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Nucleic Acids Research, ISSN 0305-1048, 11/2001, Volume 29, Issue 21, pp. 4378 - 4386
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 43, pp. 33010 - 33017
Epidemiological and animal studies indicate that selenium supplementation suppresses risk of colorectal and other cancers. The majority of colorectal cancers... 
COLON-CANCER | G ARREST | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | CYCLE ARREST | IONIZING-RADIATION | MUTL-ALPHA | DOUBLE-STRAND BREAK | WERNER-SYNDROME PROTEIN | S-PHASE CHECKPOINT | Cysteine - analogs & derivatives | DNA Breaks - drug effects | MutL Protein Homolog 1 | Reactive Oxygen Species - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Colorectal Neoplasms - genetics | Humans | DNA Repair Enzymes - genetics | Guanosine - genetics | Pyrones - pharmacology | Organoselenium Compounds - pharmacology | Antioxidants | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Piperidines - pharmacology | Tumor Suppressor Proteins - genetics | Cysteine - pharmacology | DNA Repair Enzymes - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | Selenocysteine - analogs & derivatives | Anticarcinogenic Agents - pharmacology | Colorectal Neoplasms - metabolism | Protein-Serine-Threonine Kinases - metabolism | Guanosine - analogs & derivatives | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Adenosine Triphosphatases - metabolism | DNA Mismatch Repair - drug effects | Morpholines - pharmacology | Nuclear Proteins - metabolism | Sodium Selenite - pharmacology | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Guanosine - metabolism | Drug Resistance, Neoplasm - genetics | Acetylcysteine - pharmacology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adenosine Triphosphatases - genetics | Adaptor Proteins, Signal Transducing - metabolism | Drug Resistance, Neoplasm - drug effects | Checkpoint Control | Reactive Oxygen Species (ROS) | Signal Transduction | DNA Repair | Selenium | Carcinogenesis | Cell Biology
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 705 - 720
DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the... 
CYCLE CHECKPOINT CONTROL | DAMAGE RESPONSE | MRE11-RAD50-NBS1 COMPLEX | HOMOLOGOUS RECOMBINATION | RPA PHOSPHORYLATION | CELL-FREE-EXTRACTS | SACCHAROMYCES-CEREVISIAE | REPLICATION STRESS | DNA-END-RESECTION | WERNER-SYNDROME PROTEIN | CELL BIOLOGY | Protein Kinases - metabolism | Chromatin - metabolism | Meiosis - physiology | Nuclear Envelope - physiology | Antigens, Nuclear - metabolism | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | DNA Repair - physiology | Endonucleases - metabolism | DNA Breaks, Double-Stranded | CDC2 Protein Kinase - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Cell Nucleus - metabolism | Protein Binding - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Tumor Suppressor Proteins - metabolism | CDC2 Protein Kinase - antagonists & inhibitors | DNA, Single-Stranded - metabolism | Xenopus laevis | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins - antagonists & inhibitors | Cell Division - physiology | DNA Helicases - metabolism | Animals | Cell-Free System | Ku Autoantigen | Mitosis - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | S Phase - physiology | Checkpoint Kinase 1 | Xenopus Proteins - metabolism | Ovum | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Histones - metabolism | Protein Binding - physiology | Vertebrates | Phosphorylation | DNA repair | Deoxyribonucleic acid--DNA | Cells
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2012, Volume 11, Issue 1, pp. 38 - 38
Background: Tri- and tetra-nucleotide repeats in mammalian genomes can induce formation of alternative non-B DNA structures such as triplexes and guanine... 
