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1. Full Text WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation
by Wang, Yiping and Xiao, Mengtao and Chen, Xiufei and Chen, Leilei and Xu, Yanping and Lv, Lei and Wang, Pu and Yang, Hui and Ma, Shenghong and Lin, Huaipeng and Jiao, Bo and Ren, Ruibao and Ye, Dan and Guan, Kun-Liang and Xiong, Yue
Molecular cell, ISSN 1097-2765, 02/2015, Volume 57, Issue 4, pp. 662 - 673
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins - metabolism | Cell Proliferation - genetics | DNA-Binding Proteins - physiology | WT1 Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Humans | Gene Expression Regulation, Neoplastic | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | WT1 Proteins - physiology | Inhibitor of Differentiation Protein 2 - genetics | HEK293 Cells | Proto-Oncogene Proteins - physiology | HL-60 Cells | Mutation | WT1 Proteins - genetics | Leukemia, Myeloid, Acute - genetics | Enzymes | Leukemia | Genes | Genomics | Genetically modified organisms | Genetic aspects | Genetic engineering | Methylation | Gene expression | Cells | Cancer | Medical colleges | Chromatin | Genetic transcription | Nucleotide sequencing | DNA sequencing | Index Medicus | AML | TET2 | Mutual exclusive mutations | WT1
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2. Full Text WT1 peptide‐based immunotherapy for advanced thymic epithelial malignancies
by Oji, Yusuke and Inoue, Masayoshi and Takeda, Yoshito and Hosen, Naoki and Shintani, Yasushi and Kawakami, Manabu and Harada, Takuya and Murakami, Yui and Iwai, Miki and Fukuda, Mari and Nishida, Sumiyuki and Nakata, Jun and Nakae, Yoshiki and Takashima, Satoshi and Shirakata, Toshiaki and Nakajima, Hiroko and Hasegawa, Kana and Kida, Hiroshi and Kijima, Takashi and Morimoto, Soyoko and Fujiki, Fumihiro and Tsuboi, Akihiro and Morii, Eiichi and Morita, Satoshi and Sakamoto, Junichi and Kumanogoh, Atsushi and Oka, Yoshihiro and Okumura, Meinoshin and Sugiyama, Haruo
International journal of cancer, ISSN 0020-7136, 06/2018, Volume 142, Issue 11, pp. 2375 - 2382
thymic carcinoma | thymoma | WT1 | WT1 peptide vaccine | Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | WT1 Proteins - metabolism | Humans | Middle Aged | Male | Tomography, X-Ray Computed | Neoplasms, Glandular and Epithelial - immunology | Cancer Vaccines - therapeutic use | Thymus Neoplasms - immunology | WT1 Proteins - chemistry | Immunotherapy | Thymus Neoplasms - pathology | WT1 Proteins - immunology | Adult | Female | Neoplasms, Glandular and Epithelial - diagnostic imaging | Neoplasms, Glandular and Epithelial - pathology | Gene Expression | Thymus Neoplasms - diagnostic imaging | Peptides - immunology | Treatment Outcome | Combined Modality Therapy | Thymus Neoplasms - drug therapy | Cancer Vaccines - immunology | Neoplasms, Glandular and Epithelial - drug therapy | Aged | Neoplasm Staging | Medical research | Myasthenia gravis | Peptides | Medicine, Experimental | Development and progression | Cancer | Cerebellum | Immune response | Thymoma | Complications | Invasiveness | Hemorrhage | Patients | Thymus | Aplasia | Neuromuscular junctions | Myasthenia | Tumors | Index Medicus
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3. Full Text Repeated PR1 and WT1 peptide vaccination in Montanide-adjuvant fails to induce sustained high-avidity, epitope-specific CD8+ T cells in myeloid malignancies
by Katayoun Rezvani and Agnes S.M. Yong and Stephan Mielke and Behnam Jafarpour and Bipin N. Savani and Robert Q. Le and Rhoda Eniafe and Laura Musse and Carol Boss and Roger Kurlander and A. John Barrett
Haematologica (Roma), ISSN 0390-6078, 03/2011, Volume 96, Issue 3, pp. 432 - 440
Vaccine | WT1 | Immunotherapy | Leukemia | PR1 | Life Sciences & Biomedicine | Hematology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | CD8-Positive T-Lymphocytes - cytology | WT1 Proteins - chemical synthesis | Adjuvants, Immunologic - administration & dosage | Humans | Middle Aged | Male | Myeloproliferative Disorders - immunology | CD4-Positive T-Lymphocytes - immunology | Epitopes - immunology | Cancer Vaccines - chemical synthesis | Cancer Vaccines - therapeutic use | Vaccines, Subunit - therapeutic use | WT1 Proteins - immunology | Adult | Female | T-Lymphocytes, Cytotoxic - immunology | WT1 Proteins - administration & dosage | Immunization | Myeloproliferative Disorders - therapy | Vaccines, Subunit - chemical synthesis | CD4-Positive T-Lymphocytes - cytology | Cancer Vaccines - administration & dosage | Leukemia - therapy | Vaccines, Subunit - immunology | Cancer Vaccines - immunology | WT1 Proteins - therapeutic use | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Leukemia - immunology | Vaccines, Subunit - administration & dosage | Aged | CD8-Positive T-Lymphocytes - immunology | T-Lymphocytes, Cytotoxic - cytology | Index Medicus | leukemia | vaccine | Original | immunotherapy
