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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 11/2018, Volume 142, Issue 5, pp. 1589 - 1604.e11
Journal Article
Epigenetics, ISSN 1559-2294, 11/2016, Volume 11, Issue 11, pp. 780 - 790
Journal Article
EBioMedicine, ISSN 2352-3964, 09/2019, Volume 47, pp. 470 - 483
NACHT and WD repeat domain-containing protein 1 (Nwd1) is a member of the innate immune protein subfamily. Nwd1 contributes to the androgen receptor signaling... 
GluN2B phosphorylation | Neuronal hyperexcitability | NACHT and WD repeat domain-containing protein 1 | Neuronal synaptic transmission | Cognition | NMDA receptor | Hippocampus | MEDICINE, RESEARCH & EXPERIMENTAL | ACID | TEMPORAL-LOBE EPILEPSY | ALZHEIMERS-DISEASE | SYNAPTIC PLASTICITY | SEIZURE ACTIVITY | DENDRITIC SPINES | PATHOGENESIS | MOUSE MODEL | RECEPTORS | SUBUNIT
Journal Article
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 11/2018, Volume 57, Issue 11, pp. 1445 - 1457
Serous endometrial cancers (ECs) are clinically aggressive tumors that frequently harbor somatic mutations in FBXW7 (F‐box and WD repeat domain‐containing 7).... 
ARK1 | SRC‐3 | uterine cancer | Cyclin E1 | ARK2 | SRC-3 | CYCLIN-E | UBIQUITIN LIGASE | PROGNOSIS | UTERUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | UTERINE CARCINOSARCOMAS | PATTERNS | MIXED MULLERIAN TUMORS | ONCOLOGY | RECEPTOR COREGULATORS | RICTOR | CLEAR-CELL CARCINOMA | RNA, Small Interfering - genetics | Phosphorylation | Humans | Cystadenocarcinoma, Serous - metabolism | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Cystadenocarcinoma, Serous - genetics | Cystadenocarcinoma, Serous - pathology | Biomarkers, Tumor | Cystadenocarcinoma, Serous - drug therapy | Gene Editing | F-Box-WD Repeat-Containing Protein 7 - genetics | Endometrial Neoplasms - genetics | Biomarkers | Cell Line, Tumor | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | Mutation | F-Box-WD Repeat-Containing Protein 7 - metabolism | Synthesis | Endometrial cancer | Ligases | Glycogen | Analysis | Genetic aspects | Protein kinases | Cancer | Ubiquitin | AKT protein | Myc protein | Kinases | Cdc4 protein | Cullin | Proteins | Transfection | Tumorigenesis | Endometrium | Ubiquitin-protein ligase | CRISPR | Glycogen synthase kinase 3 | Src protein | Substrates | Ribosomal protein S6 kinase | Sensitivity | Inhibitors | Cell lines | Tumor suppressor genes | Tumors
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, 04/2015, Volume 290, Issue 16, pp. 10368 - 10381
A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell growth and differentiation of various cells, such as hematopoietic... 
Phosphorylation | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCFFBW7 | Ubiquitylation (Ubiquitination) | MOUSE C-MYB | ENFORCED EXPRESSION | BUTYROLACTONE-I | TUMOR-SUPPRESSOR | Ubiquitin Ligase | GATA Transcription Factor | Protein Degradation | T-CELL DEVELOPMENT | Fbw7 | TRANSCRIPTION FACTOR | F-BOX PROTEIN | FBXW7 ACTS | Cyclin-dependent Kinase (CDK) | HEMATOPOIETIC STEM | CDC2 Protein Kinase | F-Box-WD Repeat-Containing Protein 7 | RNA, Small Interfering - genetics | Cyclin-Dependent Kinases - metabolism | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Ubiquitin-Protein Ligases - antagonists & inhibitors | F-Box Proteins - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Ubiquitination | Cyclin B - genetics | Proteolysis | HEK293 Cells | Cell Cycle Proteins - genetics | Cell Differentiation | Cyclin-Dependent Kinases - genetics | GATA2 Transcription Factor - genetics | Signal Transduction | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Ubiquitin-Protein Ligases - metabolism | Ubiquitin - genetics | Glycogen Synthase Kinase 3 - metabolism | Amino Acid Motifs | Mice, Knockout | GATA2 Transcription Factor - antagonists & inhibitors | Animals | Glycogen Synthase Kinase 3 - genetics | GATA2 Transcription Factor - metabolism | K562 Cells | Protein Binding | Cyclin B - metabolism | Mice | HeLa Cells | Mutation | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 342 - 354
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article