EXON | HUMAN BREAST | GENE | SEQUENCES | ONCOLOGY | U2AF | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | IDENTIFICATION | EXPRESSION | SPLICING FACTOR | PRE-MESSENGER-RNA | RNA-Binding Proteins - genetics | Lymph Nodes - pathology | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Gene Expression Regulation, Neoplastic | Male | RecQ Helicases - genetics | DNA-Binding Proteins - metabolism | Splicing Factor U2AF | Neoplasm Metastasis | Octamer Transcription Factors - genetics | Female | Ribonucleoproteins - genetics | Exodeoxyribonucleases - genetics | Nuclear Proteins - genetics | Colorectal Neoplasms - metabolism | Octamer Transcription Factors - metabolism | Colorectal Neoplasms - mortality | Nuclear Matrix-Associated Proteins - metabolism | Nuclear Proteins - metabolism | Ribonucleoproteins - metabolism | DNA - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | PTB-Associated Splicing Factor | beta Catenin - genetics | Nuclear Matrix-Associated Proteins - genetics | Exodeoxyribonucleases - metabolism | Proteomics | Protein Binding | Colorectal Neoplasms - pathology | Neoplasm Staging | RNA-Binding Proteins - metabolism | Lymphatic diseases | Patient outcomes | Genomics | Colorectal cancer | Antibodies | Genomes | Metastasis | Viral antibodies | Cancer patients | Gastrointestinal diseases | DNA | Binding proteins | Intermediate filament proteins | Protein binding | Studies | Proteins | Medical research | Mutation | Deoxyribonucleic acid--DNA | DNA structure | TOR protein | catenin | c-Myc protein | Cyclin-dependent kinase 4 | Guanine | Lymph nodes | Western blotting | Genomic instability | Metastases | DNA-binding protein | ErbB-1 protein | splicing factors | streptavidin | proteomics | Stat5 protein | Survival | Chromosome translocations | Protein arrays | Mutagenesis | cyclin D1 | PTEN protein | Tumors
Journal Article
The EMBO Journal, ISSN 0261-4189, 09/2010, Volume 29, Issue 18, pp. 3156 - 3169
Accurate response to replication arrest is crucial to preserve genome stability and requires both the ATR and ATM functions. The Werner syndrome protein (WRN)... 
replication fork arrest | Werner syndrome | genome instability | RecQ helicases | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | WERNERS-SYNDROME PROTEIN | SYNDROME HELICASE | CELL BIOLOGY | BLOOMS-SYNDROME | S-PHASE | CELL-CYCLE | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION | FRAGILE SITE STABILITY | RECQ HELICASE | Phosphorylation | Immunoprecipitation | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Rad51 Recombinase - antagonists & inhibitors | RecQ Helicases - genetics | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Flow Cytometry | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Cell Cycle | DNA Repair | Exodeoxyribonucleases - metabolism | Fluorescent Antibody Technique | Proteins | Cell division | Molecular biology | Gene expression | Genomics | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2010, Volume 6, Issue 1, p. e1000801
WRN-1 is the Caenorhabditis elegans homolog of the human Werner syndrome protein, a RecQ helicase, mutations of which are associated with premature aging and... 
DAMAGE CHECKPOINT | LIFE-SPAN | ACTIVATION | INDUCED APOPTOSIS | PHOSPHORYLATION | GENETICS & HEREDITY | SYNDROME HELICASE | EXONUCLEASE | S-PHASE | C-ELEGANS | RECQ HELICASE | Protein Kinases - metabolism | Gamma Rays | Protein Kinases - genetics | Humans | Caenorhabditis elegans Proteins - metabolism | Drosophila Proteins - metabolism | DNA Breaks, Double-Stranded - radiation effects | DNA-Binding Proteins - metabolism | Ultraviolet Rays | Replication Protein A - genetics | Tumor Suppressor Proteins - genetics | Werner Syndrome - genetics | Cell Cycle Proteins - genetics | DNA Helicases - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Tumor Suppressor Proteins - metabolism | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Down-Regulation | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Caenorhabditis elegans - radiation effects | DNA Helicases - metabolism | Animals | Werner Syndrome - metabolism | DNA Repair | Checkpoint Kinase 1 | Drosophila Proteins - genetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans | DNA replication | DNA damage | Physiological aspects | Genetic aspects | Research | Werner syndrome | Phosphorylation | Germ cells | U.V. radiation | exonuclease | CHK1 protein | Epistasis | Genomes | DNA repair | RecQ protein | Genomic instability | Replication forks | DNA biosynthesis | DNA helicase | Signal transduction | Telomeres | Ionizing radiation | Werner's syndrome | Cell cycle | Aging | Replication | Mutation | Proteins | Genes | Deoxyribonucleic acid | DNA | Genetics
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63149
SMARCAL1 is an ATPase in the SNF2 family that functions at damaged replication forks to promote their stability and restart. It acts by translocating on DNA to... 
