X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (812) 812
index medicus (682) 682
animals (500) 500
f-box-wd repeat-containing protein 7 (480) 480
biochemistry & molecular biology (419) 419
cell biology (394) 394
cell cycle proteins - genetics (320) 320
ubiquitin-protein ligases - genetics (320) 320
f-box proteins - genetics (318) 318
proteins (283) 283
cell cycle proteins - metabolism (276) 276
ubiquitin-protein ligases - metabolism (275) 275
mutation (274) 274
f-box proteins - metabolism (272) 272
mice (262) 262
wd-repeat (260) 260
female (259) 259
molecular sequence data (230) 230
oncology (223) 223
male (212) 212
amino acid sequence (209) 209
phosphorylation (191) 191
cancer (188) 188
wd-repeat protein (188) 188
cell line, tumor (184) 184
tumor-suppressor (162) 162
research (161) 161
expression (160) 160
apoptosis (149) 149
genetic aspects (149) 149
signal transduction (148) 148
saccharomyces-cerevisiae (146) 146
article (140) 140
protein binding (139) 139
genetics & heredity (131) 131
gene (129) 129
gene expression (129) 129
c-myc (126) 126
cell cycle (120) 120
fbw7 (116) 116
fbxw7 (112) 112
cell line (110) 110
cyclin-e (109) 109
ubiquitin ligase (109) 109
wd repeat protein (106) 106
adult (105) 105
middle aged (104) 104
analysis (103) 103
cell proliferation (103) 103
sequence homology, amino acid (100) 100
ubiquitin (99) 99
ubiquitination (99) 99
base sequence (95) 95
degradation (93) 93
genes (93) 93
physiological aspects (93) 93
proteolysis (93) 93
gene expression regulation, neoplastic (89) 89
protein structure, tertiary (86) 86
f-box protein (84) 84
prognosis (84) 84
research article (84) 84
protein (83) 83
multidisciplinary sciences (80) 80
wd repeat (80) 80
complex (78) 78
identification (77) 77
differentiation (75) 75
hela cells (75) 75
aged (74) 74
mutations (74) 74
cells (71) 71
kinases (71) 71
biophysics (70) 70
yeast (70) 70
tumors (67) 67
health aspects (65) 65
molecular biology (65) 65
child (64) 64
crystal-structure (64) 64
proto-oncogene proteins c-myc - metabolism (63) 63
achalasia (61) 61
life sciences (61) 61
activation (60) 60
biology (60) 60
transfection (60) 60
articles (59) 59
cloning, molecular (59) 59
models, biological (59) 59
f-box proteins (58) 58
models, molecular (58) 58
receptor, notch1 - genetics (57) 57
rna interference (57) 57
saccharomyces cerevisiae - metabolism (57) 57
sequence alignment (57) 57
wd-repeat proteins (57) 57
f-box-wd repeat-containing protein 7 - genetics (56) 56
ligases (56) 56
phenotype (56) 56
binding sites (55) 55
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the protein... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 13, pp. 3527 - 3532
Skp1–Cul1–F-box (SCF) E3 ligases play key roles in multiple cellular processes through ubiquitination and subsequent degradation of substrate proteins.... 
Cul1 affinity | Fbxw11 | Fbxw7 | β-Trcp | SCF inhibitors | SYSTEM | BETA-TRCP1 | COMPLEX | DOMAIN | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | beta-Trcp | SUBSTRATE RECOGNITION | ROLES | FBW7 | F-Box-WD Repeat-Containing Protein 7 | SKP Cullin F-Box Protein Ligases - genetics | Ubiquitins - genetics | Humans | Molecular Sequence Data | Ubiquitin-Protein Ligases - antagonists & inhibitors | Ubiquitins - chemistry | F-Box Proteins - antagonists & inhibitors | Peptide Library | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Genetic Variation | beta-Transducin Repeat-Containing Proteins - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Drug Design | Protein Engineering | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | beta-Transducin Repeat-Containing Proteins - genetics | Amino Acid Sequence | Ubiquitins - pharmacology | F-Box Proteins - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Ubiquitin-Protein Ligases - chemistry | SKP Cullin F-Box Protein Ligases - chemistry | beta-Transducin Repeat-Containing Proteins - chemistry | Cullin Proteins - chemistry | Sequence Homology, Amino Acid | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | BASIC BIOLOGICAL SCIENCES | 60 APPLIED LIFE SCIENCES | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 15, pp. 9674 - 9689
The protein arginine methyltransferase PRMT5 is complexed with the WD repeat protein MEP50 (also known as Wdr77 or androgen coactivator p44) in vertebrates in... 
