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Journal Article
Immunobiology, ISSN 0171-2985, 2012, Volume 218, Issue 7, pp. 969 - 978
Abstract Neutrophil gelatinase-associated lipocalin (NGAL/Lipocalin-2/Lcn-2) is a 25 kDa protein which is involved in host defence against certain Gram... 
Allergy and Immunology | Advanced Basic Science | Ferroportin | Chlamydia pneumoniae | Interleukin-10 | Lipocalin-2 | Ferritin | Atherosclerosis | Hepcidin | Macrophage | HUMAN MONOCYTIC CELLS | MACROPHAGES | TYPHIMURIUM | IMMUNOLOGY | SALMONELLA-ENTERICA | INTERFERON-GAMMA | AVAILABILITY | EXPRESSION | Oncogene Proteins - genetics | Homeostasis | Iron, Dietary - administration & dosage | Acute-Phase Proteins - genetics | Acute-Phase Proteins - antagonists & inhibitors | Lipocalins - antagonists & inhibitors | Chlamydophila pneumoniae - metabolism | Ferritins - genetics | Lipocalins - genetics | Female | Acute-Phase Proteins - deficiency | Iron - pharmacology | Oncogene Proteins - immunology | Cell Line | Ferritins - immunology | Mice, Inbred C57BL | Macrophages, Peritoneal - immunology | Bacterial Load | Chlamydophila pneumoniae - growth & development | Iron - metabolism | Oncogene Proteins - antagonists & inhibitors | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Host-Pathogen Interactions | Animals | Macrophages, Peritoneal - microbiology | Lipocalins - immunology | Interleukin-10 - genetics | Oncogene Proteins - deficiency | Mice | Primary Cell Culture | Macrophages, Peritoneal - metabolism | Interleukin-10 - immunology | Acute-Phase Proteins - immunology | Chlamydophila pneumoniae - immunology | Immunohistochemistry | Purines | Medical colleges | Pneumonia | Interleukins | Chlamydia | Analysis | Bacterial pneumonia | Physiological aspects | Iron | Fpn1, ferroportin | Lcn-2 | DMT-1, divalent metal transporter-1 | Fe, iron | IL-10, interleukin-10 | wt, wildtype | HPRT, hypoxanthine guanine phosphoribosyl transferase | TfR, transferrin receptor | hamp, hepcidin | C. pneumoniae, Cpn, Chlamydia pneumoniae | aIL-10, anti-interleukin-10 | Lcn-2, Lipocalin-2
Journal Article
Translational Research, ISSN 1931-5244, 2014, Volume 164, Issue 4, pp. 323 - 335
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 03/2016, Volume 148, pp. 31 - 40
Journal Article
REDOX BIOLOGY, ISSN 2213-2317, 09/2019, Volume 26, p. 101279
The phagocyte NADPH oxidase (the NOX2 complex) generates superoxide, the precursor to reactive oxygen species (ROS). ROS possess both antimicrobial and... 
AUTOANTIBODIES | NADPH OXIDASE | NECROTIC CELLS | LUPUS | REVISED CRITERIA | DENDRITIC CELLS | CHRONIC GRANULOMATOUS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | APOPTOTIC CELLS | NEUTROPHIL CYTOSOLIC FACTOR-2 | T-CELLS
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 01/2017, Volume 429, Issue 2, pp. 280 - 294
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) that—once activated upon ligand binding—leads to receptor dimerization,... 