WRN | DOMAIN | HELICASE ACTIVITY | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | IN-VIVO | REPLICATION FORK | GENOME STABILITY | SYNDROME GENE | WERNER-SYNDROME PROTEIN | Endonucleases - genetics | Immunoprecipitation | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Immunoblotting | RecQ Helicases - genetics | Endonucleases - metabolism | DNA Breaks, Double-Stranded | DNA-Binding Proteins - metabolism | Mass Spectrometry | Replication Protein A - genetics | HEK293 Cells | Exodeoxyribonucleases - genetics | Proteomics - methods | Nucleic Acid Conformation | DNA Helicases - genetics | DNA Replication | Replication Protein A - metabolism | DNA - metabolism | DNA-Binding Proteins - genetics | S Phase - genetics | DNA - genetics | DNA Helicases - metabolism | DNA - chemistry | DNA Repair | Exodeoxyribonucleases - metabolism | Cell Line, Tumor | Protein Binding | HeLa Cells | Enzymes | Protein kinase C | Phosphorylation | Peptides | Migration | DNA damage | Biochemistry | Genomes | Kinases | Replication forks | DNA helicase | Proteins | Cell cycle | Deoxyribonucleic acid--DNA | Annealing | Immunoglobulins | Replication protein A | Protein A | Medicine | DNA-dependent protein kinase | Proteomics | Replication | Scientific imaging | Mutation | Mass spectrometry | Adenosine triphosphatase | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Oncogene, ISSN 0950-9232, 06/2012, Volume 31, Issue 23, pp. 2809 - 2823
The WRN protein belongs to the RecQ family of DNA helicases and is implicated in replication fork restart, but how its function is regulated remains unknown.... 
Werner syndrome | genome instability | replication checkpoint | RecQ helicases | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE HUS1 | DNA-POLYMERASE-BETA | COMMON PATHWAY | CELL BIOLOGY | GENOMIC INSTABILITY | CHK1 ACTIVATION | ONCOLOGY | HELICASE ACTIVITY | GENETICS & HEREDITY | S-PHASE | CELL-CYCLE | WERNER-SYNDROME PROTEIN | RNA, Small Interfering - genetics | Phosphorylation | Immunoprecipitation | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | Exodeoxyribonucleases - antagonists & inhibitors | RecQ Helicases - genetics | DNA-Binding Proteins - metabolism | Exonucleases - genetics | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Exonucleases - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Chromosome Fragile Sites - genetics | DNA Replication | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Blotting, Western | Carrier Proteins - genetics | Carrier Proteins - metabolism | RecQ Helicases - antagonists & inhibitors | Exodeoxyribonucleases - metabolism | Fluorescent Antibody Technique | DNA Damage | HeLa Cells | Proteins | Physiological aspects | DNA replication | Research | Gene expression | Health aspects | Enzymes | Oncology | Genetic disorders | Genomics | Deoxyribonucleic acid--DNA | DNA helicase | Molecular modelling | WRN protein | Cooperation | DNA damage | Data processing | Replication | Genomes | Rad1 protein | RecQ protein | Replication forks | Replication checkpoint | Genome Instability
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2008, Volume 283, Issue 12, pp. 7590 - 7598
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3598 - 3608
Journal Article