SM PROTEINS | DIMETHYLARGININE | CELLS | COMPLEX | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TRANSCRIPTION | METHYLOSOME | EXPRESSION | PREDICTION | Adaptor Proteins, Signal Transducing - chemistry | Caenorhabditis elegans - chemistry | Xenopus Proteins - genetics | Histones - chemistry | Humans | Protein Multimerization | Caenorhabditis elegans Proteins - metabolism | Xenopus Proteins - chemistry | Protein-Arginine N-Methyltransferases - genetics | Xenopus laevis - genetics | Protein-Arginine N-Methyltransferases - chemistry | Protein Structure, Tertiary | Catalytic Domain | Caenorhabditis elegans - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Caenorhabditis elegans - genetics | Models, Molecular | Chromosomal Proteins, Non-Histone - genetics | Protein-Arginine N-Methyltransferases - metabolism | Algorithms | Animals | Histones - genetics | Xenopus laevis - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Xenopus Proteins - metabolism | Histones - metabolism | Kinetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Methylation | Caenorhabditis elegans Proteins - genetics | Chromosomal Proteins, Non-Histone - chemistry | Protein Arginine N-methyltransferase 5 (PRMT5) | Histone Methylation | Peptide Array | WD Repeat | Enzyme Mechanism | Enzyme Kinetics | Enzymology
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
BMC Evolutionary Biology, ISSN 1471-2148, 2009, Volume 9, Issue 1, pp. 249 - 249
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2016, Volume 61, Issue 3, pp. 419 - 433
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, but... 
INCREASED GENOMIC INSTABILITY | CULLIN-RING LIGASES | STRAND BREAK REPAIR | DEFECTIVE-DNA REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | DEPENDENT PROTEIN-KINASE | F-BOX PROTEINS | NEDD8-ACTIVATING ENZYME-INHIBITOR | HOMOLOGOUS RECOMBINATION | FBW7 UBIQUITIN LIGASE | CELL BIOLOGY | F-Box-WD Repeat-Containing Protein 7 | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | DNA End-Joining Repair - radiation effects | Humans | Radiation Tolerance | Molecular Sequence Data | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Ubiquitins - metabolism | Polyubiquitin - metabolism | Amino Acid Sequence | F-Box Proteins - metabolism | HCT116 Cells | Pancreatic Neoplasms - pathology | Radiation-Sensitizing Agents - pharmacology | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Pancreatic Neoplasms - enzymology | Ubiquitin-Protein Ligases - metabolism | Pancreatic Neoplasms - radiotherapy | Protein Processing, Post-Translational - radiation effects | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Cyclopentanes - pharmacology | Pyrimidines - pharmacology | DNA-Binding Proteins - genetics | Ubiquitin-Activating Enzymes - metabolism | Mice, Knockout | Animals | Lysine | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Ataxia Telangiectasia Mutated Proteins - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Ubiquitins - antagonists & inhibitors | Ionizing radiation | Automated teller machines | Ancient Egypt | Ligases | Genomics | Ubiquitin | Medical colleges | DNA damage
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Journal of Cell Science, ISSN 0021-9533, 05/2003, Volume 116, Issue 9, pp. 1679 - 1688
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1983 - 1996
The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these... 
EPITHELIAL-MESENCHYMAL TRANSITION | CYCLIN-E | ONCOLOGY | PHOSPHORYLATION | POOR-PROGNOSIS | TUMOR-SUPPRESSOR GENE | DEGRADATION | CELL-PROLIFERATION | EXPRESSION | F-BOX PROTEIN | FBW7 UBIQUITIN LIGASE | Immunohistochemistry | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 | RNA-Binding Proteins - genetics | Humans | Cytoplasm - metabolism | Protein Interaction Maps | Heterografts | Neoplasms - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Binding Sites | F-Box Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Proteins - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Phenotype | Animals | Mice, Nude | Protein Isoforms | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA-Binding Proteins - metabolism | Binding | Ubiquitin | Alternative splicing | Adapters | ErbB-3 protein | Cytosol | Substrates | Cdc4 protein | Degradation | Proteins | Isoforms | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Cancer | EBP1 protein | Index Medicus | EBP1 P48 | colorectal cancer | BASIC BIOLOGICAL SCIENCES | FBXW7 | protein isoform | 60 APPLIED LIFE SCIENCES | EBP1 P42 | Protein isoform | Colorectal cancer
Journal Article