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1. Full Text Mitogen‐activated protein kinase dependency in BRAF/RAS wild‐type melanoma: A rationale for combination inhibitors
by Ming, Zizhen and Lim, Su Yin and Kefford, Richard F and Rizos, Helen
Pigment cell and melanoma research, ISSN 1755-1471, 03/2020, Volume 33, Issue 2, pp. 345 - 357
trametinib | NF1 | triple WT | targeted therapies | MAPK | survival pathways | Oncology | Life Sciences & Biomedicine | Dermatology | Science & Technology | Cell Biology | Skin Neoplasms - drug therapy | Humans | Melanoma - enzymology | ras Proteins - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Skin Neoplasms - enzymology | Melanoma - genetics | Pyrimidinones - pharmacology | Neurofibromin 1 - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Skin Neoplasms - pathology | Pyrimidinones - therapeutic use | Melanoma - pathology | Proto-Oncogene Proteins c-raf - metabolism | MAP Kinase Signaling System - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Pyridones - therapeutic use | Pyridones - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein kinases | Mitogens | Melanoma | Biotechnology | Extracellular signal-regulated kinase | MAP kinase | Ras protein | Kinases | Mutants | Proteins | Inhibitors | Immune checkpoint | Protein kinase | Cell lines | Dependence | Index Medicus
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2. Full Text Quadruple wild‐type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways
by Pantaleo, Maria A and Nannini, Margherita and Corless, Christopher L and Heinrich, Michael C
Cancer medicine (Malden, MA), ISSN 2045-7634, 01/2015, Volume 4, Issue 1, pp. 101 - 103
NF‐1 | GIST | SDH deficiency | quadruple WT | RAS | gastrointestinal stromal tumors | BRAF | wild type | SDHA | SDHB | quadruple negative | Gastrointestinal stromal tumors | Quadruple WT | NF-1 | Quadruple negative | Wild type | Life Sciences & Biomedicine | Oncology | Science & Technology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Proto-Oncogene Proteins c-kit - metabolism | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - diagnosis | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - metabolism | Proto-Oncogene Proteins c-kit - genetics | Succinate Dehydrogenase - metabolism | Mutation | Gastrointestinal Stromal Tumors - genetics | Proto-Oncogene Proteins p21(ras) - metabolism | Platelet-derived growth factor | Index Medicus | Cancer Biology
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3. Full Text Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)
by Nannini, Margherita and Astolfi, Annalisa and Urbini, Milena and Indio, Valentina and Santini, Donatella and Heinrich, Michael C and Corless, Christopher L and Ceccarelli, Claudio and Saponara, Maristella and Mandrioli, Anna and Lolli, Cristian and Ercolani, Giorgio and Brandi, Giovanni and Biasco, Guido and Pantaleo, Maria A
BMC cancer, ISSN 1471-2407, 09/2014, Volume 14, Issue 1, pp. 685 - 685
PDGFRA | Succinate dehydrogenase | RAS | KIT | QuadrupleWT | SDHA | Gastrointestinal stromal tumors (GIST) | Wild-type | Life Sciences & Biomedicine | Oncology | Science & Technology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Genomics | Humans | Transcriptome | Gene Expression Profiling | Proto-Oncogene Proteins c-kit - metabolism | DNA Copy Number Variations | Receptor, Platelet-Derived Growth Factor alpha - genetics | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Proto-Oncogene Proteins c-kit - genetics | High-Throughput Nucleotide Sequencing | Polymorphism, Single Nucleotide | Mutation | Genes, ras | Gastrointestinal Stromal Tumors - genetics | Cluster Analysis | Index Medicus
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4. Full Text MIC and upper limit of wild-type distribution for 13 antifungal agents against a Trichophyton mentagrophytes Trichophyton interdigitale complex of Indian origin
by Shaw, Dipika and Singh, Shreya and Dogra, Sunil and Jayaraman, Jyothi and Bhat, Ramesh and Panda, Saumya and Chakrabarti, Arunaloke and Anjum, Nishat and Chowdappa, Aruna and Nagamoti, Mahantesh and Varshney, Umesh and Vanam, Hari Pankaj and Savio, Jayanthi and Antony, Meryl and Rudramurthy, Shivaprakash M
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 2020, Volume 64, Issue 4
Antifungal resistance | Trichophyton mentagrophyte | UL-WT | Dermatophytes | MIC | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Arthrodermataceae - isolation & purification | Microbial Sensitivity Tests | Dermatomycoses - drug therapy | Arthrodermataceae - drug effects | Humans | Arthrodermataceae - genetics | Drug Resistance, Fungal - genetics | India | Index Medicus
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5. Full Text New hints towards a precision medicine strategy for IDH wild-type glioblastoma
by White, K and Connor, K and Clerkin, J and Murphy, B.M and Salvucci, M and O'Farrell, A.C and Rehm, M and O'Brien, D and Prehn, J.H.M and Niclou, S.P and Lamfers, M.L.M and Verreault, M and Idbaih, A and Verhaak, R and Golebiewska, A and Byrne, A.T
Annals of oncology, ISSN 0923-7534, 12/2020, Volume 31, Issue 12, pp. 1679 - 1692
multi-omics | tumour microenvironment | IDH-wt glioblastoma | precision therapy | Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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6. Full Text On-Going Electroencephalographic Rhythms Related to Cortical Arousal in Wild Type Mice: the Effect of Aging
