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1. Full Text Identification of the gene for vitamin K epoxide reductase
by Li, Tao and Khvorova, Anastasia and Jin, Da-Yun and Lin, Pen-Jen and Chang, Chun-Yun and Stafford, Darrel W
Nature, ISSN 0028-0836, 02/2004, Volume 427, Issue 6974, pp. 541 - 544
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Molecular and cellular biology | Molecular genetics | Genes. Genome | Cell Line | RNA, Small Interfering - genetics | Humans | RNA, Messenger - genetics | Mixed Function Oxygenases - metabolism | Chromosome Mapping | Mixed Function Oxygenases - antagonists & inhibitors | Mixed Function Oxygenases - chemistry | RNA, Messenger - metabolism | Vitamin K Epoxide Reductases | Spodoptera | Warfarin - pharmacology | Animals | Transfection | Cell Line, Tumor | Mixed Function Oxygenases - genetics | Drug Resistance | Chromosomes, Human, Pair 16 - genetics | RNA, Small Interfering - metabolism | Proteins | Membranes | Genes | Vitamins | Coagulation | Vitamin K epoxide reductase | chromosome 16 | VKOR gene | Index Medicus
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2. Full Text Structure of a bacterial homologue of vitamin K epoxide reductase
by Rapoport, Tom A and Schulman, Sol and Li, Weikai and Beckwith, Jon and Dutton, Rachel J and Boyd, Dana
Nature (London), ISSN 0028-0836, 01/2010, Volume 463, Issue 7280, pp. 507 - 512
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Medical sciences | Blood. Blood coagulation. Reticuloendothelial system | Pharmacology. Drug treatments | Protein Structure, Tertiary | Anticoagulants | Catalytic Domain | Electron Transport | Warfarin | Synechococcus - enzymology | Humans | Bacterial Proteins - chemistry | Models, Molecular | Mixed Function Oxygenases - chemistry | Vitamin K Epoxide Reductases | Drug Resistance - genetics | Animals | Membrane Proteins - chemistry | Disulfides - chemistry | Mixed Function Oxygenases - genetics | Proteins | Research | Structure | Escherichia coli | Vitamin K | Enzymes | Biochemistry | Heart attacks | E coli | Mass spectrometry | Methods | Bundling | Quinones | Reductases | Inhibitors | Bacteria | Vitamins | Index Medicus
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3. Full Text Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 ( VKORC1) affects gene expression and warfarin dose requirement
by Wang, Danxin and Chen, Huizi and Momary, Kathryn M and Cavallari, Larisa H and Johnson, Julie A and Sadée, Wolfgang
Blood, ISSN 0006-4971, 08/2008, Volume 112, Issue 4, pp. 1013 - 1021
Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Biological and medical sciences | Medical sciences | Promoter Regions, Genetic | Protein Subunits | Chromatin | Pharmacogenetics | Liver - enzymology | Humans | Cells, Cultured | Gene Expression Regulation | RNA, Messenger - analysis | European Continental Ancestry Group | Organ Specificity | Vitamin K Epoxide Reductases | Warfarin - administration & dosage | Warfarin - pharmacokinetics | Ethnic Groups - genetics | Biopsy | Polymorphism, Single Nucleotide | African Continental Ancestry Group | Mixed Function Oxygenases - genetics | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
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4. Full Text Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene polymorphism as determinant of differences in Covid-19-related disease severity
by Janssen, Rob and Walk, Jona
Medical hypotheses, ISSN 0306-9877, 11/2020, Volume 144, pp. 110218 - 110218
Severity of Illness Index | Vitamin K Deficiency - etiology | Pandemics | Gene Frequency | Humans | Far East - epidemiology | Europe - epidemiology | Americas - epidemiology | SARS-CoV-2 | Vitamin K - antagonists & inhibitors | COVID-19 - complications | COVID-19 - enzymology | Models, Biological | Thrombosis - etiology | Thrombosis - genetics | Polymorphism, Single Nucleotide | Thrombosis - prevention & control | COVID-19 - genetics | Vitamin K Epoxide Reductases - genetics | Proteins | Recycling industry | Genetic research | Genetic aspects | Anticoagulants (Medicine) | Health aspects | Genetic polymorphisms | Vitamins | Index Medicus
