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Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 9, p. e0137358
Macrophages are involved in low-grade inflammation in diabetes, and play pathogenic roles in proliferative diabetic retinopathy (PDR) by producing... 
VEGF | MULTIDISCIPLINARY SCIENCES | IL-17 | INTERLEUKIN-31 | EXPRESSION | T-CELLS | ANGIOGENIC FACTORS | IL-31 | Tumor Necrosis Factor-alpha - metabolism | Eye - pathology | Inflammation - pathology | Humans | Middle Aged | Male | Diabetic Retinopathy - pathology | Inflammation - metabolism | Retinal Perforations - metabolism | Th17 Cells - metabolism | Vitreous Body - metabolism | Sarcoidosis - immunology | Tumor Necrosis Factor-alpha - immunology | Aged, 80 and over | Adult | Female | Vitrectomy | Macrophages - immunology | Th2 Cells - pathology | Cytokines - blood | Cytokines - immunology | Uveitis - metabolism | Eye - metabolism | Diabetic Retinopathy - immunology | Cytokines - metabolism | Macrophages - pathology | Inflammation - immunology | Diabetic Retinopathy - surgery | Immunity, Innate | Th2 Cells - metabolism | Diabetic Retinopathy - blood | Macrophages - metabolism | Th17 Cells - immunology | Vitreous Body - immunology | Vitreous Body - pathology | Aged | Retinal Perforations - pathology | Inflammation - surgery | Sarcoidosis - metabolism | Uveitis - pathology | Sarcoidosis - pathology | Diabetic retinopathy | Cytokines | Physiological aspects | Development and progression | Genetic aspects | Research | T cells | Retinopathy | Pathogenesis | Helper cells | Homeostasis | Interleukin 22 | Retina | Interleukin 23 | Lymphocytes T | Macrophages | Dermatitis | Hemorrhage | Inflammatory diseases | Interleukin 6 | Interleukin 4 | Lymphocytes | Quality | Surgery | Uveitis | Interleukin 21 | Immune response | Sarcoidosis | Review boards | Diabetes mellitus | Inflammation | Tumor necrosis factor-α | Patients | Allergies | γ-Interferon | Interleukin 10 | Ligands | Infiltration | Interferon | Diabetes
Journal Article
Aging cell, ISSN 1474-9718, 2018, Volume 17, Issue 5, pp. e12809 - n/a
Journal Article
Journal of International Medical Research, ISSN 0300-0605, 12/2016, Volume 44, Issue 6, pp. 1403 - 1413
Objective To quantify T helper (Th)17 cells and determine interleukin (IL)-17A levels in peripheral blood mononuclear cell (PBMC) culture and vitreous fluid... 
peripheral blood mononuclear cells | type 2 diabetes mellitus | Diabetic retinopathy | interleukin-17A | T helper 17 cells | MEDICINE, RESEARCH & EXPERIMENTAL | POPULATION | MECHANISMS | PREVALENCE | PATHOGENESIS | PROTEIN-1 | INTERLEUKIN-17 | INSULIN-RESISTANCE | VITREORETINOPATHY | PHARMACOLOGY & PHARMACY | INFLAMMATORY CYTOKINES | EXPRESSION | Retinal Perforations - immunology | Diabetes Mellitus, Type 2 - genetics | Humans | Macular Edema - pathology | Middle Aged | Interleukin-17 - immunology | Epiretinal Membrane - genetics | Macular Edema - immunology | Male | Glycated Hemoglobin A - immunology | Diabetic Retinopathy - pathology | Case-Control Studies | Retinal Perforations - genetics | Vitreous Body - metabolism | Diabetes Mellitus, Type 2 - immunology | Leukocytes, Mononuclear - immunology | Female | Retinal Perforations - surgery | Vitrectomy | Epiretinal Membrane - surgery | Macular Edema - genetics | Diabetes Mellitus, Type 2 - surgery | Th17 Cells - pathology | Vitreous Body - surgery | Body Mass Index | Epiretinal Membrane - immunology | Gene Expression | Diabetic Retinopathy - immunology | Interleukin-17 - genetics | Diabetic Retinopathy - surgery | Diabetic Retinopathy - genetics | Leukocytes, Mononuclear - pathology | Macular Edema - surgery | Epiretinal Membrane - pathology | Th17 Cells - immunology | Vitreous Body - immunology | Vitreous Body - pathology | Aged | Diabetes Mellitus, Type 2 - pathology | Primary Cell Culture | Retinal Perforations - pathology | Glycated Hemoglobin A - genetics | Research Reports
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 2, p. e0211438
...) and idiopathic macular hole (MH). In this present study, we investigated the potential intraocular production of these serine proteases, and measured and compared tryptase and chymase activities in the vitreous body and serum in ERM... 
