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The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2513 - 2526
While the cytosolic events of Wnt/β‐catenin signaling (canonical Wnt signaling) pathway have been widely studied, only little is known about the molecular... 
plasma membrane lipid | canonical Wnt | lipid raft | membrane trafficking | Wnt/β‐catenin pathway | Wnt/β-catenin pathway | FC-EPSILON-RI | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | Wnt/beta-catenin pathway | FLUORESCENCE CORRELATION SPECTROSCOPY | DETERGENT-RESISTANT MEMBRANES | SIGNAL-TRANSDUCTION | B-VIRUS INFECTION | SPIM-FCS | PATHWAY | LIPID RAFTS | IN-VIVO | Wnt3A Protein - metabolism | Cricetulus | Cytoskeletal Proteins - genetics | Membrane Microdomains - metabolism | Humans | Embryo, Nonmammalian - metabolism | Receptors, Wnt - metabolism | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Wnt3 Protein - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | Wnt Proteins - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Wnt3 Protein - metabolism | Cell Membrane - metabolism | Genes, Reporter | Wnt Signaling Pathway | CHO Cells | Wnt3A Protein - genetics | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Cells, Cultured | Niemann-Pick Diseases - metabolism | Niemann-Pick Diseases - pathology | Receptors, Wnt - agonists | Zebrafish - genetics | Low Density Lipoprotein Receptor-Related Protein-6 - agonists | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Zebrafish - metabolism | Cell Line, Tumor | Luminescent Proteins - genetics | Zebrafish Proteins - genetics | Luminescent Proteins - metabolism | Lipids | Cell membranes | Binding | Niemann-Pick disease | Plasma | Wnt protein | β-catenin | Receptors | Molecular modelling | Ligands | Membrane trafficking | Coordination compounds | Molecular biology | Plasmas (physics) | Wnt | Original | β‐catenin pathway
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 21, pp. 5474 - 5479
Mammalian sex determination is controlled by the antagonistic interactions of two genetic pathways: The SRY-SOX9-FGF9 network promotes testis determination... 
SOX9 Transcription Factor/genetics | Wnt Proteins/antagonists & inhibitors | Humans | Cells, Cultured | Testis/metabolism | Male | Zebrafish | Sex Differentiation | Mutation, Missense | Disorders of Sex Development/genetics | Young Adult | Animals | Gene Expression Regulation, Developmental | Adolescent | Gonads/metabolism | Embryo, Nonmammalian/cytology | Thrombospondins/genetics | Adult | Female | beta Catenin/antagonists & inhibitors | Mice | Ubiquitin-Protein Ligases/genetics | ZNRF3 | DSD | Sex determination | WNT signaling | Organogenesis | OVARIAN DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | organogenesis | BETA-CATENIN | REVERSAL | R-SPONDIN | TUMOR-SUPPRESSOR | MICE | TESTIS DEVELOPMENT | SOX9 | DIFFERENTIATION | sex determination | CRITICAL TIME WINDOW | Embryo, Nonmammalian - cytology | Testis - metabolism | Thrombospondins - genetics | Embryo, Nonmammalian - metabolism | Gonads - pathology | Ubiquitin-Protein Ligases - physiology | Wnt Proteins - metabolism | Wnt Proteins - genetics | Disorders of Sex Development - pathology | SOX9 Transcription Factor - metabolism | Disorders of Sex Development - genetics | beta Catenin - metabolism | beta Catenin - genetics | Gonads - metabolism | Testis - pathology | beta Catenin - antagonists & inhibitors | Ubiquitin-Protein Ligases - genetics | Wnt Proteins - antagonists & inhibitors | SOX9 Transcription Factor - genetics | Thrombospondins - metabolism | Biological research | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Wnt proteins | Sex determination, Genetic | Biology, Experimental | Wnt Proteins / genetics | SOX9 Transcription Factor / metabolism | SOX9 Transcription Factor / genetics | beta Catenin / metabolism | Testis / pathology | Life Sciences | Gonads / metabolism | Thrombospondins / metabolism | Genetics | Testis / metabolism | beta Catenin / genetics | Disorders of Sex Development / pathology | beta Catenin / antagonists & inhibitors | Wnt Proteins / antagonists & inhibitors | Embryo, Nonmammalian / cytology | Wnt Proteins / metabolism | Ubiquitin-Protein Ligases / genetics | Gonads / pathology | Thrombospondins / genetics | Ubiquitin-Protein Ligases / physiology | Disorders of Sex Development / genetics | Embryo, Nonmammalian / metabolism | Human genetics | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 17053 - 17058
Uterine leiomyomas are extremely common estrogen and progesterone-dependent tumors of the myometrium and cause irregular uterine bleeding, severe anemia, and... 
