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Toxicology, ISSN 0300-483X, 07/2019, Volume 423, pp. 62 - 74
Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known... 
Enzyme inhibition | CYP3A | Tocotrienols | Vitamin E | Lithocholic acid | 3-Ketocholanoic acid
Journal Article
Neuropharmacology, ISSN 0028-3908, 2004, Volume 47, Issue 6, pp. 904 - 915
Oxidative stress and apoptosis play pivotal roles in the pathogenesis of neurodegenerative diseases. We investigated the effects of vitamin E analogs on... 
Neuroprotection | Oxidative stress | Tocotrienol | Non-antioxidant function | Apoptosis | PROTEIN-KINASE-C | LIPID-PEROXIDATION | TOCOPHEROL | apoptosis | DOPAMINERGIC-NEURONS | NEUROSCIENCES | tocotrienol | ANTIOXIDANT PROPERTIES | BREAST-CANCER CELLS | PALM OIL | neuroprotection | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | non-antioxidant function | MUSCLE-CELL-PROLIFERATION | oxidative stress | Immunohistochemistry | L-Lactate Dehydrogenase - metabolism | Rats, Wistar | Apoptosis - drug effects | Bisbenzimidazole | Vitamin E - analogs & derivatives | Chromatography, High Pressure Liquid | Carcinogens - toxicity | Tetrazolium Salts | Staurosporine - toxicity | Neuroprotective Agents - pharmacology | Carcinogens - antagonists & inhibitors | Neostriatum - drug effects | Thiazoles | Neurons - drug effects | Hydrogen Peroxide - toxicity | In Situ Nick-End Labeling | Cell Survival - drug effects | Neostriatum - cytology | Antimetabolites - antagonists & inhibitors | Cells, Cultured | Rats | Antioxidants - pharmacology | Tocotrienols | Antimetabolites - toxicity | Buthionine Sulfoximine - antagonists & inhibitors | Staurosporine - antagonists & inhibitors | Animals | Oxidative Stress - drug effects | Hydrogen Peroxide - antagonists & inhibitors | Fluorescent Dyes | Buthionine Sulfoximine - toxicity | Vitamin E - pharmacology | Index Medicus
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 11/2011, Volume 28, Issue 11, pp. 2896 - 2909
To investigate of an approach to stabilize a novel pyridinol based α–tocopherol analogue (1) as a prodrug by acetylation of its phenol moiety.Biochemical... 
Biochemistry, general | prodrug | α-tocopherol acetate | antioxidant | pyridinol | analogue | reactive oxygen species (ROS) | Biomedical Engineering | Biomedicine | Pharmacy | Medical Law | Pharmacology/Toxicology | stability | Pyridinol | Stability | Analogue | Reactive oxygen species (ROS) | Prodrug | Antioxidant | alpha-tocopherol acetate | OXIDATIVE STRESS | INTACT-CELLS | FRIEDREICHS-ATAXIA | C-11-BODIPY581/591 | ALPHA-TOCOPHEROL | CHEMISTRY, MULTIDISCIPLINARY | NEURODEGENERATIVE DISEASES | MITOCHONDRIAL PERMEABILITY TRANSITION | REACTIVE OXYGEN | CHAIN-BREAKING ANTIOXIDANTS | PHARMACOLOGY & PHARMACY | GLUTATHIONE DEPLETION | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Oxidative Stress | Antioxidants - metabolism | Humans | Vitamin E - analogs & derivatives | Acetates - chemistry | Prodrugs - chemistry | Prodrugs - metabolism | Drug Delivery Systems | Acetates - analysis | Membrane Potential, Mitochondrial | Drug Compounding | Vitamin E - chemistry | Cell Culture Techniques | Drug Evaluation, Preclinical | Boron Compounds - metabolism | Liposomes - chemical synthesis | Oxidation-Reduction | Cell Survival | Acetates - metabolism | Acetates - chemical synthesis | Mitochondria - metabolism | Antioxidants - pharmacology | Reactive Oxygen Species - analysis | Liposomes - chemistry | Cell-Free System | Cell Line, Tumor | Prodrugs - chemical synthesis | Vitamin E - metabolism | Lipid Peroxidation | Prodrugs - pharmacology | Vitamin E - pharmacology | Hydrolysis | Tocopherols | Enzymes | Mitochondrial DNA | Acetates | Analysis | Antioxidants | Oxygen | Biochemistry | Phenology | Index Medicus
Journal Article
Chemical Science, ISSN 2041-6520, 2016, Volume 7, Issue 8, pp. 5559 - 5567
The down regulation of the cellular power generator, adenosine triphosphate (ATP) synthase, in various cancer cells plays an obstructive role in... 
CANCER-CELLS | TARGETED NANOPARTICLES | ALPHA-TOCOPHERYL SUCCINATE | APOPTOSIS | INHIBITION | COMPLEX-II | ROS | PERMEABILIZATION | BIOENERGETIC SIGNATURE | MITOCHONDRIAL ATP SYNTHASE | CHEMISTRY, MULTIDISCIPLINARY | Formulations | Cellular | Vitamin E | Generators | Activation | Adenosine triphosphate | Apoptosis | Cancer
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 11/2016, Volume 17, Issue 11, pp. 1937 - 1937
Journal Article