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wee1 (391) 391
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1. Full Text Sequential combination of bortezomib and WEE1 inhibitor, MK-1775, induced apoptosis in multiple myeloma cell lines
by Barbosa, Rebecca S.S and Dantonio, Paola M and Guimarães, Taís and de Oliveira, Mariana B and Fook Alves, Veruska L and Sandes, Alex Freire and Fernando, Rodrigo Carlini and Colleoni, Gisele W.B
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 597 - 604
Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. is a cell cycle related gene that regulates the G2/M... 
Myeloma | WEE1 | MK-1775
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2. Full Text An essential role for dNTP homeostasis following CDK-induced replication stress
by Pai, Chen-Chun and Pai, Chen-Chun and Hsu, Kuo-Feng and Hsu, Kuo-Feng and Durley, Samuel C and Durley, Samuel C and Keszthelyi, Andrea and Keszthelyi, Andrea and Kearsey, Stephen E and Kearsey, Stephen E and Rallis, Charalampos and Rallis, Charalampos and Folkes, Lisa K and Folkes, Lisa K and Deegan, Rachel and Deegan, Rachel and Wilkins, Sarah E and Pfister, Sophia X and Pfister, Sophia X and De León, Nagore and León, Nagore De and Schofield, Christopher J and Schofield, Christopher J and Bahler, Jurg and Bähler, Jürg and Carr, Antony M and Carr, Antony M and Humphrey, Timothy C and Humphrey, Timothy C
Journal of cell science, ISSN 0021-9533, 03/2019, Volume 132, Issue 6, p. jcs226969
Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase... 
MBF | Wee1 | Histone H3K36 modification | Set2 | Schizosaccharomyces pombe | CDK | Synthetic lethality | SYNTHETIC LETHAL INTERACTIONS | TRANSCRIPTION | GENOME STABILITY | RIBONUCLEOTIDE REDUCTASE-ACTIVITY | DNA-REPLICATION | CELL BIOLOGY | HOMOLOGOUS RECOMBINATION REPAIR | NUCLEOTIDE SYNTHESIS | WEE1 KINASE | INHIBITION | S-PHASE
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3. Full Text Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck
by Lee, Jong Woo and Parameswaran, Janaki and Sandoval-Schaefer, Teresa and Eoh, Kyung Jin and Yang, Dong-hua and Zhu, Fang and Mehra, Ranee and Sharma, Roshan and Gaffney, Stephen G and Perry, Elizabeth B and Townsend, Jeffrey P and Serebriiskii, Ilya G and Golemis, Erica A and Issaeva, Natalia and Yarbrough, Wendell G and Koo, Ja Seok and Burtness, Barbara
Clinical Cancer Research, ISSN 1078-0432, 06/2019, Volume 25, Issue 11, pp. 3430 - 3442
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in , resulting in treatment resistance.... 
Aurora Kinase A | WEE1 | adavosertib | alisertib | HNSCC
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4. Full Text Cell cycle checkpoint in cancer: A therapeutically targetable double-edged sword
by Visconti, Roberta and Della Monica, Rosa and Grieco, Domenico
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 09/2016, Volume 35, Issue 1, p. 153
Major currently used anticancer therapeutics either directly damage DNA or target and upset basic cell division mechanisms like DNA replication and chromosome... 
Wee1 | Mitosis | Spindle assembly checkpoint | DNA damage | Cell cycle checkpoint | Cancer drug | Chk1 | Taxane | Vinca alkaloids | Fcp1 | ADVANCED SOLID TUMORS | WEE1 KINASE INHIBITOR | ANTITUMOR-ACTIVITY | I DOSE-ESCALATION | CHK1 INHIBITOR | SMALL-MOLECULE INHIBITOR | DNA-DAMAGING AGENTS | ONCOLOGY | IONIZING-RADIATION | PHASE-I | SPINDLE-ASSEMBLY CHECKPOINT | Physiological aspects | Influence | Reactive oxygen species | Research | Cell cycle
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5. Full Text Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Irrespective of TP53 Mutational Status through the Induction of Replication Stress
by Cuneo, Kyle C and Morgan, Meredith A and Davis, Mary A and Parcels, Leslie A and Parcels, Joshua and Karnak, David and Liu, Na and Maybaum, Jon and Lawrence, Theodore S
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 6/2016, Volume 95, Issue 2, pp. 782 - 790
Wee1 inhibition with AZD1775 has the potential to be an effective strategy of radiosensitization in hepatocellular carcinoma given the high prevalence of CDK1... 
