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Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7409, pp. 106 - 110
Medulloblastomas are themost commonmalignant brain tumours in children(1). Identifying and understanding the genetic events that drive these tumours is... 
COMPLEX | STRUCTURAL BASIS | LANDSCAPE | CHILDHOOD | MULTIDISCIPLINARY SCIENCES | GENES | Transcription Factors - chemistry | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Tumor Suppressor Protein p53 - genetics | TCF Transcription Factors - metabolism | Patched Receptors | Cerebellar Neoplasms - classification | DEAD-box RNA Helicases - metabolism | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DEAD-box RNA Helicases - chemistry | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | DNA Helicases - chemistry | Histone-Lysine N-Methyltransferase - genetics | Signal Transduction | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Protein Structure, Tertiary - genetics | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nuclear Proteins - chemistry | beta Catenin - metabolism | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Histone-Lysine N-Methyltransferase - metabolism | LIM Domain Proteins - genetics | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Nucleotide sequencing | Metastasis | DNA sequencing | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
Journal Article
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6744 - 6744
Pancreatic ductal adenocarcinoma (PDA) has a dismal prognosis and insights into both disease etiology and targeted intervention are needed. A total of 109... 
SIGNATURES | MODELS | DUCTAL ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | TUMOR | SOMATIC MUTATION | COPY-NUMBER ALTERATION | GENOMIC CHARACTERIZATION | CARCINOMA | PROGRESSION | DISCOVERY | Cell Cycle - genetics | RNA-Binding Proteins - genetics | Prognosis | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Carcinoma, Adenosquamous - drug therapy | Male | Antineoplastic Agents - therapeutic use | DNA Repair - genetics | Molecular Targeted Therapy | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Copy Number Variations | Genetic Variation | Pancreatic Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Nuclear Proteins - genetics | Carcinoma, Adenosquamous - pathology | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Pancreatic Neoplasms - genetics | Carcinoma, Adenosquamous - genetics | Transcription Factors - genetics | Carcinoma, Pancreatic Ductal - pathology | Sequence Analysis, DNA | Carcinoma, Pancreatic Ductal - drug therapy | Drug Resistance, Neoplasm - genetics | Exome - genetics | Gene Amplification | Sulfonamides - therapeutic use | Wnt Signaling Pathway - genetics | Proto-Oncogene Proteins B-raf - genetics | Retinoblastoma Protein - genetics | Genes, myc - genetics | Indoles - therapeutic use | Aged | BRCA2 Protein - genetics | Index Medicus
Journal Article
by Jones, David T. W and Jäger, Natalie and Kool, Marcel and Zichner, Thomas and Hutter, Barbara and Sultan, Marc and Cho, Yoon-Jae and Pugh, Trevor J and Hovestadt, Volker and Stütz, Aian M and Rausch, Tobias and Warnatz, Hans-Jörg and Ryzhova, Marina and Bender, Sebastian and Sturm, Dominik and Pleier, Sabrina and Cin, Huriye and Pfaff, Elke and Sieber, Laura and Wittmann, Anea and Remke, Marc and Witt, Henik and Hutter, Sonja and Tzaridis, Theophilos and Weischenfeldt, Joachim and Raeder, Benjamin and Avci, Meryem and Amstislavskiy, Vyacheslav and Zapatka, Marc and Weber, Ursula D and Wang, Qi and Lasitschka, Bärbel and Bartholomae, Cynthia C and Schmidt, Manfred and von Kalle, Christof and Ast, Volker and Lawerenz, Chris and Eils, Jürgen and Kabbe, Rolf and Benes, Vladimir and van Sluis, Peter and Koster, Jan and Volckmann, Richard and Shih, David and Betts, Matthew J and Russell, Robert B and Coco, Simona and Tonini, Gian Paolo and Schüller, Ulrich and Hans, Volkmar and Graf, Norbert and Kim, Yoo-Jin and Monoranu, Camelia and Roggendorf, Wolfgang and Unterberg, Aneas and Herold-Mende, Christel and Milde, Till and Kulozik, Aneas E and von Deimling, Aneas and Witt, Olaf and Maass, Eberhard and Rössler, Jochen and Ebinger, Martin and Schuhmann, Martin U and Frühwald, Michael C and Hasselblatt, Martin and Jabado, Nada and Rutkowski, Stefan and von Bueren, Ané O and Williamson, Dan and Clifford, Steven C and McCabe, Martin G and Collins, V. Peter and Wolf, Stephan and Wiemann, Stefan and Lehrach, Hans and Brors, Benedikt and Scheurlen, Wolfram and Felsberg, Jörg and Reifenberger, Guido and Northcott, Paul A and Taylor, Michael D and Meyerson, Matthew and Pomeroy, Scott L and Yaspo, Marie-Laure and Korbel, Jan O and Korshunov, Aney and Eils, Roland and Pfister, Stefan M and Lichter, Peter
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7409, pp. 100 - 105
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children,... 
