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Structure, ISSN 0969-2126, 10/2011, Volume 19, Issue 10, pp. 1433 - 1442
Journal Article
Nature, ISSN 0028-0836, 04/2003, Volume 422, Issue 6934, pp. 905 - 909
Inappropriate activation of downstream target genes by the oncoprotein β-catenin is implicated in development of numerous human cancers. β-catenin and its... 
PROTEIN | GENE | WINGLESS SIGNAL | MULTIDISCIPLINARY SCIENCES | XENOPUS EMBRYOS | INTERFERENCE | MAMMALIAN-CELLS | EXPRESSION | DROSOPHILA | ARMADILLO | LEF-1 | Wnt1 Protein | Cytoskeletal Proteins - antagonists & inhibitors | Humans | Transcriptional Activation | Molecular Sequence Data | Wnt Proteins | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Trans-Activators - chemistry | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Armadillo Domain Proteins | RNA Interference | Trans-Activators - genetics | Conserved Sequence | Carrier Proteins - chemistry | Cytoskeletal Proteins - metabolism | Nuclear Proteins - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | beta Catenin | RNA, Messenger - genetics | Zebrafish Proteins | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Cytoskeletal Proteins - chemistry | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Phenotype | Animals | Carrier Proteins - metabolism | Epistasis, Genetic | Protein Binding | Trans-Activators - metabolism | Drosophila Proteins - genetics | Trans-Activators - antagonists & inhibitors | COS Cells | Proteins | Genetics | Genes | Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 15, pp. 5954 - 5963
Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a... 
Molecules | HT29 cells | HEK293 cells | HCT116 cells | Epithelial cells | Drosophila | Medical treatment | Cell lines | Cells | Tumors | High-throughput s.creen | T.hiazole | T.hiazolidinedione | Beta-catenin | O.xazole | beta-catenin | thiazolidinedione | MULTIDISCIPLINARY SCIENCES | E-CADHERIN | PHOSPHORYLATED BETA-CATENIN | DROSOPHILA | oxazole | high-throughput screen | BREAST-CANCER CELLS | WNT PROTEINS | APC | WNT/BETA-CATENIN | COLORECTAL-CANCER | thiazole | ACTIVATED-RECEPTOR-GAMMA | HOT-SPOTS | Transcription, Genetic - drug effects | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Colonic Neoplasms - drug therapy | Humans | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Oxazoles - chemistry | Wnt Proteins - genetics | RNA Interference | Antineoplastic Agents - isolation & purification | Oxazoles - isolation & purification | Drosophila Proteins - antagonists & inhibitors | Oxazoles - therapeutic use | Genes, Reporter | Antineoplastic Agents - chemistry | beta Catenin - genetics | Xenograft Model Antitumor Assays | Animals | High-Throughput Screening Assays | Small Molecule Libraries | beta Catenin - antagonists & inhibitors | Cell Line, Tumor | Mice | Drosophila Proteins - genetics | Wnt Proteins - antagonists & inhibitors | Drosophila melanogaster | Drug Screening Assays, Antitumor | Cellular signal transduction | Genetic aspects | Genetic screening | Methods | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, p. e112698
Background: Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and in more advanced cases, aberrant matrix... 
PROGENITOR CELLS | REGENERATION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | ALCOHOLIC LIVER-DISEASE | DEFINITIVE ENDODERM | PANCREAS | SPECIFICATION | BETA-CATENIN | HEPATOCYTE-LIKE CELLS | EFFICIENT DIFFERENTIATION | Cyclin D1 - metabolism | Embryonic Stem Cells - metabolism | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Embryonic Stem Cells - cytology | Nitriles - pharmacology | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Wnt1 Protein - metabolism | Hepatocytes - metabolism | Quinolines - pharmacology | Cyclin D1 - antagonists & inhibitors | Hepatocytes - cytology | MAP Kinase Kinase 4 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Hepatocytes - drug effects | Imides - pharmacology | Cell Line | Butadienes - pharmacology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Feeder Cells | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | beta Catenin - metabolism | beta Catenin - genetics | Ethanol - pharmacology | Animals | Activins - pharmacology | Cyclin D1 - genetics | Embryonic Stem Cells - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | beta Catenin - antagonists & inhibitors | MAP Kinase Kinase 4 - genetics | Fibroblasts - cytology | Mice | Mitogen-Activated Protein Kinase 1 - metabolism | Wnt protein | Liver | Differentiation (biology) | Alcohol | Cyclin D1 | β-catenin | Signal transduction | Pathways | Cell fate | Rodents | Cell cycle | Inhibition | Injuries | Biomedical engineering | Ethanol | Internal medicine | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Inflammation | Cell differentiation | Embryos | Medicine | Regeneration | Signaling | Inhibitors | Hepatocytes | Stem cells | Cells (biology) | Alcoholic beverages | Aberration
Journal Article
Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7598, pp. 250 - 254
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 713 - 721
The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null... 
