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Journal of allergy and clinical immunology, ISSN 0091-6749, 2012, Volume 129, Issue 4, pp. 1031 - 1039.e1
Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH.... 
Allergy and Immunology | skin barrier | transepidermal water loss | confocal Raman spectroscopy | Flgft/Flgft (FlgdelAPfal) mice | Atopic dermatitis | IL-1 | IL-18 | FLG gene mutations | eczema | filaggrin | natural moisturizing factor | UNCONVENTIONAL PROTEIN SECRETION | INTERLEUKIN-1 RECEPTOR ANTAGONIST | TERM CULTURE | IMMUNOLOGY | PERMEABILITY BARRIER HOMEOSTASIS | HUMAN KERATINOCYTES | IN-VITRO | ALLERGY | Flg(ft)/Flg(ft)(Flg(delAPfal)) mice | EPIDERMIS | pH | IL-1-BETA | Interleukin-1 - genetics | Interleukin-1 - metabolism | Dermatitis, Atopic - genetics | Cytokines - metabolism | Skin - metabolism | Humans | Mice, Inbred C57BL | Child, Preschool | Genotype | Infant | Male | Mice, Knockout | Animals | Adolescent | Alleles | Intermediate Filament Proteins - genetics | Female | Mice | Mutation | Child | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | Hydrogen-Ion Concentration | Medical colleges | Cytokines | Proteases | Genes | Respiratory agents | Genetic aspects | Skin | Inflammation | Universities and colleges | Dermatitis | Proteins | Enzymes | Genotype & phenotype | Hypotheses | Families & family life | Values | Homeostasis | Animal models | Stratum corneum | Interleukin 1 receptor antagonist | Proteinase | Keratinocytes | mRNA | Filaggrin | Raman spectroscopy | pH effects | Tails | Interleukin 18 | Polymerase chain reaction | Water loss | Primers | Interleukin 1 | Interleukin 8 | FLG | SC, Stratum corneum | Flgft | Patient homozygous for null alleles (ie, 2 null alleles) | AD, Atopic dermatitis | FLG, Filaggrin gene | Homozygote wild-type (ie, 0 null alleles) | TEWL, Transepidermal water loss | Heterozygote null allele | Flgft (FlgdelAPfal) mice | IL-1RA, IL-1 receptor antagonist | wild-type (ie, 1 null allele) | NMF, Natural moisturizing factor | ADFLG, AD with FLG mutations | Atopic Dermatitis and Skin Disease | NESS, Nottingham Eczema Severity Score | ADNON-FLG, AD without FLG mutations
Journal Article
Cancer discovery, ISSN 2159-8290, 2012, Volume 2, Issue 3, pp. 227 - 235
BRAF mutations occur in 10% to 15% of colorectal cancers and confer adverse outcome in the metastatic setting. Although RAF inhibitors such as vemurafenib... 
CELLS | CETUXIMAB | MELANOMA | ONCOLOGY | KINASE | MUTATION | RESISTANCE | WILD-TYPE BRAF | KRAS | ANTITUMOR-ACTIVITY | MEK INHIBITORS
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2017, Volume 170, Issue 6, pp. 1062 - 1078
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 34, pp. E4966 - E4975
Journal Article
Chemical science (Cambridge), ISSN 2041-6539, 2019, Volume 10, Issue 2, pp. 354 - 358
By developing lithium-ion-active aerolysin, for the first time we have achieved aerolysin detection of single-stranded DNA longer than 100 nt. Wild-type... 
WILD-TYPE | TRANSLOCATION | TRANSPORT | ALPHA-HEMOLYSIN | DISCRIMINATION | RESOLUTION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal Article