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1. Full Text Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome
by Maciejczyk, Mateusz and Mikoluc, Bozena and Pietrucha, Barbara and Heropolitanska - Pliszka, Edyta and Pac, Malgorzata and Motkowski, Radosław and Car, Halina
Redox biology, ISSN 2213-2317, 04/2017, Volume 11, pp. 375 - 383
Antioxidants | Oxidative stress | Nijmegen breakage syndrome (NBS) | Oxidative damage | Bloom syndrome (BS) | Ataxia-telangiectasia (A-T) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Bloom Syndrome - pathology | Nijmegen Breakage Syndrome - pathology | NADPH Oxidase 4 - genetics | Reactive Oxygen Species - metabolism | Signal Transduction | Humans | Nijmegen Breakage Syndrome - metabolism | Gene Expression Regulation | Oxidative Stress - genetics | Bloom Syndrome - metabolism | Ataxia Telangiectasia - metabolism | Mitochondria - metabolism | Bloom Syndrome - genetics | Mitochondria - pathology | Lipoproteins, LDL - genetics | Nijmegen Breakage Syndrome - genetics | NADPH Oxidase 4 - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Ataxia Telangiectasia - pathology | DNA Repair | Ataxia Telangiectasia - genetics | Lipoproteins, LDL - metabolism | DNA Damage | Index Medicus
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2. Full Text NAD(+) augmentation restores mitophagy and limits accelerated aging in Werner syndrome
by Fang, Evandro F and Hou, Yujun and Lautrup, Sofie and Jensen, Martin Borch and Yang, Beimeng and SenGupta, Tanima and Caponio, Domenica and Khezri, Rojyar and Demarest, Tyler G and Aman, Yahyah and Figueroa, David and Morevati, Marya and Lee, Ho-Joon and Kato, Hisaya and Kassahun, Henok and Lee, Jong-Hyuk and Filippelli, Deborah and Okur, Mustafa Nazir and Mangerich, Aswin and Croteau, Deborah L and Maezawa, Yoshiro and Lyssiotis, Costas A and Tao, Jun and Yokote, Koutaro and Rusten, Tor Erik and Mattson, Mark P and Jasper, Heinrich and Nilsen, Hilde and Bohr, Vilhelm A
Nature communications, ISSN 2041-1723, 11/2019, Volume 10, Issue 1, pp. 5284 - 18
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Nicotinamide-Nucleotide Adenylyltransferase - metabolism | Humans | Aging, Premature - genetics | Autophagy-Related Protein-1 Homolog - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Mitophagy | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Animals | Werner Syndrome Helicase - metabolism | Werner Syndrome - metabolism | Cation Transport Proteins - metabolism | Werner Syndrome - genetics | Nicotinamide-Nucleotide Adenylyltransferase - genetics | Cation Transport Proteins - genetics | Werner Syndrome Helicase - genetics | Mutation | Aging, Premature - metabolism | Autophagy-Related Protein-1 Homolog - genetics | Intracellular Signaling Peptides and Proteins - genetics | NAD - metabolism | Disease Models, Animal | Phenotypes | Transcription | Nucleotides | Metabolism | DNA helicase | NAD | Mitochondria | Molecular modelling | Depletion | Werner's syndrome | Life span | Stem cells | Aging | Fruit flies | Nicotinamide | Invertebrates | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions
by Oshima, Junko and Sidorova, Julia M and Monnat, Raymond J
Ageing research reviews, ISSN 1568-1637, 2016, Volume 33, pp. 105 - 114
Neurology | Internal Medicine | Human | Werner syndrome | Progeroid syndrome | Genomic instability | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Werner Syndrome - metabolism | DNA Repair | Humans | Werner Syndrome - genetics | DNA Replication | Aging, Premature - genetics | Werner Syndrome Helicase - genetics | Mutation | Exodeoxyribonucleases | Aging, Premature - metabolism | Werner Syndrome - diagnosis | Werner Syndrome - physiopathology | Telomeres | Genetic transcription | Health aspects | Genomics | Genes | Index Medicus
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4. Full Text A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
by Weiqi Zhang and Jingyi Li and Keiichiro Suzuki and Jing Qu and Ping Wang and Junzhi Zhou and Xiaomeng Liu and Ruotong Ren and Xiuling Xu and Alejandro Ocampo and Tingting Yuan and Jiping Yang and Ying Li and Liang Shi and Dee Guan and Huize Pan and Shunlei Duan and Zhichao Ding and Mo Li and Fei Yi and Ruijun Bai and Yayu Wang and Chang Chen and Fuquan Yang and Xiaoyu Li and Zimei Wang and Emi Aizawa and April Goebl and Rupa Devi Soligalla and Pradeep Reddy and Concepcion Rodriguez Esteban and Fuchou Tang and Guang-Hui Liu and Juan Carlos Izpisua Belmonte
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2015, Volume 348, Issue 6239, pp. 1160 - 1163
REPORTS | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Physiological aspects | Aging | Chromatin | Werner syndrome | Health aspects | Stem cells | Proteins | Genetic disorders | Cellular | Alterations | Disorders | Determinants | Maintenance | Anchoring
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5. Full Text LMNA mutations in atypical Werner's syndrome
