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humans (322) 322
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wnk lysine-deficient protein kinase 1 (234) 234
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transport (42) 42
middle aged (41) 41
gene (40) 40
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aldosterone (39) 39
intracellular signaling peptides and proteins - genetics (39) 39
osr1 (39) 39
potassium - metabolism (39) 39
protein-kinases (39) 39
wnk1 (39) 39
distal convoluted tubule (38) 38
gene expression regulation (38) 38
intracellular signaling peptides and proteins - metabolism (38) 38
na+-cl-cotransporter (38) 38
wnk kinase (38) 38
signal transduction - physiology (37) 37
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sodium-potassium-chloride symporters - metabolism (36) 36
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potassium (32) 32
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epithelial sodium-channel (30) 30
sodium (30) 30
xenopus laevis (30) 30
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kelch-like 3 (29) 29
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sodium chloride symporters - metabolism (28) 28
symporters - metabolism (28) 28
angiotensin-ii (27) 27
blood pressure - genetics (27) 27
na+-k+-2cl cotransporter (27) 27
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Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 559 - 573
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | γ-aminobutyric acid (GABA) | Cl | Blood pressure/hypertension | 2Cl | co-transporter 2 (KCC2) | Ion homoeostasis | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | Potassium - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Signal Transduction | Humans | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - metabolism | Symporters - metabolism | Transcription Factors - metabolism | Protein Isoforms - metabolism | Chlorides - metabolism | Symporters - antagonists & inhibitors | Phosphopeptides - metabolism | Protein Isoforms - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2004, Volume 279, Issue 9, pp. 7826 - 7831
Journal Article
Journal of Hypertension, ISSN 0263-6352, 09/2017, Volume 36, Issue 2, pp. 361 - 367
OBJECTIVE:The hypertensive effect of angiotensin II (AngII), a peptide hormone, is dependent on its intrarenal actions and the activation of the renal Na–Cl... 
thiazide | distal convoluted tubule | with no lysine kinase 4 | salt transport | aldosterone | DISTAL NEPHRON | SPAK | ACTIVATION | SODIUM-REABSORPTION | KELCH-LIKE 3 | BLOOD-PRESSURE | NA+-CL-COTRANSPORTER | PERIPHERAL VASCULAR DISEASE | MICE | WNK KINASES | VASOCONSTRICTION | Hypertension | Diagnosis | Kidney tubules | Health aspects | Risk factors | ORIGINAL PAPERS | Kidney
Journal Article
Frontiers in Plant Science, ISSN 1664-462X, 09/2016, Volume 7, Issue September, p. 1400
Journal Article
Journal Article
Autophagy, ISSN 1554-8627, 03/2015, Volume 11, Issue 3, pp. 560 - 572
The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a... 
RNA interference screen | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | autophagy | autophagy response | RNAi, RNA interference | Cyto-ID | FBS, fetal bovine serum | LAMP1, lysosomal-associated membrane protein 1 | MAP3K6, mitogen-activated protein kinase kinase kinase 6 | shRNA, short-hairpin RNA | RAB5A, member RAS oncogene family | spectrophotometric assay | 3-MA, 3-methyladenine | SQSTM1, sequestosome 1 | MDC, monodansylcadaverine | NS, nonsilencing | WNK2, WNK lysine deficient protein kinase 2 | mRFP, monomeric red fluorescent protein | small molecule screen | autophagy flux | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta | Utophagy | Spectrophotometric assay | Autophagy flux | Small molecule screen | Autophagy response | member RAS oncogene family | RNA interference | LC3B | sequestosome 1 | mechanistic target of rapamycin | MDC | monodansylcadaverine | CELL BIOLOGY | GFP | MAP1LC3B | LAMP1 | shRNA | FBS | lysosomal-associated membrane protein 1 | MAP3K6 | LC3 | SIRNA SCREEN | CELLS | RNAi | WNK lysine deficient protein kinase 2 | MARKER | microtubule-associated protein 1 light chain 3 beta | mitogen-activated protein kinase kinase kinase 6 | nonsilencing | CHLOROQUINE | green fluorescent protein | MTOR | short-hairpin RNA | fetal bovine serum | WNK2 | DISEASE | 3-MA | monomeric red fluorescent protein | mRFP | RAB5A | SQSTM1 | 3-methyladenine | Fluorescent Dyes - chemistry | Neoplasm Transplantation | Spectrometry, Fluorescence - methods | Dactinomycin - chemistry | Lysosomes - chemistry | Cell Survival | Humans | Mice, Inbred C57BL | Leukemia - metabolism | MAP Kinase Kinase Kinases - metabolism | Gene Expression Regulation, Leukemic | Mice, SCID | Autophagy | Imatinib Mesylate - chemistry | Animals | RNA Interference | Chloroquine - chemistry | HEK293 Cells | K562 Cells | Endosomes - chemistry | Mice | HeLa Cells | Microscopy, Fluorescence | Protein-Serine-Threonine Kinases - metabolism
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)-SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 325 - 337
Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has... 