non-small cell lung cancer | protein–protein interaction | two-hybrid screening | oncogenic signaling | EGFR | Protein-protein interaction | PATHWAYS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | FAMILY | ACIDIC COILED-COIL | TACC3 | protein-protein interaction | FUSIONS | PROTEINS | EXPRESSION | AURORA | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Immunoprecipitation | Microtubule-Associated Proteins - genetics | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Cell Survival | Microtubule-Associated Proteins - metabolism | Humans | Computational Biology | Gene Expression Regulation, Neoplastic | Receptor, Epidermal Growth Factor - metabolism | Gene Deletion | HEK293 Cells | Mitogen-Activated Protein Kinases - genetics | Protein Interaction Domains and Motifs | HeLa Cells | Mitogen-Activated Protein Kinases - metabolism | RNA, Small Interfering - metabolism | Tyrosine | Epidermal growth factor | Drug discovery | Lung cancer, Non-small cell | Mitogens | Protein kinases | Protein-protein interactions | FGFR, fibroblast growth factor receptor | SH, Src homology | EGF, epidermal growth factor | TF, transcription factor | EGFR-ex19del, EGFR-exon19 deletion | TACC, transforming acidic coiled-coil protein | PBS, phosphate-buffered saline | DMEM, Dulbecco's modified Eagle's medium | PEI, polyethylenimine | Nub, N-terminal half of ubiquitin | SRE, serum response element | GFP, green fluorescent protein | NSCLC, non-small cell lung cancer | GO, gene ontology | TKI, TK inhibitor | EGFR, epidermal growth factor receptor | TK, tyrosine kinase | ERK, extracellular signal-regulated kinase | EGFR-WT, EGFR-wildtype | MOI, multiplicity of infection | MaMTH, mammalian membrane two-hybrid | KM, Kaplan–Meier | Grb2, growth factor receptor-bound protein 2 | Cub, C-terminal half of ubiquitin | MAPK, mitogen-activated protein kinase
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 11/2015, Volume 5, Issue 6, pp. 506 - 519
Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide... 
Calpain | Cathepsin | Enzyme inhibitors | Cysteine protease | Neurodegeneration | Alzheimer's disease | BETA-SECRETASE | ALZHEIMERS-DISEASE | FOCAL CEREBRAL-ISCHEMIA | AMYLOID PRECURSOR PROTEIN | TRAUMATIC BRAIN-INJURY | PEPTIDE-BIPHENYL HYBRIDS | AFFINITY LABEL CONCEPT | IN-VIVO | PHARMACOLOGY & PHARMACY | SPINAL-CORD-INJURY | TRANSGENIC MOUSE MODEL | APP | AppLon, London familial amyloid precursor protein mutation, APP (V717I) | NFT, neurofibrilliary tangles | Ile, isoleucine | Arg, arginine | Lys, lysine | Gln, glutamine | Thr, threonine | AppSwe, Swedish amyloid precursor protein mutation, APP (K670N | Gly, glutamine | ERK1 | PD, Parkinson׳s disease | MMP-9, matrix metalloproteinase 9 | Tyr, tyrosine | WT, wildtype | WRX, Trp-Arg containing epoxysuccinate cysteine protease inhibitor | TNF, tumor necrosis factor | SP, senile plaques | Alzheimer׳s disease | PS1, Aβ overexpressing mice APP (K670N | EGFR, epidermal growth factor receptor | pGlu, pyroglutamate | p35, activator of cyclin-dependent kinase 5 | AD, Alzheimer׳s disease | CaMKII, Ca2 | KO, knockout | PK, pharmacokinetic | Phe, phenylalanine | Aβ, amyloid β | TBI, traumatic brain injury | calmodulin-dependent protein kinases II | DTT, dithioerythritol | APP, amyloid precursor protein | isoAsp, isoaspartate | Glu, glutamic acid | Leu, leucine | GSH, glutathione | PTP1B, protein-tyrosine phosphatase 1B | Review | ALS, amyotrophic lateral sclerosis | CREB, cyclic adenosine monophosphate response element binding protein | 2, extracellular signal-regulated kinase 1 | MAP-2, microtubule-associated protein 2 | M671L) and PS1 (M146L) mutants | Nle, norleucine | CANP, calcium-activated neutral protease | Hsp70.1, heat shock protein 70.1 | Met, methionine | BACE-1, β-amyloid cleaving enzyme | M671L | Aβ1-42, amyloid β, 42 amino acid protein | PKC, protein kinase C | BBB, blood–brain barrier | Pro, proline | CNS, central nervous system | Val, valine | Cdk5 | pyroGluAβ, pyroglutamate-amyloid β | Ala, alanine
Journal Article