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1. Full Text WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1
by Vassallo, I and Zinn, P and Lai, M and Rajakannu, P and Hamou, M.-F and Hegi, M.E
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Glioblastoma is the most aggressive primary brain tumor in adults and due to the invasive nature cannot be completely removed. The WNT inhibitory factor 1... 
GLIOMA-CELL LINES | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | BETA-CATENIN | CELL BIOLOGY | COLON-CANCER | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | EXPRESSION | TYROSINE KINASE ROR2 | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Wnt-5a Protein | Wnt Proteins - metabolism | Brain Neoplasms - metabolism | Cell Movement - physiology | Heterografts | Wnt Proteins - genetics | Glioblastoma - genetics | Glioblastoma - metabolism | Wnt Signaling Pathway | Proto-Oncogene Proteins - metabolism | Signal Transduction | Down-Regulation | Cell Proliferation - physiology | Brain Neoplasms - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | RNA, Long Noncoding - genetics | Animals | Repressor Proteins - biosynthesis | Mice, Nude | Glioblastoma - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Mice | RNA, Long Noncoding - metabolism | Cellular proteins | Development and progression | Genetic aspects | Cellular signal transduction | Genetic regulation | Glioblastoma multiforme | Health aspects | Oncology | Ribonucleic acid--RNA | Brain cancer | Cell adhesion & migration
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2. Full Text WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
by Anastas, Jamie N and Kulikauskas, Rima M and Tamir, Tigist and Rizos, Helen and Long, Georgina V and Von Euw, Erika M and Yang, Pei-Tzu and Chen, Hsiao-Wang and Haydu, Lauren and Toroni, Rachel A and Lucero, Olivia M and Chien, Andy J and Moon, Randall T
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 2877 - 2890
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V6005E/K)) that can be selectively inhibited by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | SIGNALING PATHWAY | COLORECTAL-CANCER | CUTANEOUS MELANOMA | THERAPEUTIC TARGET | ACQUIRED-RESISTANCE | MALIGNANT-MELANOMA | WNT/BETA-CATENIN PATHWAY | MEDIATES RESISTANCE | Frizzled Receptors - antagonists & inhibitors | Humans | Cell Survival - genetics | Wnt-5a Protein | Wnt Proteins - metabolism | Wnt Proteins - genetics | RNA Interference | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Frizzled Receptors - metabolism | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | beta Catenin - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Frizzled Receptors - genetics | Wnt Signaling Pathway - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Wnt Proteins - antagonists & inhibitors | Care and treatment | Oncology, Experimental | Melanoma | Genetic aspects | Research | Drug resistance | Cancer | Proteins | Studies | Medical research | Kinases | Gene expression | Experiments | Drug dosages | Patients | Tumors
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3. Full Text Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele
by Tarui, Tomo and Kim, Aimee and Flake, Alan and McClain, Lauren and Stratigis, John D and Fried, Inbar and Newman, Rebecca and Slonim, Donna K and Bianchi, Diana W
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 11/2017, Volume 217, Issue 5, pp. 587.e1 - 587.e10
Cell-free RNA in amniotic fluid supernatant reflects developmental changes in gene expression in the living fetus, which includes genes that are specific to... 