by Chen, Lishan and Lee, Lin and Kudlow, Brian A and Dos Santos, Heloisa G and Sletvold, Olav and Shafeghati, Yousef and Botha, Eleanor G and Garg, Abhimanyu and Hanson, Nancy B and Martin, George M and Mian, I Saira and Kennedy, Brian K and Oshima, Junko
The Lancet (British edition), ISSN 0140-6736, 08/2003, Volume 362, Issue 9382, pp. 440 - 445
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | Complex syndromes | Medical sciences | Medical genetics | Werner Syndrome - classification | Humans | RNA, Messenger - genetics | Werner Syndrome Helicase | Cells, Cultured | Exons - genetics | Male | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mutation, Missense - genetics | RecQ Helicases | DNA Mutational Analysis | Pedigree | Werner Syndrome - genetics | Adolescent | Lamin Type A - genetics | Fibroblasts | Female | Registries | Exodeoxyribonucleases | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Werner Syndrome - diagnosis | Physiological aspects | Genetic aspects | Genetic disorders | Diagnosis | Werner syndrome | Gene mutations | Medical disorders | Patients | Mutation | Laboratories | Exons | mRNA | Lamins | Nuclei | Muscular dystrophy | Gene sequencing | DNA helicase | Proteins | Osteoporosis | Missense mutation | Atherosclerosis | Age | Deoxyribonucleic acid--DNA | Phenotypes | Cloning | Insulin | Molecular chains | Heterozygosity | Polymerase chain reaction | Studies | Werner's syndrome | Morphology | Skin | Diabetes | Index Medicus | Abridged Index Medicus
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6. Full Text The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease
by Campisi, Judith and Gray, Matthew D and Mian, I. Saira and Huang, Shurong and Li, Baomin and Oshima, Junko
Nature genetics, ISSN 1061-4036, 10/1998, Volume 20, Issue 2, pp. 114 - 116
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | DNA Helicases - metabolism | RecQ Helicases | Electrophoresis, Polyacrylamide Gel | Humans | Werner Syndrome - genetics | Werner Syndrome Helicase | Exodeoxyribonucleases - metabolism | DNA - metabolism | Exodeoxyribonuclease V | Werner Syndrome - enzymology | DNA Helicases - genetics | Index Medicus
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7. Full Text Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases
by de Renty, Christelle and Ellis, Nathan A
Ageing research reviews, ISSN 1568-1637, 01/2017, Volume 33, pp. 36 - 51
Aging | BLM | Cancer susceptibility | Bloom's syndrome | RecQ helicases | Genomic instability | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Genomic Instability | Humans | DNA Replication | RecQ Helicases - genetics | Aging, Premature - genetics | Bloom Syndrome - genetics | Aging - genetics | Werner Syndrome - genetics | Werner Syndrome Helicase - genetics | Bloom Syndrome - diagnosis | Mutation | DNA Helicases - physiology | Werner Syndrome - diagnosis | DNA replication | Disease susceptibility | Genetic transcription | Comparative analysis | Genes | Genomics | Index Medicus | Bloom’s syndrome | cancer susceptibility | aging | genomic instability
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8. Full Text Do you know this syndrome? Werner syndrome
by Bilgiç, Özlem
Anais brasileiros de dermatología, ISSN 0365-0596, 2017, Volume 92, Issue 2, pp. 271 - 272
Leg ulcer | Werner syndrome | Scleroderma | Progeria | Localized | Life Sciences & Biomedicine | Dermatology | Science & Technology | Leg Ulcer - etiology | Diagnosis, Differential | Scleroderma, Localized | Humans | Adult | Male | Werner Syndrome - complications | Werner Syndrome - diagnosis | Scleroderma, localized | Syndrome in Question
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9. Full Text Premature Aging Syndrome
by Coppedè, Fabio
2012, Advances in Experimental Medicine and Biology, ISBN 1461406528, Volume 724
LMNA Gene | Werner Syndrome | Progeroid Syndrome | LMNA Mutation | Sensory Peripheral Neuropathy | Werner Syndrome - etiology | Werner Syndrome - metabolism | Humans | Werner Syndrome - genetics | Aging, Premature - complications | Aging, Premature - genetics | Progeria - genetics | Progeria - metabolism | Aging, Premature - metabolism | Progeria - etiology
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10. Full Text Werner syndrome: a rare mutation
by Castagna, Alberto and Castagna, Alberto and Gareri, Pietro and Gareri, Pietro and Falvo, Francesca and Falvo, Francesca and Sestito, Simona and Sestito, Simona and Rocca, Maurizio and Rocca, Maurizio and Pensabene, Licia and Pensabene, Licia and Concolino, Daniela and Concolino, Daniela and Coppolino, Giuseppe and Coppolino, Giuseppe and Ruotolo, Giovanni and Ruotolo, Giovanni
Aging clinical and experimental research, ISSN 1594-0667, 3/2019, Volume 31, Issue 3, pp. 425 - 429
Hypercholesterolemia | Medicine & Public Health | Geriatrics/Gerontology | Diabetes mellitus | Atherosclerosis | Werner syndrome |