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Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 488, Issue 7413, pp. 665 - 669
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor signals. Here we find that the... 
IN-VITRO | INHIBITION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | UBIQUITYLATION | SMALL-INTESTINE | COLON | BETA-CATENIN | LGR5 | CANCER | NEGATIVE REGULATOR | Oncogene Proteins - genetics | Receptors, Wnt - antagonists & inhibitors | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Ubiquitin - metabolism | Paneth Cells - pathology | Stem Cells - cytology | Receptors, Wnt - metabolism | Stem Cells - metabolism | DNA-Binding Proteins - deficiency | Adenoma - metabolism | DNA-Binding Proteins - metabolism | Endocytosis | Ubiquitination | Lysosomes - metabolism | Stem Cells - enzymology | Tumor Suppressor Proteins - deficiency | Organoids - metabolism | Tumor Suppressor Proteins - genetics | HEK293 Cells | Colorectal Neoplasms - metabolism | Paneth Cells - metabolism | Tumor Suppressor Proteins - metabolism | Organoids - pathology | Oncogene Proteins - metabolism | Organoids - cytology | Ubiquitin-Protein Ligases - metabolism | Frizzled Receptors - metabolism | DNA-Binding Proteins - genetics | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Adenoma - pathology | Ubiquitin-Protein Ligases - deficiency | Oncogene Proteins - deficiency | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Colorectal cancer | Physiological aspects | Development and progression | Research | Gene expression | Risk factors | Proteins | Epidermal growth factor | Mutation | Kinases | Rodents | Stem cells | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 667 - 678
Long noncoding RNAs (lncRNAs) are key regulators of chromatin state, yet the nature and sites of RNA-chromatin interaction are mostly unknown. Here we... 
X-CHROMOSOME | TELOMERASE | DOSAGE COMPENSATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | COMPLEXES | POLYCOMB RESPONSE ELEMENT | GENE-EXPRESSION | PROTEINS | DROSOPHILA | SCAFFOLD | CELL BIOLOGY | Chromatin - metabolism | RNA-Binding Proteins - genetics | RNA, Untranslated - metabolism | Nucleotide Motifs - genetics | Genomics | Humans | Molecular Sequence Data | Chromatin Assembly and Disassembly - genetics | Male | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | RNA, Untranslated - genetics | Breast Neoplasms - metabolism | RNA - genetics | DNA-Binding Proteins - metabolism | Drosophila melanogaster - metabolism | Telomerase - genetics | Base Sequence | Chromosome Mapping - methods | Female | RNA, Untranslated - chemistry | Telomerase - metabolism | Chromatin - chemistry | RNA - metabolism | Genome-Wide Association Study | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Animals | Breast Neoplasms - genetics | High-Throughput Screening Assays | Histones - genetics | Wnt Signaling Pathway - genetics | RNA, Long Noncoding | Cell Line, Tumor | Drosophila Proteins - genetics | Histones - metabolism | Chromatin - genetics | RNA-Binding Proteins - metabolism | Chromatin | Lysine | DNA | Genes | Antisense RNA | Telomerase | Protein binding | Index Medicus | Nucleotide sequence | RNA | Wnt protein | Oligonucleotides | X chromosome | protein purification | Genomes | polycomb group proteins | Telomeres | genomics | Gene mapping | Methylation | Histone H3
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 03/2011, Volume 39, Issue 5, pp. 1880 - 1893
The Epstein-Barr virus (EBV) is an oncogenic human Herpes virus found in similar to 15% of diffuse large B-cell lymphoma (DLBCL). EBV encodes miRNAs and... 
TRANSCRIPTION FACTORS | MIR-155 | ACTIVATION | MESSENGER-RNA | GENE | INDUCED CYTIDINE DEAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | EXPRESSION PROFILES | BETA-CATENIN | C-MYB PROTOONCOGENE | Herpesvirus 4, Human - genetics | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-myb - genetics | MicroRNAs - metabolism | Gene Expression Profiling | Wnt Proteins - metabolism | Epstein-Barr Virus Infections - genetics | RNA, Small Untranslated - genetics | Nuclear Proteins - genetics | Binding Sites | Cell Line | Epstein-Barr Virus Infections - virology | Gene Library | Molecular Sequence Annotation | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | Lymphoma, Large B-Cell, Diffuse - virology | Proto-Oncogene Proteins c-myb - metabolism | MicroRNAs - genetics | Herpesvirus 4, Human - metabolism | Ubiquitin-Protein Ligases - genetics | Lymphoma, Large B-Cell, Diffuse - genetics | Index Medicus | Lymphoma, Large B-Cell, Diffuse | beta Catenin | Wnt Proteins | Proto-Oncogene Proteins c-myb | Herpesvirus 4, Human | Nuclear Proteins | Ubiquitin-Protein Ligases | Life Sciences | MicroRNAs | Proto-Oncogene Proteins | RNA, Small Untranslated | Epstein-Barr Virus Infections | DNA-Binding Proteins | Cancer | RNA
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2010, Volume 29, Issue 1, pp. 41 - 54
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 195 - 202
Journal Article
Developmental Cell, ISSN 1534-5807, 07/2009, Volume 17, Issue 1, pp. 110 - 122
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7493, pp. 448 - 454
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during ageing are... 
LIFE-SPAN | CAENORHABDITIS-ELEGANS | PROTEIN | CHROMATIN | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | NEURONS | MILD COGNITIVE IMPAIRMENT | SEL-12 PRESENILIN | REPRESSOR | C. ELEGANS | Neurons - pathology | Up-Regulation | Humans | Oxidative Stress - physiology | Caenorhabditis elegans Proteins - metabolism | Phagosomes | Neurons - cytology | Cognition | Autophagy | Neuroprotective Agents - metabolism | Alzheimer Disease - pathology | Brain - metabolism | DNA-Binding Proteins - metabolism | Frontotemporal Dementia - metabolism | Young Adult | Cell Nucleus - metabolism | Aging - genetics | Cell Death - genetics | Chromatin Immunoprecipitation | Repressor Proteins - deficiency | Aged, 80 and over | Neurons - metabolism | Repressor Proteins - metabolism | Wnt Signaling Pathway | Frontotemporal Dementia - pathology | Brain - cytology | Amyloid beta-Peptides - toxicity | Cognitive Dysfunction - metabolism | Down-Regulation | Gene Expression Regulation | Lewy Body Disease - pathology | Oxidative Stress - genetics | Repressor Proteins - genetics | Longevity | Aging - pathology | Lewy Body Disease - metabolism | Transcription Factors - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Alzheimer Disease - metabolism | Brain - pathology | Aged | Mice | Alzheimer Disease - genetics | Aging - metabolism | Oxidative stress | Control | Transcription factors | Neurons | Aging | Physiological aspects | Genetic aspects | Research | Alzheimer's disease | Studies | Pathology | Cognitive ability | Epigenetics | Kinases | Stress response | Gene expression | Alzheimers disease | Age | Apoptosis | Index Medicus
Journal Article
Journal Article