Signal transduction | Na | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | Cl | K | 2Cl | Coiled-coil domain | Osmotic stress | KINASE-ACTIVITY | SPAK | coiled-coil domain | HOMEOSTASIS | Na+/K+/2Cl(-) co-transporter 1 (NKCC1) | signal transduction | PHOSPHORYLATION | PROTEIN-KINASE | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinase | BLOOD-PRESSURE | osmotic stress | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | MUTATIONS | HYPERTENSION | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Transcription Factors - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Protein Isoforms | HEK293 Cells | Embryonic Stem Cells | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CCD, coiled-coil domain | PI3K, phosphoinositide 3-kinase | WNK, with no lysine (K) kinase | 2Cl− co-transporter | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | ES, embryonic stem | DMEM, Dulbecco's modified Eagle's medium | CCT, conserved C-terminal | GST, glutathione transferase | HEK-293, human embryonic kidney 293 | 2Cl− co-transporter 1 (NKCC1) | Cl− co-transporter | NKCC, Na+ | SPAK, SPS1-related proline | Cl− co-transporter (NCC) | OSR, oxidative stress-responsive kinase | LRRK2, leucine-repeat-rich kinase 2 | CATCHtide, cation chloride co-transporter peptide substrate | Na+ | NCC, Na+ | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 1, pp. 17 - 24
Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the cause of Gordon's hypertension... 
Hypertension | Pseudohypoaldosteronism type II (PHAII) | Na | Protein kinase | Mass spectrometry (MS) | K | 2Cl | Gordon's syndrome | co-transporter-1 (NKCC1) | pseudohypoaldosteronism type II (PHAII) | CL COTRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | NA+-K+-2CL(-) COTRANSPORTER | STRAD | LKB1 | protein kinase | BLOOD-PRESSURE | Na+-K+-2Cl(-)co-transporter-1 (NKCC1) | TRANSPORT | INTERACT | GENE | MUTATIONS | hypertension | mass spectrometry (MS) | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Hyperkalemia - metabolism | Minor Histocompatibility Antigens | Humans | Molecular Sequence Data | Male | Hyperkalemia - genetics | WNK Lysine-Deficient Protein Kinase 1 | Testis - enzymology | Hypertension - enzymology | Hypertension - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Sequence | Cell Line | Protein-Serine-Threonine Kinases - genetics | Rats | Mutation - genetics | Syndrome | Hypertension - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Gene Expression Regulation, Enzymologic - genetics | Enzyme Activation | Na+–K+–2Cl− co-transporter-1 (NKCC1) | WNK, with no K (lysine) protein kinase | PHAII, pseudohypoaldosteronism type II | GST, glutathione S-transferase | H2A, histone 2A | wt, wild-type | Accelerated Publication | NKCC1, Na+–K+–2Cl− co-transporter-1 | DTT, dithiothreitol | SPAK, STE20 | ERK, extracellular-signal-regulated kinase | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | MBP, myelin basic protein | OSR1, oxidative stress response kinase-1 | pseudohypoaldosteronism type II (PHAII) | SPS1-related proline | ki, kinase-inactive | WNK1-(CT), WNK1 C-terminus | alanine-rich kinase
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 08/2016, Volume 311, Issue 2, pp. F330 - F342
The stimulation of postprandial K+ clearance involves aldosterone-independent and -dependent mechanisms. In this context, serum- and glucocorticoidinduced... 
Epithelial transport | Phosphorylation | Neural precursor cell expressed developmentally downregulated protein 4-2 | Serum- and glucocorticoid-induced kinase 1 | Ubiquitylation | channel | Aldosterone | With no lysine kinase 1 | Potassium | Epithelial Na | PROTEOLYTIC CLEAVAGE | PHYSIOLOGY | potassium | serum- and glucocorticoid-induced kinase 1 | CL-COTRANSPORTER NCC | UBIQUITIN LIGASE | aldosterone | CELL-SURFACE EXPRESSION | SODIUM-CHANNEL | neural precursor cell expressed developmentally downregulated protein 4-2 | POTASSIUM HOMEOSTASIS | epithelial transport | CORTICAL COLLECTING DUCT | INDUCIBLE KINASE SGK1 | ALDOSTERONE-INDUCED KINASE | UROLOGY & NEPHROLOGY | with no lysine kinase 1 | epithelial Na+ channel | phosphorylation | ubiquitylation | Amino Acid Sequence | Protein-Serine-Threonine Kinases - deficiency | Potassium, Dietary - pharmacology | Endosomal Sorting Complexes Required for Transport - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Male | Antibodies, Blocking - pharmacology | Epithelial Sodium Channels - metabolism | Mice, Knockout | Minor Histocompatibility Antigens - metabolism | Animals | Immediate-Early Proteins - genetics | WNK Lysine-Deficient Protein Kinase 1 | Diet | Potassium - urine | Potassium Channels, Inwardly Rectifying - immunology | Immediate-Early Proteins - deficiency | Nedd4 Ubiquitin Protein Ligases | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Mice | Kidney Tubules - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus
Journal Article