AZD1775 | Hepatocellular carcinoma | Wee1 | radiosensitizer
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6. Full Text AZD1775 induces toxicity through double-stranded DNA breaks independently of chemotherapeutic agents in p53-mutated colorectal cancer cells
by Webster, Peter John and Littlejohns, Anna Tiffany and Gaunt, Hannah Jane and Prasad, K. Raj and Beech, David John and Burke, Dermot Anthony
Cell Cycle, ISSN 1538-4101, 11/2017, Volume 16, Issue 22, pp. 2176 - 2182
AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells.... 
colorectal cancer | mitosis | cell cycle | checkpoint kinase | DNA damage | DAMAGING AGENTS | WEE1 KINASE INHIBITOR | TARGETING WEE1 | MK-1775 | CELL BIOLOGY | Index Medicus
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7. Full Text Targeting the replication stress response in cancer
by Forment, Josep V and O’Connor, Mark J
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2018, Volume 188, pp. 155 - 167
Many conventional chemotherapies used in cancer treatment exert their effect by inflicting DNA damage. Highly proliferative tissues, as well as tumour cells,... 
WEE1 | DNA damage checkpoint response | CHK1 | Replication stress | Cancer | ATR | DNA-DAMAGE RESPONSE | ACQUIRED-RESISTANCE | KINASE INHIBITOR | OLAPARIB MAINTENANCE THERAPY | CHK1 INHIBITION | ATR INHIBITORS | WEE1 INHIBITION | GENOME INTEGRITY | SYNTHETIC LETHALITY | PHARMACOLOGY & PHARMACY | HOMOLOGOUS RECOMBINATION | Telomeres | Chemotherapy | DNA replication | DNA damage | Pharmaceutical industry | DNA repair | Protein kinases | Index Medicus
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8. Full Text A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis
by Duda, Heike and Arter, Meret and Gloggnitzer, Jiradet and Teloni, Federico and Wild, Philipp and Blanco, Miguel G and Altmeyer, Matthias and Matos, Joao
Developmental Cell, ISSN 1534-5807, 12/2016, Volume 39, Issue 6, pp. 740 - 755
While DNA replication and mitosis occur in a sequential manner, precisely how cells maintain their temporal separation and order remains elusive. Here, we... 
MUS81 | WEE1 | DNA replication | SLX4 | cell cycle | EME2 | PLK1 | chromosome pulverization | CDK1 | HOLLIDAY JUNCTION RESOLUTION | WEE1 KINASE | REPAIR | COMPLEX | MITOTIC ENTRY | DNA-DAMAGE RESPONSE | GENOME INTEGRITY | S-PHASE | CELL-CYCLE | DEVELOPMENTAL BIOLOGY | MUS81-EME1 | CELL BIOLOGY | Phosphorylation | Recombinases - metabolism | Cell Survival | Mitosis | Humans | Cell Cycle Proteins - metabolism | DNA Replication | Chromosomes, Human - metabolism | Endonucleases - metabolism | CDC2 Protein Kinase - metabolism | DNA-Binding Proteins - metabolism | Models, Biological | DNA Fragmentation | S Phase | Cell Death | Protein Binding | DNA Damage | HeLa Cells | Nucleases | Chromosomes | Cell death | DNA | Index Medicus
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9. Full Text A phase I clinical trial of AZD1775 in combination with neoadjuvant weekly docetaxel and cisplatin before definitive therapy in head and neck squamous cell carcinoma
by Mendez, Eduardo and Rodriguez, Cristina P and Kao, Michael C and Raju, Sharat and Diab, Ahmed and Harbison, R. Alex and Konnick, Eric Q and Mugundu, Ganesh M and Santana-Davila, Rafael and Martins, Renato and Futran, Neal D and Chow, Laura Q.M
Clinical Cancer Research, ISSN 1078-0432, 06/2018, Volume 24, Issue 12, pp. 2740 - 2748
Purpose: The WEE1 tyrosine kinase regulates G(2)-M transition and maintains genomic stability, particularly in p53-deficient tumors which require DNA repair... 