Leiomyoma | Cell growth | Receptors | Estrogens | Stem cells | Coculture techniques | Human growth | Cells | Tumors | Mesenchymal stem cells | Tumor biology | Paracrine signaling | WNT/β-catenin signaling | WNT SIGNALING PATHWAY | MOLECULAR-MECHANISM | FIBROSIS | SIDE POPULATION | paracrine signaling | MULTIDISCIPLINARY SCIENCES | CANONICAL WNT | tumor biology | BETA-CATENIN | WNT/beta-catenin signaling | COLORECTAL-CANCER | THERAPEUTIC TARGET | DISEASE | FIBROIDS | Cell Proliferation | Axin Protein - genetics | Uterine Neoplasms - pathology | Humans | Middle Aged | Leiomyoma - metabolism | Neoplasm Proteins - metabolism | Transcription Factor 7-Like 2 Protein - metabolism | Axin Protein - metabolism | Leiomyoma - pathology | Wnt Proteins - genetics | Neoplastic Stem Cells - metabolism | Estrogens - genetics | Neoplastic Stem Cells - pathology | Adult | Female | Estrogens - metabolism | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Wnt Signaling Pathway | Uterine Neoplasms - genetics | Uterine Neoplasms - metabolism | Transcription Factor 7-Like 2 Protein - genetics | Paracrine Communication | Mice, SCID | beta Catenin - metabolism | beta Catenin - genetics | Pregnancy | Animals | Progesterone - metabolism | Mice, Inbred NOD | Mice | Progesterone - genetics | Wnt Proteins - biosynthesis | Leiomyoma - genetics | Biological Sciences | β-catenin signaling | WNT
Journal Article
Scientific reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 8042
Wnt5a activates the Wnt/beta-catenin-independent pathway and its overexpression is associated with tumor aggressiveness enhancing invasive activity. For this... 
BREAST-CANCER | GASTRIC-CANCER | SIGNALING PATHWAY | WNT/BETA-CATENIN | MULTIDISCIPLINARY SCIENCES | MELANOMA-CELLS | GROWTH-FACTOR | BETA-CATENIN | EXPRESSION | BINDING | LRP6 | Humans | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Stomach Neoplasms - pathology | Transplantation, Heterologous | Peptide Library | Wnt-5a Protein | Receptors, Wnt - metabolism | Wnt Proteins - metabolism | Epitopes - immunology | Antibodies, Neutralizing - immunology | RNA Interference | Antibodies, Neutralizing - therapeutic use | Proto-Oncogene Proteins - immunology | src-Family Kinases - metabolism | Liver Neoplasms - secondary | Antibodies, Monoclonal - immunology | Liver Neoplasms - prevention & control | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Endocytosis - drug effects | Antibodies, Neutralizing - pharmacology | Wnt Proteins - immunology | Cell Movement - drug effects | Receptors, Wnt - immunology | Animals | Wnt Signaling Pathway - drug effects | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | HeLa Cells | Wnt Proteins - antagonists & inhibitors | RNA, Small Interfering - metabolism | Cell proliferation | Clathrin | Wnt protein | Invasiveness | Lung cancer | Cervix | Src protein | β-catenin | Endocytosis | Cell growth | Gastric cancer | Cervical cancer | Cancer
Journal Article