TARGETED DISRUPTION | ZEBRAFISH | LACKING HUNTINGTIN | EMBRYONIC STEM-CELLS | MUTANT HUNTINGTIN | ADAM10 | MICE | DISEASE GENE HOMOLOG | WILD-TYPE HUNTINGTIN | NEUROSCIENCES | N-CADHERIN CLEAVAGE | Body Patterning - drug effects | Guanylate Kinases - genetics | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Wnt1 Protein - genetics | Brain - embryology | PAX2 Transcription Factor - metabolism | Cadherins - metabolism | Apoptosis - drug effects | Embryo, Mammalian | Hedgehog Proteins - metabolism | Apoptosis - genetics | Green Fluorescent Proteins - genetics | Brain - metabolism | NFI Transcription Factors - metabolism | Cadherins - genetics | Tissue Inhibitor of Metalloproteinase-1 - pharmacology | Discs Large Homolog 1 Protein | Membrane Proteins - genetics | Gene Expression Regulation, Developmental - drug effects | PAX2 Transcription Factor - genetics | Cell Adhesion - drug effects | Mutation - genetics | Biological Evolution | Brain - drug effects | Huntingtin Protein | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Analysis of Variance | Membrane Proteins - antagonists & inhibitors | Cell Adhesion - physiology | Embryo, Nonmammalian | Guanylate Kinases - metabolism | Neuroepithelial Cells - physiology | Mice | Zebrafish Proteins - genetics | ADAM Proteins - genetics | Cerebral Ventricles - cytology | Drosophila melanogaster | Neuroepithelial Cells - drug effects | Embryonic Stem Cells - metabolism | Nestin | Immunoprecipitation | Gene Expression Regulation, Developmental - genetics | Wnt1 Protein - metabolism | Zebrafish - embryology | Cell Differentiation - genetics | Transfection | Hedgehog Proteins - genetics | Intermediate Filament Proteins - genetics | Neurons - physiology | Membrane Proteins - metabolism | Cerebral Ventricles - embryology | Neurons - drug effects | Nuclear Proteins - genetics | Hydroxamic Acids - pharmacology | Green Fluorescent Proteins - metabolism | Brain - cytology | ADAM Proteins - antagonists & inhibitors | Animals, Genetically Modified | Zebrafish Proteins - metabolism | Dipeptides - pharmacology | Cells, Cultured | ADAM10 Protein | Morpholines - pharmacology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Dictyostelium | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Body Patterning - genetics | Huntington's chorea | Physiological aspects | Cadherins | Genetic aspects | Research | Embryonic stem cells | Risk factors
Journal Article
Annals of Hematology, ISSN 0939-5555, 5/2012, Volume 91, Issue 5, pp. 645 - 669
Animal models are established tools to study basic questions of biology in a systematic way. They have greatly facilitated our understanding of the mechanisms... 
Wnt/ß-Catenin | Hedgehog | Medicine & Public Health | Hematology | Notch | Oncology | MLL | Runt | Wnt/β-Catenin | INHIBITORY FACTOR-I | ACUTE MYELOID-LEUKEMIA | HUMAN BREAST-CANCER | BETA-CATENIN | SIGNALING PATHWAY | ACUTE LYMPHOBLASTIC-LEUKEMIA | HEMATOPOIETIC STEM-CELLS | CHRONIC LYMPHOCYTIC-LEUKEMIA | HEMATOLOGY | Wnt/beta-Catenin | SET-DOMAIN PROTEIN | SONIC-HEDGEHOG | Neoplasms - metabolism | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Prognosis | Receptors, Notch - metabolism | Humans | Hedgehog Proteins - metabolism | Receptors, Notch - genetics | Antineoplastic Agents - therapeutic use | Wnt1 Protein - metabolism | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Receptors, Notch - antagonists & inhibitors | Hedgehog Proteins - genetics | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | Drosophila - genetics | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Histone-Lysine N-Methyltransferase | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Myeloid-Lymphoid Leukemia Protein - genetics | Nuclear Proteins - antagonists & inhibitors | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Myeloid-Lymphoid Leukemia Protein - antagonists & inhibitors | Magneto-electric machines | Fruit-flies | Developmental biology | Analysis | Drosophila | Oncology, Experimental | Research | Machinery | Cancer
Journal Article
Development (Cambridge, England), ISSN 0950-1991, 04/2018, Volume 145, Issue 8, pp. dev155325 - dev155325
Journal Article
Cancer Research, ISSN 0008-5472, 10/2013, Volume 73, Issue 19, pp. 6068 - 6079
Chromosomal translocations juxtaposing the androgen-responsive TMPRSS2 promoter with the ETS-family transcription factor ERG result in aberrant ERG... 
ANDROGEN RECEPTOR | CELLS | ACTIVATION | ONCOLOGY | GENE REARRANGEMENTS | TMPRSS2-ERG FUSION | FAVORABLE PROGNOSIS | TRANSCRIPTION | BETA-CATENIN | WNT | TMPRSS2/ERG FUSION | Transcriptional Regulator ERG | Prostatic Neoplasms - metabolism | RNA, Small Interfering - genetics | Wnt1 Protein - antagonists & inhibitors | Wnt1 Protein - genetics | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Humans | Lymphoid Enhancer-Binding Factor 1 - genetics | Receptors, Androgen - metabolism | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Wnt1 Protein - metabolism | Immunoenzyme Techniques | Prostatic Neoplasms - genetics | Chromatin Immunoprecipitation | Trans-Activators - genetics | Biomarkers, Tumor - metabolism | Real-Time Polymerase Chain Reaction | Prostatic Neoplasms - pathology | Signal Transduction | Neoplasm Invasiveness | RNA, Messenger - genetics | Lymphoid Enhancer-Binding Factor 1 - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Lymphoid Enhancer-Binding Factor 1 - metabolism | beta Catenin - metabolism | Blotting, Western | beta Catenin - genetics | Receptors, Androgen - genetics | Fluorescent Antibody Technique | Cell Line, Tumor | Trans-Activators - metabolism | Biomarkers, Tumor - genetics | Trans-Activators - antagonists & inhibitors | Cell Movement
Journal Article
Medical Science Monitor, ISSN 1234-1010, 09/2018, Volume 24, pp. 6608 - 6616
Background: G-protein receptor 125 (GPR125), as a transmembrane signal transducer, is involved in regulating cancer development. Although GPR125 is related... 
Genes, suppressor | Prognosis |