cell-free RNA | myelomeningocele | gene | fetus | amniotic fluid transcriptomics | RNA | PLACODE | MOUSE | NEUROPSIN | SERPINB6 | OBSTETRICS & GYNECOLOGY | Pregnancy Trimester, Second | Up-Regulation | Wnt1 Protein - genetics | Meningomyelocele - surgery | Wnt-5a Protein - genetics | Humans | Fetal Therapies | Male | rab GTP-Binding Proteins - genetics | Gene Expression Profiling | GAP-43 Protein - genetics | Zinc Finger E-box-Binding Homeobox 1 - genetics | Case-Control Studies | Amniotic Fluid - metabolism | Microarray Analysis | Adult | Female | Membrane Proteins - genetics | Down-Regulation | Gestational Age | Nerve Tissue Proteins - genetics | Zinc Finger Protein Gli3 - genetics | Pregnancy | Meningomyelocele - genetics | Transcription Factor HES-1 - genetics | Folate Receptor 1 - genetics | LIM Domain Proteins - genetics | GTPase-Activating Proteins - genetics | Inositol 1,4,5-Trisphosphate Receptors - genetics | Nervous system diseases | Pregnant women | Analysis | Genes | Myelomeningocele | Gene expression
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4. Full Text Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer
by Shi, Jian and Wang, Yifan and Wang, Chi and Zeng, Lei and Zeng, Yi-Xin and Wu, Yadi and Deng, Jiong and Zhang, Qiang and Zhang, Guangtao and Lin, Yiwei and Li, Junlin and Kang, Tiebang and Tao, Min and Rusinova, Elena and Zhu, Haining and Yao, Jun and Evers, B. Mark and Zhou, Binhua P and Zhou, Ming-Ming
Cancer Cell, ISSN 1535-6108, 02/2014, Volume 25, Issue 2, pp. 210 - 225
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a... 
TARGET | RECRUITMENT | NMR | INHIBITION | CHROMATIN | ONCOLOGY | DISEASE | SWITCH | LEUKEMIA | BROMODOMAIN | BINDING | CELL BIOLOGY | Transcription Factors - chemistry | Carcinoma, Basal Cell - genetics | Humans | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | Histone Acetyltransferases - metabolism | Carcinoma, Basal Cell - prevention & control | Neoplastic Stem Cells - pathology | Female | Transcription, Genetic | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Acetylation | Tumor Cells, Cultured | Lysine Acetyltransferase 5 | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Twist-Related Protein 1 - antagonists & inhibitors | Neoplasm Invasiveness | Nuclear Proteins - metabolism | Carcinoma, Basal Cell - pathology | Transcription Factors - genetics | Mice, SCID | Nuclear Proteins - chemistry | Blotting, Western | Breast Neoplasms - prevention & control | Transcription Factors - metabolism | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Transformation, Neoplastic | Nuclear Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Mice, Inbred NOD | Mice | HeLa Cells | Twist-Related Protein 1 - metabolism | Gene expression | Medical colleges | Breast cancer
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5. Full Text Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress
by Zhang, Peng and Zhou, Lujun and Pei, Chunli and Lin, Xinhua and Yuan, Zengqiang
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, p. 19418
Secreted Wnts play diverse roles in a non-cell-autonomous fashion. However, the cell-autonomous effect of unsecreted Wnts remains unknown. Endoplasmic... 
UNFOLDED PROTEIN RESPONSE | WNT SECRETION | WG SECRETION | MULTIDISCIPLINARY SCIENCES | PARKINSON DISEASE | RETROMER COMPLEX | ENDOPLASMIC-RETICULUM STRESS | FOCAL DERMAL HYPOPLASIA | P24 PROTEINS | DROSOPHILA | TRANSMEMBRANE PROTEIN | Cell Line | Wnt1 Protein - genetics | Endoplasmic Reticulum - genetics | Receptors, G-Protein-Coupled - metabolism | Wnt-5a Protein - genetics | Membrane Proteins - genetics | Humans | Endoplasmic Reticulum - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Wnt1 Protein - metabolism | Coat Protein Complex I - genetics | Coat Protein Complex I - metabolism | Drosophila Proteins - metabolism | Protein Transport - genetics | Wnt-5a Protein - metabolism | Animals | Endoplasmic Reticulum Stress | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Receptors, G-Protein-Coupled - genetics | Drosophila Proteins - genetics | Drosophila melanogaster | Intracellular Signaling Peptides and Proteins - genetics | Golgi Apparatus - genetics | Wnt protein | Retrograde transport | Secretion | Endoplasmic reticulum | Mammalian cells | Golgi apparatus
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6. Full Text Wnt5a regulates distinct signalling pathways by binding to Frizzled2
by Sakane, Hiroshi and Sato, Akira and Yamamoto, Hideki and Kikuchi, Akira and Koyama, Hirofumi
The EMBO Journal, ISSN 0261-4189, 01/2010, Volume 29, Issue 1, pp. 41 - 54
Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the specificity of these pathways is not well understood. This study... 
