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The Biochemical journal, ISSN 0264-6021, 07/2014, Volume 461, Issue 2, pp. 233 - 245
NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple... 
Protein Kinases - metabolism | Cell Cycle - genetics | Protein Kinases - genetics | Cell Proliferation | SKP Cullin F-Box Protein Ligases - genetics | Humans | Molecular Sequence Data | Repressor Proteins - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | Myosin-Light-Chain Phosphatase - metabolism | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Myosin-Light-Chain Phosphatase - genetics | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Sequence Alignment | Animals | Cell Line, Tumor | Protein Binding | Protein Kinase Inhibitors - pharmacology | Ubiquitin-Protein Ligases - genetics | Index Medicus | Polo kinase (PLK) ubiquitylation | WT, wild-type | HEK, human embryonic kidney | AMPK, AMP-activated protein kinase | HRP, horseradish peroxidase | PP1, protein phosphatase 1 | AMP-activated protein kinase (AMPK) | PEI, polyethylenimine | CDK, cyclin-dependent kinase | Wee1, WEE1 G2 checkpoint kinase | GST, glutathione transferase | DTB, double thymidine block | IKK, inhibitor of nuclear factor κB kinase | LKB1, liver kinase B1 | NEM, N-ethylmaleimide | cell cycle | PI, propidium iodide | PLK1, Polo kinase 1 | SKP1, S-phase kinase-associated protein 1 | Emi1, early mitotic inhibitor 1 | mitosis | HA, haemagglutinin | NUAK, NUAK family SnF1-like kinase | degron | CK1, casein kinase 1 | XIC, extracted ion chromatogram analysis | DMEM, Dulbecco’s modified Eagle’s medium | AMPK-related kinase 5 (ARK5) | MEF, mouse embryonic fibroblast | SCFβTrCP, Skp, Cullin and F-boxβTrCP | Cul1, cullin 1
Journal Article
Leukemia, ISSN 0887-6924, 04/2015, Volume 29, Issue 4, pp. 807 - 818
AZD1775 targets the cell cycle checkpoint kinase Wee1 and potentiates genotoxic agent cytotoxicity through p53-dependent or -independent mechanisms. Here, we... 
CYCLIN-DEPENDENT KINASES | GENOMIC INSTABILITY | HISTONE DEACETYLASE INHIBITOR | DNA-DAMAGING AGENTS | ONCOLOGY | MITOTIC CATASTROPHE | THERAPEUTIC TARGET | TUMOR-CELLS | HOMOLOGOUS RECOMBINATION | HEMATOLOGY | PRECLINICAL EVALUATION | CANCER-THERAPY | Protein Kinases - metabolism | CDC2 Protein Kinase | Phosphorylation | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | fms-Like Tyrosine Kinase 3 - genetics | Protein-Tyrosine Kinases - genetics | Cell Cycle Proteins - genetics | Leukemia, Myeloid, Acute - drug therapy | Cyclin-Dependent Kinases - antagonists & inhibitors | DNA Fragmentation - drug effects | Cyclin-Dependent Kinases - genetics | Drug Therapy, Combination | Nuclear Proteins - genetics | Hydroxamic Acids - pharmacology | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | fms-Like Tyrosine Kinase 3 - metabolism | Drug Synergism | Leukemia, Myeloid, Acute - mortality | Xenograft Model Antitumor Assays | Animals | Cell Cycle Checkpoints - drug effects | Nuclear Proteins - antagonists & inhibitors | Survival Analysis | Myeloid Cells - metabolism | Checkpoint Kinase 1 | Histone Deacetylase Inhibitors - pharmacology | Mice | Protein Kinase Inhibitors - pharmacology | Myeloid Cells - pathology | Primary Cell Culture | Leukemia, Myeloid, Acute - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | checkpoint | AML | HDAC inhibitor | Cdk1 | Chk1 | Wee1 inhibitor | cdc2
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 392, pp. 71 - 82
Abstract The genomic alterations identified in head and neck squamous cell carcinoma (HNSCC) tumors have not resulted in any changes in clinical care, making... 