ACTIVATION | PATHWAY | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | GENES | TETRAPLOID TUMOR-CELLS | TBR1 | MUTATIONS | SUBGROUPS | CANCER | Chromatin - metabolism | Cerebellar Neoplasms - diagnosis | Genomics | Humans | Hedgehog Proteins - metabolism | Wnt Proteins - metabolism | Histone Demethylases - genetics | Aging - genetics | Medulloblastoma - pathology | Cerebellar Neoplasms - pathology | Patched Receptors | Cerebellar Neoplasms - classification | Medulloblastoma - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Child | DNA Helicases - genetics | Amino Acid Sequence | Polyploidy | Signal Transduction | Chromosomes, Human - genetics | Medulloblastoma - diagnosis | Mutation Rate | Cerebellar Neoplasms - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | T-Box Domain Proteins - genetics | Genome, Human - genetics | beta Catenin - genetics | DEAD-box RNA Helicases - genetics | Phosphoprotein Phosphatases - genetics | Sequence Analysis, RNA | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | High-Throughput Nucleotide Sequencing | Methylation | Medulloblastoma - classification | Patched-1 Receptor | Receptors, Cell Surface - genetics | Medulloblastoma | Physiological aspects | Development and progression | Genetic aspects | Research | Metastasis | Cancer | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 667 - 678
Long noncoding RNAs (lncRNAs) are key regulators of chromatin state, yet the nature and sites of RNA-chromatin interaction are mostly unknown. Here we... 
X-CHROMOSOME | TELOMERASE | DOSAGE COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | COMPLEXES | POLYCOMB RESPONSE ELEMENT | GENE-EXPRESSION | PROTEINS | DROSOPHILA | SCAFFOLD | CELL BIOLOGY | Chromatin - metabolism | RNA-Binding Proteins - genetics | RNA, Untranslated - metabolism | Nucleotide Motifs - genetics | Genomics | Humans | Molecular Sequence Data | Chromatin Assembly and Disassembly - genetics | Male | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | RNA, Untranslated - genetics | Breast Neoplasms - metabolism | RNA - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Telomerase - genetics | Base Sequence | Chromosome Mapping - methods | Female | RNA, Untranslated - chemistry | Telomerase - metabolism | Chromatin - chemistry | RNA - metabolism | Genome-Wide Association Study | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Animals | Breast Neoplasms - genetics | High-Throughput Screening Assays | Histones - genetics | Wnt Signaling Pathway - genetics | RNA, Long Noncoding | Cell Line, Tumor | Drosophila Proteins - genetics | Histones - metabolism | Chromatin - genetics | RNA-Binding Proteins - metabolism | Chromatin | Lysine | DNA | Genes | Antisense RNA | Telomerase | Protein binding | Index Medicus | Nucleotide sequence | RNA | Wnt protein | Oligonucleotides | X chromosome | protein purification | Genomes | polycomb group proteins | Telomeres | genomics | Gene mapping | Methylation | Histone H3
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 03/2011, Volume 39, Issue 5, pp. 1880 - 1893
The Epstein-Barr virus (EBV) is an oncogenic human Herpes virus found in similar to 15% of diffuse large B-cell lymphoma (DLBCL). EBV encodes miRNAs and... 
TRANSCRIPTION FACTORS | MIR-155 | ACTIVATION | MESSENGER-RNA | GENE | INDUCED CYTIDINE DEAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | EXPRESSION PROFILES | BETA-CATENIN | C-MYB PROTOONCOGENE | Herpesvirus 4, Human - genetics | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-myb - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Wnt Proteins - metabolism | Epstein-Barr Virus Infections - genetics | RNA, Small Untranslated - genetics | Nuclear Proteins - genetics | Binding Sites | Cell Line | Epstein-Barr Virus Infections - virology | Gene Library | Molecular Sequence Annotation | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Lymphoma, Large B-Cell, Diffuse - virology | Proto-Oncogene Proteins c-myb - metabolism | MicroRNAs - genetics | Herpesvirus 4, Human - metabolism | Ubiquitin-Protein Ligases - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Index Medicus | Lymphoma, Large B-Cell, Diffuse | beta Catenin | Wnt Proteins | Proto-Oncogene Proteins c-myb | Herpesvirus 4, Human | Nuclear Proteins | Ubiquitin-Protein Ligases | Life Sciences | MicroRNAs | Proto-Oncogene Proteins | RNA, Small Untranslated | Epstein-Barr Virus Infections | DNA-Binding Proteins | Cancer | RNA
Journal Article
Nature medicine, ISSN 1078-8956, 2015, Volume 21, Issue 11, pp. 1350 - 1356
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 195 - 202
Journal Article