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Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 2012, Volume 13, Issue 1, pp. 129 - 136
.... Sulfonyladenosine analogues of the cognate reaction intermediate, OSB‐AMP, have been developed as inhibitors of the MenE enzymes from Mycobacterium tuberculosis (mtMenE... 
docking | inhibitors | adenylation | drug design | antibiotics | Docking | Drug design | Inhibitors | Adenylation | Antibiotics | COENZYME-A LIGASE | MYCOBACTERIUM-TUBERCULOSIS | CHEMISTRY, MEDICINAL | ALPHA,BETA-UNSATURATED SULFONATES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-K2 BIOSYNTHESIS | SIDEROPHORE BIOSYNTHESIS | TRANSFER-RNA SYNTHETASES | STRUCTURAL BASIS | CARRIER PROTEIN LIGASE | SMALL-MOLECULE INHIBITION | Catalytic Domain - drug effects | Staphylococcus aureus - enzymology | Escherichia coli - enzymology | Succinate-CoA Ligases - metabolism | Stereoisomerism | Phenylbutyrates - chemical synthesis | Adenosine Monophosphate - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Vitamin K 2 - metabolism | Succinate-CoA Ligases - antagonists & inhibitors | Vitamin K 2 - chemistry | Enzyme Inhibitors - chemistry | Mycobacterium tuberculosis - enzymology | Escherichia coli - metabolism | Phenylbutyrates - chemistry | Phenylbutyrates - pharmacology | Adenosine Monophosphate - pharmacology | Molecular Structure | Adenosine Monophosphate - chemical synthesis | Mycobacterium tuberculosis - metabolism | Staphylococcus aureus - metabolism | ANTIBIOTICS | DESIGN | ESCHERICHIA COLI | BASIC BIOLOGICAL SCIENCES | CRYSTAL STRUCTURE | 60 APPLIED LIFE SCIENCES | OXYGEN | STAPHYLOCOCCUS | KETONES | BIOSYNTHESIS | ENZYMES | KINETICS | KETO ACIDS | LIGASES | AROMATICS | CHAINS | REACTION INTERMEDIATES | MYCOBACTERIUM TUBERCULOSIS | RESIDUES
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2013, Volume 57, Issue 11, pp. 5432 - 5437
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
SIGNAL-TRANSDUCTION | VIRULENCE FACTOR REGULATION | EXOTOXIN PRODUCTION | IN-VIVO | 2-COMPONENT SYSTEM | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | TOXIC-SHOCK-SYNDROME | HYDROGEN-PEROXIDE | GLYCEROL MONOLAURATE | SACCHAROMYCES-CEREVISIAE | SYNDROME STAPHYLOCOCCUS-AUREUS | Streptococcus agalactiae - drug effects | Reactive Oxygen Species - metabolism | Streptococcus pyogenes - growth & development | Humans | Monoglycerides - pharmacology | Repressor Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Bacillus anthracis - growth & development | Bacillus anthracis - drug effects | Staphylococcal Infections - microbiology | Cell Membrane - drug effects | Repressor Proteins - metabolism | Staphylococcus aureus - metabolism | Bacterial Proteins - antagonists & inhibitors | Rabbits | Staphylococcal Infections - drug therapy | Streptococcus pyogenes - drug effects | Streptococcus agalactiae - growth & development | Shock, Septic - microbiology | Drug Synergism | Animals | Exotoxins - secretion | Exotoxins - antagonists & inhibitors | Bacterial Proteins - metabolism | Laurates - pharmacology | Anti-Bacterial Agents - pharmacology | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Administration, Topical | Vitamin K 2 - pharmacology | Index Medicus | Experimental Therapeutics
Journal Article
Nephrology, dialysis, transplantation, ISSN 1460-2385, 2017, Volume 32, Issue 7, pp. 1114 - 1127
Journal Article
Biochemistry, ISSN 0006-2960, 10/2015, Volume 54, Issue 42, pp. 6514 - 6524
.... The enzyme catalyzes CoA ligation via an acyl-adenylate intermediate, and we have previously reported tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogues... 
COENZYME-A LIGASE | MYCOBACTERIUM-TUBERCULOSIS | FIREFLY LUCIFERASE | BACILLUS-SUBTILIS | MENAQUINONE VITAMIN-K2 BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOMAIN ALTERNATION MECHANISM | ESCHERICHIA-COLI | O-SUCCINYLBENZOIC ACID | COA SYNTHETASE | ELECTRON-TRANSPORT | Cercopithecus aethiops | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Vitamin K 2 - metabolism | Microbial Sensitivity Tests | Succinate-CoA Ligases - antagonists & inhibitors | Anti-Bacterial Agents - chemistry | Phenylbutyrates - chemistry | Conserved Sequence | Phenylbutyrates - pharmacology | Anti-Bacterial Agents - toxicity | Escherichia coli Proteins - antagonists & inhibitors | Vero Cells | Staphylococcus aureus - metabolism | Amino Acid Sequence | Succinate-CoA Ligases - genetics | Mutagenesis, Site-Directed | Phenylbutyrates - toxicity | Catalytic Domain - genetics | Models, Molecular | Drug Discovery | Arginine - chemistry | Sequence Homology, Amino Acid | Succinate-CoA Ligases - chemistry | Animals | Escherichia coli Proteins - genetics | Protein Conformation | Anti-Bacterial Agents - pharmacology | Escherichia coli K12 - genetics | Escherichia coli Proteins - chemistry | Staphylococcus aureus - drug effects | Escherichia coli K12 - enzymology | Enzyme inhibitors | Research | Structure-activity relationships (Biochemistry) | Index Medicus
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 41, pp. 15896 - 15901
Journal Article