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Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
MYCN amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 08/2017, Volume 146, Issue 2, pp. 305 - 313
•We describe molecular alterations that contribute to vulvar cancer pathogenesis.•Squamous cell carcinoma and adenocarcinoma of the vulva have differing... 
Molecular targets | Vulvar cancer | Molecular alterations | Targeted therapy | MULTIDRUG TRANSPORTER | ONCOLOGY-GROUP | THYMIDYLATE SYNTHASE | PHASE-II | CERVICAL-CANCER | INTRAEPITHELIAL NEOPLASIA | OBSTETRICS & GYNECOLOGY | GROWTH-FACTOR RECEPTOR | LUNG-CANCER | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | ADVANCED NSCLC | Immunohistochemistry | Adenocarcinoma - pathology | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - pathology | Humans | Middle Aged | GTP-Binding Protein alpha Subunits, Gs - genetics | Vulvar Neoplasms - pathology | Adenocarcinoma - metabolism | Vulvar Neoplasms - metabolism | Chromogranins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Precision Medicine | Membrane Proteins - genetics | Vulvar Neoplasms - drug therapy | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | In Situ Hybridization, Fluorescence | Adenocarcinoma - drug therapy | Sequence Analysis, DNA | Carcinoma, Squamous Cell - drug therapy | Class I Phosphatidylinositol 3-Kinases | GTP Phosphohydrolases - metabolism | GTP Phosphohydrolases - genetics | Receptor, ErbB-4 - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | GTP-Binding Protein alpha Subunits, Gs - metabolism | Receptor, ErbB-4 - metabolism | F-Box-WD Repeat-Containing Protein 7 | Ataxia Telangiectasia Mutated Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Molecular Targeted Therapy | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Chromogranins - metabolism | Cell Cycle Proteins - genetics | Female | Adenocarcinoma - genetics | Membrane Proteins - metabolism | Retrospective Studies | Proto-Oncogene Proteins p21(ras) - metabolism | F-Box Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Phosphatidylinositol 3-Kinases - genetics | BRCA2 Protein - metabolism | Gene Amplification | Vulvar Neoplasms - genetics | Proto-Oncogene Proteins B-raf - genetics | Aged | High-Throughput Nucleotide Sequencing | Ataxia Telangiectasia Mutated Proteins - genetics | Neoplasm Staging | BRCA2 Protein - genetics | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Squamous cell carcinoma | Tumor proteins | Analysis
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1983 - 1996
The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these... 
EPITHELIAL-MESENCHYMAL TRANSITION | CYCLIN-E | ONCOLOGY | PHOSPHORYLATION | POOR-PROGNOSIS | TUMOR-SUPPRESSOR GENE | DEGRADATION | CELL-PROLIFERATION | EXPRESSION | F-BOX PROTEIN | FBW7 UBIQUITIN LIGASE | Immunohistochemistry | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 | RNA-Binding Proteins - genetics | Humans | Cytoplasm - metabolism | Protein Interaction Maps | Heterografts | Neoplasms - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Binding Sites | F-Box Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Proteins - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Phenotype | Animals | Mice, Nude | Protein Isoforms | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA-Binding Proteins - metabolism | Binding | Ubiquitin | Alternative splicing | Adapters | ErbB-3 protein | Cytosol | Substrates | Cdc4 protein | Degradation | Proteins | Isoforms | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Cancer | EBP1 protein | Index Medicus | EBP1 P48 | colorectal cancer | BASIC BIOLOGICAL SCIENCES | FBXW7 | protein isoform | 60 APPLIED LIFE SCIENCES | EBP1 P42 | Protein isoform | Colorectal cancer
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. 3527 - 3532
Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins.... 