Hematology, Oncology and Palliative Medicine | WEE1 | Head neck squamous cell carcinoma | Polo-like kinase 1 | CHK1 | AJUBA | CISPLATIN RESISTANCE | OVARIAN-CANCER | BREAST-CANCER | WEE1 KINASE | POLO-LIKE-KINASE | ONCOLOGY | PLK EXPRESSION | VOLASERTIB BI 6727 | CANCER STATISTICS | PROGNOSTIC-SIGNIFICANCE | PHASE-I | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Carcinoma, Squamous Cell - pathology | Humans | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Smad4 Protein - genetics | Time Factors | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Head and Neck Neoplasms - drug therapy | Thiophenes - pharmacology | Genotype | Pyrimidines - pharmacology | Head and Neck Neoplasms - pathology | Checkpoint Kinase 1 - metabolism | Phenotype | Carcinoma, Squamous Cell - drug therapy | Signal Transduction - drug effects | Mice, Nude | Checkpoint Kinase 2 - antagonists & inhibitors | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Mutation | Urea - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Carcinoma, Squamous Cell - genetics | Molecular Targeted Therapy | Cell Cycle Proteins - antagonists & inhibitors | Checkpoint Kinase 2 - metabolism | Dose-Response Relationship, Drug | Squamous Cell Carcinoma of Head and Neck | Transfection | Urea - analogs & derivatives | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Head and Neck Neoplasms - enzymology | Pyrazoles - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Carcinoma, Squamous Cell - enzymology | Pteridines - pharmacology | Checkpoint Kinase 1 - antagonists & inhibitors | Nuclear Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Nuclear Proteins - antagonists & inhibitors | LIM Domain Proteins - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Squamous cell carcinoma | Care and treatment | Genetic aspects | Drug therapy | Analysis | Cancer | Medical research | DNA damage | Cell division | Roles | Kinases | Gene expression | Proteins | Studies | Cell cycle | Biomarkers | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18457 - 18468
Environmental conditions modulate cell cycle progression in many cell types. A key component of the eukaryotic cell cycle is the protein kinase Wee1, which... 
FISSION YEAST | ACTIVATED PROTEIN-KINASE | cell cycle | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | mitosis | protein kinase | yeast | FAMILY KINASE | osmotic stress | REQUIRES P38 KINASE | Wee1 | NIM1/CDR1 MITOTIC INDUCER | Schizosaccharomyces pombe | CELL-CYCLE | CHECKPOINT | HYPERTONIC STRESS | Cdr1 | SCHIZOSACCHAROMYCES-POMBE | Osmotic Pressure | Schizosaccharomyces pombe Proteins - chemistry | Up-Regulation | Phosphorylation | Schizosaccharomyces - growth & development | Mitosis | Protein-Tyrosine Kinases - metabolism | Stress, Physiological | Cytoplasm - metabolism | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Mitogen-Activated Protein Kinases - chemistry | Protein-Tyrosine Kinases - genetics | Gene Deletion | Protein-Tyrosine Kinases - chemistry | Schizosaccharomyces pombe Proteins - metabolism | Protein Interaction Domains and Motifs | Peptide Fragments - genetics | Protein-Serine-Threonine Kinases - metabolism | Cytoplasm - enzymology | Green Fluorescent Proteins - metabolism | Peptide Fragments - metabolism | Mutagenesis, Site-Directed | Schizosaccharomyces pombe Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Schizosaccharomyces - physiology | Recombinant Fusion Proteins - chemistry | Protein Interaction Mapping | Protein Transport | Peptide Fragments - chemistry | Mitogen-Activated Protein Kinases - genetics | Schizosaccharomyces - enzymology | Protein Processing, Post-Translational | Protein-Serine-Threonine Kinases - chemistry | Mutation | Schizosaccharomyces - cytology | Amino Acid Substitution | Mitogen-Activated Protein Kinases - metabolism | Index Medicus | Cell Biology
Journal Article
Nature, ISSN 0028-0836, 06/2009, Volume 459, Issue 7248, pp. 852 - 856
Cells normally grow to a certain size before they enter mitosis and divide. Entry into mitosis depends on the activity of Cdk1, which is inhibited by the Wee1... 
FISSION YEAST | WEE1 | PHOSPHORYLATION | NIM1/CDR1 MITOTIC INDUCER | PROTEIN-KINASE | NEGATIVE REGULATION | MULTIDISCIPLINARY SCIENCES | GROWTH | DIVISION PLANE | DUAL-SPECIFICITY KINASE | SCHIZOSACCHAROMYCES-POMBE | Protein Kinases - metabolism | Cell Polarity | Phosphorylation | Mitosis | Protein-Tyrosine Kinases - metabolism | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Protein Transport | Cell Cycle Proteins - antagonists & inhibitors | Schizosaccharomyces - metabolism | Nuclear Proteins - antagonists & inhibitors | ras-GRF1 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle - physiology | G2 Phase | Protein-Serine-Threonine Kinases - metabolism | Schizosaccharomyces - cytology | Fungal Proteins - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Schizosaccharomyces pombe Proteins - antagonists & inhibitors | Arctic research | Cell cycle | Physiological aspects | Cell physiology | Genetic aspects | Research | Protein kinases | Proteins | Cell growth | Kinases | Molecular biology | Monitoring systems | Index Medicus | ras-GRF1 | Protein-Serine-Threonine Kinases | Schizosaccharomyces pombe Proteins | Fungal Proteins | Cellular Biology | Nuclear Proteins | Life Sciences | Cell Cycle | Protein Kinases | Protein-Tyrosine Kinases | Cell Cycle Proteins | Schizosaccharomyces
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2014, Volume 20, Issue 16, pp. 4274 - 4288
Purpose: To identify novel therapeutic drug targets for p53-mutant head and neck squamous cell carcinoma (HNSCC). Experimental Design: RNAi kinome viability... 