REPLICATION | INDUCTION CHEMOTHERAPY | ONCOLOGY | LOCALLY ADVANCED HEAD | TP53 MUTATIONS | WEE1 INHIBITOR AZD1775 | CANCER | MK-1775 | Tyrosine | Therapy | Squamous cell carcinoma | Pharmacodynamics | Toxicity | p53 Protein | Genotoxicity | Diarrhea | Clinical trials | Pharmacology | Patients | DNA repair | Cisplatin | Anticancer properties | Head and neck cancer | Antitumor activity | Neck | Pharmacokinetics | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Cancer | Tumors | Index Medicus | clinical trial | AZD1775 | WEE1 | head and neck cancer | squamous cell carcinoma
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10. Full Text Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint
by Lin, Xiaoting and Chen, Dongshao and Zhang, Cheng and Zhang, Xiaotian and Li, Zhongwu and Dong, Bin and Gao, Jing and Shen, Lin
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 06/2018, Volume 37, Issue 1, pp. 129 - 11
Background: Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP... 
DNA damage checkpoint | WEE1/PLK1 dual inhibitor | HR deficiency | Gastric cancer | Combination | PARP inhibitor | CELLS | ACTIVATION | WEE1 KINASE INHIBITOR | SPINDLE ASSEMBLY CHECKPOINT | ONCOLOGY | THERAPEUTIC-EFFICACY | DOUBLE-BLIND | CDK1 | HOMOLOGOUS RECOMBINATION | PHASE-I | MK-1775 | Apoptosis - drug effects | Humans | Stomach Neoplasms - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Disease Models, Animal | Pyrazoles - pharmacology | DNA Damage - drug effects | Stomach Neoplasms - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | DNA Repair - drug effects | Pyrimidines - pharmacology | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | Physiological aspects | Genetic aspects | Research | Drug therapy | Stomach cancer | DNA damage | Immunoglobulins | Laboratories | Breast cancer | Cancer therapies | Pancreatic cancer | Medical prognosis | Rodents | Cell cycle | Prostate cancer | Deoxyribonucleic acid--DNA | Apoptosis
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11. Full Text Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors
by Liu, Weizhen and Zeng, Xiangyu and Yin, Yuping and Li, Chengguo and Yang, Wenchang and Wan, Wenze and Shi, Liang and Wang, Guobin and Tao, Kaixiong and Zhang, Peng
Gastric Cancer, ISSN 1436-3291, 2019
Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has a revolutionary... 
Gastrointestinal stromal tumors | WEE1 | Autophagic degradation | Antitumor | MK1775
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12. WEE1, historie and tumor
by Liu, Bin
Journal of Central South University (Medical Sciences), ISSN 1672-7347, 07/2015, Volume 40, Issue 7, pp. 806 - 810
WEE1 | Tumor | Histone
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13. Full Text Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy
by Fang, Yong and McGrail, Daniel J and Sun, Chaoyang and Labrie, Marilyne and Chen, Ken and Chen, Xiaohua and Zhang, Dong and Ju, Zhenlin and Vellano, Christopher P and Lu, Yiling and Li, Yongsheng and Jeong, Kang Jin and Ding, Zhiyong and Liang, Jiyong and Wang, Steven W and Dai, Hui and Lee, Sanghoon and Sahni, Nidhi and Mercado-Uribe, Imelda and Kim, Tae-beom and Lin, Shiaw-Yih and Peng, Guang and Westin, Shannon N and Liu, Jinsong and O'Connor, Mark J and Yap, Timothy A and Mills, Gordon B
Cancer Cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 851 - 867.e7
We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly... 
WEE1 inhibitor | sequential therapy | replication stress | PARP inhibitor | Sugars | Monosaccharides | Ovarian cancer
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14. Full Text Bistability of mitotic entry and exit switches during open mitosis in mammalian cells
by Hégarat, Nadia and Rata, Scott and Hochegger, Helfrid
BioEssays, ISSN 0265-9247, 07/2016, Volume 38, Issue 7, pp. 627 - 643
Mitotic entry and exit are switch‐like transitions that are driven by the activation and inactivation of Cdk1 and mitotic cyclins. This simple on/off reaction... 
Greatwall | MPF | Cdc25 | Wee1 | mammalian cells | mitosis | Mitosis | Mammalian cells | XENOPUS EGG EXTRACTS | CDK-ACTIVATING KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLIN-A | DNA-DAMAGE | PROTEIN PHOSPHATASE 2A | GREATWALL KINASE | INHIBITORY KINASE | HUMAN WEE1 KINASE | PHASE-PROMOTING FACTOR | BIOLOGY | NUCLEAR-ENVELOPE BREAKDOWN | Cell Cycle Checkpoints | Animals | Cell Cycle Proteins - physiology | Humans | Multistable perception | Analysis | Cell cycle | Prophase | Cyclin D proteins | Research
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