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PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e75127
Mice lacking either T-cell intracellular antigen 1 (TIA1) or TIA1 related/like protein (TIAR/TIAL1) show high rates of embryonic lethality, suggesting a... 
REGULATOR | PROTEIN TIA-1 | MESSENGER-RNA | GENE | DNA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | NORMALIZATION | IDENTIFICATION | BINDING | LYMPHOCYTES | RNA-Binding Proteins - genetics | Lysosome-Associated Membrane Glycoproteins - metabolism | Fibroblasts - physiology | Microtubule-Associated Proteins - metabolism | Embryonic Development - genetics | Embryonic Development - physiology | Autophagy - physiology | Gene Expression Profiling | Signal Transduction - genetics | Microscopy, Electron | Blotting, Western | Mice, Knockout | Animals | Flow Cytometry | Cell Cycle - physiology | Mice | T-Cell Intracellular Antigen-1 | Real-Time Polymerase Chain Reaction | Microscopy, Fluorescence | Antigens | Embryonic development | Cell death | Analysis | Genomics | Cell cycle | Physiological aspects | Bone morphogenetic proteins | Genomes | Transforming growth factors | T cells | Cell proliferation | Wnt protein | Transforming growth factor-b | DNA damage | TIA-1 protein | Homeostasis | Phagosomes | Lymphocytes T | Mitochondrial DNA | Lethality | Inactivation | Autophagy | Proteins | Signal transduction | Embryogenesis | Cell growth | Pathways | Lymphocytes | Fibroblasts | Extracellular matrix | Physiology | Bioinformatics | Deoxyribonucleic acid--DNA | Cell survival | Deactivation | MAP kinase | Embryo fibroblasts | RNA polymerase | Gene expression | Survival | Embryonic growth stage | Signaling | Microscopy | Cell size | Intracellular | Phagocytosis | Methods | Apoptosis | Deoxyribonucleic acid
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 195 - 202
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells
Journal Article
Journal Article
New England Journal of Medicine, ISSN 0028-4793, 06/2016, Volume 374, Issue 26, pp. 2553 - 2562
Journal Article
Neuron, ISSN 0896-6273, 09/2011, Volume 71, Issue 6, pp. 1030 - 1042
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7447, pp. 122 - 126
TET (ten-eleven-translocation) proteins are Fe(II)- and alpha-ketogluta-rate-dependent dioxygenases(1-3) that modify the methylation status of DNA by... 
WNT SIGNALING PATHWAY | COMPLEX | DNA METHYLATION | MAMMALIAN DNA | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | 5-HYDROXYMETHYLCYTOSINE CONTENT | DIFFERENTIATION | BINDING PROTEIN | CPG ISLANDS | 5-CARBOXYLCYTOSINE | Embryonic Stem Cells - metabolism | Dioxygenases - metabolism | Transcription Factors - chemistry | Humans | Transcription Factors - deficiency | Proto-Oncogene Proteins - chemistry | Proto-Oncogene Proteins - biosynthesis | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Caspases - metabolism | U937 Cells | Base Sequence | HEK293 Cells | Protein Interaction Domains and Motifs | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Catalytic Domain | Dioxygenases - chemistry | Oxidation-Reduction | Down-Regulation | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Dioxygenases - genetics | 5-Methylcytosine - metabolism | CpG Islands - genetics | Mice | Enzyme Activation | DNA-Binding Proteins - biosynthesis | Physiological aspects | Oxidation-reduction reaction | Cytosine | Genetic aspects | Research | Gene expression | Methylation | Proteins | Enzymes | Oxidation | Rodents | Cytoplasm
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2010, Volume 29, Issue 1, pp. 41 - 54
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 405 - 412
The signaling molecule Wnt regulates bone homeostasis through beta-catenin-dependent canonical and beta-catenin-independent noncanonical pathways. Impairment... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECESSIVE ROBINOW-SYNDROME | CELL BIOLOGY | BONE-FORMATION | PATHWAY | DIFFERENTIATION | ROR2 | C-JUN | WNT | EXPRESSION | RECEPTOR TYROSINE KINASE | Arthritis - metabolism | Wnt Proteins - deficiency | Bone Diseases - metabolism | Wnt-5a Protein | Osteoclasts - cytology | Wnt Proteins - metabolism | X-Ray Microtomography | MAP Kinase Kinase 4 - metabolism | Wnt Proteins - genetics | Osteoblasts - cytology | Receptor Activator of Nuclear Factor-kappa B - metabolism | Wnt Signaling Pathway | Promoter Regions, Genetic | Proto-Oncogene Proteins c-jun - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - metabolism | Gene Expression Regulation | Receptor Tyrosine Kinase-like Orphan Receptors - deficiency | Osteoclasts - metabolism | Cell Lineage | Animals | Proto-Oncogene Proteins c-jun - metabolism | Skull - cytology | Receptor Activator of Nuclear Factor-kappa B - genetics | Receptor Tyrosine Kinase-like Orphan Receptors - genetics | Mice | Osteoblasts - metabolism | Skull - growth & development | Osteoporosis | Care and treatment | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Osteoclasts (Biology) | Proteins | Signal transduction | Bone density | Cellular biology | Gene expression
Journal Article