GROWTH-FACTOR RECEPTOR | DNA-DAMAGING AGENTS | WEE1 KINASE | ONCOLOGY | FOCAL-ADHESION KINASE | TYROSINE KINASE | SQUAMOUS-CELL CARCINOMA | LOCALLY ADVANCED HEAD | TUMOR-CELLS | SRC FAMILY KINASES | MALIGNANT PROGRESSION | Protein Kinases - metabolism | RNA, Small Interfering - genetics | Protein Kinases - genetics | Tumor Suppressor Protein p53 - antagonists & inhibitors | Protein-Tyrosine Kinases - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Protein Kinases - chemistry | Head and Neck Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | RNA Interference | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Cell Cycle Proteins - metabolism | Head and Neck Neoplasms - drug therapy | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Mice, SCID | Mutation - genetics | Animals | Carcinoma, Squamous Cell - drug therapy | High-Throughput Screening Assays | Nuclear Proteins - antagonists & inhibitors | Head and Neck Neoplasms - genetics | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | MK-1775 (a.k.a, AZD-1775) | WEE1 | functional genomics | HNSCC | p53
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2011, Volume 17, Issue 17, pp. 5638 - 5648
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e79364 - e79364
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 05/2010, Volume 36, Issue 5, pp. 1175 - 1182
Somatic Wee1 is a protein kinase that plays a key role in cell cycle progression at the onset of mitosis by phosphorylating CDK1 at the inhibitory Tyr15 amino... 
CATALYTIC-SUBUNIT | DEATH | CK2 | protein association | SOMATIC WEE1 | Wee1 | CHK1 | ONCOLOGY | CDK1 | CELL-CYCLE | phosphorylation | CK2-BETA | TYROSINE-15
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2015, Volume 10, Issue 7, pp. e0130748 - e0130748
The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by... 
GEL-ELECTROPHORESIS | MITOSIS | ACTIVATING KINASE | TYROSINE PHOSPHORYLATION | CDK REGULATION | WEE1 PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | P34CDC2 KINASE | S-PHASE | CHECKPOINT | SCHIZOSACCHAROMYCES-POMBE | Protein Kinases - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Phosphorylation | Protein Kinases - genetics | Protein-Tyrosine Kinases - metabolism | Molecular Sequence Data | CDC2 Protein Kinase - metabolism | Schizosaccharomyces - genetics | Protein-Tyrosine Kinases - genetics | Cyclin B - genetics | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | CDC2 Protein Kinase - chemistry | Nuclear Proteins - genetics | Amino Acid Sequence | CDC2 Protein Kinase - genetics | Schizosaccharomyces pombe Proteins - genetics | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Schizosaccharomyces - metabolism | Cell Cycle | Protein Binding | Checkpoint Kinase 1 | Cyclin B - metabolism | Protein Processing, Post-Translational | DNA Damage | Protein Isoforms - genetics | Amino acids | DNA repair | DNA damage | DNA | Cells | Cell cycle | Tyrosine | Cdc2 protein | Yeast | Threonine | CHK1 protein | Pools | Kinases | Cyclin B | S phase | Mutation | Isoelectric focusing | Inhibition | Aberration | Lesions | Damage | Repair | Binding sites | Deoxyribonucleic acid--DNA | Index Medicus | Deoxyribonucleic acid
Journal Article
Cell Cycle, ISSN 1538-4101, 07/2012, Volume 11, Issue 13, pp. 2507 - 2517
Targeting Chk1 protein kinase can enhance the antitumor effects of radio- and chemotherapy. Recent evidence disclosed a role of Chk1 in unperturbed cell... 
targeted therapy | WEE1 | Chk1 | in vivo antitumor activity | synthetic lethality | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | In vivo antitumor activity | Wee1 | Synthetic lethality | Targeted therapy | CHECKPOINT KINASE 1 | PHOSPHORYLATION | PROTEIN-KINASE | DNA-DAMAGE | G CHECKPOINT | CANCER-THERAPY | CELL BIOLOGY | GENOME INTEGRITY | CELL-CYCLE | ATR | Protein Kinases - metabolism | Protein Kinases - genetics | Pyrazoles - therapeutic use | Apoptosis - drug effects | DNA Replication - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Protein Kinases - chemistry | Transplantation, Heterologous | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | RNA Interference | Cell Cycle Proteins - genetics | Female | Drug Therapy, Combination | Nuclear Proteins - genetics | Ovarian Neoplasms - drug therapy | Pyrazoles - pharmacology | Benzodiazepinones - pharmacology | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Drug Synergism | Animals | Mitosis - drug effects | Mice, Nude | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Checkpoint Kinase 1 | Mice | Protein Kinase Inhibitors - pharmacology | Benzodiazepinones - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | RNA, Small Interfering - metabolism | Index Medicus
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