Cul1 affinity | Fbxw11 | Fbxw7 | β-Trcp | SCF inhibitors | SYSTEM | BETA-TRCP1 | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | beta-Trcp | SUBSTRATE RECOGNITION | ROLES | FBW7 | F-Box-WD Repeat-Containing Protein 7 | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitins - genetics | Humans | Molecular Sequence Data | Ubiquitin-Protein Ligases - antagonists & inhibitors | Ubiquitins - chemistry | F-Box Proteins - antagonists & inhibitors | Peptide Library | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Genetic Variation | beta-Transducin Repeat-Containing Proteins - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Drug Design | Protein Engineering | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | beta-Transducin Repeat-Containing Proteins - genetics | Amino Acid Sequence | Ubiquitins - pharmacology | F-Box Proteins - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Ubiquitin-Protein Ligases - chemistry | SKP Cullin F-Box Protein Ligases - chemistry | beta-Transducin Repeat-Containing Proteins - chemistry | Cullin Proteins - chemistry | Sequence Homology, Amino Acid | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 45, pp. 30540 - 30548
The c- myb proto-oncogene product (c-Myb) is degraded in response to Wnt-1 signaling via a pathway involving TAK1 ( t ransforming growth factor-β- a ctivated... 
CYCLIN-E | GENE | PROTEIN-DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT UBIQUITINATION | MULTISITE PHOSPHORYLATION | TUMOR-SUPPRESSOR | COACTIVATOR CBP | LEUKEMIA | B-MYB | V-MYB | Phosphorylation - physiology | F-Box-WD Repeat-Containing Protein 7 | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Cell Proliferation | Humans | Proto-Oncogene Proteins c-myb - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | F-Box Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - metabolism | Wnt1 Protein - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Ubiquitination - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Oncogene Proteins v-myb - metabolism | Cell Line | F-Box Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | MAP Kinase Kinase Kinases - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Cullin Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Oncogene Proteins v-myb - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Protein Binding - physiology | Protein Structure, Tertiary - physiology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 15, pp. 9674 - 9689
The protein arginine methyltransferase PRMT5 is complexed with the WD repeat protein MEP50 (also known as Wdr77 or androgen coactivator p44) in vertebrates in... 
SM PROTEINS | DIMETHYLARGININE | CELLS | COMPLEX | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TRANSCRIPTION | METHYLOSOME | EXPRESSION | PREDICTION | Adaptor Proteins, Signal Transducing - chemistry | Caenorhabditis elegans - chemistry | Xenopus Proteins - genetics | Histones - chemistry | Humans | Protein Multimerization | Caenorhabditis elegans Proteins - metabolism | Xenopus Proteins - chemistry | Protein-Arginine N-Methyltransferases - genetics | Xenopus laevis - genetics | Protein-Arginine N-Methyltransferases - chemistry | Protein Structure, Tertiary | Catalytic Domain | Caenorhabditis elegans - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Caenorhabditis elegans - genetics | Models, Molecular | Chromosomal Proteins, Non-Histone - genetics | Protein-Arginine N-Methyltransferases - metabolism | Algorithms | Animals | Histones - genetics | Xenopus laevis - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Xenopus Proteins - metabolism | Histones - metabolism | Kinetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Caenorhabditis elegans Proteins - genetics | Chromosomal Proteins, Non-Histone - chemistry | Protein Arginine N-methyltransferase 5 (PRMT5) | Histone Methylation | Peptide Array | WD Repeat | Enzyme Mechanism | Enzyme Kinetics | Enzymology
Journal Article
Journal Article
Journal of Cell Science, ISSN 0021-9533, 07/2010, Volume 123, Issue 14, pp. 2423 - 2433
Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the Delta... 
MDM2 | p63 | Fbw7 | DNA damage | TRANSCRIPTIONAL ACTIVITY | CYCLIN-E | UBIQUITIN LIGASE | PHOSPHORYLATION | STABILITY | P53 REGULATION | CELL BIOLOGY | TUMOR-SUPPRESSOR | C-JUN | PROMOTES | HUMAN CANCER | F-Box-WD Repeat-Containing Protein 7 | RNA, Small Interfering - genetics | Protein Binding - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Transcriptional Activation - genetics | Humans | Cell Nucleus - metabolism | Cell Nucleus - radiation effects | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | DNA Damage - genetics | Active Transport, Cell Nucleus - genetics | Active Transport, Cell Nucleus - radiation effects | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Differentiation - radiation effects | Tumor Suppressor Proteins - metabolism | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Protein Structure, Tertiary - genetics | Mutation - genetics | Ultraviolet Rays - adverse effects | Animals | Cell Differentiation - drug effects | Active Transport, Cell Nucleus - drug effects | Cell Line, Tumor | Trans-Activators - metabolism | Cell Proliferation - drug effects | Mice | Transcription Factors | Cell Nucleus - drug effects | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Doxorubicin - pharmacology | Cell Proliferation - radiation effects
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2016, Volume 61, Issue 3, pp. 419 - 433
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but... 