STEM-CELLS | MULTIDISCIPLINARY SCIENCES | VITREOMACULAR TRACTION | LYMPH-NODES | IN-VIVO | PRECORTICAL VITREOUS POCKET | TNF-ALPHA | ANGIOTENSIN-CONVERTING ENZYME | FACTOR-1 CXCL12 | FIBROBLASTS | ENDOTHELIAL GROWTH-FACTOR | Immunohistochemistry | Retinal Detachment - etiology | Tryptases - metabolism | Retinal Detachment - pathology | Chymases - metabolism | Tryptases - blood | Humans | Middle Aged | Macula Lutea - enzymology | Male | Diabetic Retinopathy - pathology | Retinal Diseases - etiology | Retinal Perforations - enzymology | Retinal Diseases - pathology | Female | Retinal Perforations - etiology | Diabetic Retinopathy - etiology | Epiretinal Membrane - etiology | Macula Lutea - pathology | Chymases - blood | Mast Cells - enzymology | Vitreous Body - enzymology | Retinal Detachment - enzymology | Retinal Diseases - enzymology | Diabetic Retinopathy - enzymology | Epiretinal Membrane - enzymology | Epiretinal Membrane - pathology | Mast Cells - pathology | Vitreous Body - pathology | Aged | Retinal Perforations - pathology | Viral antibodies | Antibodies | Diabetic retinopathy | Ocriplasmin | Research | Proteases | Enzymes | Toluidine blue | Lymphatic system | Retinopathy | Pathogenesis | Serine | Diabetes mellitus | Staining | Retina | Patients | Diseases | Chymase | Medicine | Studies | Hyaluronan | Toluidine | Surgery | Morphology | Tryptase | Fibroblasts | Mast cells | Hyaluronic acid
Journal Article
Journal Article
Journal Article
Journal Article
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 12/2013, Volume 54, Issue 14, pp. ORSF54 - ORSF59
Reduced quality of life and financial burden due to visual impairment and blindness begin to increase dramatically when individuals reach the age of 40. The... 
Presbyopia | Vitreous humor | Cataract | PCO | CELLS | cataract | PREVENTION | ALPHA-B-CRYSTALLIN | vitreous humor | CHAPERONE | EYE | OPACIFICATION | PEPTIDES | presbyopia | OPHTHALMOLOGY | NUCLEAR CATARACT | EXPRESSION | Prevalence | Global Health | Humans | Eye Diseases - etiology | Aging | Eye Diseases - epidemiology | Vitreous Body - pathology | Lens, Crystalline - pathology | Disease Progression | Eye Diseases - diagnosis
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 12, pp. e8158 - e8158
Inflammation affects the formation and the progression of various vitreoretinal diseases. We performed a comprehensive analysis of inflammatory immune... 
