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PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 7, p. e0180154
Ion channels regulate a variety of physiological processes and represent an important class of drug target... 
TARGET | DYE | KV1.3 | NA(V)1.7 | MODULATORS | MULTIDISCIPLINARY SCIENCES | EXTREME PAIN DISORDER | PATCH-CLAMP | MUTATIONS | Cricetulus | High-Throughput Screening Assays - instrumentation | NAV1.3 Voltage-Gated Sodium Channel - genetics | NAV1.1 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.4 Voltage-Gated Sodium Channel - metabolism | Kv1.3 Potassium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - metabolism | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Patch-Clamp Techniques - methods | Kv1.3 Potassium Channel - deficiency | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | NAV1.5 Voltage-Gated Sodium Channel - genetics | Drug Evaluation, Preclinical | Transgenes | Potassium Channel Blockers - pharmacology | CHO Cells | High-Throughput Screening Assays - methods | Gene Expression | NAV1.4 Voltage-Gated Sodium Channel - genetics | NAV1.2 Voltage-Gated Sodium Channel - genetics | Rats | Sodium Channel Blockers - pharmacology | Membrane Potentials - physiology | Animals | T-Lymphocytes - cytology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | NAV1.7 Voltage-Gated Sodium Channel - metabolism | NAV1.6 Voltage-Gated Sodium Channel - genetics | Sodium Channels - genetics | Primary Cell Culture | Patch-Clamp Techniques - instrumentation | Ion channels | Information management | Drug discovery | T cells | Modules | Electrophysiology | Patching | Lymphocytes T | Boundaries | Assaying | Channels | Step voltage | Immunology | Pain | Lymphocytes | Sodium channels (voltage-gated) | Physiology | Potassium channels (voltage-gated) | Gold | Platforms | Data points | Automation | Cloning | Pharmacology | Sodium | Antigen-presenting cells | Ligands | Mutation | Recording | Potassium
Journal Article
The Journal of general physiology, ISSN 1540-7748, 2016, Volume 147, Issue 1, pp. 1 - 24
Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action potentials and served as an early muse for biophysicists laying the foundation for our current understanding of electrical signaling... 
LOCAL-ANESTHETIC RECEPTOR | PHYSIOLOGY | SQUID GIANT-AXONS | SCORPION BETA-TOXIN | POLYPEPTIDE ANTHOPLEURIN-B | AMINO-ACID-RESIDUES | SEA-ANEMONE TOXIN | SURFACE-PLASMON RESONANCE | MU-CONOTOXIN-KIIIA | PLANAR LIPID-BILAYERS | QUATERNARY AMMONIUM ION | Voltage-Gated Sodium Channels - chemistry | Animals | Permeability | Ions - metabolism | Humans | Protein Structure, Tertiary - physiology | Review
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8428 - 8433
Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range... 
Sodium channels | Bromine | Maps | Sodium | Channel blockers | Crystals | Atoms | Binding sites | Crystal structure | Local anesthetics | Pharmacology | QUALITY | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | NA+ CHANNELS | MOLECULAR DETERMINANTS | INHIBITION | LOCAL-ANESTHETICS | LIDOCAINE | pharmacology | DRUGS | crystal structure | STATE-DEPENDENT BLOCK | BINDING | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | NAV1.1 Voltage-Gated Sodium Channel - metabolism | NAV1.1 Voltage-Gated Sodium Channel - chemistry | Ion Channel Gating - physiology | HEK293 Cells | Sodium Channels - metabolism | Membrane Potentials - drug effects | Protein Structure, Tertiary | Amino Acid Sequence | Triazines - metabolism | Triazines - pharmacology | Alphaproteobacteria - metabolism | Bacterial Proteins - genetics | Models, Molecular | Sodium Channel Blockers - metabolism | Sodium Channel Blockers - pharmacology | Binding Sites - genetics | Membrane Potentials - physiology | Alphaproteobacteria - chemistry | Sequence Homology, Amino Acid | Alphaproteobacteria - genetics | Ion Channel Gating - genetics | Sodium Channels - chemistry | Bacterial Proteins - metabolism | Sodium Channels - genetics | Mutation | Ion Channel Gating - drug effects | Physiological aspects | Prokaryotes | Biological Sciences
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7093 - 7118
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2018, Volume 293, Issue 43, pp. 16546 - 16558
Journal Article
蛋白质与细胞:英文版, ISSN 1674-800X, 2017, Volume 8, Issue 6, pp. 401 - 438
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2013, Volume 288, Issue 34, pp. 24316 - 24331
Voltage-gated sodium channel (NaV) trafficking is incompletely understood. Post-translational modifications of NaVs and/or auxiliary subunits and protein-protein interactions have been posited as NaV-trafficking mechanisms... 
SPINAL SENSORY NEURONS | NEUROPATHIC PAIN | TRAUMATIC BRAIN-INJURY | RESPONSE MEDIATOR PROTEIN-2 | ROOT GANGLION NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SLOW INACTIVATION | ANTICONVULSANT LACOSAMIDE | SUMO MODIFICATION | GROWTH CONE COLLAPSE | NAV1.3 Voltage-Gated Sodium Channel - genetics | Humans | NAV1.1 Voltage-Gated Sodium Channel - genetics | Multienzyme Complexes - metabolism | Protein Transport - physiology | NAV1.1 Voltage-Gated Sodium Channel - metabolism | Protein Transport - drug effects | Sumoylation - physiology | Mutation, Missense | NAV1.3 Voltage-Gated Sodium Channel - metabolism | Sumoylation - drug effects | Intercellular Signaling Peptides and Proteins - metabolism | Cysteine Endopeptidases - metabolism | SUMO-1 Protein - genetics | HEK293 Cells | Sodium Channels - metabolism | NAV1.7 Voltage-Gated Sodium Channel - genetics | Sensory Receptor Cells - metabolism | Cell Differentiation - physiology | Endopeptidases - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Conjugating Enzymes - genetics | Multienzyme Complexes - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Endopeptidases - genetics | Sensory Receptor Cells - cytology | Cell Differentiation - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | NAV1.7 Voltage-Gated Sodium Channel - metabolism | SUMO-1 Protein - metabolism | Sodium Channels - genetics | Catecholamines - pharmacology | Amino Acid Substitution | Signaling | Patch Clamp Electrophysiology | Signal Transduction | Post-translational Modification | Trafficking | CRMP2 | Sodium Channels | Sumoylation | NaV1.1 | NaV1.7
Journal Article
Journal Article