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Cell, ISSN 0092-8674, 02/2018, Volume 172, Issue 4, pp. 857 - 868.e15
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 1, pp. 177 - 186
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 232 - 236
KRAS and BRAF activating mutations drive tumorigenesis through constitutive activation of the MAPK pathway. As these tumours represent an area of high unmet... 
PATHWAYS | WILD-TYPE | ACTIVATION | PI3K | MULTIDISCIPLINARY SCIENCES | C-RAF | MAP KINASE KINASE-1 | B-RAF | MUTATIONS | TUMOR-GROWTH INHIBITION | RAF PROTEINS | Niacinamide - analogs & derivatives | Humans | Crystallography, X-Ray | Azetidines - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Piperidines - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Genes, ras - genetics | Allosteric Regulation - drug effects | Cell Survival - drug effects | HCT116 Cells | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Clinical Trials as Topic | Imidazoles - pharmacology | Enzyme Activation - drug effects | Phosphoserine - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Feedback, Physiological - drug effects | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Neoplasms - pathology | Oncogene Protein p21(ras) - genetics | Gene mutations | Cancer cells | Cellular control mechanisms | Physiological aspects | Properties | Phosphotransferases | Mitogen-activated protein kinases | Studies | Phosphorylation | Hydrogen bonds | Melanoma | Kinases | Tumors | Cancer | Index Medicus
Journal Article
Human Pathology, ISSN 0046-8177, 01/2019, Volume 83, pp. 14 - 21
Journal Article
Modern Pathology, ISSN 0893-3952, 06/2013, Volume 26, Issue 6, pp. 825 - 834
KRAS-mutated carcinomas comprise 35-40% of all colorectal carcinomas but little is known about their characteristics. The aim of this study was to examine the... 
KRAS mutation | colorectal cancer | survival analysis | MGMT | colorectal polyp | molecular pathology | BRAF mutation | WILD-TYPE | PROMOTER METHYLATION | MICROSATELLITE INSTABILITY | PATHOLOGY | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | RECTAL-CANCER | BRAF MUTATIONS | LOW CIMP-LOW | KIRSTEN-RAS | KI-RAS MUTATIONS | Immunohistochemistry | ras Proteins - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Prognosis | Prospective Studies | Colonic Polyps - pathology | Colorectal Neoplasms - genetics | Humans | Middle Aged | DNA Repair Enzymes - genetics | Carcinoma - mortality | Colorectal Neoplasms - chemistry | Male | Colonic Polyps - mortality | DNA Methylation | Colonic Polyps - genetics | Time Factors | DNA Mutational Analysis | Tumor Suppressor Proteins - genetics | Adult | Female | Cell Differentiation | Carcinoma - pathology | DNA Modification Methylases - analysis | Colorectal Neoplasms - mortality | Genetic Predisposition to Disease | Biomarkers, Tumor - analysis | Risk Factors | Victoria | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Chi-Square Distribution | DNA Repair Enzymes - analysis | DNA Modification Methylases - genetics | Phenotype | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Aged | Biomarkers, Tumor - genetics | Mutation | Colorectal Neoplasms - pathology | Tumor Suppressor Proteins - analysis | Index Medicus
Journal Article
BMC Cancer, ISSN 1471-2407, 04/2015, Volume 15, Issue 1, pp. 258 - 258
Journal Article
Clinical cancer research, ISSN 1078-0432, 2015, Volume 21, Issue 24, pp. 5469 - 5479
Journal Article