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4. Full Text Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide
by Oji, Yusuke and Hashimoto, Naoya and Tsuboi, Akihiro and Murakami, Yui and Iwai, Miki and Kagawa, Naoki and Chiba, Yasuyoshi and Izumoto, Shuichi and Elisseeva, Olga and Ichinohasama, Ryo and Sakamoto, Junichi and Morita, Satoshi and Nakajima, Hiroko and Takashima, Satoshi and Nakae, Yoshiki and Nakata, Jun and Kawakami, Manabu and Nishida, Sumiyuki and Hosen, Naoki and Fujiki, Fumihiro and Morimoto, Soyoko and Adachi, Mayuko and Iwamoto, Masahiro and Oka, Yoshihiro and Yoshimine, Toshiki and Sugiyama, Haruo
International journal of cancer, ISSN 0020-7136, 09/2016, Volume 139, Issue 6, pp. 1391 - 1401
WT1 IgG antibody | glioblastoma | predictive marker | WT1 peptide‐based immunotherapy | WT1 peptide-based immunotherapy | Glioblastoma | Predictive marker | Life Sciences & Biomedicine | Oncology | Science & Technology | Prognosis | Immunoglobulin G - blood | Humans | Middle Aged | Vaccination | Male | Th1 Cells - immunology | Peptides - administration & dosage | Th1 Cells - metabolism | Young Adult | WT1 Proteins - chemistry | Immunoglobulin G - immunology | Immunotherapy | WT1 Proteins - immunology | Adult | Female | T-Lymphocytes, Cytotoxic - immunology | HLA-A24 Antigen - immunology | Enzyme-Linked Immunosorbent Assay | Cancer Vaccines - administration & dosage | Peptides - immunology | Treatment Outcome | Combined Modality Therapy | Glioblastoma - therapy | Cancer Vaccines - immunology | Glioblastoma - immunology | T-Lymphocytes, Cytotoxic - metabolism | Biomarkers | Cell Line, Tumor | Aged | Glioblastoma - mortality | Peptides | Glioblastoma multiforme | Patient outcomes | Immunoglobulin G | Antigens | Immunoglobulins | Immunization | Brain cancer | Index Medicus | Tumor Immunology and Microenvironment
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5. Full Text Wt1 and Epicardial Fate Mapping
by Rudat, Carsten and Kispert, Andreas
Circulation research, ISSN 0009-7330, 07/2012, Volume 111, Issue 2, pp. 165 - 169
epicardium | lineage tracing | Wt1 | cardiomyocyte | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Vertebrates: cardiovascular system | Myocytes, Cardiac - cytology | Gene Expression Regulation, Developmental - genetics | Mice, Transgenic | Pericardium - metabolism | Random Allocation | Pericardium - cytology | Gene Knock-In Techniques | Pregnancy | WT1 Proteins - physiology | Animals | Organogenesis - genetics | Chromosome Mapping - methods | Myocytes, Cardiac - metabolism | Pericardium - embryology | Female | Mice | WT1 Proteins - biosynthesis | Integrases - genetics | WT1 Proteins - genetics | Cell Lineage - genetics | Index Medicus
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6. Full Text Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney
by Weiss, Anna‐Carina and Rivera‐Reyes, Reginaldo and Englert, Christoph and Kispert, Andreas
The Journal of pathology, ISSN 0022-3417, 11/2020, Volume 252, Issue 3, pp. 290 - 303
Ret | kidney | retinoic acid signalling | Wilms' tumour | Wt1 | development branching morphogenesis | Biomarkers - metabolism | Cryptorchidism - metabolism | WT1 Proteins - metabolism | Kidney - embryology | Ureter - abnormalities | Male | Ureter - embryology | Cryptorchidism - embryology | Kidney - metabolism | Animals | Kidney - abnormalities | Gene Expression Regulation, Developmental | Organogenesis - genetics | Gene Deletion | Mice | Ureter - metabolism | Cryptorchidism - genetics | WT1 Proteins - genetics | Genes | Analysis | Genetic research | Cryptorchism | Nephroblastoma | Tumors | Tretinoin | Cell culture | Kidneys | Mesenchyme | Stroma | Cryptorchidism | Gene deletion | Epithelium | Morphogenesis | WT1 protein | Ureter | Collecting duct | Retinoic acid | Renal cortex | Index Medicus
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7. Full Text Wilms’ tumour 1 (WT1) in development, homeostasis and disease
by Hastie, Nicholas D
