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Glia, ISSN 0894-1491, 09/2018, Volume 66, Issue 9, pp. 1881 - 1895
Microglia show a rich repertoire of activation patterns regulated by a complex ensemble of surface ion channels, receptors, and transporters. We and others... 
PAP‐1 | potassium channel | pro‐inflammatory | Kv1.3 | microglia | Kir2.1 | PAP-1 | pro-inflammatory | TARGET | STIMULATION | SYNAPTIC PLASTICITY | NEUROSCIENCES | AMYLOID-BETA | MICE | LONG-TERM POTENTIATION | K+ CHANNEL | MEMORY T-CELLS | EXPRESSION | BLOCKER | Calcium-Binding Proteins - metabolism | Microglia - metabolism | Cytokines - metabolism | Immunity, Innate - drug effects | Microglia - drug effects | Tissue Culture Techniques | Escherichia coli | Mice, Inbred C57BL | Kv1.3 Potassium Channel - antagonists & inhibitors | Kv1.3 Potassium Channel - genetics | Long-Term Potentiation - immunology | Lipopolysaccharides | Mice, Knockout | Brain - drug effects | Brain - metabolism | Inflammation - metabolism | Animals | Kv1.3 Potassium Channel - metabolism | Microfilament Proteins - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Nervous system diseases | Analysis | Potassium channels | Potentiation | Cell culture | Brain | Animal models | Pathogenesis | Brain slice preparation | Activation | Neurotoxicity | Receptors | Rodents | Ion channels | Potassium channels (voltage-gated) | Immune response | Potassium channels (inwardly-rectifying) | Pharmacology | Inflammation | Gene expression | Ribonucleic acid--RNA | Nitric-oxide synthase | Microglia | Neurological diseases | Tumor necrosis factor | Immunoreactivity | Potassium | Hippocampus | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2005, Volume 102, Issue 31, pp. 11094 - 11099
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2008, Volume 3, Issue 12, pp. e4009 - e4009
The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including... 
MULTIDISCIPLINARY SCIENCES | Skin Transplantation - immunology | Humans | Clofazimine - pharmacology | Kv1.3 Potassium Channel - genetics | Transfection | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Calcium Signaling - immunology | Kv1.3 Potassium Channel - metabolism | Drug Evaluation, Preclinical | Interleukin-2 - metabolism | Jurkat Cells | NFATC Transcription Factors - metabolism | Cells, Cultured | Clofazimine - metabolism | Anti-Bacterial Agents - metabolism | Kv1.3 Potassium Channel - antagonists & inhibitors | Animals | Calcium Signaling - drug effects | Models, Biological | Protein Binding | Anti-Bacterial Agents - pharmacology | Mice | Immunologic Factors - metabolism | Immunologic Factors - pharmacology | Protein Multimerization - drug effects | Calcium channels | Multiple sclerosis | Clofazimine | Interleukins | Type 1 diabetes | Genetic transcription | T cells | Animal models | Biomedical research | Calcium | Calcineurin | Interleukin | Effector cells | Clinical trials | Intracellular signalling | Lymphocytes T | Arthritis | Diabetes mellitus (insulin dependent) | Biochemistry | NF-AT protein | Phosphatase | Dermatitis | T-cell receptor | Signal transduction | Cell activation | Interleukin 2 | Lymphocytes | Human immunodeficiency virus--HIV | Gastroenterology | Potassium channels (voltage-gated) | Libraries | Skin grafts | Drug therapy | Lupus | Immunological memory | Memory cells | Psoriasis | Cytokines | Channel gating | Immunomodulation | Diabetes mellitus | T cell receptors | Pharmacology | Crohns disease | Graft rejection | Medicine | Inflammatory bowel disease | Inhibitors | Antibiotics | Skin | Autoimmune diseases | Molecular biology | Potassium | Human immunodeficiency virus | HIV
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, p. 45310
The voltage-gated potassium channel subfamily A member 3 (Kv1.3) dominantly expresses on T cells and neurons. Recently, the interaction between Kv1.3 and... 
MOLECULAR-MECHANISM | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NEURITE OUTGROWTH | MULTIPLE-SCLEROSIS | GATED K+ CHANNELS | LYMPHOCYTE | MULTIDISCIPLINARY SCIENCES | IN-VIVO | BETA-1 SUBUNITS | MEMORY T-CELLS | MODULATION | Deactivation | Channel gating | Sodium channels (voltage-gated) | Potassium channels (voltage-gated) | Lymphocytes T | Kinetics | Potassium | Gating
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2004, Volume 101, Issue 9, pp. 3112 - 3117
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2012, Volume 586, Issue 22, pp. 3996 - 4001
► ShK is a potent blocker of potassium channels. ► A new ShK analogue with a C-terminal Lys residue and amide was designed. ► ShK-K-amide is a potent and... 
Electrophysiology | Potential of mean force | Potassium channel | Umbrella sampling | C-terminal amide | ShK | voltage-gated K | ShK with a C-terminal Lys and amide | effector memory T-cells | ShK-K-amide | channel | PMF | Stichodactyla helianthus | molecular dynamics | channel toxin from | potential of mean force | ShK-amide | C-terminally amidated ShK | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | PEPTIDE | CELL BIOLOGY | BIOPHYSICS | AUTOIMMUNE-DISEASES | STICHODACTYLA-HELIANTHUS | RAT-BRAIN | INHIBITOR | MEMORY T-CELLS | FREE-ENERGY | K+ CHANNELS | Kv1.1 Potassium Channel - metabolism | Humans | Cnidarian Venoms - metabolism | Kv1.3 Potassium Channel - genetics | Cnidarian Venoms - pharmacology | Potassium Channel Blockers - metabolism | Kv1.1 Potassium Channel - physiology | Dose-Response Relationship, Drug | Ion Channel Gating - physiology | T-Lymphocytes - drug effects | Kv1.3 Potassium Channel - metabolism | Binding Sites | Potassium Channel Blockers - pharmacology | Binding, Competitive | Kv1.1 Potassium Channel - genetics | Protein Structure, Tertiary | Cells, Cultured | Models, Molecular | Kv1.3 Potassium Channel - physiology | Molecular Dynamics Simulation | Cnidarian Venoms - chemistry | Patch-Clamp Techniques | Algorithms | Animals | Ion Channel Gating - genetics | T-Lymphocytes - cytology | Amides - chemistry | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Potassium Channel Blockers - chemistry | Ion Channel Gating - drug effects | Potassium channels | Peptides | T cells | Analysis | potassium channel | umbrella sampling | electrophysiology
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 01/2018, Volume 314, Issue 1, pp. C27 - C40
Journal Article
Journal of Asian Natural Products Research, ISSN 1028-6020, 09/2019, Volume 21, Issue 9, pp. 887 - 894
Three new phenylspirodrimanes derivatives named stachybotrysins H and I (1 and 2) and stachybotrin E (3), together with one known compound stachybotrylactam... 
Stachybotrys chartarum | Phenylspirodrimanes derivatives | potassium channel Kv1.3 | TARGET | METABOLITES | CHEMISTRY, MEDICINAL | ATRANONES | DIMERS | PLANT SCIENCES | ANTI-HIV ACTIVITY | PHARMACOLOGY & PHARMACY | A-G | CHEMISTRY, APPLIED | potassium channel Kv1 | Fungi | Potassium channels (voltage-gated) | Nuclear magnetic resonance--NMR | Derivatives | Potassium
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, pp. e88642 - e88642
Journal Article