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5. Full Text Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
by Bodin, Laurent and Verstuyft, Céline and Tregouet, David-Alexandre and Robert, Annie and Dubert, Liliane and Funck-Brentano, Christian and Jaillon, Patrice and Beaune, Philippe and Laurent-Puig, Pierre and Becquemont, Laurent and Loriot, Marie-Anne
Blood, ISSN 0006-4971, 07/2005, Volume 106, Issue 1, pp. 135 - 140
Biological and medical sciences | Medical sciences | Blood. Blood coagulation. Reticuloendothelial system | Pharmacology. Drug treatments | Cytochrome P-450 CYP2C9 | Haplotypes | Predictive Value of Tests | Anticoagulants - administration & dosage | Administration, Oral | Gene Frequency | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Linear Models | Male | Liver Neoplasms | Vitamin K Epoxide Reductases | Luciferases - genetics | Drug Resistance - genetics | Acenocoumarol - administration & dosage | Adolescent | Cell Line, Tumor | Adult | Female | Aged | Carcinoma, Hepatocellular | Mixed Function Oxygenases - genetics | Genes, Reporter | Index Medicus | Abridged Index Medicus
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6. Full Text The influence of sequence variations in factor VII, γ -glutamyl carboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement
by Darja Herman and Polona Peternel and Mojca Stegnar and Katja Breskvar and Vita Dolzan
Thrombosis and haemostasis, ISSN 0340-6245, 05/2006, Volume 95, Issue 5, pp. 782 - 787
regression model | polymorphism | cytochrome P450 2C9 | pharmacodynamic factors | warfarin | Blood Coagulation, Fibrinolysis and Cellular Haemostasis | Cytochrome P450 2C9 | Warfarin | Pharmacodynamics factors | Regression model | Polymorphism | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Hematologic and hematopoietic diseases | Biological and medical sciences | Blood coagulation. Blood cells | Molecular and cellular biology | Medical sciences | Platelet diseases and coagulopathies | Cytochrome P-450 CYP2C9 | Amino Acid Sequence | Factor VII - genetics | Pharmacogenetics | Humans | Aryl Hydrocarbon Hydroxylases - genetics | Genotype | Male | Vitamin K Epoxide Reductases | Warfarin - administration & dosage | Polymorphism, Genetic | Female | Carbon-Carbon Ligases - genetics | Mixed Function Oxygenases - genetics | Index Medicus
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7. Full Text Evaluation of warfarin resistance using transcription activator‐like effector nucleases‐mediated vitamin K epoxide reductase knockout HEK293 cells
by Tie, J.‐K and Jin, D.‐Y and Tie, K and Stafford, D. W
Journal of thrombosis and haemostasis, ISSN 1538-7933, 08/2013, Volume 11, Issue 8, pp. 1556 - 1564
gene knockout techniques | anticoagulants | VKORC1L1 protein | vitamin K epoxidase | warfarin | Anticoagulants | Gene knockout techniques | Warfarin | Vitamin K epoxidase | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Humans | Warfarin - chemistry | Vitamin K Epoxide Reductases - metabolism | Gene Knockout Techniques | Vitamin K - metabolism | Phenotype | Anticoagulants - chemistry | HEK293 Cells | Oxygen - chemistry | Transcription, Genetic | Polymorphism, Single Nucleotide | Dithiothreitol - chemistry | Mutation | Drug Resistance | Vitamin K Epoxide Reductases - genetics | Enzymes | Nucleases | Analysis | Genomics | Physiological aspects | Genetic research | DNA binding proteins | Genetic transcription | Vitamins | Cells | Coagulation | Index Medicus
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8. Full Text New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data
by Beato, Silvia and Marques, Carlos and Laize, Vincent and Gavaia, Paulo J and Fernandez, Ignacio