endocytosis | β‐catenin | Wnt5a | Rac | Frizzled2 | β-catenin | Endocytosis | beta-catenin | ACTIVATION | LRP6 PHOSPHORYLATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | RECEPTOR | MOUSE EMBRYO | CELL BIOLOGY | AXIS FORMATION | WNT-5A | LDL-Receptor Related Proteins - metabolism | Wnt Proteins - pharmacology | RNA, Small Interfering - genetics | Phosphorylation | Cricetulus | Receptors, G-Protein-Coupled - metabolism | Humans | Wnt Proteins - deficiency | rac GTP-Binding Proteins - metabolism | L Cells (Cell Line) | Wnt-5a Protein | Wnt Proteins - metabolism | Wnt Proteins - genetics | CHO Cells | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | Recombinant Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Cricetinae | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Mice, Inbred C57BL | Frizzled Receptors - metabolism | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | beta Catenin - metabolism | Clathrin - metabolism | Mice, Knockout | Animals | Protein Binding | Wnt3 Protein | Mice | HeLa Cells | Wnt Proteins - antagonists & inhibitors | Wnt3A Protein | Proteins | Signal transduction | Cellular biology | Molecular biology | Binding sites
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7. Full Text LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
by Gong, Y and Slee, R. B and Fukai, N and Rawadi, G and Roman-Roman, S and Reginato, A. M and Wang, H and Cundy, T and Glorieux, F. H and Lev, D and Zacharin, M and Oexle, K and Marcelino, J and Suwairi, W and Heeger, S and Sabatakos, G and Apte, S and Adkins, W. N and Allgrove, J and Arslan-Kirchner, M and Batch, J. A and Beighton, P and Black, G. C and Boles, R. G and Boon, L. M and Borrone, C and Brunner, H. G and Carle, G. F and Dallapiccola, B and de Paepe, A and Floege, B and Halfhide, M. L and Hall, B and Hennekam, R. C and Hirose, T and Jans, A and Jüppner, H and Kim, C. A and Keppler-Noreuil, K and Kohlschuetter, A and Lacombe, D and Lambert, M and Lemyre, E and Letteboer, T and Peltonen, L and Ramesar, R. S and Romanengo, M and Somer, H and Steichen-Gersdorf, E and Steinmann, B and Sullivan, B and Superti-Furga, A and Swoboda, W and van den Boogaard, M. J and van Hul, W and Vikkula, M and Votruba, M and Zabel, B and Garcia, T and Baron, R and Olsen, B. R and Warman, M. L and Osteoporosis Pseudoglioma Syndrome and Osteoporosis-Pseudoglioma Syndrome Collaborative Group
Cell, ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Osteoporosis | Bones | Density | Low density lipoproteins | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
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8. Full Text Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I
by Dass, Randall A and Sarshad, Aishe A and Carson, Brittany B and Feenstra, Jennifer M and Kaur, Amanpreet and Obrdlik, Ales and Parks, Matthew M and Prakash, Varsha and Love, Damon K and Pietras, Kristian and Serra, Rosa and Blanchard, Scott C and Percipalle, Piergiorgio and Brown, Anthony M. C and Vincent, C. Theresa and Avdelningen för translationell cancerforskning and Lund University and BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation and Division of Translational Cancer Research and Lunds universitet
PLoS Genetics, ISSN 1553-7390, 08/2016, Volume 12, Issue 8, p. e1006217
Ribosome biogenesis is essential for cell growth and proliferation and is commonly elevated in cancer. Accordingly, numerous oncogene and tumor suppressor... 
