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Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 2877 - 2890
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V6005E/K)) that can be selectively inhibited by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | SIGNALING PATHWAY | COLORECTAL-CANCER | CUTANEOUS MELANOMA | THERAPEUTIC TARGET | ACQUIRED-RESISTANCE | MALIGNANT-MELANOMA | WNT/BETA-CATENIN PATHWAY | MEDIATES RESISTANCE | Frizzled Receptors - antagonists & inhibitors | Humans | Cell Survival - genetics | Wnt-5a Protein | Wnt Proteins - metabolism | Wnt Proteins - genetics | RNA Interference | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Frizzled Receptors - metabolism | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | beta Catenin - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Frizzled Receptors - genetics | Wnt Signaling Pathway - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Wnt Proteins - antagonists & inhibitors | Care and treatment | Oncology, Experimental | Melanoma | Genetic aspects | Research | Drug resistance | Cancer | Proteins | Studies | Medical research | Kinases | Gene expression | Experiments | Drug dosages | Patients | Tumors
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 210 - 225
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a... 
TARGET | RECRUITMENT | NMR | INHIBITION | CHROMATIN | ONCOLOGY | DISEASE | SWITCH | LEUKEMIA | BROMODOMAIN | BINDING | CELL BIOLOGY | Transcription Factors - chemistry | Carcinoma, Basal Cell - genetics | Humans | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | Histone Acetyltransferases - metabolism | Carcinoma, Basal Cell - prevention & control | Neoplastic Stem Cells - pathology | Female | Transcription, Genetic | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Acetylation | Tumor Cells, Cultured | Lysine Acetyltransferase 5 | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | Nuclear Proteins - metabolism | Carcinoma, Basal Cell - pathology | Transcription Factors - genetics | Mice, SCID | Nuclear Proteins - chemistry | Blotting, Western | Breast Neoplasms - prevention & control | Transcription Factors - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Transformation, Neoplastic | Nuclear Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Mice, Inbred NOD | Mice | HeLa Cells | Twist-Related Protein 1 - metabolism | Gene expression | Medical colleges | Breast cancer
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 01/2010, Volume 29, Issue 1, pp. 41 - 54
Journal Article
Cell, ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Osteoporosis | Bones | Density | Low density lipoproteins | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
Journal Article
PLoS Genetics, ISSN 1553-7390, 08/2016, Volume 12, Issue 8, p. e1006217
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 09/2009, Volume 28, Issue 36, pp. 3197 - 3208
The receptor tyrosine kinase Ror2 regulates cell migration by acting as a receptor or co-receptor for Wnt5a. Although Wnt5a has been implicated in the... 
Invadopodia | MMP-13 | Ror2 | Wnt5a | Osteosarcoma | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | CANCER | CELL BIOLOGY | invadopodia | INVASION | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | WNT-5A | EXPRESSION | osteosarcoma | RECEPTOR TYROSINE KINASE | DISHEVELLED PHOSPHORYLATION | RNA, Small Interfering - genetics | Oligonucleotide Array Sequence Analysis | src-Family Kinases | Protein-Tyrosine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Immunoblotting | Green Fluorescent Proteins - genetics | Receptor Tyrosine Kinase-like Orphan Receptors | Wnt-5a Protein | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cell Movement - genetics | Cell Movement - physiology | Transfection | Wnt Proteins - genetics | Osteosarcoma - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Neoplasm Invasiveness | Matrix Metalloproteinase 13 - genetics | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Matrix Metalloproteinase 13 - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Cell Surface - genetics | Control | Physiological aspects | Protein tyrosine kinase | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Cell migration | Proteins | Signal transduction | Bone cancer | Cellular biology | Gene expression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12752 - 12757
The Drosophila porcupine gene is required for secretion of wingless and other Wnt proteins, and sporadic mutations in its unique human ortholog, PORCN, cause a... 
Hypoplasia | Phenotypes | Secretion | Cell lines | Stem cells | HeLa cells | Ligands | Skin | Embryos | Porcupines | Dermis | Epidermis | Hair follicle | Skeletal development | MULTIDISCIPLINARY SCIENCES | hair follicle | GOLTZ-SYNDROME | BETA-CATENIN | skeletal development | dermis | GASTRULATION | SIGNALING PATHWAY | WINGLESS | MICE | AXIS FORMATION | MUTATIONS | PROTEINS | epidermis | SONIC-HEDGEHOG | Ectoderm - embryology | Wnt1 Protein - genetics | Humans | Molecular Sequence Data | Male | Wnt1 Protein - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | TCF Transcription Factors - metabolism | Ectoderm - metabolism | Wnt Proteins - genetics | Gene Deletion | Female | Membrane Proteins - metabolism | Disease Models, Animal | Fibroblasts - metabolism | Acyltransferases | Amino Acid Sequence | Focal Dermal Hypoplasia - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Focal Dermal Hypoplasia - genetics | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Mice, Knockout | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Wnt3 Protein | Fibroblasts - cytology | Mice | TCF Transcription Factors - genetics | Body Patterning - genetics | Drosophila | Ligands (Biochemistry) | Physiological aspects | Genetic aspects | Focal dermal hypoplasia | Research | Wnt proteins | Health aspects | Biological Sciences
Journal Article