of a novel c-lactone vitamin B12 (B12) derivative generates a... 
Vitamin B 12 - chemistry | Molecular Structure | Stereoisomerism | Vitamin B 12 - chemical synthesis | Vitamin B 12 - analogs & derivatives
Journal Article
Journal of Dairy Science, ISSN 0022-0302, 09/2009, Volume 92, Issue 9, pp. 4524 - 4529
The aim of the project was to calculate the apparent synthesis or destruction of cobalamin (vitamin B(12)) and its analogs in the rumen as well as their... 
Intestinal absorption | Ruminal synthesis | Dairy cow | Cattle - metabolism | Animals | Rumen - metabolism | Vitamin B 12 - analogs & derivatives | Dairying | Female | Intestines - metabolism | Vitamin B 12 - metabolism
Journal Article
Chemical Communications, ISSN 1359-7345, 12/2013, Volume 49, Issue 97, pp. 11406 - 11408
A straightforward, reduction-free method for the synthesis of organometallic cobalamins has been developed. Stable phenylacetylide derivatives were... 
VITAMIN-B12 | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | Copper - chemistry | Acetylene - chemistry | Molecular Conformation | Vitamin B 12 - analogs & derivatives | Acetylene - analogs & derivatives | Crystallography, X-Ray | Catalysis | Vitamin B 12 - chemical synthesis
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146797
Many studies indicate a crucial role for the vitamin B-12 and folate-dependent enzyme methionine synthase (MS) in brain development and function, but vitamin... 
METHYLENETETRAHYDROFOLATE REDUCTASE | MEDIATED PHOSPHOLIPID METHYLATION | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SPECTRUM DISORDERS | EPIGENETIC REGULATION | METHIONINE SYNTHASE | METABOLIC BIOMARKERS | INCREASED OXIDATIVE STRESS | DNA-METHYLATION | GROWTH-FACTOR-I | Schizophrenia - metabolism | Autistic Disorder - metabolism | Frontal Lobe - metabolism | Glutathione - metabolism | Antioxidants - metabolism | Humans | Middle Aged | Vitamin B 12 - analogs & derivatives | Vitamin B 12 - genetics | Child, Preschool | Infant | Young Adult | Schizophrenia - genetics | Aged, 80 and over | Adult | Child | Infant, Newborn | Autistic Disorder - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | DNA Methylation - genetics | Mice, Knockout | Animals | Adolescent | Glutamate-Cysteine Ligase - genetics | Aged | Mice | Vitamin B 12 - metabolism | Aging - metabolism | Complications and side effects | Autism | Care and treatment | Growth | Patient outcomes | Schizophrenia | Fetus | Research | Brain | Oxidative stress | Neurosciences | Mental disorders | Bipolar disorder | Vitamin B12 | Neurodevelopmental disorders | Cofactors | Folic acid | Defects | Antioxidants | Mitochondria | Cortex (frontal) | Vitamin B | DNA methylation | Aging | Pharmaceutical sciences | Deoxyribonucleic acid--DNA | Age | Glutathione | Glutamate-cysteine ligase | Dopamine | Adenosylcobalamin | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Fetuses | Methionine | Metabolism | Gene expression | Substrates | Cyanocobalamin | Meta-analysis | Hospitals | Life span | Pharmacy | Epigenetics | Homocysteine | Psychiatry | Deoxyribonucleic acid | DNA
Journal Article