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British journal of cancer, ISSN 1532-1827, 06/2017, Volume 117, Issue 1, pp. 33 - 40
Background: Pembrolizumab (P) is an anti-PD-1 antibody that blocks the interaction between programmed cell death protein 1 (PD-1) on T-cells and PD-L1 and... 
clinical trial | pembrolizumab | advanced/metastatic solid tumours | phase I | chemotherapy | immunotherapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Nausea - chemically induced | Humans | Middle Aged | Male | Fatigue - chemically induced | Vinblastine - administration & dosage | Diarrhea - chemically induced | Small Cell Lung Carcinoma - drug therapy | Pancreatic Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Adult | Camptothecin - administration & dosage | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Camptothecin - analogs & derivatives | Doxorubicin - administration & dosage | Drug Eruptions - etiology | Deoxycytidine - administration & dosage | Albumins - administration & dosage | Treatment Outcome | Sarcoma - drug therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Taxoids - administration & dosage | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Index Medicus | metastatic solid tumours | advanced | Clinical Study
Journal Article
The lancet oncology, ISSN 1470-2045, 02/2012, Volume 13, Issue 2, pp. e58 - e68
Journal Article
The New England journal of medicine, ISSN 1533-4406, 04/2012, Volume 366, Issue 15, pp. 1382 - 1392
Journal Article
by Wang-Gillam, Andrea and Li, Chung-Pin and Bodoky, György and Dean, Andrew and Shan, Yan-Shen and Jameson, Gayle and Macarulla, Teresa and Lee, Kyung-Hun and Cunningham, David and Blanc, Jean F and Hubner, Richard A and Chiu, Chang-Fang and Schwartsmann, Gilberto and Siveke, Jens T and Braiteh, Fadi and Moyo, Victor and Belanger, Bruce and Dhindsa, Navreet and Bayever, Eliel and Von Hoff, Daniel D and Chen, Li-Tzong and Adoo, Clarence and Anderson, Thomas and Asselah, Jamil and Azambuja, Alan and Bampton, Carolyn and Barrios, Carlos Henrique and Bekaii-Saab, Tanios and Bohuslav, Melichar and Chang, David and Chen, Jen-Shi and Chen, Yeu-Chin and Choi, Hye Jin and Chung, Ik Joo and Chung, Vincent and Csoszi, Tibor and Cubillo, Antonio and DeMarco, Linda and de Wit, Maike and Dragovich, Tomislav and Edenfield, William and Fein, Luis Enrique and Franke, Fábio and Fuchs, Martin and Gonzales-Cruz, Vega and Gozza, Alberto and Fernando, Rivera Herrero and Iaffaioli, Rosario and Jakesova, Jitka and Kahan, Zsuzsanna and Karimi, Misagh and Kim, Jun Suk and Korbenfeld, Ernesto and Lang, Istvan and Lee, Fa-Chyi and Lee, Kuan-Der and Lipton, Lara and Ma, Wen Wee and Mangel, Laszlo and Mena, Raul and Palmer, Daniel and Pant, Shubham and Park, Joon Oh and Piacentini, Paolo and Pelzer, Uwe and Plazas, Javier Gallego and Prasad, Cooray and Rau, Kun-Ming and Raoul, Jean-Luc and Richards, Donald and Ross, Paul and Schlittler, Luis and Smakal, Martin and Stahalova, Vladimira and Sternberg, Cora and Seufferlein, Thomas and Tebbutt, Niall and Vinholes, Jeferson Jose and Wadlow, Raymond and Wenczl, Milkos and Wong, Mark and NAPOLI-1 Study Group and NAPOLI-1 Study Grp
The Lancet (British edition), ISSN 0140-6736, 02/2016, Volume 387, Issue 10018, pp. 545 - 557
Summary Background Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapies... 
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Leucovorin - administration & dosage | Humans | Middle Aged | Male | Fatigue - chemically induced | Diarrhea - chemically induced | Pancreatic Neoplasms - drug therapy | Neoplasm Metastasis | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Camptothecin - administration & dosage | Carcinoma, Pancreatic Ductal - mortality | Deoxycytidine - adverse effects | Female | Pancreatic Neoplasms - mortality | Neutropenia - chemically induced | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Treatment Outcome | Carcinoma, Pancreatic Ductal - drug therapy | Irinotecan | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Liposomes | Deoxycytidine - analogs & derivatives | Antimitotic agents | Medical colleges | Pancreatic cancer | Leucovorin | Product development | Research institutes | Metastasis | Antineoplastic agents | Analysis | Antigens | Chemotherapy | Medical prognosis | Clinical trials | Drug dosages | Cancer therapies | Tumors | Adenocarcinoma | Therapy | Gemcitabine | Toxicity | Evidence-based medicine | Metastases | Nanoparticles | Randomization | Vomiting | Safety management | Toxic diseases | Neutropenia | Folinic acid | Lymphatic system | Medical treatment | Diarrhea | FDA approval | Survival | Patients | Acids | Equivalence | Interactive systems | Index Medicus | Abridged Index Medicus
Journal Article
The New England journal of medicine, ISSN 1533-4406, 12/2015, Volume 373, Issue 25, pp. 2425 - 2437
Journal Article
European journal of cancer (1990), ISSN 0959-8049, 05/2017, Volume 76, pp. 144 - 151
Abstract Purpose In tumours with wild-type TP53 , the tumour-suppressive function of p53 is frequently inhibited by HDM2. This phase I, dose-escalating study... 
Hematology, Oncology and Palliative Medicine | HDM2 | De-differentiated liposarcoma | Pharmacodynamics | Solid tumours | MDM2 | Pharmacokinetics | SAR405838 | p53 | Life Sciences & Biomedicine | Oncology | Science & Technology | Lung Neoplasms - drug therapy | Skin Neoplasms - drug therapy | Nausea - chemically induced | Gastrointestinal Neoplasms - drug therapy | Humans | Middle Aged | Spiro Compounds - administration & dosage | Lung Neoplasms - pathology | Male | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Spiro Compounds - adverse effects | Indoles - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Gastrointestinal Neoplasms - pathology | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - pathology | Skin Neoplasms - pathology | Liposarcoma - drug therapy | Liposarcoma - pathology | Thrombocytopenia - chemically induced | Melanoma - pathology | Spiro Compounds - pharmacokinetics | Neoplasms - drug therapy | Vomiting - chemically induced | Maximum Tolerated Dose | Indoles - adverse effects | Melanoma - drug therapy | Anorexia - chemically induced | Indoles - pharmacokinetics | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Neoplasms - pathology | Tumor proteins | Care and treatment | Tumors | Index Medicus
Journal Article