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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2019, Volume 519, Issue 3, pp. 597 - 604
Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. is a cell cycle related gene that regulates the G2/M... 
Myeloma | WEE1 | MK-1775
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2019, Volume 25, Issue 11, pp. 3430 - 3442
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in , resulting in treatment resistance.... 
Aurora Kinase A | WEE1 | adavosertib | alisertib | HNSCC
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 09/2016, Volume 35, Issue 1, p. 153
Journal Article
International journal of radiation oncology, biology, physics, ISSN 0360-3016, 6/2016, Volume 95, Issue 2, pp. 782 - 790
Wee1 inhibition with AZD1775 has the potential to be an effective strategy of radiosensitization in hepatocellular carcinoma given the high prevalence of CDK1... 
AZD1775 | Hepatocellular carcinoma | Wee1 | radiosensitizer
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2017, Volume 16, Issue 22, pp. 2176 - 2182
AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells.... 
colorectal cancer | mitosis | cell cycle | checkpoint kinase | DNA damage | DAMAGING AGENTS | WEE1 KINASE INHIBITOR | TARGETING WEE1 | MK-1775 | CELL BIOLOGY | Index Medicus
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2018, Volume 188, pp. 155 - 167
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 06/2018, Volume 37, Issue 1, pp. 129 - 11
Background: Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP... 
DNA damage checkpoint | WEE1/PLK1 dual inhibitor | HR deficiency | Gastric cancer | Combination | PARP inhibitor | CELLS | ACTIVATION | WEE1 KINASE INHIBITOR | SPINDLE ASSEMBLY CHECKPOINT | ONCOLOGY | THERAPEUTIC-EFFICACY | DOUBLE-BLIND | CDK1 | HOMOLOGOUS RECOMBINATION | PHASE-I | MK-1775 | Apoptosis - drug effects | Humans | Stomach Neoplasms - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Disease Models, Animal | Pyrazoles - pharmacology | DNA Damage - drug effects | Stomach Neoplasms - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | DNA Repair - drug effects | Pyrimidines - pharmacology | Piperazines - pharmacology | Drug Synergism | Xenograft Model Antitumor Assays | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein-Tyrosine Kinases - antagonists & inhibitors | Physiological aspects | Genetic aspects | Research | Drug therapy | Stomach cancer | DNA damage | Immunoglobulins | Laboratories | Breast cancer | Cancer therapies | Pancreatic cancer | Medical prognosis | Rodents | Cell cycle | Prostate cancer | Deoxyribonucleic acid--DNA | Apoptosis
Journal Article
Gastric Cancer, ISSN 1436-3291, 2019
Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has a revolutionary... 
Gastrointestinal stromal tumors | WEE1 | Autophagic degradation | Antitumor | MK1775
Journal Article
Journal of Central South University (Medical Sciences), ISSN 1672-7347, 07/2015, Volume 40, Issue 7, pp. 806 - 810
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2019, Volume 35, Issue 6, pp. 851 - 867.e7
We demonstrate that concurrent administration of poly(ADP-ribose) polymerase (PARP) and WEE1 inhibitors is effective in inhibiting tumor growth but poorly... 
WEE1 inhibitor | sequential therapy | replication stress | PARP inhibitor | Sugars | Monosaccharides | Ovarian cancer
Journal Article
BioEssays, ISSN 0265-9247, 07/2016, Volume 38, Issue 7, pp. 627 - 643
Journal Article