PROTEIN | INHIBITION | DEACETYLATION | BIOGENESIS | PHOSPHORYLATION | QUANTIFICATION | GENETICS & HEREDITY | UBF | SIRT7 | BETA-CATENIN | CANCER | Promoter Regions, Genetic | Wnt-5a Protein - genetics | Humans | Gene Expression Regulation, Neoplastic | Dishevelled Proteins - metabolism | Nucleolus Organizer Region - genetics | RNA, Ribosomal - genetics | Wnt-5a Protein - metabolism | Breast Neoplasms - genetics | MCF-7 Cells | Wnt Signaling Pathway - genetics | Breast Neoplasms - pathology | Protein Binding | Transcription, Genetic | Dishevelled Proteins - genetics | Sirtuins - genetics | Chromatin - genetics | RNA Polymerase I - genetics | DNA, Ribosomal - genetics | Physiological aspects | Genetic transcription | Wnt proteins | Observations | RNA polymerases | Immunoglobulins | Funding | Genes | Biosynthesis | Breast cancer | Experiments | Proteins | Studies | Cell growth | Microscopy | Rodents | Localization | Deoxyribonucleic acid--DNA | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi | Deoxyribonucleic acid | DNA
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9. Full Text Transcriptional Profiling Shows Altered Expression of Wnt Pathway– and Lipid Metabolism–Related Genes as Well as Melanogenesis-Related Genes in Melasma
by Kang, Hee Young and Suzuki, Itaru and Lee, Dong Jun and Ha, Jaehyun and Reiniche, Pascale and Aubert, Jérôme and Deret, Sophie and Zugaj, Didier and Voegel, Johannes J and Ortonne, Jean-Paul
Journal of Investigative Dermatology, ISSN 0022-202X, 08/2011, Volume 131, Issue 8, pp. 1692 - 1700
Melasma is a commonly acquired hyperpigmentary disorder of the face, but its pathogenesis is poorly understood and its treatment remains challenging. We... 
PATHOGENESIS | IRRADIATION | SKIN | IN-VIVO | DISEASE | DERMATOLOGY | Immunohistochemistry | Wnt1 Protein - genetics | Membrane Glycoproteins - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Middle Aged | Gene Expression Profiling | Wnt1 Protein - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | In Situ Hybridization | Wnt Proteins - genetics | Adult | Lipid Metabolism - genetics | Repressor Proteins - metabolism | Melanosis - genetics | Proto-Oncogene Proteins - metabolism | Melanosis - metabolism | Oxidoreductases - metabolism | Oxidoreductases - genetics | Frizzled Receptors - metabolism | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Melanocytes - physiology | Melanosis - pathology | Membrane Glycoproteins - genetics | Frizzled Receptors - genetics | Adaptor Proteins, Signal Transducing - genetics | Receptors, G-Protein-Coupled - genetics | Adaptor Proteins, Signal Transducing - metabolism
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10. Full Text Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a Ror2 signaling
by Enomoto, M and Hayakawa, S and Itsukushima, S and Ren, D.Y and Matsuo, M and Tamada, K and Oneyama, C and Okada, M and Takumi, T and Nishita, M and Minami, Y
Oncogene, ISSN 0950-9232, 09/2009, Volume 28, Issue 36, pp. 3197 - 3208
The receptor tyrosine kinase Ror2 regulates cell migration by acting as a receptor or co-receptor for Wnt5a. Although Wnt5a has been implicated in the... 