International journal of molecular sciences, ISSN 1422-0067, 05/2020, Volume 21, Issue 10, p. 3489
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Amino Acid Sequence | Fish Proteins - chemistry | DNA, Complementary - genetics | Fish Proteins - metabolism | Vitamin K Epoxide Reductases - metabolism | Flatfishes - genetics | Phylogeny | Organ Specificity | Vitamin K - metabolism | Gene Expression Regulation, Enzymologic | Fish Proteins - genetics | Flatfishes - growth & development | Animals | Gene Expression Regulation, Developmental | Conserved Sequence | Flatfishes - metabolism | Vitamin K Epoxide Reductases - chemistry | Vitamin K Epoxide Reductases - genetics | Reductases | Blood coagulation | Peptides | Taxonomy | Amino acids | Ontogeny | Nutritional requirements | Clotting | Proteins | Signal transduction | Physiology | Supplementation | Deoxyribonucleic acid--DNA | Vitamin K | Nutrition | Fertilization | Dietary supplements | Bone turnover | Metabolism | Gene expression | Biological activity | Environmental conditions | Phylloquinone | Aquaculture | Reductase | Index Medicus | flatfish | nutrition | evolution | pollution | gene expression
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9. Full Text Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements
by Aquilante, Christina L and Langaee, Taimour Y and Lopez, Larry M and Yarandi, Hossein N and Tromberg, Jennifer S and Mohuczy, Dagmara and Gaston, Katherine L and Waddell, Cassandra D and Chirico, Mark J and Johnson, Julie A
Clinical pharmacology and therapeutics, ISSN 0009-9236, 04/2006, Volume 79, Issue 4, pp. 291 - 302
Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Cytochrome P-450 CYP2C9 | Anticoagulants - administration & dosage | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Warfarin - metabolism | Male | Warfarin - administration & dosage | Warfarin - therapeutic use | Factor X - genetics | Polymerase Chain Reaction | Aged, 80 and over | Adult | Female | Factor VII - genetics | Anticoagulants - metabolism | Anticoagulants - therapeutic use | Genotype | Blood Coagulation Factors - genetics | DNA Primers | Vitamin K Epoxide Reductases | Polymorphism, Genetic | International Normalized Ratio | Prothrombin - genetics | Aged | Mixed Function Oxygenases - genetics | Warfarin | Pharmacy | Cytochrome P-450 | Genetic research | Dosage and administration | Genetic aspects | Vitamins | Index Medicus | Abridged Index Medicus
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10. Full Text VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy
by Hammed, Abdessalem and Matagrin, Benjamin and Spohn, Gabriele and Prouillac, Caroline and Benoit, Etienne and Lattard, Virginie
The Journal of biological chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 28733 - 28742
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Organ Specificity - drug effects | Liver - enzymology | Humans | Male | Mixed Function Oxygenases - metabolism | Gene Expression Profiling | NAD(P)H Dehydrogenase (Quinone) - genetics | RNA, Messenger - metabolism | Vitamin K - metabolism | Warfarin - pharmacology | Organ Specificity - genetics | Vitamin K - antagonists & inhibitors | Liver - drug effects | Biocatalysis - drug effects | Vitamin K Epoxide Reductases - genetics | Vitamin K Epoxide Reductases - deficiency | Cell Line | Mice, Inbred C57BL | RNA, Messenger - genetics | Rats | Vitamin K Epoxide Reductases - metabolism | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | Animals | Anticoagulants - pharmacology | NAD(P)H Dehydrogenase (Quinone) - metabolism | Mice | Kinetics | Mixed Function Oxygenases - genetics | Index Medicus | Life Sciences | VKORC1 | VKORC1L1 | Enzyme Inhibitors | Hemostasis | Vitamin K Antagonist | Vitamin K Epoxide Reductase | Enzyme Kinetics | Enzymology | Drug Resistance | Vitamin K
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