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The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 11/2018, Volume 142, Issue 5, pp. 1589 - 1604.e11
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2019, Volume 41, Issue 3, pp. 1827 - 1836
Salivary adenoid cystic carcinoma (SACC) is one of the most common types of salivary gland cancer that causes substantial morbidity and mortality. Despite the... 
WD repeat-containing protein 66 | Epithelial-mesenchymal transition | Salivary adenoid cystic carcinoma | Phosphatase and tensin homolog | HEAD | CELLS | GLAND CANCER | phosphatase and tensin homolog | salivary adenoid cystic carcinoma | EMT | ONCOLOGY | PLATELETS | BIOLOGY | TARGETS | epithelial-mesenchymal transition | NECK | EXPRESSION
Journal Article
STEM CELLS, ISSN 1066-5099, 09/2017, Volume 35, Issue 9, pp. 2027 - 2036
The cancer stem cell (CSC) paradigm suggests that tumors are organized hierarchically. Chugai previously established an LGR5+ human colorectal cancer (CRC)... 
Cancer stem cells | F‐box/WD repeat‐containing protein 7 | c‐Myc | Colorectal cancer | Chemoresistance | F-box/WD repeat-containing protein 7 | c-Myc | INITIATING CELLS | HEMATOPOIETIC-CELL | COLON | IDENTIFICATION | CHROMOSOMAL INSTABILITY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DIFFERENTIATION | LEUKEMIA | HEMATOLOGY | TUMOR-GROWTH | EXPRESSION | Receptors, G-Protein-Coupled - metabolism | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | F-Box-WD Repeat-Containing Protein 7 - genetics | Proteolysis - drug effects | Neoplastic Stem Cells - metabolism | Colorectal Neoplasms - drug therapy | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Cell Line, Tumor | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | F-Box-WD Repeat-Containing Protein 7 - metabolism | Drug Resistance, Neoplasm - drug effects | Cell death | Liver | Colorectal carcinoma | c-Myc protein | Myc protein | Drug resistance | Cdc4 protein | Metastases | Anticancer properties | Antitumor agents | Cell cycle | siRNA | Tumor cell lines | Ribonucleic acid--RNA | Irinotecan | Chemotherapy | Molecular modelling | Overexpression | Stem cells | Regulatory mechanisms (biology) | Sensitivity enhancement | Differentiation | Tumors | Cancer
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 342 - 354
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 03/2018, Volume 92, Issue 5
Replication of negative-strand RNA viruses occurs in association with discrete cytoplasmic foci called inclusion bodies. Whereas inclusion bodies represent a... 
WDR5 | Innate immunity | Inclusion body | WD repeat-containing protein | Measles virus | LINEAGE LEUKEMIA PROTEIN-1 | ADENOSINE-DEAMINASE ADAR1 | TERMINAL DOMAIN | GRANULE FORMATION | C-PROTEIN | RIBONUCLEOPROTEIN COMPLEX | KINASE PKR | VIRAL REPLICATION | inclusion body | H3 LYSINE 4 | VIROLOGY | innate immunity | RESPIRATORY-SYNCYTIAL-VIRUS | measles virus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. 3527 - 3532
Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins.... 
Cul1 affinity | Fbxw11 | Fbxw7 | β-Trcp | SCF inhibitors | SYSTEM | BETA-TRCP1 | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | beta-Trcp | SUBSTRATE RECOGNITION | ROLES | FBW7 | F-Box-WD Repeat-Containing Protein 7 | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitins - genetics | Humans | Molecular Sequence Data | Ubiquitin-Protein Ligases - antagonists & inhibitors | Ubiquitins - chemistry | F-Box Proteins - antagonists & inhibitors | Peptide Library | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Genetic Variation | beta-Transducin Repeat-Containing Proteins - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Drug Design | Protein Engineering | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | beta-Transducin Repeat-Containing Proteins - genetics | Amino Acid Sequence | Ubiquitins - pharmacology | F-Box Proteins - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Ubiquitin-Protein Ligases - chemistry | SKP Cullin F-Box Protein Ligases - chemistry | beta-Transducin Repeat-Containing Proteins - chemistry | Cullin Proteins - chemistry | Sequence Homology, Amino Acid | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences
Journal Article
Oncology Letters, ISSN 1792-1074, 04/2018, Volume 15, Issue 4, pp. 4439 - 4444
Breast cancer is the most common type of malignant cancer in females. An increasing number of studies have revealed that microRNAs (miR), which belong to a... 
Breast cancer | MicroRNA | Proliferation | F-box/WD repeat-containing protein 7 | FBXW7 EXPRESSION | CYCLIN-E | SEL-10 | proliferation | C-MYC | breast cancer | GENE | ONCOLOGY | GASTRIC-CANCER | PATHWAY | MIRNA | microRNA | MIR-194
Journal Article
Journal Article