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wnk lysine-deficient protein kinase 1 (233) 233
minor histocompatibility antigens (207) 207
humans (202) 202
protein-serine-threonine kinases - genetics (155) 155
index medicus (151) 151
animals (149) 149
protein-serine-threonine kinases - metabolism (136) 136
intracellular signaling peptides and proteins (110) 110
hypertension (91) 91
blood-pressure (84) 84
mice (84) 84
male (71) 71
female (67) 67
biochemistry & molecular biology (66) 66
phosphorylation (64) 64
mutation (55) 55
protein-serine-threonine kinases - physiology (50) 50
urology & nephrology (50) 50
hypertension - genetics (43) 43
cell biology (38) 38
kinases (38) 38
protein-kinase (38) 38
intracellular signaling peptides and proteins - genetics (37) 37
urogenital system (37) 37
intracellular signaling peptides and proteins - metabolism (36) 36
physiology (36) 36
signal transduction (36) 36
expression (35) 35
wnk1 (35) 35
adult (33) 33
blood pressure (33) 33
molecular sequence data (33) 33
pseudohypoaldosteronism type-ii (33) 33
amino acid sequence (32) 32
kidney - metabolism (32) 32
rats (32) 32
spak (32) 32
research (31) 31
na-cl cotransporter (30) 30
gene (29) 29
middle aged (29) 29
gene expression regulation (28) 28
hek293 cells (28) 28
hyperkalemia (27) 27
kidney (27) 27
mutations (27) 27
cell line (26) 26
pseudohypoaldosteronism - genetics (26) 26
alanine-rich kinase (25) 25
mice, knockout (25) 25
protein-serine-threonine kinases - chemistry (25) 25
wnk kinases (25) 25
inherited hypertension (24) 24
peripheral vascular disease (23) 23
signal transduction - physiology (23) 23
genetic aspects (22) 22
mice, inbred c57bl (22) 22
multidisciplinary sciences (22) 22
mutant wnk4 (22) 22
osr1 (22) 22
homeostasis (21) 21
research article (21) 21
sodium - metabolism (21) 21
article (20) 20
blood pressure - genetics (20) 20
gene expression (20) 20
kinase (20) 20
phenotype (20) 20
proteins (20) 20
transcription factors - metabolism (20) 20
transport (20) 20
epithelial sodium-channel (19) 19
genotype (19) 19
physiological aspects (19) 19
potassium - metabolism (19) 19
protein kinases (19) 19
sodium-potassium-chloride symporters - metabolism (19) 19
cells (18) 18
genetics & heredity (18) 18
analysis (17) 17
hela cells (17) 17
hereditary sensory and autonomic neuropathies - genetics (17) 17
protein structure, tertiary (17) 17
protein-kinases (17) 17
human hypertension (16) 16
hypertension - physiopathology (16) 16
mice, transgenic (16) 16
potassium (16) 16
sodium (16) 16
aged (15) 15
channel (15) 15
chlorides - metabolism (15) 15
genetics (15) 15
kidneys (15) 15
molecular pathogenesis (15) 15
base sequence (14) 14
biological sciences (14) 14
blood pressure - physiology (14) 14
carrier proteins - metabolism (14) 14
cotransporter (14) 14
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Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 5/2009, Volume 458, Issue 1, pp. 111 - 135
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2015, Volume 21, Issue 1, pp. 39 - 50
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
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