Development (Cambridge), ISSN 0950-1991, 08/2017, Volume 144, Issue 16, pp. 2862 - 2872
Developmental disorders | Homeostasis | Molecular mechanisms of disease | WT1 | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Kidney Neoplasms - genetics | WT1 Proteins - metabolism | Animals | Protein Isoforms - metabolism | Wilms Tumor - genetics | Humans | Kidney Neoplasms - metabolism | Wilms Tumor - metabolism | WT1 Proteins - genetics | Evolution, Molecular | Protein Isoforms - genetics | Post-transcription | Molecular modelling | Kidneys | Isoforms | Nervous system | Mutation | Gonads | Tumors | Index Medicus
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8. Full Text A new peptide vaccine OCV-501: in vitro pharmacology and phase 1 study in patients with acute myeloid leukemia
by Kobayashi, Yukio and Sakura, Toru and Miyawaki, Shuichi and Toga, Kazuyuki and Sogo, Shinji and Heike, Yuji
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 07/2017, Volume 66, Issue 7, pp. 851 - 863
Helper peptide | OCV-501 | Cancer vaccine | WT1 | Acute myeloid leukemia | Immunotherapy | Oncology | Immunology | Life Sciences & Biomedicine | Science & Technology | HLA-A2 Antigen - genetics | Cancer Vaccines - pharmacology | Humans | Middle Aged | Male | Th1 Cells - immunology | Dose-Response Relationship, Drug | T-Lymphocytes, Cytotoxic - drug effects | WT1 Proteins - pharmacology | WT1 Proteins - immunology | Aged, 80 and over | Female | Leukemia, Myeloid, Acute - therapy | T-Lymphocytes, Cytotoxic - immunology | Th1 Cells - drug effects | WT1 Proteins - administration & dosage | Cancer Vaccines - administration & dosage | Vaccines, Subunit - immunology | HLA-DR beta-Chains - genetics | Remission Induction | Cancer Vaccines - immunology | Maximum Tolerated Dose | Vaccines, Subunit - pharmacology | Lymphocyte Activation - drug effects | Vaccines, Subunit - administration & dosage | Cell Line, Tumor | Aged | Cohort Studies | Peptides | Oncology, Experimental | Clinical trials | Research | Vaccines | T cells | Cancer | Cytolytic activity | Hypersensitivity (delayed) | Myeloid leukemia | Leukemia | Hypersensitivity | Cytotoxicity | Leukocytes (mononuclear) | Pharmacology | Lymphocytes T | In vitro testing | Blast | Wilms' tumor | Patients | WT1 protein | Lymphocytes B | Lymphocytes | Peripheral blood mononuclear cells | Remission | Histocompatibility antigen HLA | Blast cells | Index Medicus | Original
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9. Full Text WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1
by Belali, Tareg and Wodi, Chigeru and Clark, Bethany and Cheung, Man-Kim and Craig, Tim J and Wheway, Gabrielle and Wagner, Nicole and Wagner, Kay-Dietrich and Roberts, Stefan and Porazinski, Sean and Ladomery, Michael
Biochimica et biophysica acta. Gene regulatory mechanisms, ISSN 1874-9399, 12/2020, Volume 1863, Issue 12, p. 194642
Splice factor kinases | WT1 | BASP1 | VEGF | SRSF1 | SRPK1 | Promoter Regions, Genetic | WT1 Proteins - metabolism | Cell Proliferation | PC-3 Cells | Humans | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | WT1 Proteins - antagonists & inhibitors | Male | Vascular Endothelial Growth Factor A - metabolism | Nerve Tissue Proteins - metabolism | Protein Isoforms - metabolism | RNA Interference | K562 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Membrane Proteins - metabolism | Binding Sites | WT1 Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Cell Movement | Life Sciences
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10. Full Text Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence
by Hashimoto, Hideharu and Olanrewaju, Yusuf Olatunde and Zheng, Yu and Wilson, Geoffrey G and Zhang, Xing and Cheng, Xiaodong
Genes & development, ISSN 0890-9369, 10/2014, Volume 28, Issue 20, pp. 2304 - 2313
Epigenetics | DNA modification | 5-carboxylcytosine | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Protein Structure, Tertiary | Cytosine - analogs & derivatives | WT1 Proteins - metabolism | Oxidation-Reduction | Humans | Crystallization | Early Growth Response Protein 1 - chemistry | Models, Molecular | DNA Methylation | WT1 Proteins - chemistry | Cytosine - metabolism | Protein Binding | Mutation | WT1 Proteins - genetics | Early Growth Response Protein 1 - metabolism | Genetic transcription | Tumor proteins | Health aspects | DNA | Analysis | Index Medicus | Research Paper | epigenetics
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