INCREASED GENOMIC INSTABILITY | CULLIN-RING LIGASES | STRAND BREAK REPAIR | DEFECTIVE-DNA REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DEPENDENT PROTEIN-KINASE | F-BOX PROTEINS | NEDD8-ACTIVATING ENZYME-INHIBITOR | HOMOLOGOUS RECOMBINATION | FBW7 UBIQUITIN LIGASE | CELL BIOLOGY | F-Box-WD Repeat-Containing Protein 7 | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | DNA End-Joining Repair - radiation effects | Humans | Radiation Tolerance | Molecular Sequence Data | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Ubiquitins - metabolism | Polyubiquitin - metabolism | Amino Acid Sequence | F-Box Proteins - metabolism | HCT116 Cells | Pancreatic Neoplasms - pathology | Radiation-Sensitizing Agents - pharmacology | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Pancreatic Neoplasms - enzymology | Ubiquitin-Protein Ligases - metabolism | Pancreatic Neoplasms - radiotherapy | Protein Processing, Post-Translational - radiation effects | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | DNA-Binding Proteins - genetics | Ubiquitin-Activating Enzymes - metabolism | Mice, Knockout | Animals | Lysine | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Ubiquitins - antagonists & inhibitors | Ionizing radiation | Automated teller machines | Ancient Egypt | Ligases | Genomics | Ubiquitin | Medical colleges | DNA damage
Journal Article
FEBS Letters, ISSN 0014-5793, 11/2015, Volume 589, Issue 22, pp. 3343 - 3353
Autophagy is an intracellular degradation system that, as a basic mechanism it delivers cytoplasmic components to the lysosomes in order to maintain adequate... 
Autophagosome biogenesis | Rab GTPase | Autophagosome–lysosome fusion | Autophagy | SNAP receptor | GTP | PAS | PtdIns3P | sequestosome 1 | TRAPP | LRRK1 | mechanistic target of rapamycin | 200 kD focal adhesion kinase family-interacting protein | unc-51 like autophagy activating kinase 1 | GAS-containing autophagosome-like vacuoles | FYCO1 | guanosine diphosphate | GDP | WD-repeat-interacting phosphoinositide proteins | CMA | guanosine nucleotide exchange factor | STX | AMD | mTOR | Group A Streptococcus | LC3 | GTPase activating protein | N-ethyl-maleimide-sensitive factor | NSF | endoplasmic reticulum exit sites | chaperone-mediated autophagy | autophagy-related protein | phosphatidylinositol 3-phosphate | light chain 3 | coat protein complex II | phagophore assembly site | Huntington disease | PKA | GEF | cAMP-dependent protein kinase | transport protein particle | GAP | NS4B | soluble N-ethyl-maleimide attachment proteins | FIP200 | GAS | MVB | AMPK | HCV | PIK3C3 | ULK1 | ERES | epidermal growth factor | SQSTM1 | class III phosphatidylinositol 3 kinase | AMP-activated protein kinase | FYVE and coiled-coil domain-containing 1 | SNARE | vacuolar protein sorting | COPII | non-structural protein 4B | age-related macular degeneration of the eye | multivesicular body | VPS | leucine-rich repeat kinase 1 | recycling endosome | WIPI | EGF | guanosine triphosphate | molecular weight | SNAP | Syntaxin | phosphatidylethanolamine | ATG | GcAVs | Hepatitis C virus | DFCP1 | endoplasmic reticulum | double FYVE domain-containing protein 1 | Autophagosome-lysosome fusion | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMA-MEMBRANE | RAB24 GTPASE | SMALL GTPASE | NEGATIVE REGULATOR | CELL BIOLOGY | MEMBRANE-FUSION | PROMOTES AUTOPHAGY | LONGIN DOMAIN | BIOPHYSICS | MULTIVESICULAR BODIES | WIPI PROTEINS | rab GTP-Binding Proteins - metabolism | Animals | Proteins - metabolism | Biological Transport | Humans | Intracellular Space - metabolism | SNARE Proteins - metabolism | Proteins
Journal Article