C-C CHEMOKINES | INTRAVITREAL TRIAMCINOLONE | PROLIFERATIVE DIABETIC-RETINOPATHY | VITREOUS FLUID | MACULAR EDEMA | MULTIDISCIPLINARY SCIENCES | MULTIPLEX BEAD ANALYSIS | RETINAL VEIN OCCLUSION | MONOCYTE CHEMOTACTIC PROTEIN-1 | NF-KAPPA-B | ENDOTHELIAL GROWTH-FACTOR | Vitreoretinopathy, Proliferative - blood | Retinal Diseases - immunology | Humans | Middle Aged | Retinal Diseases - blood | Male | Diabetic Retinopathy - pathology | Retinal Vein Occlusion - pathology | Inflammation Mediators - metabolism | Retinal Diseases - pathology | Female | Cytokines - blood | Diabetic Retinopathy - immunology | Retinal Vein Occlusion - immunology | Vitreoretinopathy, Proliferative - pathology | Inflammation Mediators - blood | Solubility | Vascular Endothelial Growth Factor A - blood | Vitreoretinopathy, Proliferative - immunology | Retinal Vein Occlusion - blood | Diabetic Retinopathy - blood | Models, Biological | Vitreous Body - immunology | Vitreous Body - pathology | Aged | Diabetic retinopathy | Development and progression | Inflammation | Interleukins | Vascular endothelial growth factor | Analysis | Occlusion | Multiplexing | Membranes | Retinopathy | Pathogenesis | Interleukin | Retina | Interleukin 6 | Proteins | Angiogenesis | Ischemia | Granulocytes | Tumor necrosis factor-TNF | Growth factors | Interleukin 8 | Edema | Factor analysis | Cytokines | Diabetes mellitus | Patients | Diseases | Detachment | Correlation analysis | Monocyte chemoattractant protein | Medical prognosis | Photoreceptors | Hypoxia | Diabetes | Chemokines | Monocyte chemoattractant protein 1 | Apoptosis
Journal Article
Acta ophthalmologica (Oxford, England), ISSN 1755-375X, 2011, Volume 89, Issue 200
Purpose To measure levels of high‐mobility group box‐1 (HMGB1), and soluble receptor for advanced glycation end products (sRAGE) in the vitreous fluid from... 
CELLS | ENDOTHELIAL DYSFUNCTION | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | OPHTHALMOLOGY | ADHESION MOLECULES | HMGB1 | EXPRESSION | BRAIN | GLYCATION END-PRODUCTS | SOLUBLE RECEPTOR | Diabetes Mellitus - pathology | Retina - metabolism | Retinal Neovascularization - surgery | Vitreoretinopathy, Proliferative - etiology | Humans | Middle Aged | Male | Retinal Neovascularization - metabolism | Diabetic Retinopathy - pathology | Vitreoretinopathy, Proliferative - surgery | HMGB1 Protein - biosynthesis | Inflammation - metabolism | Receptors, Immunologic - biosynthesis | Vitreous Body - metabolism | Intercellular Adhesion Molecule-1 - biosynthesis | Adult | Female | Vitrectomy | Diabetes Complications - surgery | Interleukin-1beta - biosynthesis | Diabetes Complications - pathology | Diabetic Retinopathy - etiology | Receptor for Advanced Glycation End Products | Intercellular Adhesion Molecule-1 - analysis | Vitreous Body - surgery | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | HMGB1 Protein - analysis | Diabetes Complications - metabolism | Mice, Inbred C57BL | Vitreoretinopathy, Proliferative - pathology | Biomarkers - analysis | Diabetes Mellitus - metabolism | Diabetic Retinopathy - surgery | Receptors, Immunologic - analysis | Vitreoretinopathy, Proliferative - metabolism | Retinal Neovascularization - etiology | Blotting, Western | Diabetic Retinopathy - metabolism | Animals | Chemokine CCL2 - biosynthesis | Vitreous Body - pathology | Aged | Mice | Diabetes Mellitus - surgery | Retina - pathology | Chemokine CCL2 - analysis | Retinal Neovascularization - pathology | Diabetic retinopathy | Chromosomal proteins | Analysis | Macrophage colony stimulating factor | Ophthalmology | Biological markers | Macrophages | Enzyme-linked immunosorbent assay | Advanced glycosylation end products | Retinopathy | Diabetes mellitus | Mobility | Glycosylation | Inflammation | Hemorrhage | HMGB1 protein | Western blotting | Vascularization | Monocytes | Monocyte chemoattractant protein | Rodents | Cell adhesion | Biomarkers | Diabetes | Immunofluorescence | Leukocytes (granulocytic) | Granulocyte-macrophage colony-stimulating factor | biomarkers | Retina | intercellular adhesion molecule 1 | Interleukin 1 | vascularization | Monocyte chemoattractant protein 1
Journal Article