Invadopodia | MMP-13 | Ror2 | Wnt5a | Osteosarcoma | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | CANCER | CELL BIOLOGY | invadopodia | INVASION | ONCOLOGY | PATHWAY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | WNT-5A | EXPRESSION | osteosarcoma | RECEPTOR TYROSINE KINASE | DISHEVELLED PHOSPHORYLATION | RNA, Small Interfering - genetics | Oligonucleotide Array Sequence Analysis | src-Family Kinases | Protein-Tyrosine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Extracellular Matrix - metabolism | Immunoblotting | Green Fluorescent Proteins - genetics | Receptor Tyrosine Kinase-like Orphan Receptors | Wnt-5a Protein | Wnt Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cell Movement - genetics | Cell Movement - physiology | Transfection | Wnt Proteins - genetics | Osteosarcoma - metabolism | Proto-Oncogene Proteins - metabolism | Green Fluorescent Proteins - metabolism | Neoplasm Invasiveness | Matrix Metalloproteinase 13 - genetics | Receptors, Cell Surface - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Pyrimidines - pharmacology | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Matrix Metalloproteinase 13 - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Osteosarcoma - genetics | Microscopy, Fluorescence | Osteosarcoma - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Receptors, Cell Surface - genetics | Control | Physiological aspects | Protein tyrosine kinase | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors | Cell migration | Proteins | Signal transduction | Bone cancer | Cellular biology | Gene expression
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11. Full Text Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
by Jared J. Barrott and Gabriela M. Cash and Aaron P. Smith and Jeffery R. Barrow and L. Charles Murtaugh
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2011, Volume 108, Issue 31, pp. 12752 - 12757
The Drosophila porcupine gene is required for secretion of wingless and other Wnt proteins, and sporadic mutations in its unique human ortholog, PORCN, cause a... 
Hypoplasia | Phenotypes | Secretion | Cell lines | Stem cells | HeLa cells | Ligands | Skin | Embryos | Porcupines | Dermis | Epidermis | Hair follicle | Skeletal development | MULTIDISCIPLINARY SCIENCES | hair follicle | GOLTZ-SYNDROME | BETA-CATENIN | skeletal development | dermis | GASTRULATION | SIGNALING PATHWAY | WINGLESS | MICE | AXIS FORMATION | MUTATIONS | PROTEINS | epidermis | SONIC-HEDGEHOG | Ectoderm - embryology | Wnt1 Protein - genetics | Humans | Molecular Sequence Data | Male | Wnt1 Protein - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Embryo, Mammalian - metabolism | TCF Transcription Factors - metabolism | Ectoderm - metabolism | Wnt Proteins - genetics | Gene Deletion | Female | Membrane Proteins - metabolism | Disease Models, Animal | Fibroblasts - metabolism | Acyltransferases | Amino Acid Sequence | Focal Dermal Hypoplasia - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Focal Dermal Hypoplasia - genetics | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Mice, Knockout | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Wnt3 Protein | Fibroblasts - cytology | Mice | TCF Transcription Factors - genetics | Body Patterning - genetics | Drosophila | Ligands (Biochemistry) | Physiological aspects | Genetic aspects | Focal dermal hypoplasia | Research | Wnt proteins | Health aspects | Biological Sciences
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12. Full Text Wnt-5a/frizzled9 receptor signaling through the Gαo-Gβγ complex regulates dendritic spine formation
by Ramírez, Valerie T and Ramos-Fernández, Eva and Henríquez, Juan Pablo and Lorenzo, Alfredo and Inestrosa, Nibaldo C
Journal of Biological Chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 36, pp. 19092 - 19107
Wnt ligands play crucial roles in the development and regulation of synapse structure and function. Specifically, Wnt-5a acts as a secreted growth factor that... 
GTP-Binding Protein gamma Subunits - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Wnt-5a Protein - genetics | GTP-Binding Protein gamma Subunits - genetics | Rats | GTP-Binding Protein alpha Subunits - genetics | Dendritic Spines - metabolism | Hippocampus - cytology | Receptors, Neurotransmitter - genetics | Rats, Sprague-Dawley | Hippocampus - metabolism | Wnt-5a Protein - metabolism | Animals | Signal Transduction - physiology | Dendritic Spines - genetics | Mice | Receptors, Neurotransmitter - metabolism | GTP-Binding Protein beta Subunits - metabolism | Cell Line, Transformed | GTP-Binding Protein beta Subunits - genetics | Wnt signaling | Neurobiology | G protein-coupled receptor (GPCR) | dendritic spine | synaptic plasticity | Frizzled receptor | heterotrimeric G protein | hippocampal neuron
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