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Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 614 - 625
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we... 
WILD-TYPE CONFORMATION | DNA-BINDING DOMAIN | RESCUE | ONCOLOGY | IRON CHELATORS | MUTATION | REDOX ACTIVITY | TUMOR-SUPPRESSOR | CANCER MUTANTS | RESTORATION | ANTITUMOR-ACTIVITY | CELL BIOLOGY | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Zinc - metabolism | Humans | Transcriptional Activation - drug effects | Structure-Activity Relationship | Mutation, Missense | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Chelating Agents - pharmacology | DNA - metabolism | Tumor Suppressor Protein p53 - drug effects | Gene Knock-In Techniques | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Alleles | Protein Conformation | Mice | Mice, Inbred BALB C | Tumor Suppressor Protein p53 - chemistry | Oxidative Stress - drug effects | Neoplasms - pathology | Care and treatment | Nuclear radiation | Oncology, Experimental | Research | Tumor proteins | Health aspects | Cancer | Index Medicus | Antitumor agents | Lymphocytes B | Xenografts | Data processing | Drug development | Zinc | p53 protein | Apoptosis | Structure-function relationships | Tumors
Journal Article
Journal of molecular cell biology, ISSN 1674-2788, 04/2019, Volume 11, Issue 4, pp. 317 - 329
TP53 is the most frequently mutated gene across all cancer types. Our understanding of its functions has evolved since its discovery four decades ago.... 
WILD-TYPE P53 | IMMUNOCHEMICAL ANALYSIS | conformation | CELL-CYCLE ARREST | POSTTRANSLATIONAL MODIFICATIONS | LARGE T-ANTIGEN | p53 | DNA-BINDING ACTIVITY | TUMOR-ANTIGEN | CELL BIOLOGY | TRANSFORMATION-RELATED PROTEIN | MUTANT-LIKE CONFORMATION | antibodies | post-translational modifications | mutant | MONOCLONAL-ANTIBODIES
Journal Article
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 04/2019, Volume 54, Issue 4, pp. 1168 - 1182
Gain-of-function (GOF) mutations in the TP53 gene lead to acquisition of new functions by the mutated tumor suppressor p53 protein. A number of the... 
WILD-TYPE P53 | INTEGRIN | DRIVES | hot spot | MOUSE MODELS | p53 | EPITHELIAL-MESENCHYMAL TRANSITION | invasiveness | INVASION | ONCOLOGY | gain-of-function | metastasis | CELL-MIGRATION | MUTANT P53 | EXPRESSION
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2007, Volume 26, Issue 1, pp. 113 - 122
Journal Article