by Del Percio, Claudio and Drinkenburg, Wilhelmus and Lopez, Susanna and Infarinato, Francesco and Bastlund, Jesper Frank and Clausen, Bettina and Pedersen, Jan T and Christensen, Ditte Zerlang and Forloni, Gianluigi and Frasca, Angelisa and Noè, Francesco M and Bentivoglio, Marina and Fabene, Paolo Francesco and Bertini, Giuseppe and Colavito, Valeria and Kelley, Jonathan and Dix, Sophie and Richardson, Jill C and Babiloni, Claudio and PharmaCog Consortium
Neurobiology of aging, ISSN 0197-4580, 2016, Volume 49, pp. 20 - 30
Neurology | Internal Medicine | Awake passive state | Awake active state | C57 wild-type (WT) mice | Electroencephalographic (EEG) rhythms | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Rest - physiology | Arousal - physiology | Animals | Aging - physiology | Mice, Inbred C57BL | Wakefulness - physiology | Cerebral Cortex - physiology | Female | Male | Electroencephalography | Drug Discovery | Drug discovery | Pharmaceutical industry | Neurophysiology | Index Medicus
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7. Full Text Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through the NF-κB pathway in MCF-7 cells
by Wang, Xuedong and Wu, Xingang and Wang, Chengkun and Zhang, Weijia and Ouyang, Yongmei and Yu, Yanhui and He, Zhimin
FEBS letters, ISSN 0014-5793, 2010, Volume 584, Issue 15, pp. 3392 - 3397
Nuclear factor kappa-B | Electrophoretic mobility shift assay (EMSA) | Multidrug resistance (MDR) | Wild-type p53 | Breast cancer resistance protein | BCRP | PBS | multidrug resistance | ABC | RNAi | P-gp | RNA interference | MRP | P-glycoprotein | NF-κB | electrophoretic mobility shift assay | EMSA | multidrug resistance-associated protein | wt-p53 | ATP-binding cassette | nuclear factor kappa-B | phosphate balanced solution | MDR | wild-type p53 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology
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8. Full Text Effect of Primary Tumor Location on Second- or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies
by Boeckx, Nele and Koukakis, Reija and Op de Beeck, Ken and Rolfo, Christian and Van Camp, Guy and Siena, Salvatore and Tabernero, Josep and Douillard, Jean-Yves and André, Thierry and Peeters, Marc
Clinical colorectal cancer, ISSN 1533-0028, 09/2018, Volume 17, Issue 3, pp. 170 - 178.e3
Tumor location | RAS mutant | Treatment lines | mCRC | RAS WT | Life Sciences & Biomedicine | Oncology | Science & Technology | Colorectal Neoplasms - mortality | Prognosis | Membrane Proteins - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Exons - genetics | Male | Randomized Controlled Trials as Topic | Clinical Trials, Phase III as Topic | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Colorectal Neoplasms - drug therapy | Progression-Free Survival | Aged, 80 and over | Adult | Female | Panitumumab - therapeutic use | Aged | Retrospective Studies | Mutation | Colorectal Neoplasms - pathology | Gene mutations | Panitumumab | Colorectal cancer | Dosage and administration | Genetic aspects | Research | Metastasis | Drug therapy | Index Medicus | Life Sciences | Human health and pathology | Hépatology and Gastroenterology | Immunology | Immunotherapy | Cancer
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9. Full Text AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer
by Cardone, Claudia and Blauensteiner, Bernadette and Moreno-Viedma, Veronica and Martini, Giulia and Simeon, Vittorio and Vitiello, Pietro P and Ciardiello, Davide and Belli, Valentina and Matrone, Nunzia and Troiani, Teresa and Morgillo, Floriana and Zito Marino, Federica and Dentice, Monica and Nappi, Annarita and Boccaccino, Alessandra and Antoniotti, Carlotta and Cremolini, Chiara and Pietrantonio, Filippo and Prager, Gerald W and Normanno, Nicola and Maiello, Evaristo and Argiles, Guillem and Elez, Elena and Signoriello, Giuseppe and Franco, Renato and Falcone, Alfredo and Tabernero, Josep and Sibilia, Maria and Ciardiello, Fortunato and Martinelli, Erika
European journal of cancer (1990), ISSN 0959-8049, 10/2020, Volume 138, pp. 1 - 10
AXL | EGFR resistance | RAS WT | Colorectal cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Colorectal Neoplasms - mortality | ErbB Receptors - antagonists & inhibitors | Humans | Colorectal Neoplasms - chemistry | Drug Resistance, Neoplasm | Xenograft Model Antitumor Assays | Neoplasm Metastasis | Animals | Colorectal Neoplasms - drug therapy | Proto-Oncogene Proteins - analysis | Biomarkers | Cell Line, Tumor | Receptor Protein-Tyrosine Kinases - analysis | Mice | Colorectal Neoplasms - pathology | Genes, ras | Analysis | Metastasis | Immunohistochemistry | Cell culture | Therapy | Biotechnology | Mesenchyme | Xenotransplantation | Colorectal carcinoma | Drug resistance | Metastases | Axl protein | Angiogenesis | Transfection | Epidermal growth factor | Xenografts | Growth factors | Epidermal growth factor receptors | Ribonucleic acid--RNA | Gene expression | Survival | Patients | Antiangiogenics | Human performance | Medical prognosis | Data sets | Mutation | Tumors | Cancer | Index Medicus
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